1,531 Matching Annotations
  1. Feb 2024
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mutations in the non-catalytic polyproline motif destabilize TREX1 and amplify cGAS-STING signaling
    1
    1. scibot 01 Feb 2024
      12259

      DOI: 10.1101/2024.01.04.574136

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    ncbi.nlm.nih.gov/pmc/articles/PMC10802300/
  3. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Generation of a Porcine Cell Line Stably Expressing Pig TMPRSS2 for Efficient Isolation of Swine Influenza Virus
    1
    1. scibot 01 Feb 2024
      RRID:Addgene_12259

      DOI: 10.3390/pathogens13010018

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    ncbi.nlm.nih.gov/pmc/articles/PMC10818301/
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation
    1
    1. scibot 01 Feb 2024
      Addgene_12259

      DOI: 10.1038/s42255-024-00978-0

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    ncbi.nlm.nih.gov/pmc/articles/PMC10896723/
  5. Jan 2024
  6. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    ASPM stabilizes the NOTCH intracellular domain 1 and promotes oncogenesis by blocking FBXW7 binding in hepatocellular carcinoma cells
    1
    1. scibot 31 Jan 2024
      RRID:Addgene_12259

      DOI: 10.1002/1878-0261.13589

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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13589
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The CUL5 E3 ligase complex negatively regulates central signaling pathways in CD8+ T cells
    1
    1. scibot 30 Jan 2024
      12259

      DOI: 10.1038/s41467-024-44885-0

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    ncbi.nlm.nih.gov/pmc/articles/PMC10798966/
  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CircNUP50 is a novel therapeutic target that promotes cisplatin resistance in ovarian cancer by modulating p53 ubiquitination
    1
    1. scibot 30 Jan 2024
      pMD2

      DOI: 10.1186/s12951-024-02295-w

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    ncbi.nlm.nih.gov/pmc/articles/PMC10799427/
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Characterizing the secretome of EGFR mutant lung adenocarcinoma
    1
    1. scibot 30 Jan 2024
      Plasmid #12259

      DOI: 10.3389/fonc.2023.1286821

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    ncbi.nlm.nih.gov/pmc/articles/PMC10801028/
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Chimeric antigen-receptor (CAR) engineered natural killer cells in a chronic myeloid leukemia (CML) blast crisis model
    1
    1. scibot 30 Jan 2024
      pMD2.G

      DOI: 10.3389/fimmu.2023.1309010

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    ncbi.nlm.nih.gov/pmc/articles/PMC10801069/
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RBL2 represses the transcriptional activity of Multicilin to inhibit multiciliogenesis
    1
    1. scibot 30 Jan 2024
      12259

      DOI: 10.1038/s41419-024-06440-z

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    ncbi.nlm.nih.gov/pmc/articles/PMC10803754/
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PICH deficiency limits the progression of MYC-induced B-cell lymphoma
    1
    1. scibot 30 Jan 2024
      12259

      DOI: 10.1038/s41408-024-00979-y

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    ncbi.nlm.nih.gov/pmc/articles/PMC10803365/
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Epigenetic priming targets tumor heterogeneity to shift transcriptomic phenotype of pancreatic ductal adenocarcinoma towards a Vitamin D susceptible state
    1
    1. scibot 30 Jan 2024
      pMD2.G

      DOI: 10.1038/s41419-024-06460-9

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    ncbi.nlm.nih.gov/pmc/articles/PMC10810848/
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    UBR5 promotes antiviral immunity by disengaging the transcriptional brake on RIG-I like receptors
    1
    1. scibot 30 Jan 2024
      #12259

      DOI: 10.1038/s41467-024-45141-1

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    ncbi.nlm.nih.gov/pmc/articles/PMC10817939/
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Reconstitution of human PDAC using primary cells reveals oncogenic transcriptomic features at tumor onset
    1
    1. scibot 30 Jan 2024
      Addgene, Watertown, MA, #12259

      DOI: 10.1038/s41467-024-45097-2

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    ncbi.nlm.nih.gov/pmc/articles/PMC10821902/
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Novel mechanism of drug resistance triggered by tumor-associated macrophages through Heat Shock Factor-1 activation
    1
    1. scibot 30 Jan 2024
      pMD2.G

      DOI: 10.1007/s00262-023-03612-2

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    ncbi.nlm.nih.gov/pmc/articles/PMC10821977/
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LDLR is used as a cell entry receptor by multiple alphaviruses
    1
    1. scibot 30 Jan 2024
      plasmid_12259

      DOI: 10.1038/s41467-024-44872-5

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    ncbi.nlm.nih.gov/pmc/articles/PMC10799924/
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LUBAC-mediated M1 Ub regulates necroptosis by segregating the cellular distribution of active MLKL
    1
    1. scibot 30 Jan 2024
      plasmid_12259

      DOI: 10.1038/s41419-024-06447-6

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    ncbi.nlm.nih.gov/pmc/articles/PMC10799905/
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Loss of postsynaptic NMDARs drives nanoscale reorganization of Munc13-1 and PSD-95
    1
    1. scibot 30 Jan 2024
      RRID:Addgene_12259

      DOI: 10.1101/2024.01.12.574705

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    ncbi.nlm.nih.gov/pmc/articles/PMC10802569/
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functional Analysis of KAP1/TRIM28 Requirements for HIV-1 Transcription Activation
    1
    1. scibot 29 Jan 2024
      Addgene, Watertown, MA, USA, catalog 12259

      DOI: 10.3390/v16010116

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    ncbi.nlm.nih.gov/pmc/articles/PMC10819576/
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Secreted Particle Information Transfer (SPIT) – A Cellular Platform for In Vivo Genetic Engineering
    1
    1. scibot 29 Jan 2024
      VSV-g (12259)

      DOI: 10.1101/2024.01.11.575257

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    ncbi.nlm.nih.gov/pmc/articles/PMC10802600/
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Vascular injury activates the ELK1/SND1/SRF pathway to promote vascular smooth muscle cell proliferative phenotype and neointimal hyperplasia
    1
    1. scibot 29 Jan 2024
      RRID:Addgene_12259

      DOI: 10.1007/s00018-023-05095-x

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    ncbi.nlm.nih.gov/pmc/articles/PMC10817852/
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Isolation and Characterization of Neutralizing Monoclonal Antibodies from a Large Panel of Murine Antibodies against RBD of the SARS-CoV-2 Spike Protein
    1
    1. scibot 29 Jan 2024
      Addgene_12259

      DOI: 10.3390/antib13010005

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    ncbi.nlm.nih.gov/pmc/articles/PMC10801580/
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Novel Anti-CD47 Nanobody Tetramer for Cancer Therapy
    1
    1. scibot 28 Jan 2024
      12259

      DOI: 10.3390/antib13010002

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    ncbi.nlm.nih.gov/pmc/articles/PMC10801496/
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hepatitis C virus E1 recruits high-density lipoprotein to support infectivity and evade antibody recognition
    1
    1. scibot 28 Jan 2024
      pMD2 plasmid (Addgene)

      DOI: 10.1128/jvi.00849-23

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    ncbi.nlm.nih.gov/pmc/articles/PMC10804985/
  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    N-acetyltransferase 10 regulates alphavirus replication via N4-acetylcytidine (ac4C) modification of the lymphocyte antigen six family member E (LY6E) mRNA
    1
    1. scibot 28 Jan 2024
      pMD2.G

      DOI: 10.1128/jvi.01350-23

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    ncbi.nlm.nih.gov/pmc/articles/PMC10805074/
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SLC2A9 rs16890979 reduces uric acid absorption by kidney organoids
    1
    1. scibot 28 Jan 2024
      pMD2. G plasmids (Addgene

      DOI: 10.3389/fcell.2023.1268226

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    ncbi.nlm.nih.gov/pmc/articles/PMC10806012/
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Loss of filamentous actin, tight junction protein expression, and paracellular barrier integrity in frataxin-deficient human brain microvascular endothelial cells—implications for blood-brain barrier physiology in Friedreich’s ataxia
    1
    1. scibot 28 Jan 2024
      12,259

      DOI: 10.3389/fmolb.2023.1299201

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    ncbi.nlm.nih.gov/pmc/articles/PMC10808331/
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Abscisic acid signaling through LANCL2 and PPARγ induces activation of p38MAPK resulting in dormancy of prostate cancer metastatic cells
    1
    1. scibot 28 Jan 2024
      plasmid_12259

      DOI: 10.3892/or.2024.8698

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    ncbi.nlm.nih.gov/pmc/articles/PMC10804438/
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TFCP2 is a transcriptional regulator of heparan sulfate assembly and melanoma cell growth
    1
    1. scibot 26 Jan 2024
      plasmid_12259

      DOI: 10.1016/j.jbc.2023.104713

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    ncbi.nlm.nih.gov/pmc/articles/PMC10200990/
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Engineered MED12 mutations drive leiomyoma-like transcriptional and metabolic programs by altering the 3D genome compartmentalization
    1
    1. scibot 25 Jan 2024
      Plasmid_12259

      DOI: 10.1038/s41467-023-39684-y

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    ncbi.nlm.nih.gov/pmc/articles/PMC10333368/
  32. www.nature.com www.nature.com
    Cell-type-directed design of synthetic enhancers
    1
    1. scibot 25 Jan 2024
      RRID:Addgene_12259

      DOI: 10.1038/s41586-023-06936-2

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    nature.com/articles/s41586-023-06936-2
  33. www.sciencedirect.com www.sciencedirect.com
    EXO1 protects BRCA1-deficient cells against toxic DNA lesions
    1
    1. scibot 25 Jan 2024
      Addgene_12259

      DOI: 10.1016/j.molcel.2023.12.039

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    sciencedirect.com/science/article/pii/S1097276523010857
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Epstein-Barr virus induces germinal center light zone chromatin architecture and promotes survival through enhancer looping at the BCL2A1 locus
    1
    1. scibot 20 Jan 2024
      RRID:Addgene_12259

      DOI: 10.1128/mbio.02444-23

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    ncbi.nlm.nih.gov/pmc/articles/PMC10790771/
  35. www.sciencedirect.com www.sciencedirect.com
    Recruitment of BAG2 to DNAJ-PKAc scaffolds promotes cell survival and resistance to drug-induced apoptosis in fibrolamellar carcinoma
    1
    1. scibot 19 Jan 2024
      Plasmid_12259

      DOI: 10.1016/j.celrep.2024.113678

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    sciencedirect.com/science/article/pii/S2211124724000068
  36. link.springer.com link.springer.com
    Generation and optimization of off-the-shelf immunotherapeutics targeting TCR-Vβ2+ T cell malignancy
    1
    1. scibot 18 Jan 2024
      RRID:Addgene_12259

      DOI: 10.1038/s41467-024-44786-2

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    link.springer.com/article/10.1038/s41467-024-44786-2
  37. www.sciencedirect.com www.sciencedirect.com
    TALK-1-mediated alterations of β-cell mitochondrial function and insulin secretion impair glucose homeostasis on a diabetogenic diet
    1
    1. scibot 18 Jan 2024
      RRID:Addgene_12259

      DOI: 10.1016/j.celrep.2024.113673

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    sciencedirect.com/science/article/pii/S2211124724000019
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genomic analysis reveals HDAC1 regulates clinically relevant transcriptional programs in Pancreatic cancer
    1
    1. scibot 18 Jan 2024
      Addgene_12

      DOI: 10.1186/s12885-023-11645-0

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    ncbi.nlm.nih.gov/pmc/articles/PMC10666341/
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transcriptional determinants of lipid mobilization in human adipocytes
    1
    1. scibot 11 Jan 2024
      Addgene_12259

      DOI: 10.1126/sciadv.adi2689

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    ncbi.nlm.nih.gov/pmc/articles/PMC10776019/
  40. www.sciencedirect.com www.sciencedirect.com
    hRpn13 shapes the proteome and transcriptome through epigenetic factors HDAC8, PADI4, and transcription factor NF-κB p50
    1
    1. scibot 11 Jan 2024
      Plasmid_12259

      DOI: 10.1016/j.molcel.2023.11.035

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    sciencedirect.com/science/article/pii/S1097276523009802
  41. www.sciencedirect.com www.sciencedirect.com
    ABCG2 is an itaconate exporter that limits antibacterial innate immunity by alleviating TFEB-dependent lysosomal biogenesis
    1
    1. scibot 11 Jan 2024
      Addgene_12259

      DOI: 10.1016/j.cmet.2023.12.015

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    sciencedirect.com/science/article/pii/S1550413123004655
  42. www.sciencedirect.com www.sciencedirect.com
    Pioneer and PRDM transcription factors coordinate bivalent epigenetic states to safeguard cell fate
    1
    1. scibot 11 Jan 2024
      RRID:Addgene_12259

      DOI: 10.1016/j.molcel.2023.12.007

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    sciencedirect.com/science/article/pii/S1097276523010262
  43. link.springer.com link.springer.com
    Selective gene expression maintains human tRNA anticodon pools during differentiation
    1
    1. scibot 11 Jan 2024
      RRID:Addgene_12259

      DOI: 10.1038/s41556-023-01317-3

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    link.springer.com/article/10.1038/s41556-023-01317-3
  44. www.sciencedirect.com www.sciencedirect.com
    Interferon-stimulated neutrophils as a predictor of immunotherapy response
    1
    1. scibot 09 Jan 2024
      Plasmid_12259

      DOI: 10.1016/j.ccell.2023.12.005

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    sciencedirect.com/science/article/pii/S1535610823004336
  45. www.sciencedirect.com www.sciencedirect.com
    Intron retention as a productive mechanism in human MAPT: RNA species generated by retention of intron 3
    1
    1. scibot 09 Jan 2024
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    A Functional Single-Nucleotide Polymorphism Upstream of the Collagen Type III Gene Is Associated with Catastrophic Fracture Risk in Thoroughbred Horses
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    Impact of eIF2α phosphorylation on the translational landscape of mouse embryonic stem cells
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    Akt activation ameliorates deficits in hippocampal-dependent memory and activity-dependent synaptic protein synthesis in an Alzheimer’s disease mouse model
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    Direct effects of adipocyte lipolysis on AMPK through intracellular long-chain acyl-CoA signaling
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    A SNAI2/CTCF Interaction is Required for NOTCH1 Expression in Rhabdomyosarcoma
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    Screening the human druggable genome identifies ABHD17B as an anti-fibrotic target in hepatic stellate cells
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  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A synthetic notch (synNotch) system linking intratumoral immune-cancer cell communication to a synthetic blood biomarker assay
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    Serine-129 phosphorylation of α-synuclein is an activity-dependent trigger for physiologic protein-protein interactions and synaptic function
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    High-throughput PRIME-editing screens identify functional DNA variants in the human genome
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    Non-canonical Hedgehog signaling mediates profibrotic hematopoiesis-stroma crosstalk in myeloproliferative neoplasms
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    FEZ1 participates in human embryonic brain development by modulating neuronal progenitor subpopulation specification and migration
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    The MHC-E peptide ligands for checkpoint CD94/NKG2A are governed by inflammatory signals, whereas LILRB1/2 receptors are peptide indifferent
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    KDM5B predicts temozolomide-resistant subclones in glioblastoma
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    Topoisomerase 1 Inhibition in MYC-Driven Cancer Promotes Aberrant R-Loop Accumulation to Induce Synthetic Lethality
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    Proteomic characterization of the colorectal cancer response to chemoradiation and targeted therapies reveals potential therapeutic strategies
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    Deep learning and CRISPR-Cas13d ortholog discovery for optimized RNA targeting
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    B3GALT6 promotes dormant breast cancer cell survival and recurrence by enabling heparan sulfate-mediated FGF signaling
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    Single-cell functional genomics reveals determinants of sensitivity and resistance to natural killer cells in blood cancers
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    Reprogramming of tumor-associated macrophages via NEDD4-mediated CSF1R degradation by targeting USP18
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    Heterogeneity and transcriptional drivers of triple-negative breast cancer
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    Stem cell quiescence requires PRC2/PRC1-mediated mitochondrial checkpoint
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    Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson’s disease-linked LRRK2 kinase
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    Epstein-Barr virus induces germinal center light zone chromatin architecture and promotes survival through enhancer looping at the BCL2A1 locus
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    RAAS-deficient organoids indicate delayed angiogenesis as a possible cause for autosomal recessive renal tubular dysgenesis
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  72. 52.53.155.43 52.53.155.43
    ATOH8 Expression is Regulated by BMP2 and Plays a Key Role in Human Endometrial Stromal Cell Decidualization
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    The tumor-derived cytokine Chi3l1 induces neutrophil extracellular traps that promote T cell exclusion in triple-negative breast cancer
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    Engineering CD276/B7-H3-targeted antibody-drug conjugates with enhanced cancer-eradicating capability
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    A novel antagonist of the CCL5/CCR5 axis suppresses the tumor growth and metastasis of triple-negative breast cancer by CCR5-YAP1 regulation
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    Downstream STING pathways IRF3 and NF-κB differentially regulate CCL22 in response to cytosolic dsDNA
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    Ammonia inhibits antitumor activity of NK cells by decreasing mature perforin
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    Unraveling the Mechanisms of Sensitivity to Anti-FGF Therapies in Imatinib-Resistant Gastrointestinal Stromal Tumors (GIST) Lacking Secondary KIT Mutations
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  79. Nov 2023
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SIX4 Controls Anti-PD-1 Efficacy by Regulating STING Expression
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    PIM1 targeted degradation prevents the emergence of chemoresistance in prostate cancer
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    Targeting the TCA cycle through cuproptosis confers synthetic lethality on ARID1A-deficient hepatocellular carcinoma
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    A combinatorial therapeutic approach to enhance FLT3-ITD AML treatment
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    Copine-6 is a Ca2+ sensor for activity-induced AMPA receptor exocytosis
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    Therapeutic targeting of EP300/CBP by bromodomain inhibition in hematologic malignancies
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    Nuclear RNA catabolism controls endogenous retroviruses, gene expression asymmetry, and dedifferentiation
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    Aurora A kinase inhibition induces accumulation of SCLC tumor cells in mitosis with restored interferon signaling to increase response to PD-L1
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  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Molecular Determinants of Calcitriol Signaling and Sensitivity in Glioma Stem-like Cells
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    A partial human LCK defect causes a T cell immunodeficiency with intestinal inflammation
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    rupress.org/jem/article/221/1/e20230927/276408/A-partial-human-LCK-defect-causes-a-T-cell
  90. www.biorxiv.org www.biorxiv.org
    Kaposi’s sarcoma-associated herpesvirus (KSHV) gB dictates a low-pH endocytotic entry pathway as revealed by a dual-fluorescent virus system and a rhesus monkey rhadinovirus expressing KSHV gB
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    1. scibot 17 Nov 2023
      plasmid_12259

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    biorxiv.org/content/10.1101/2023.11.07.566061v1
  91. www.biorxiv.org www.biorxiv.org
    A systematic screening assay identifies efficient small guide RNAs for CRISPR activation
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      RRID:Addgene_12259

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    biorxiv.org/content/10.1101/2023.11.10.566523v1
  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Generation of porcine PK-15 cells lacking the Ifnar1 or Stat2 gene to optimize the efficiency of viral isolation
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    1. scibot 11 Nov 2023
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      DOI: 10.1371/journal.pone.0289863

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    ncbi.nlm.nih.gov/pmc/articles/PMC10631621/
  93. www.sciencedirect.com www.sciencedirect.com
    Hepatic palmitoyl-proteomes and acyl-protein thioesterase protein proximity networks link lipid modification and mitochondria
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    1. scibot 10 Nov 2023
      plasmid_12259

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    sciencedirect.com/science/article/pii/S2211124723014018
  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In Vivo Screening Unveils Pervasive RNA-Binding Protein Dependencies in Leukemic Stem Cells and Identifies ELAVL1 as a Therapeutic Target
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    ncbi.nlm.nih.gov/pmc/articles/PMC10150294/
  95. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In vitro formation and extended culture of highly metabolically active and contractile tissues
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    ncbi.nlm.nih.gov/pmc/articles/PMC10619834/
  96. www.sciencedirect.com www.sciencedirect.com
    Global identification of SWI/SNF targets reveals compensation by EP400
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    sciencedirect.com/science/article/pii/S0092867423010887
  97. www.nature.com www.nature.com
    Engineering a scalable and orthogonal platform for synthetic communication in mammalian cells
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      DOI: 10.1038/s41467-023-42810-5

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    nature.com/articles/s41467-023-42810-5
  98. www.biorxiv.org www.biorxiv.org
    Dissecting signaling regulators driving AXL-mediated bypass resistance and associated phenotypes by phosphosite perturbations
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    biorxiv.org/content/10.1101/2023.10.20.563266v1
  99. www.sciencedirect.com www.sciencedirect.com
    Targeting intracellular oncoproteins with dimeric IgA promotes expulsion from the cytoplasm and immune-mediated control of epithelial cancers
    2
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    sciencedirect.com/science/article/pii/S1074761323004181
  100. www.sciencedirect.com www.sciencedirect.com
    Functional interrogation of twenty type 2 diabetes-associated genes using isogenic human embryonic stem cell-derived β-like cells
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    sciencedirect.com/science/article/pii/S1550413123003698
  101. www.sciencedirect.com www.sciencedirect.com
    m6A demethylase FTO stabilizes LINK-A to exert oncogenic roles via MCM3-mediated cell-cycle progression and HIF-1α activation
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    sciencedirect.com/science/article/pii/S2211124723012858
  102. Oct 2023
  103. www.sciencedirect.com www.sciencedirect.com
    Highly efficient cellular expression of circular mRNA enables prolonged protein expression
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    sciencedirect.com/science/article/pii/S2451945623003343
  104. www.sciencedirect.com www.sciencedirect.com
    Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation
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    1. scibot 28 Oct 2023
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    sciencedirect.com/science/article/pii/S1934590923003284
  105. www.sciencedirect.com www.sciencedirect.com
    A PINK1 input threshold arises from positive feedback in the PINK1/Parkin mitophagy decision circuit
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      Plasmid_12259

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    sciencedirect.com/science/article/pii/S221112472301272X
  106. www.sciencedirect.com www.sciencedirect.com
    Primary cilia control oligodendrocyte precursor cell proliferation in white matter injury via Hedgehog-independent CREB signaling
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    sciencedirect.com/science/article/pii/S2211124723012846
  107. www.biorxiv.org www.biorxiv.org
    Mapping ovarian cancer spatial organization uncovers immune evasion drivers at the genetic, cellular, and tissue level
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    biorxiv.org/content/10.1101/2023.10.16.562592v1
  108. www.biorxiv.org www.biorxiv.org
    Generation of a porcine cell line stably expressing pig TMPRSS2 for efficient isolation of viruses from pigs with respiratory diseases
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    1. scibot 24 Oct 2023
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      DOI: 10.1101/2023.10.14.562371

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    biorxiv.org/content/10.1101/2023.10.14.562371v1
  109. www.nature.com www.nature.com
    Chromatin-modifying enzymes as modulators of nuclear size during lineage differentiation
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      DOI: 10.1038/s41420-023-01639-z

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    nature.com/articles/s41420-023-01639-z
  110. www.nature.com www.nature.com
    Pentapeptide PYRAE triggers ER stress-mediated apoptosis of breast cancer cells in mice by targeting RHBDF1-BiP interaction
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      DOI: 10.1038/s41401-023-01163-x

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    nature.com/articles/s41401-023-01163-x
  111. www.mdpi.com www.mdpi.com
    In Cerebellar Atrophy of 12-Month-Old ATM-Null Mice, Transcriptome Upregulations Concern Most Neurotransmission and Neuropeptide Pathways, While Downregulations Affect Prominently Itpr1, Usp2 and Non-Coding RNA
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      DOI: 10.3390/cells12192399

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    mdpi.com/2073-4409/12/19/2399
  112. www.biorxiv.org www.biorxiv.org
    A synthetic Notch (synNotch) system linking intratumoral immune-cancer cell communication to a synthetic blood biomarker assay
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    biorxiv.org/content/10.1101/2023.09.26.559329v1
  113. www.sciencedirect.com www.sciencedirect.com
    The mesodermal and myogenic specification of hESCs depend on ZEB1 and are inhibited by ZEB2
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    sciencedirect.com/science/article/pii/S2211124723012342
  114. www.sciencedirect.com www.sciencedirect.com
    Allosterically inhibited PFKL via prostaglandin E2 withholds glucose metabolism and ovarian cancer invasiveness
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    sciencedirect.com/science/article/pii/S2211124723012585
  115. www.sciencedirect.com www.sciencedirect.com
    DNA damage induces nuclear envelope rupture through ATR-mediated phosphorylation of lamin A/C
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    sciencedirect.com/science/article/pii/S1097276523007505
  116. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Increased degradation of FMRP contributes to neuronal hyperexcitability in tuberous sclerosis complex
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    ncbi.nlm.nih.gov/pmc/articles/PMC10529098/
  117. www.cell.com www.cell.com
    Multivalent antigen display on nanoparticle immunogens increases B cell clonotype diversity and neutralization breadth to pneumoviruses
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    cell.com/immunity/abstract/S1074-7613(23)00367-9
  118. www.sciencedirect.com www.sciencedirect.com
    TET3 plays a critical role in white adipose development and diet-induced remodeling
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    sciencedirect.com/science/article/pii/S2211124723012081
  119. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Optimizing Bioink Composition for Human Chondrocyte Expression of Lubricin
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      DOI: 10.3390/bioengineering10090997

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    ncbi.nlm.nih.gov/pmc/articles/PMC10526043/
  120. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR/Cas9-Mediated CtBP1 Gene Editing Enhances Chemosensitivity and Inhibits Metastatic Potential in Esophageal Squamous Cell Carcinoma Cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10530806/
  121. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An Early Neoplasia Index (ENI10), Based on Molecular Identity of CD10 Cells and Associated Stemness Biomarkers, is a Predictor of Patient Outcome in Many Cancers
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    ncbi.nlm.nih.gov/pmc/articles/PMC10540743/
  122. Sep 2023
  123. www.sciencedirect.com www.sciencedirect.com
    Essential role of the amino-terminal region of Drosha for the Microprocessor function
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    sciencedirect.com/science/article/pii/S2589004223020485
  124. www.sciencedirect.com www.sciencedirect.com
    TGS1/PIMT knockdown reduces lipid accumulation in adipocytes, limits body weight gain and promotes insulin sensitivity in mice
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    sciencedirect.com/science/article/pii/S0925443923002624
  125. www.sciencedirect.com www.sciencedirect.com
    Hyperpolarization-activated cyclic nucleotide-gated cation channel 3 promotes HCC development in a female-biased manner
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    sciencedirect.com/science/article/pii/S2211124723011695
  126. www.biorxiv.org www.biorxiv.org
    Discovering chromatin dysregulation induced by protein-coding perturbations at scale
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    biorxiv.org/content/10.1101/2023.09.20.555752v1
  127. www.biorxiv.org www.biorxiv.org
    Differential Modulation of Polycomb-Associated Histone Marks by cBAF, pBAF, and gBAF Complexes
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    biorxiv.org/content/10.1101/2023.09.23.557848v1
  128. journals.asm.org journals.asm.org
    Nectin-3 and shed forms of CSPG4 can serve as epithelial cell receptors for Clostridioides difficile TcdB
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      DOI: 10.1128/mbio.01857-23

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    journals.asm.org/doi/10.1128/mbio.01857-23
  129. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Myeloid leukemia vulnerabilities embedded in long noncoding RNA locus MYNRL15
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    ncbi.nlm.nih.gov/pmc/articles/PMC10520325/
  130. www.sciencedirect.com www.sciencedirect.com
    TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal
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    sciencedirect.com/science/article/pii/S1934590923002461
  131. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Differential nanoscale organization of excitatory synapses onto excitatory vs inhibitory neurons
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      DOI: 10.1101/2023.09.06.556279

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  132. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BAP1 promotes osteoclast function by metabolic reprogramming
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  133. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Alterations of lipid-mediated mitophagy result in aging-dependent sensorimotor defects
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  134. 52.53.155.43 52.53.155.43
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  135. www.nature.com www.nature.com
    HERC1 deficiency causes osteopenia through transcriptional program dysregulation during bone remodeling
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  136. www.nature.com www.nature.com
    MC1R signaling through the cAMP-CREB/ATF-1 and ERK-NFκB pathways accelerates G1/S transition promoting breast cancer progression
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  137. www.sciencedirect.com www.sciencedirect.com
    CBFA2T3-GLIS2-dependent pediatric acute megakaryoblastic leukemia is driven by GLIS2 and sensitive to navitoclax
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  138. www.biorxiv.org www.biorxiv.org
    A Meta-Atlas of the Developing Human Cortex Identifies Modules Driving Cell Subtype Specification
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  139. www.sciencedirect.com www.sciencedirect.com
    Mitotic perturbation is a key mechanism of action of decitabine in myeloid tumor treatment
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  140. www.nature.com www.nature.com
    m6A RNA methylation orchestrates transcriptional dormancy during paused pluripotency
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  141. link.springer.com link.springer.com
    Host-derived growth factors drive ERK phosphorylation and MCL1 expression to promote osteosarcoma cell survival during metastatic lung colonization
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  142. www.biorxiv.org www.biorxiv.org
    TPX2 expression promotes sensitivity to dasatinib in breast cancer by activating the YAP transcriptional signaling
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  143. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    C9orf72 poly(PR) mediated neurodegeneration is associated with nucleolar stress
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  144. link.springer.com link.springer.com
    The Endolysosomal Transporter DMT1 is Required for Morphine Regulation of Neuronal Ferritin Heavy Chain
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  145. www.sciencedirect.com www.sciencedirect.com
    TMEM127 suppresses tumor development by promoting RET ubiquitination, positioning, and degradation
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  146. Aug 2023
  147. www.sciencedirect.com www.sciencedirect.com
    Multiple genes in a single GWAS risk locus synergistically mediate aberrant synaptic development and function in human neurons
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  148. www.biorxiv.org www.biorxiv.org
    Endothelial Lipase Variant, T111I, Does Not Alter Inhibition by Angiopoietin-like Proteins
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  149. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cas phosphorylation regulates focal adhesion assembly
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  150. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Paralog-dependent isogenic cell assay cascade generates highly selective SLC16A3 inhibitors
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  151. www.sciencedirect.com www.sciencedirect.com
    Novel fourth generation-like CARmiR cells release therapeutic miRNA via exosomes and enhance glioblastoma cell killing activity
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  152. www.nature.com www.nature.com
    Efficient generation of functional neurons from mouse embryonic stem cells via neurogenin-2 expression
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  153. www.nature.com www.nature.com
    TIGIT can inhibit T cell activation via ligation-induced nanoclusters, independent of CD226 co-stimulation
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  154. 52.53.155.43 52.53.155.43
    Deneddylation of ribosomal proteins promotes synergy between MLN4924 and chemotherapy to elicit complete therapeutic responses
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  155. 52.53.155.43 52.53.155.43
    L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab
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  156. www.biorxiv.org www.biorxiv.org
    Culture substrate stiffness impacts human myoblast contractility-dependent proliferation and nuclear envelope wrinkling
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  157. 52.53.155.43 52.53.155.43
    2023.08.14.553170v1.full-html.html
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  158. 52.53.155.43 52.53.155.43
    Targeting TCF19 sensitizes MSI endometrial cancer to anti-PD-1 therapy by alleviating CD8+ T cell exhaustion via TRIM14-IFN-β axis
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  159. www.sciencedirect.com www.sciencedirect.com
    Cohesin mediates DNA loop extrusion and sister chromatid cohesion by distinct mechanisms
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  160. www.sciencedirect.com www.sciencedirect.com
    Conserved use of the sodium/bile acid cotransporter (NTCP) as an entry receptor by hepatitis B virus and domestic cat hepadnavirus
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  161. www.biorxiv.org www.biorxiv.org
    Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
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  162. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Fluid shear stress enhances natural killer cell's cytotoxicity toward circulating tumor cells through NKG2D-mediated mechanosensing
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  163. 52.53.155.43 52.53.155.43
    Membrane-localized neoantigens predict the efficacy of cancer immunotherapy
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  164. www.biorxiv.org www.biorxiv.org
    TIM3 is a context-dependent co-regulator of cytotoxic T cell function
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  165. 52.53.155.43 52.53.155.43
    A MYC-controlled redox switch protects B lymphoma cells from EGR1-dependent apoptosis
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  166. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Reinvestigating the clinical relevance of the m6A writer METTL3 in urothelial carcinoma of the bladder
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  167. 52.53.155.43 52.53.155.43
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  168. www.sciencedirect.com www.sciencedirect.com
    Mapping the dynamic high-density lipoprotein synapse
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  169. www.sciencedirect.com www.sciencedirect.com
    DPPA3-HIF1α axis controls colorectal cancer chemoresistance by imposing a slow cell-cycle phenotype
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  170. www.embopress.org www.embopress.org
    The cell cycle protein MAD2 facilitates endocytosis of the serotonin transporter in the neuronal soma
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    embopress.org/doi/10.15252/embr.202153408
  171. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tissue tension permits β-catenin phosphorylation to drive mesoderm specification in human embryonic stem cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10370032/
  172. Jul 2023
  173. www.nature.com www.nature.com
    Collateral lethality between HDAC1 and HDAC2 exploits cancer-specific NuRD complex vulnerabilities
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    nature.com/articles/s41594-023-01041-4
  174. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Early protective effect of a (“pan”) coronavirus vaccine (PanCoVac) in Roborovski dwarf hamsters after single-low dose intranasal administration
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  175. www.sciencedirect.com www.sciencedirect.com
    Targeting of multiple tumor-associated antigens by individual T cell receptors during successful cancer immunotherapy
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    sciencedirect.com/science/article/pii/S0092867423006967
  176. www.sciencedirect.com www.sciencedirect.com
    Parallel CRISPR-Cas9 screens identify mechanisms of PLIN2 and lipid droplet regulation
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  177. 52.53.155.43 52.53.155.43
    rational-design-and-development-of-selective-brd7-bromodomain-inhibitors-and-their-activity-in-prostate-cancer-html.html
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  178. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Coding and non-coding elements comprise a regulatory network controlling transcription in Kaposi’s sarcoma-associated herpesvirus
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  179. www.sciencedirect.com www.sciencedirect.com
    A spatially defined human Notch receptor interaction network reveals Notch intracellular storage and Ataxin-2-mediated fast recycling
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  180. www.sciencedirect.com www.sciencedirect.com
    Activation of GPR44 decreases severity of myeloid leukemia via specific targeting of leukemia initiating stem cells
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  181. 52.53.155.43 52.53.155.43
    Copine-6 is a Ca2+ sensor for activity-induced AMPA receptor exocytosis
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  182. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Inhibition of CDK1 Overcomes Oxaliplatin Resistance by Regulating ACSL4-mediated Ferroptosis in Colorectal Cancer
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  183. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Actin nucleators safeguard replication forks by limiting nascent strand degradation
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  184. pubs.acs.org pubs.acs.org
    SIRIUS, Ultra-Scintillating Upconversion Breast Implant for Remote Orthotopic Photodynamic Therapy
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  185. www.sciencedirect.com www.sciencedirect.com
    Calcium dysregulation combined with mitochondrial failure and electrophysiological maturity converge in Parkinson’s iPSC-dopamine neurons
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  186. www.nature.com www.nature.com
    Kinome-wide CRISPR-Cas9 knockout screens revealed PLK1 as a therapeutic target for osteosarcoma
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  187. 52.53.155.43 52.53.155.43
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  188. www.sciencedirect.com www.sciencedirect.com
    TMEM106B is a receptor mediating ACE2-independent SARS-CoV-2 cell entry
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  189. www.biorxiv.org www.biorxiv.org
    Cell-based assay to determine Type 3 Secretion System translocon assembly in Pseudomonas aeruginosa using split luciferase
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  190. www.sciencedirect.com www.sciencedirect.com
    Oncogenic K-Ras suppresses global miRNA function
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  191. www.sciencedirect.com www.sciencedirect.com
    Super-resolution imaging unveils the self-replication of tau aggregates upon seeding
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  192. www.sciencedirect.com www.sciencedirect.com
    Alpha-tocopherylquinone differentially modulates claudins to enhance intestinal epithelial tight junction barrier via AhR and Nrf2 pathways
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  193. 52.53.155.43 52.53.155.43
    cd-22-0411-html.html
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  194. 52.53.155.43 52.53.155.43
    cir-22-0815-html.html
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  195. Jun 2023
  196. www.sciencedirect.com www.sciencedirect.com
    Identification of XAF1 as an endogenous AKT inhibitor
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    sciencedirect.com/science/article/pii/S2211124723007015
  197. www.sciencedirect.com www.sciencedirect.com
    Microbiota-produced indole metabolites disrupt mitochondrial function and inhibit Cryptosporidium parvum growth
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  198. www.sciencedirect.com www.sciencedirect.com
    QKI shuttles internal m7G-modified transcripts into stress granules and modulates mRNA metabolism
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      DOI: 10.1016/j.cell.2023.05.047

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    sciencedirect.com/science/article/pii/S0092867423005986
  199. www.sciencedirect.com www.sciencedirect.com
    An EZH2-NF-κB Regulatory Axis Drives Expression of Pro-Oncogenic Gene Signatures in Triple Negative Breast Cancer
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      DOI: 10.1016/j.isci.2023.107115

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