329 Matching Annotations
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    Profound synthetic lethality between SMARCAL1 and FANCM
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    sciencedirect.com/science/article/pii/S1097276524008566
  3. Nov 2024
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    IL-21/IL-21R signaling renders acute myeloid leukemia stem cells more susceptible to cytarabine treatment and CAR T cell therapy
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    sciencedirect.com/science/article/pii/S2666379124005974
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    Acute multi-level response to defective de novo chromatin assembly in S-phase
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    sciencedirect.com/science/article/pii/S1097276524008633
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    Chromatin protein complexes involved in gene repression in lamina-associated domains
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    pmc.ncbi.nlm.nih.gov/articles/PMC11535540/
  7. Oct 2024
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    Type I IFN drives unconventional IL-1β secretion in lupus monocytes
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      plasmid_12253

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    sciencedirect.com/science/article/pii/S1074761324004485
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    Protocol for the efficient and inducible generation of CRISPR-Cas9-edited human cortical neurons from the iCas9-iNgn2 hPSCs
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      RRID: Addgene_12253

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    sciencedirect.com/science/article/pii/S2666166724005173
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    Generation of a PARPi-sensitive homozygous BRCA1-methylated OVCAR8 cell line using targeted CRISPR gene editing
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      RRID:Addgene_12253

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    biorxiv.org/content/10.1101/2024.09.23.614644v1
  11. Sep 2024
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    P53-dependent hypusination of eIF5A affects mitochondrial translation and senescence immune surveillance
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    ncbi.nlm.nih.gov/pmc/articles/PMC11358140/
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    SLC13A3 is a major effector downstream of activated β-catenin in liver cancer pathogenesis
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    ncbi.nlm.nih.gov/pmc/articles/PMC11364541/
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    Atlastin-1 regulates endosomal tubulation and lysosomal proteolysis in human cortical neurons
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    1. scibot 29 Sep 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11300884/
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    EFFECTS OF ARYL HYDROCARBON RECEPTOR LIGAND TCDD ON HUMAN TROPHOBLAST CELL DEVELOPMENT
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    1. scibot 28 Sep 2024
      12253

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    ncbi.nlm.nih.gov/pmc/articles/PMC11383004/
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neuroendocrine Prostate Cancer Drivers SOX2 and BRN2 Confer Differential Responses to Imipridones ONC201, ONC206, and ONC212 in Prostate Cancer Cell Lines
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      12253

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    Atrial fibrillation variant-to-gene prioritization through cross-ancestry eQTL and single-nucleus multiomic analyses
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    SHANK3 depletion leads to ERK signalling overdose and cell death in KRAS-mutant cancers
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    CD8α Structural Domains Enhance GUCY2C CAR-T Cell Efficacy
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    ncbi.nlm.nih.gov/pmc/articles/PMC11423665/
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    IKKɛ induces STING non-IFN immune responses via a mechanism analogous to TBK1
    1
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      Plasmid_12253

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    Ligand requirements for immunoreceptor triggering
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    The Proteasome and Cul3-Dependent Protein Ubiquitination Is Required for Gli Protein-Mediated Activation of Gene Expression in the Hedgehog Pathway
    1
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      pRSV-Rev

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    ncbi.nlm.nih.gov/pmc/articles/PMC11394618/
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    Exploring the transcriptional cooperation between RUNX2 and its associated elncRNA RAIN
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    ncbi.nlm.nih.gov/pmc/articles/PMC11399121/
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    CCR2 cooperativity promotes hematopoietic stem cell homing to the bone marrow
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    Cancer cell stiffening via CoQ10 and UBIAD1 regulates ECM signaling and ferroptosis in breast cancer
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    Targeting NAT10 inhibits osteosarcoma progression via ATF4/ASNS-mediated asparagine biosynthesis
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    GCN2 is a determinant of the response to WEE1 kinase inhibition in small-cell lung cancer
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      RRID:Addgene_12253

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    Targeting heterozygous dominant negative variant of KCNA2 using Gapmer antisense oligonucleotides (ASO) for the treatment of drug-resistant epilepsy
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  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A naturally occurring 22-amino acid fragment of human hemoglobin A inhibits autophagy and HIV-1
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      plasmid_12

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    Protocol to identify receptors of secreted proteins through CRISPR-Cas9 whole-genome screening technology
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    RUVBL1/2 Blockade Targets YTHDF1 Activity to Suppress m6A-Dependent Oncogenic Translation and Colorectal Tumorigenesis
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  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mitigation of synaptic and memory impairments via F-actin stabilization in Alzheimer’s disease
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  33. www.biorxiv.org www.biorxiv.org
    Inseparable/IER3IP1 are essential for cytokinesis in Drosophila neuroblast and human cells
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  34. Aug 2024
  35. www.sciencedirect.com www.sciencedirect.com
    Gemcitabine therapeutically disrupts essential SIRT1-mediated p53 repression in atypical teratoid/rhabdoid tumors
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    Disruption of nuclear speckle integrity dysregulates RNA splicing in C9ORF72-FTD/ALS
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    Engineering a “muco‐trapping” ACE2‐immunoglobulin hybrid with picomolar affinity as an inhaled, pan‐variant immunotherapy for COVID‐19
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      pRSV‐Rev

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    ncbi.nlm.nih.gov/pmc/articles/PMC11256170/
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    De Novo Multi-Omics Pathway Analysis Designed for Prior Data Independent Inference of Cell Signaling Pathways
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    Development of KoRV-pseudotyped lentiviral vectors for efficient gene transfer into freshly isolated immune cells
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    Evaluation of DNA minicircles for delivery of adenine and cytosine base editors using activatable gene on “GO” reporter imaging systems
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    The molecular basis underlying T cell specificity towards citrullinated epitopes presented by HLA-DR4
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      pRSV-REV

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    ncbi.nlm.nih.gov/pmc/articles/PMC11266596/
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Distinctive In Vitro Phenotypes in iPSC-Derived Neurons From Patients With Gain- and Loss-of-Function SCN2A Developmental and Epileptic Encephalopathy
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      12253

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    ncbi.nlm.nih.gov/pmc/articles/PMC10883610/
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Time-of-day effects of cancer drugs revealed by high-throughput deep phenotyping
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    ncbi.nlm.nih.gov/pmc/articles/PMC11339390/
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The NR4A2/VGF pathway fuels inflammation-induced neurodegeneration via promoting neuronal glycolysis
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      DOI: 10.1172/JCI177692

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    EphA3-targeted chimeric antigen receptor T cells are effective in glioma and generate curative memory T cell responses
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    Nuclear PKM2 binds pre-mRNA at folded G-quadruplexes and reveals their gene regulatory role
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    Protocol for the application of single-cell damage in murine intestinal organoid models
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      plasmid_12253

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  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Peptidylarginine deiminase 3 modulates response to neratinib in HER2 positive breast cancer
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  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Circular RNAs regulate neuron size and migration of midbrain dopamine neurons during development
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  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Novel Luciferase-Based Reporter Gene Technology for Simultaneous Optical and Radionuclide Imaging of Cells
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      pRSV-REV

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  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation
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  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Intercellular transfer of cancer cell invasiveness via endosome-mediated protease shedding
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  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Acetylation-induced proteasomal degradation of the activated glucocorticoid receptor limits hormonal signaling
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  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Safety and feasibility of anti-CD19 CAR T cells expressing inducible IL-7 and CCL19 in patients with relapsed or refractory large B-cell lymphoma
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  55. www.researchsquare.com www.researchsquare.com
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  56. Jul 2024
  57. www.sciencedirect.com www.sciencedirect.com
    ATAD1 prevents clogging of TOM and damage caused by un-imported mitochondrial proteins
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  58. www.embopress.org www.embopress.org
    DUSP6 inhibition overcomes neuregulin/HER3-driven therapy tolerance in HER2+ breast cancer
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  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DUSP6 inhibition overcomes neuregulin/HER3-driven therapy tolerance in HER2+ breast cancer
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  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Metformin synergizes with gilteritinib in treating FLT3-mutated leukemia via targeting PLK1 signaling
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  61. www.cell.com www.cell.com
    Endoplasmic reticulum morphology regulation by RTN4 modulates neuronal regeneration by curbing luminal transport
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    Early rhombic lip Protogenin+ve stem cells in a human-specific neurovascular niche initiate and maintain group 3 medulloblastoma
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    Genetic ablation of adhesion ligands mitigates rejection of allogeneic cellular immunotherapies
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  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    High-Throughput Discovery and Characterization of Viral Transcriptional Effectors in Human Cells
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  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Generation and characterization of inducible KRAB-dCas9 iPSCs from primates for cross-species CRISPRi
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  66. Jun 2024
  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genetically Encoded XTEN‐based Hydrogels with Tunable Viscoelasticity and Biodegradability for Injectable Cell Therapies
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  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR/Cas9 screening reveals a distinct class of MHC-I binders with precise HLA-peptide recognition
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  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tumour-derived Extracellular Vesicle and Particle Reprogramming of Interstitial Macrophages in the Lung Pre-Metastatic Niche Enhances Vascular Permeability and Metastatic Potential
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  70. www.sciencedirect.com www.sciencedirect.com
    STING orchestrates the neuronal inflammatory stress response in multiple sclerosis
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    The epithelial adherens junction component PLEKHA7 regulates ECM remodeling and cell behavior through miRNA-mediated regulation of MMP1 and LOX
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  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cadherin-11 contributes to the heterogenous and dynamic Wnt-Wnt-β-catenin pathway activation in Ewing sarcoma
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  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mechanistic patterns and clinical implications of oncogenic tyrosine kinase fusions in human cancers
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  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TPX2 overexpression promotes sensitivity to dasatinib in breast cancer by activating YAP transcriptional signaling
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  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR-Cas9 editing of synaptic genes in human embryonic stem cells for functional analysis in induced human neurons
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  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Prickle1‐driven basement membrane deposition of the iPSC‐derived embryoid bodies is separable from the establishment of apicobasal polarity
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  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BRCA1/BARD1 ubiquitinates PCNA in unperturbed conditions to promote continuous DNA synthesis
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  78. www.sciencedirect.com www.sciencedirect.com
    The ribotoxic stress response drives UV-mediated cell death
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  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Disease-linked mutations in Munc18-1 deplete synaptic Doc2
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  80. www.sciencedirect.com www.sciencedirect.com
    Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress
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  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lack of SPNS1 results in accumulation of lysolipids and lysosomal storage disease in mouse models
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      DOI: 10.1172/jci.insight.175462

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  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ATP6AP2, a regulator of LRP6/β-catenin protein trafficking, promotes Wnt/β-catenin signaling and bone formation in a cell type dependent manner
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  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Protocol for preclinical evaluation of locoregionally delivered CAR T cells in patient-derived xenograft models of brain tumors
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  84. May 2024
  85. journals.asm.org journals.asm.org
    The recruitment of TRiC chaperonin in rotavirus viroplasms correlates with virus replication
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  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Catalytically distinct IDH1 mutants tune phenotype severity in tumor models
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  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR/Cas9 genome editing of CCR5 combined with C46 HIV-1 fusion inhibitor for cellular resistant to R5 and X4 tropic HIV-1
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  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    KDM7A-DT induces genotoxic stress, tumorigenesis, and progression of p53 missense mutation-associated invasive breast cancer
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  89. link.springer.com link.springer.com
    Sex- and species-specific contribution of CD99 to T cell costimulation during multiple sclerosis
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  90. link.springer.com link.springer.com
    Imaging CAR-NK cells targeted to HER2 ovarian cancer with human sodium-iodide symporter-based positron emission tomography
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  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    New AAV9 engineered variants with enhanced neurotropism and reduced liver off-targeting in mice and marmosets
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  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Prolonged depletion of profilin 1 or F-actin causes an adaptive response in microtubules
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      12253

      DOI: 10.1083/jcb.202309097

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    ncbi.nlm.nih.gov/pmc/articles/PMC11082369/
  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Hippo kinases control inflammatory Hippo signaling and restrict bacterial infection in phagocytes
    1
    1. scibot 12 May 2024
      Addgene_12253

      DOI: 10.1128/mbio.03429-23

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    ncbi.nlm.nih.gov/pmc/articles/PMC11078001/
  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cell competition promotes metastatic intestinal cancer through a multistage process
    1
    1. scibot 09 May 2024
      Addgene12253

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    ncbi.nlm.nih.gov/pmc/articles/PMC11068562/
  95. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Method for the Production of Recombinant VSVs with Confirmation of Biological Activity
    1
    1. scibot 05 May 2024
      12253

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    ncbi.nlm.nih.gov/pmc/articles/PMC11062106/
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NFATC2IP is a mediator of SUMO-dependent genome integrity
    1
    1. scibot 05 May 2024
      12253

      DOI: 10.1101/gad.350914.123

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    ncbi.nlm.nih.gov/pmc/articles/PMC11065178/
  97. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MILIP Binding to tRNAs Promotes Protein Synthesis to Drive Triple-Negative Breast Cancer
    1
    1. scibot 04 May 2024
      RRID:Addgene_12253

      DOI: 10.1158/0008-5472.CAN-23-3046

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    ncbi.nlm.nih.gov/pmc/articles/PMC11063688/
  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Influenza Virus Reduces Ubiquitin E3 Ligase MARCH10 Expression to Decrease Ciliary Beat Frequency
    1
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      RRID:Addgene_12253

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    ncbi.nlm.nih.gov/pmc/articles/PMC10151042/
  99. Apr 2024
  100. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A disease-associated PPP2R3C-MAP3K1 phospho-regulatory module controls centrosome function
    1
    1. scibot 30 Apr 2024
      Addgene_12253

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    ncbi.nlm.nih.gov/pmc/articles/PMC11014585/
  101. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Combined SNPs sequencing and allele specific proteomics capture reveal functional causality underpinning the 2p25 prostate cancer susceptibility locus
    1
    1. scibot 30 Apr 2024
      12253

      DOI: 10.21203/rs.3.rs-3943095/v1

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    ncbi.nlm.nih.gov/pmc/articles/PMC11030545/
  102. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Temporal coordination of the transcription factor response to H2O2 stress
    1
    1. scibot 30 Apr 2024
      12253

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    ncbi.nlm.nih.gov/pmc/articles/PMC11039679/
  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Stepwise Stiffening/Softening of and Cell Recovery from Reversibly Formulated Hydrogel Double Networks
    1
    1. scibot 30 Apr 2024
      Addgene_12253

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    ncbi.nlm.nih.gov/pmc/articles/PMC11030224/
  104. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IQGAP3 Is an Important Mediator of Skin Inflammatory Diseases
    1
    1. scibot 29 Apr 2024
      2253

      DOI: 10.3390/ijms25084545

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    ncbi.nlm.nih.gov/pmc/articles/PMC11050236/
  105. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MHC class I-dressing is mediated via phosphatidylserine recognition and is enhanced by polyI:C
    1
    1. scibot 29 Apr 2024
      Addgene_12253

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    ncbi.nlm.nih.gov/pmc/articles/PMC11046299/
  106. www.sciencedirect.com www.sciencedirect.com
    Exploiting a subtype-specific mitochondrial vulnerability for successful treatment of colorectal peritoneal metastases
    1
    1. scibot 26 Apr 2024
      AddGene12253

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    sciencedirect.com/science/article/pii/S2666379124001927
  107. www.sciencedirect.com www.sciencedirect.com
    Functional sensory circuits built from neurons of two species
    1
    1. scibot 26 Apr 2024
      Addgene Cat# 12253

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    sciencedirect.com/science/article/pii/S0092867424003581
  108. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An EBV-related CD4 TCR immunotherapy inhibits tumor growth in an HLA-DP5+ nasopharyngeal cancer mouse model
    1
    1. scibot 23 Apr 2024
      REV

      DOI: 10.1172/JCI172092

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    ncbi.nlm.nih.gov/pmc/articles/PMC11014665/
  109. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Histone H2A variant H2A.B is enriched in transcriptionally active and replicating HSV-1 lytic chromatin
    1
    1. scibot 23 Apr 2024
      pRSV-Rev

      DOI: 10.1128/jvi.02015-23

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    ncbi.nlm.nih.gov/pmc/articles/PMC11019955/
  110. aacrjournals.org aacrjournals.org
    Sarcoma cells secrete hypoxia-modified collagen VI to weaken the lung endothelial barrier and promote metastasis
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      RRID:Addgene_12253

      DOI: 10.1158/0008-5472.CAN-23-0910

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    aacrjournals.org/cancerres/article/84/7/977/742043/Sarcoma-Cells-Secrete-Hypoxia-Modified-Collagen-VI
  111. aacrjournals.org aacrjournals.org
    Hypoxia-responsive CAR-T cells exhibit reduced exhaustion and enhanced efficacy in solid tumors
    1
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      RRID:Addgene_12253

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    aacrjournals.org/cancerres/article/84/1/84/731816/Hypoxia-Responsive-CAR-T-Cells-Exhibit-Reduced
  112. www.sciencedirect.com www.sciencedirect.com
    Targeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti-tumor secretome
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    1. scibot 16 Apr 2024
      RRID:Addgene_12253

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    sciencedirect.com/science/article/pii/S221112472400439X
  113. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Detecting subtle transcriptomic perturbations induced by lncRNAs knock-down in single-cell CRISPRi screening using a new sparse supervised autoencoder neural network
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    1. scibot 15 Apr 2024
      12,253

      DOI: 10.3389/fbinf.2024.1340339

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    ncbi.nlm.nih.gov/pmc/articles/PMC10945021/
  114. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Insulin signalling regulates Pink1 mRNA localization via modulation of AMPK activity to support PINK1 function in neurons
    1
    1. scibot 15 Apr 2024
      pRSV-Rev

      DOI: 10.1038/s42255-024-01007-w

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    ncbi.nlm.nih.gov/pmc/articles/PMC10963278/
  115. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Small-molecule correctors divert CFTR-F508del from ERAD by stabilizing sequential folding states
    1
    1. scibot 15 Apr 2024
      12253

      DOI: 10.1091/mbc.E23-08-0336

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    ncbi.nlm.nih.gov/pmc/articles/PMC10881158/
  116. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Original research: Circular RNA as a source of neoantigens for cancer vaccines
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    1. scibot 15 Apr 2024
      Addgene_12253

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    ncbi.nlm.nih.gov/pmc/articles/PMC10952939/
  117. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting of vulnerabilities of drug-tolerant persisters identified through functional genetics delays tumor relapse
    1
    1. scibot 14 Apr 2024
      12253

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    ncbi.nlm.nih.gov/pmc/articles/PMC10983104/
  118. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mesenchymal glioma stem cells trigger vasectasia—distinct neovascularization process stimulated by extracellular vesicles carrying EGFR
    1
    1. scibot 13 Apr 2024
      12253

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    ncbi.nlm.nih.gov/pmc/articles/PMC10991552/
  119. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrated proteomics reveals autophagy landscape and an autophagy receptor controlling PKA-RI complex homeostasis in neurons
    1
    1. scibot 13 Apr 2024
      12253

      DOI: 10.1038/s41467-024-47440-z

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    ncbi.nlm.nih.gov/pmc/articles/PMC11006854/
  120. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FcRn regulates antigen presentation in dendritic cells downstream of DEC205-targeted vaccines
    1
    1. scibot 13 Apr 2024
      12253

      DOI: 10.1038/s41541-024-00854-8

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    ncbi.nlm.nih.gov/pmc/articles/PMC11003989/
  121. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The recruitment of TRiC chaperonin in rotavirus viroplasms correlates with virus replication
    1
    1. scibot 13 Apr 2024
      RRID:Addgene_12253

      DOI: 10.1128/mbio.00499-24

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    ncbi.nlm.nih.gov/pmc/articles/PMC11005421/
  122. www.sciencedirect.com www.sciencedirect.com
    Human iPSC 4R tauopathy model uncovers modifiers of tau propagation
    1
    1. scibot 09 Apr 2024
      Addgene_12253

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    sciencedirect.com/science/article/pii/S0092867424003064
  123. Mar 2024
  124. www.sciencedirect.com www.sciencedirect.com
    RPGR is a guanine nucleotide exchange factor for the small GTPase RAB37 required for retinal function via autophagy regulation
    1
    1. scibot 28 Mar 2024
      12253, Addgene

      DOI: 10.1016/j.celrep.2024.114010

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    sciencedirect.com/science/article/pii/S2211124724003383
  125. www.sciencedirect.com www.sciencedirect.com
    Endocytic activation and exosomal secretion of matriptase stimulate the second wave of EGF signaling to promote skin and breast cancer invasion
    1
    1. scibot 28 Mar 2024
      Addgene plasmid#12253

      DOI: 10.1016/j.celrep.2024.114002

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    sciencedirect.com/science/article/pii/S2211124724003309
  126. www.sciencedirect.com www.sciencedirect.com
    A gut-derived hormone regulates cholesterol metabolism
    1
    1. scibot 19 Mar 2024
      RRID: Addgene_12253

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    sciencedirect.com/science/article/pii/S0092867424002265
  127. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NOTUM-MEDIATED WNT SILENCING DRIVES EXTRAVILLOUS TROPHOBLAST CELL LINEAGE DEVELOPMENT
    1
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      12253

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    ncbi.nlm.nih.gov/pmc/articles/PMC10888853/
  128. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Novel meriolin derivatives activate the mitochondrial apoptosis pathway in the presence of antiapoptotic Bcl-2
    1
    1. scibot 17 Mar 2024
      12253

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    ncbi.nlm.nih.gov/pmc/articles/PMC10924942/
  129. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An engineered biosensor enables dynamic aspartate measurements in living cells
    1
    1. scibot 17 Mar 2024
      12253

      DOI: 10.7554/eLife.90024

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    ncbi.nlm.nih.gov/pmc/articles/PMC10942590/
  130. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Novel Estrogen Receptor Dimerization BRET-Based Biosensors for Screening Estrogenic Endocrine-Disrupting Chemicals
    1
    1. scibot 17 Mar 2024
      12253

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    ncbi.nlm.nih.gov/pmc/articles/PMC10923609/
  131. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The ubiquitin ligase HUWE1 enhances WNT signaling by antagonizing destruction complex-mediated β-catenin degradation and through a mechanism independent of β-catenin stability
    1
    1. scibot 17 Mar 2024
      plasmid_12253

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  132. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR/Cas9 model of prostate cancer identifies Kmt2c deficiency as a metastatic driver by Odam/Cabs1 gene cluster expression
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    1. scibot 17 Mar 2024
      Addgene_12253

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  133. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FH variant pathogenicity promotes purine salvage pathway dependence in kidney cancer
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      RRID:Addgene_12253

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    ncbi.nlm.nih.gov/pmc/articles/PMC10527600/
  134. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    scAbsolute: measuring single-cell ploidy and replication status
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      RRID:Addgene_12253

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    ncbi.nlm.nih.gov/pmc/articles/PMC10910719/
  135. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Disease-associated polyalanine expansion mutations impair UBA6-dependent ubiquitination
    1
    1. scibot 01 Mar 2024
      pRSV-Rev

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    ncbi.nlm.nih.gov/pmc/articles/PMC10897158/
  136. Feb 2024
  137. www.sciencedirect.com www.sciencedirect.com
    A di-acetyl-decorated chromatin signature couples liquid condensation to suppress DNA end synapsis
    1
    1. scibot 29 Feb 2024
      AddgeneCat#12253

      DOI: 10.1016/j.molcel.2024.02.002

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    sciencedirect.com/science/article/pii/S1097276524000984
  138. www.sciencedirect.com www.sciencedirect.com
    The proteomic landscape of genotoxic stress-induced micronuclei
    1
    1. scibot 29 Feb 2024
      Addgene 12253

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    sciencedirect.com/science/article/pii/S1097276524000972
  139. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structural basis for antibody recognition of the proximal MUC16 ectodomain
    1
    1. scibot 29 Feb 2024
      pRSV-Rev

      DOI: 10.1186/s13048-024-01373-9

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    ncbi.nlm.nih.gov/pmc/articles/PMC10875768/
  140. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Epigenomic analyses identify FOXM1 as a key regulator of anti-tumor immune response in esophageal adenocarcinoma
    1
    1. scibot 29 Feb 2024
      12253

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    ncbi.nlm.nih.gov/pmc/articles/PMC10876663/
  141. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Production of infectious reporter murine norovirus by VP2 trans-complementation
    1
    1. scibot 29 Feb 2024
      pRSV-Rev

      DOI: 10.1128/jvi.01261-23

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    ncbi.nlm.nih.gov/pmc/articles/PMC10878090/
  142. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SARS-CoV-2 and oncolytic EV-D68-encoded proteases differentially regulate pyroptosis
    1
    1. scibot 29 Feb 2024
      12253

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    ncbi.nlm.nih.gov/pmc/articles/PMC10878271/
  143. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    POZ/BTB and AT hook containing zinc finger 1 (PATZ1) suppresses differentiation and regulates metabolism in human embryonic stem cells
    1
    1. scibot 29 Feb 2024
      REV

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  144. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The exocyst complex and intracellular vesicles mediate soluble protein trafficking to the primary cilium
    1
    1. scibot 29 Feb 2024
      pRSV-rev

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  145. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Engineering an Autonucleolytic Mammalian Suspension Host Cell Line to Reduce DNA Impurity Levels in Serum-Free Lentiviral Process Streams
    1
    1. scibot 29 Feb 2024
      12253

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  146. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Agent-based modeling of the prostate tumor microenvironment uncovers spatial tumor growth constraints and immunomodulatory properties
    1
    1. scibot 29 Feb 2024
      pRSV-Rev

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  147. link.springer.com link.springer.com
    Endothelial lipase variant T111I does not alter inhibition by angiopoietin-like proteins
    1
    1. scibot 22 Feb 2024
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    link.springer.com/article/10.1038/s41598-024-54705-6
  148. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Combined therapy of CAR-IL-15/IL-15Rα-T cells and GLIPR1 knockdown in cancer cells enhanced anti-tumor effect against gastric cancer
    1
    1. scibot 21 Feb 2024
      pRSV-Rev

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  149. www.sciencedirect.com www.sciencedirect.com
    Stem-like progenitor and terminally differentiated TFH-like CD4+ T cell exhaustion in the tumor microenvironment
    2
    1. scibot 16 Feb 2024
      Addgene_12253

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    sciencedirect.com/science/article/pii/S2211124724001256
  150. www.biorxiv.org www.biorxiv.org
    PTPRZ1-targeting RNA CAR-T cells exert antigen-specific and bystander antitumor activity in glioblastoma
    1
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    biorxiv.org/content/10.1101/2023.12.23.573190v1
  151. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hyaluronic acid turnover controls the severity of cerebral cavernous malformations in bioengineered human micro-vessels
    1
    1. scibot 15 Feb 2024
      12253

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  152. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sequential CRISPR screening reveals partial NatB inhibition as a strategy to mitigate alpha-synuclein levels in human neurons
    1
    1. scibot 15 Feb 2024
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  153. journals.plos.org journals.plos.org
    CRISPR screen for protein inclusion formation uncovers a role for SRRD in the regulation of intermediate filament dynamics and aggresome assembly
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    1. scibot 09 Feb 2024
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    journals.plos.org/plosgenetics/article
  154. www.sciencedirect.com www.sciencedirect.com
    Retrospective identification of cell-intrinsic factors that mark pluripotency potential in rare somatic cells
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    1. scibot 09 Feb 2024
      Plasmid_12253

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    sciencedirect.com/science/article/pii/S240547122400022X
  155. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting the SphK1/S1P/PFKFB3 axis suppresses hepatocellular carcinoma progression by disrupting glycolytic energy supply that drives tumor angiogenesis
    1
    1. scibot 08 Feb 2024
      pRSV-Rev

      DOI: 10.1186/s12967-023-04830-z

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    ncbi.nlm.nih.gov/pmc/articles/PMC10782643/
  156. www.sciencedirect.com www.sciencedirect.com
    Pharmacological inhibition of neddylation impairs long interspersed element 1 retrotransposition
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    1. scibot 08 Feb 2024
      RRID:Addgene_12253

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    sciencedirect.com/science/article/pii/S2211124724000779
  157. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A synthetic agent ameliorates polycystic kidney disease by promoting apoptosis of cystic cells through increased oxidative stress
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    1. scibot 01 Feb 2024
      pRSV-Rev

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    ncbi.nlm.nih.gov/pmc/articles/PMC10823221/
  158. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    K-Ras(V12) differentially affects the three Akt isoforms in lung and pancreatic carcinoma cells and upregulates E-cadherin and NCAM via Akt3
    1
    1. scibot 01 Feb 2024
      pRSV-REV

      DOI: 10.1186/s12964-024-01484-2

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    ncbi.nlm.nih.gov/pmc/articles/PMC10826106/
  159. Jan 2024
  160. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RBL2 represses the transcriptional activity of Multicilin to inhibit multiciliogenesis
    1
    1. scibot 30 Jan 2024
      12253

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    ncbi.nlm.nih.gov/pmc/articles/PMC10803754/
  161. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PICH deficiency limits the progression of MYC-induced B-cell lymphoma
    1
    1. scibot 30 Jan 2024
      12253

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    ncbi.nlm.nih.gov/pmc/articles/PMC10803365/
  162. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Isolation and Characterization of Neutralizing Monoclonal Antibodies from a Large Panel of Murine Antibodies against RBD of the SARS-CoV-2 Spike Protein
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    1. scibot 29 Jan 2024
      Addgene #12253

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    ncbi.nlm.nih.gov/pmc/articles/PMC10801580/
  163. www.mdpi.com www.mdpi.com
    Exo70 Promotes the Invasion of Pancreatic Cancer Cells via the Regulation of Exosomes
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    1. scibot 18 Jan 2024
      RRID:Addgene_12253

      DOI: 10.3390/cancers16020336

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    mdpi.com/2072-6694/16/2/336
  164. link.springer.com link.springer.com
    Selective gene expression maintains human tRNA anticodon pools during differentiation
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      RRID:Addgene_12253

      DOI: 10.1038/s41556-023-01317-3

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  165. www.sciencedirect.com www.sciencedirect.com
    PAPAS promotes differentiation of mammary epithelial cells and suppresses breast carcinogenesis
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  166. Dec 2023
  167. www.sciencedirect.com www.sciencedirect.com
    KDM5B predicts temozolomide-resistant subclones in glioblastoma
    2
    1. scibot 20 Dec 2023
      RRID: Addgene_12253

      DOI: 10.1016/j.isci.2023.108596

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    sciencedirect.com/science/article/pii/S2589004223026731
  168. www.sciencedirect.com www.sciencedirect.com
    The MHC-E peptide ligands for checkpoint CD94/NKG2A are governed by inflammatory signals, whereas LILRB1/2 receptors are peptide indifferent
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    1. scibot 20 Dec 2023
      Addgene Cat: 12253

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    sciencedirect.com/science/article/pii/S2211124723015280
  169. link.springer.com link.springer.com
    Rational optimization of a transcription factor activation domain inhibitor
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    1. scibot 08 Dec 2023
      RRID:Addgene_12253

      DOI: 10.1038/s41594-023-01159-5

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    link.springer.com/article/10.1038/s41594-023-01159-5
  170. Nov 2023
  171. www.sciencedirect.com www.sciencedirect.com
    An integrated in vitro human iPSCs-derived neuron and in vivo animal approach for preclinical screening of anti-seizure compounds
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      RRID:Addgene_12253

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  172. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Optimized peptide nanofibrils as efficient transduction enhancers for in vitro and ex vivo gene transfer
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    1. scibot 26 Nov 2023
      plasmid_12253

      DOI: 10.3389/fimmu.2023.1270243

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  173. www.sciencedirect.com www.sciencedirect.com
    CRISPR/Cas9 screens unravel miR-3689a-3p regulating sorafenib resistance in hepatocellular carcinoma via suppressing CCS/SOD1-dependent mitochondrial oxidative stress
    1
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      RRID:Addgene_12

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  174. Oct 2023
  175. www.sciencedirect.com www.sciencedirect.com
    Regulation of STING activity in DNA sensing by ISG15 modification
    1
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      RRID: Addgene_12253

      DOI: 10.1016/j.celrep.2023.113277

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  176. www.sciencedirect.com www.sciencedirect.com
    Sequential activation of E2F via Rb degradation and c-Myc drives resistance to CDK4/6 inhibitors in breast cancer
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      RRID: Addgene_12253

      DOI: 10.1016/j.celrep.2023.113198

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  177. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Preclinical development of a chimeric antigen receptor T cell therapy targeting FGFR4 in rhabdomyosarcoma
    1
    1. scibot 26 Oct 2023
      Plasmid_12253

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  178. www.nature.com www.nature.com
    Chromatin-modifying enzymes as modulators of nuclear size during lineage differentiation
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      DOI: 10.1038/s41420-023-01639-z

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  179. Sep 2023
  180. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Insights into product and process related challenges of lentiviral vector bioprocessing
    1
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      RRID:Addgene_12253

      DOI: 10.1002/bit.28498

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  181. www.sciencedirect.com www.sciencedirect.com
    Mechanosensitive accumulation of non-muscle myosin IIB during mitosis requires its translocation activity
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      plasmid_12253

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  182. 52.53.155.43 52.53.155.43
    vdad120-html.html
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  183. www.biorxiv.org www.biorxiv.org
    TPX2 expression promotes sensitivity to dasatinib in breast cancer by activating the YAP transcriptional signaling
    1
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      DOI: 10.1101/2023.09.04.556165

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  184. Aug 2023
  185. www.sciencedirect.com www.sciencedirect.com
    Multiple genes in a single GWAS risk locus synergistically mediate aberrant synaptic development and function in human neurons
    1
    1. scibot 30 Aug 2023
      RRID:Addgene_12253

      DOI: 10.1016/j.xgen.2023.100399

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    sciencedirect.com/science/article/pii/S2666979X23002136
  186. www.biorxiv.org www.biorxiv.org
    Endothelial Lipase Variant, T111I, Does Not Alter Inhibition by Angiopoietin-like Proteins
    1
    1. scibot 29 Aug 2023
      plasmid_12253

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    biorxiv.org/content/10.1101/2023.08.18.553740v1
  187. www.sciencedirect.com www.sciencedirect.com
    MARCH7-mediated ubiquitination decreases the solubility of ATG14 to inhibit autophagy
    1
    1. scibot 27 Aug 2023
      RRID:Addgene_12253

      DOI: 10.1016/j.celrep.2023.113045

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    sciencedirect.com/science/article/pii/S2211124723010562
  188. www.nature.com www.nature.com
    Efficient generation of functional neurons from mouse embryonic stem cells via neurogenin-2 expression
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    1. scibot 24 Aug 2023
      plasmid_12253

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    nature.com/articles/s41596-023-00863-2
  189. www.sciencedirect.com www.sciencedirect.com
    IL-2 can signal via chemokine receptors to promote regulatory T cells’ suppressive function
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    1. scibot 23 Aug 2023
      RRID:Addgene_12253

      DOI: 10.1016/j.celrep.2023.112996

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    sciencedirect.com/science/article/pii/S2211124723010070
  190. 52.53.155.43 52.53.155.43
    Membrane-localized neoantigens predict the efficacy of cancer immunotherapy
    3
    1. scibot 12 Aug 2023
      Addgene #12253

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    3. scibot 10 Aug 2023
      Addgene_12253

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    52.53.155.43/9f1a09025b86686c62561e67323b0c82e4153e7b/PIIS2666379123002987-html.html
  191. Jul 2023
  192. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Early protective effect of a (“pan”) coronavirus vaccine (PanCoVac) in Roborovski dwarf hamsters after single-low dose intranasal administration
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    1. scibot 29 Jul 2023
      plasmid_12253

      DOI: 10.3389/fimmu.2023.1166765

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    ncbi.nlm.nih.gov/pmc/articles/PMC10372429/
  193. www.sciencedirect.com www.sciencedirect.com
    Parallel CRISPR-Cas9 screens identify mechanisms of PLIN2 and lipid droplet regulation
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    sciencedirect.com/science/article/pii/S1534580723003313
  194. www.sciencedirect.com www.sciencedirect.com
    Targeting of multiple tumor-associated antigens by individual T cell receptors during successful cancer immunotherapy
    1
    1. scibot 27 Jul 2023
      RRID:Addgene_12253

      DOI: 10.1016/j.cell.2023.06.020

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    sciencedirect.com/science/article/pii/S0092867423006967
  195. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Coding and non-coding elements comprise a regulatory network controlling transcription in Kaposi’s sarcoma-associated herpesvirus
    1
    1. scibot 25 Jul 2023
      plasmid_12253

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    ncbi.nlm.nih.gov/pmc/articles/PMC10350069/
  196. pubs.acs.org pubs.acs.org
    SIRIUS, Ultra-Scintillating Upconversion Breast Implant for Remote Orthotopic Photodynamic Therapy
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      RRID:Addgene_12253

      DOI: 10.1021/acsnano.3c01916

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  197. 52.53.155.43 52.53.155.43
    cir-22-0815-html.html
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      DOI: 10.1158/2326-6066.CIR-22-0815

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    52.53.155.43/0c7b493d1804c631a7718bd69d23acbb033c9efb/cir-22-0815-html.html
  198. Jun 2023
  199. www.sciencedirect.com www.sciencedirect.com
    Microbiota-produced indole metabolites disrupt mitochondrial function and inhibit Cryptosporidium parvum growth
    1
    1. scibot 29 Jun 2023
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    sciencedirect.com/science/article/pii/S2211124723006915
  200. www.sciencedirect.com www.sciencedirect.com
    FIRRM/C1orf112 is synthetic lethal with PICH and mediates RAD51 dynamics
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    1. scibot 23 Jun 2023
      plasmid_12253

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    sciencedirect.com/science/article/pii/S2211124723006794
  201. www.biorxiv.org www.biorxiv.org
    Transcriptional landscape of DTP-DTEP transition reveals DUSP6 as a driver of HER2 inhibitor tolerance via Neuregulin/HER3 axis
    1
    1. scibot 22 Jun 2023
      addgene_12253

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    biorxiv.org/content/10.1101/2023.06.14.544493v1
  202. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CDT1 inhibits CMG helicase in early S phase to separate origin licensing from DNA synthesis
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      Addgene_12253

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    ncbi.nlm.nih.gov/pmc/articles/PMC7614657/
  203. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SLIT2/ROBO1 signaling suppresses mTORC1 for organelle control and bacterial killing
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      RRID:Addgene_12253

      DOI: 10.26508/lsa.202301964

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    ncbi.nlm.nih.gov/pmc/articles/PMC10264968/
  204. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Disruption of the gut microbiota confers cisplatin resistance in epithelial ovarian cancer
    1
    1. scibot 17 Jun 2023
      RRID:Addgene_12253

      DOI: 10.1158/0008-5472.CAN-22-0455

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    ncbi.nlm.nih.gov/pmc/articles/PMC9772178/
  205. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IKKβ primes inflammasome formation by recruiting NLRP3 to the trans-Golgi network
    1
    1. scibot 14 Jun 2023
      RRID:Addgene_12253

      DOI: 10.1016/j.immuni.2022.10.021

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    ncbi.nlm.nih.gov/pmc/articles/PMC7614333/
  206. aacrjournals.org aacrjournals.org
    Targeting RNA exonuclease XRN1 potentiates efficacy of cancer immunotherapy
    1
    1. scibot 09 Jun 2023
      RRID:Addgene_12253

      DOI: 10.1158/0008-5472.CAN-21-3052

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    aacrjournals.org/cancerres/article/83/6/922/718565/Targeting-RNA-Exonuclease-XRN1-Potentiates
  207. May 2023
  208. www.embopress.org www.embopress.org
    Presynaptic targeting of botulinum neurotoxin type A requires a tripartite PSG-Syt1-SV2 plasma membrane nanocluster for synaptic vesicle entry
    1
    1. scibot 28 May 2023
      RRID:Addgene_12253

      DOI: 10.15252/embj.2022112095

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    embopress.org/doi/10.15252/embj.2022112095
  209. www.sciencedirect.com www.sciencedirect.com
    Actuation of single downstream nodes in growth factor network steers immune cell migration
    1
    1. scibot 24 May 2023
      Plasmid_12253

      DOI: 10.1016/j.devcel.2023.04.019

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    sciencedirect.com/science/article/pii/S1534580723001958
  210. www.mdpi.com www.mdpi.com
    Optimal Expression, Function, and Immunogenicity of an HIV-1 Vaccine Derived from the Approved Ebola Vaccine, rVSV-ZEBOV
    1
    1. scibot 18 May 2023
      RRID:Addgene_12253

      DOI: 10.3390/vaccines11050977

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    mdpi.com/2076-393X/11/5/977
  211. www.sciencedirect.com www.sciencedirect.com
    MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells
    1
    1. scibot 10 May 2023
      RRID: Addgene 12253

      DOI: 10.1016/j.celrep.2023.112484

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    sciencedirect.com/science/article/pii/S2211124723004953
  212. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A rabies virus–based toolkit for efficient retrograde... : Neural Regeneration Research
    1
    1. scibot 06 May 2023
      Addgene, Cat# 12253

      DOI: 10.4103/1673-5374.358618

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    ncbi.nlm.nih.gov/pmc/articles/PMC10154474/
  213. www.sciencedirect.com www.sciencedirect.com
    TOPK inhibits TNF-α-induced granulosa cell apoptosis via regulation SIRT1/p53
    1
    1. scibot 04 May 2023
      RRID:Addgene_12253

      DOI: 10.1016/j.bbrc.2023.04.113

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    sciencedirect.com/science/article/pii/S0006291X23005508
  214. Apr 2023
  215. www.nature.com www.nature.com
    Arg-tRNA synthetase links inflammatory metabolism to RNA splicing and nuclear trafficking via SRRM2
    1
    1. scibot 18 Apr 2023
      RRID:Addgene_12253

      DOI: 10.1038/s41556-023-01118-8

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    nature.com/articles/s41556-023-01118-8