1,593 Matching Annotations
  1. Jan 2024
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LDLR is used as a cell entry receptor by multiple alphaviruses
    1
    1. scibot 30 Jan 2024
      plasmid_12260

      DOI: 10.1038/s41467-024-44872-5

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    ncbi.nlm.nih.gov/pmc/articles/PMC10799924/
  3. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Characterizing the secretome of EGFR mutant lung adenocarcinoma
    1
    1. scibot 30 Jan 2024
      Plasmid_12260

      DOI: 10.3389/fonc.2023.1286821

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    ncbi.nlm.nih.gov/pmc/articles/PMC10801028/
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Unexpected inhibition of the lipid kinase PIKfyve reveals an epistatic role for p38 MAPKs in endolysosomal fission and volume control
    1
    1. scibot 30 Jan 2024
      plasmid_12260

      DOI: 10.1038/s41419-024-06423-0

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    ncbi.nlm.nih.gov/pmc/articles/PMC10803372/
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Loss of postsynaptic NMDARs drives nanoscale reorganization of Munc13-1 and PSD-95
    1
    1. scibot 30 Jan 2024
      RRID:Addgene_12260

      DOI: 10.1101/2024.01.12.574705

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    ncbi.nlm.nih.gov/pmc/articles/PMC10802569/
  6. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Nonsynonymous Mutations in Intellectual Disability and Autism Spectrum Disorder Gene PTCHD1 Disrupt N-Glycosylation and Reduce Protein Stability
    1
    1. scibot 29 Jan 2024
      #12260; Addgene

      DOI: 10.3390/cells13020199

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    ncbi.nlm.nih.gov/pmc/articles/PMC10814814/
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functional Analysis of KAP1/TRIM28 Requirements for HIV-1 Transcription Activation
    1
    1. scibot 29 Jan 2024
      Addgene, Watertown, MA, USA, catalog 12260

      DOI: 10.3390/v16010116

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    ncbi.nlm.nih.gov/pmc/articles/PMC10819576/
  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeted chemotherapy via HER2-based chimeric antigen receptor (CAR) engineered T-cell membrane coated polymeric nanoparticles
    1
    1. scibot 29 Jan 2024
      plasmid_12260

      DOI: 10.1016/j.bioactmat.2023.12.027

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    ncbi.nlm.nih.gov/pmc/articles/PMC10821609/
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HPV16 E6 Oncogene Contributes to Cancer Immune Evasion by Regulating PD-L1 Expression through a miR-143/HIF-1a Pathway
    1
    1. scibot 29 Jan 2024
      Addgene_12260

      DOI: 10.3390/v16010113

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    ncbi.nlm.nih.gov/pmc/articles/PMC10819893/
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Vascular injury activates the ELK1/SND1/SRF pathway to promote vascular smooth muscle cell proliferative phenotype and neointimal hyperplasia
    1
    1. scibot 29 Jan 2024
      RRID:Addgene_12260

      DOI: 10.1007/s00018-023-05095-x

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    ncbi.nlm.nih.gov/pmc/articles/PMC10817852/
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    D-type cyclins regulate DNA mismatch repair in the G1 and S phases of the cell cycle, maintaining genome stability
    1
    1. scibot 29 Jan 2024
      Plasmid_12260

      DOI: 10.1101/2024.01.12.575420

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    ncbi.nlm.nih.gov/pmc/articles/PMC10802603/
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hepatitis C virus E1 recruits high-density lipoprotein to support infectivity and evade antibody recognition
    1
    1. scibot 28 Jan 2024
      psPAX2 plasmid (Addgene)

      DOI: 10.1128/jvi.00849-23

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    ncbi.nlm.nih.gov/pmc/articles/PMC10804985/
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    N-acetyltransferase 10 regulates alphavirus replication via N4-acetylcytidine (ac4C) modification of the lymphocyte antigen six family member E (LY6E) mRNA
    1
    1. scibot 28 Jan 2024
      PsPAX2

      DOI: 10.1128/jvi.01350-23

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    ncbi.nlm.nih.gov/pmc/articles/PMC10805074/
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SLC2A9 rs16890979 reduces uric acid absorption by kidney organoids
    1
    1. scibot 28 Jan 2024
      psPAX2

      DOI: 10.3389/fcell.2023.1268226

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    ncbi.nlm.nih.gov/pmc/articles/PMC10806012/
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Loss of filamentous actin, tight junction protein expression, and paracellular barrier integrity in frataxin-deficient human brain microvascular endothelial cells—implications for blood-brain barrier physiology in Friedreich’s ataxia
    1
    1. scibot 28 Jan 2024
      12,260

      DOI: 10.3389/fmolb.2023.1299201

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    ncbi.nlm.nih.gov/pmc/articles/PMC10808331/
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Novel Anti-CD47 Nanobody Tetramer for Cancer Therapy
    1
    1. scibot 28 Jan 2024
      plasmid_12260

      DOI: 10.3390/antib13010002

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    ncbi.nlm.nih.gov/pmc/articles/PMC10801496/
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Abscisic acid signaling through LANCL2 and PPARγ induces activation of p38MAPK resulting in dormancy of prostate cancer metastatic cells
    1
    1. scibot 28 Jan 2024
      plasmid_12260

      DOI: 10.3892/or.2024.8698

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    ncbi.nlm.nih.gov/pmc/articles/PMC10804438/
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TFCP2 is a transcriptional regulator of heparan sulfate assembly and melanoma cell growth
    1
    1. scibot 26 Jan 2024
      plasmid_12260

      DOI: 10.1016/j.jbc.2023.104713

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    ncbi.nlm.nih.gov/pmc/articles/PMC10200990/
  19. www.nature.com www.nature.com
    Cell-type-directed design of synthetic enhancers
    1
    1. scibot 25 Jan 2024
      RRID:Addgene_12260

      DOI: 10.1038/s41586-023-06936-2

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    nature.com/articles/s41586-023-06936-2
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Epstein-Barr virus induces germinal center light zone chromatin architecture and promotes survival through enhancer looping at the BCL2A1 locus
    1
    1. scibot 20 Jan 2024
      RRID:Addgene_12260

      DOI: 10.1128/mbio.02444-23

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    ncbi.nlm.nih.gov/pmc/articles/PMC10790771/
  21. www.sciencedirect.com www.sciencedirect.com
    Recruitment of BAG2 to DNAJ-PKAc scaffolds promotes cell survival and resistance to drug-induced apoptosis in fibrolamellar carcinoma
    1
    1. scibot 19 Jan 2024
      Plasmid_12260

      DOI: 10.1016/j.celrep.2024.113678

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    sciencedirect.com/science/article/pii/S2211124724000068
  22. www.sciencedirect.com www.sciencedirect.com
    SPOP negatively regulates mTORC1 activity by ubiquitinating Sec13
    1
    1. scibot 19 Jan 2024
      RRID:Addgene_12260

      DOI: 10.1016/j.cellsig.2024.111060

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    sciencedirect.com/science/article/pii/S0898656824000287
  23. www.sciencedirect.com www.sciencedirect.com
    A novel antagonist of the CCL5/CCR5 axis suppresses the tumor growth and metastasis of triple-negative breast cancer by CCR5-YAP1 regulation
    1
    1. scibot 19 Jan 2024
      RRID:Addgene_12

      DOI: 10.1016/j.canlet.2024.216635

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    sciencedirect.com/science/article/pii/S0304383524000296
  24. link.springer.com link.springer.com
    Generation and optimization of off-the-shelf immunotherapeutics targeting TCR-Vβ2+ T cell malignancy
    1
    1. scibot 18 Jan 2024
      RRID:Addgene_12260

      DOI: 10.1038/s41467-024-44786-2

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    link.springer.com/article/10.1038/s41467-024-44786-2
  25. www.sciencedirect.com www.sciencedirect.com
    TALK-1-mediated alterations of β-cell mitochondrial function and insulin secretion impair glucose homeostasis on a diabetogenic diet
    1
    1. scibot 18 Jan 2024
      RRID:Addgene_12260

      DOI: 10.1016/j.celrep.2024.113673

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    sciencedirect.com/science/article/pii/S2211124724000019
  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Distinct spatiotemporal dynamics of CD8+ T cell-derived cytokines in the tumor microenvironment
    1
    1. scibot 13 Jan 2024
      Addgene_12260

      DOI: 10.1016/j.ccell.2023.12.010

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    ncbi.nlm.nih.gov/pmc/articles/PMC10783802/
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SARS-CoV-2 NSP14 MTase activity is critical for inducing canonical NF-κB activation
    1
    1. scibot 12 Jan 2024
      Addgene_12260

      DOI: 10.1042/BSR20231418

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    ncbi.nlm.nih.gov/pmc/articles/PMC10776897/
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrin-αvβ3 is a Therapeutically Targetable Fundamental Factor in Medulloblastoma Tumorigenicity and Radioresistance
    1
    1. scibot 12 Jan 2024
      plasmid_12260

      DOI: 10.1158/2767-9764.CRC-23-0298

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    ncbi.nlm.nih.gov/pmc/articles/PMC10702273/
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Direct translation of incoming retroviral genomes
    1
    1. scibot 12 Jan 2024
      Addgene_12260

      DOI: 10.1038/s41467-023-44501-7

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    ncbi.nlm.nih.gov/pmc/articles/PMC10770327/
  30. www.sciencedirect.com www.sciencedirect.com
    Endothelial Jagged1 levels and distribution are post-transcriptionally controlled by ZFP36 decay proteins
    1
    1. scibot 11 Jan 2024
      RRID:Addgene_12260

      DOI: 10.1016/j.celrep.2023.113627

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    sciencedirect.com/science/article/pii/S2211124723016388
  31. www.sciencedirect.com www.sciencedirect.com
    Metabolic reprogramming by histone deacetylase inhibition preferentially targets NRF2-activated tumors
    1
    1. scibot 11 Jan 2024
      RRID:Addgene_12260

      DOI: 10.1016/j.celrep.2023.113629

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    sciencedirect.com/science/article/pii/S2211124723016406
  32. 52.53.155.43 52.53.155.43
    JNEUROSCI.2324-22.2023.full-html.html
    1
    1. scibot 11 Jan 2024
      Addgene_12260

      DOI: 10.1523/jneurosci.2324-22.2023

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    52.53.155.43/e3800d3a01c4a2c48734bb4b10f425b6dda51575/JNEUROSCI.2324-22.2023.full-html.html
  33. www.sciencedirect.com www.sciencedirect.com
    Pioneer and PRDM transcription factors coordinate bivalent epigenetic states to safeguard cell fate
    1
    1. scibot 11 Jan 2024
      RRID:Addgene_12260

      DOI: 10.1016/j.molcel.2023.12.007

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    sciencedirect.com/science/article/pii/S1097276523010262
  34. www.sciencedirect.com www.sciencedirect.com
    Structural and functional basis of VLDLR usage by Eastern equine encephalitis virus
    1
    1. scibot 11 Jan 2024
      Addgene_12260

      DOI: 10.1016/j.cell.2023.11.031

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    sciencedirect.com/science/article/pii/S0092867423013181
  35. dx.doi.org dx.doi.org
    Kaposi's sarcoma herpesvirus exploits the DNA damage response to circularize its genome
    1
    1. scibot 10 Jan 2024
      RRID:Addgene_12260

      DOI: 10.1093/nar/gkad1224

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    dx.doi.org/10.1093/nar/gkad1224
  36. www.sciencedirect.com www.sciencedirect.com
    Impact of eIF2α phosphorylation on the translational landscape of mouse embryonic stem cells
    1
    1. scibot 07 Jan 2024
      RRID:Addgene_12260

      DOI: 10.1016/j.celrep.2023.113615

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    sciencedirect.com/science/article/pii/S2211124723016273
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Direct effects of adipocyte lipolysis on AMPK through intracellular long-chain acyl-CoA signaling
    1
    1. scibot 06 Jan 2024
      Addgene #12260

      DOI: 10.1038/s41598-023-50903-w

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    ncbi.nlm.nih.gov/pmc/articles/PMC10761689/
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A SNAI2/CTCF Interaction is Required for NOTCH1 Expression in Rhabdomyosarcoma
    1
    1. scibot 05 Jan 2024
      Addgene#12260

      DOI: 10.1080/10985549.2023.2256640

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    ncbi.nlm.nih.gov/pmc/articles/PMC10761179/
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FEBS Press
    1
    1. scibot 05 Jan 2024
      plasmid_12260

      DOI: 10.1002/2211-5463.13741

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    ncbi.nlm.nih.gov/pmc/articles/PMC10761937/
  40. Dec 2023
  41. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Transgelin Promotes Glioblastoma Stem Cell Hypoxic Responses and Maintenance Through p53 Acetylation
    1
    1. scibot 29 Dec 2023
      RRID:Addgene_12260

      DOI: 10.1002/advs.202305620

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    onlinelibrary.wiley.com/doi/10.1002/advs.202305620
  42. www.mdpi.com www.mdpi.com
    Comparative Analysis of Cyclization Techniques in Stapled Peptides: Structural Insights into Protein–Protein Interactions in a SARS-CoV-2 Spike RBD/hACE2 Model System
    1
    1. scibot 29 Dec 2023
      RRID:Addgene_12260

      DOI: 10.3390/ijms25010166

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    mdpi.com/1422-0067/25/1/166
  43. www.sciencedirect.com www.sciencedirect.com
    Human inherited CCR2 deficiency underlies progressive polycystic lung disease
    1
    1. scibot 29 Dec 2023
      plasmid_12260

      DOI: 10.1016/j.cell.2023.11.036

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    sciencedirect.com/science/article/pii/S0092867423013235
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FBXW7-loss sensitizes cells to ATR inhibition through induced mitotic catastrophe
    1
    1. scibot 23 Dec 2023
      Addgene_12260

      DOI: 10.1158/2767-9764.CRC-23-0306

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    ncbi.nlm.nih.gov/pmc/articles/PMC10734389/
  45. www.sciencedirect.com www.sciencedirect.com
    Decoupling NAD+ metabolic dependency in chondrosarcoma by targeting the SIRT1-HIF-2α axis
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    Serine-129 phosphorylation of α-synuclein is an activity-dependent trigger for physiologic protein-protein interactions and synaptic function
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    High-throughput PRIME-editing screens identify functional DNA variants in the human genome
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    The MHC-E peptide ligands for checkpoint CD94/NKG2A are governed by inflammatory signals, whereas LILRB1/2 receptors are peptide indifferent
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    Topoisomerase 1 Inhibition in MYC-Driven Cancer Promotes Aberrant R-Loop Accumulation to Induce Synthetic Lethality
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    Proteomic characterization of the colorectal cancer response to chemoradiation and targeted therapies reveals potential therapeutic strategies
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    Profiling nuclear cysteine ligandability and effects on nuclear localization using proximity labeling-coupled chemoproteomics
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    Deep learning and CRISPR-Cas13d ortholog discovery for optimized RNA targeting
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    B3GALT6 promotes dormant breast cancer cell survival and recurrence by enabling heparan sulfate-mediated FGF signaling
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    Reprogramming of tumor-associated macrophages via NEDD4-mediated CSF1R degradation by targeting USP18
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  56. www.biorxiv.org www.biorxiv.org
    Stem cell quiescence requires PRC2/PRC1-mediated mitochondrial checkpoint
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  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson’s disease-linked LRRK2 kinase
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  58. journals.asm.org journals.asm.org
    Epstein-Barr virus induces germinal center light zone chromatin architecture and promotes survival through enhancer looping at the BCL2A1 locus
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  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RAAS-deficient organoids indicate delayed angiogenesis as a possible cause for autosomal recessive renal tubular dysgenesis
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  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Helicobacter pylori CagA promotes immune evasion of gastric cancer by upregulating PD-L1 level in exosomes
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    The tumor-derived cytokine Chi3l1 induces neutrophil extracellular traps that promote T cell exclusion in triple-negative breast cancer
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    Engineering CD276/B7-H3-targeted antibody-drug conjugates with enhanced cancer-eradicating capability
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  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hypoxia potentiates the inflammatory fibroblast phenotype promoted by pancreatic cancer cell-derived cytokines
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  64. www.biorxiv.org www.biorxiv.org
    A novel antagonist of the CCL5/CCR5 axis suppresses the tumor growth and metastasis of triple-negative breast cancer by CCR5-YAP1 regulation
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  65. www.nature.com www.nature.com
    Downstream STING pathways IRF3 and NF-κB differentially regulate CCL22 in response to cytosolic dsDNA
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  66. www.biorxiv.org www.biorxiv.org
    Ammonia inhibits antitumor activity of NK cells by decreasing mature perforin
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  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Unraveling the Mechanisms of Sensitivity to Anti-FGF Therapies in Imatinib-Resistant Gastrointestinal Stromal Tumors (GIST) Lacking Secondary KIT Mutations
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  69. Nov 2023
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SIX4 Controls Anti-PD-1 Efficacy by Regulating STING Expression
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  71. www.sciencedirect.com www.sciencedirect.com
    Targeting the TCA cycle through cuproptosis confers synthetic lethality on ARID1A-deficient hepatocellular carcinoma
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    The RNA helicase DDX39A binds a conserved structure in chikungunya virus RNA to control infection
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    A combinatorial therapeutic approach to enhance FLT3-ITD AML treatment
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    PIM1 targeted degradation prevents the emergence of chemoresistance in prostate cancer
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    Nuclear RNA catabolism controls endogenous retroviruses, gene expression asymmetry, and dedifferentiation
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  76. www.nature.com www.nature.com
    Selective inhibition of CDK9 in triple negative breast cancer
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  77. www.sciencedirect.com www.sciencedirect.com
    Aurora A kinase inhibition induces accumulation of SCLC tumor cells in mitosis with restored interferon signaling to increase response to PD-L1
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  78. www.sciencedirect.com www.sciencedirect.com
    Differences in syncytia formation by SARS-CoV-2 variants modify host chromatin accessibility and cellular senescence via TP53
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  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Molecular Determinants of Calcitriol Signaling and Sensitivity in Glioma Stem-like Cells
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  80. www.biorxiv.org www.biorxiv.org
    Kaposi’s sarcoma-associated herpesvirus (KSHV) gB dictates a low-pH endocytotic entry pathway as revealed by a dual-fluorescent virus system and a rhesus monkey rhadinovirus expressing KSHV gB
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  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transcriptional reprogramming by mutated IRF4 in lymphoma
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  82. www.sciencedirect.com www.sciencedirect.com
    Head and neck cancer stem cell maintenance relies on mTOR signaling, specifically involving the mechanistic target of rapamycin complexes 1 and 2 (mTORC1 and mTORC2)
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    Gasdermin D permeabilization of mitochondrial inner and outer membranes accelerates and enhances pyroptosis
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    Hepatic palmitoyl-proteomes and acyl-protein thioesterase protein proximity networks link lipid modification and mitochondria
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  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neuronal activation of Gαq EGL-30/GNAQ late in life rejuvenates cognition across species
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  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Vimentin intermediate filaments provide structural stability to the mammalian Golgi complex
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  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In Vivo Screening Unveils Pervasive RNA-Binding Protein Dependencies in Leukemic Stem Cells and Identifies ELAVL1 as a Therapeutic Target
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  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In vitro formation and extended culture of highly metabolically active and contractile tissues
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  89. www.sciencedirect.com www.sciencedirect.com
    Global identification of SWI/SNF targets reveals compensation by EP400
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  90. www.biorxiv.org www.biorxiv.org
    ZNF397 Loss Triggers TET2-driven Epigenetic Rewiring, Lineage Plasticity, and AR-targeted Therapy Resistance in AR-dependent Cancers
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  91. www.sciencedirect.com www.sciencedirect.com
    Targeting intracellular oncoproteins with dimeric IgA promotes expulsion from the cytoplasm and immune-mediated control of epithelial cancers
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  92. www.sciencedirect.com www.sciencedirect.com
    Functional interrogation of twenty type 2 diabetes-associated genes using isogenic human embryonic stem cell-derived β-like cells
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    m6A demethylase FTO stabilizes LINK-A to exert oncogenic roles via MCM3-mediated cell-cycle progression and HIF-1α activation
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    Efficient exon skipping by base-editor-mediated abrogation of exonic splicing enhancers
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  95. Oct 2023
  96. www.sciencedirect.com www.sciencedirect.com
    Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation
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  97. www.sciencedirect.com www.sciencedirect.com
    Primary cilia control oligodendrocyte precursor cell proliferation in white matter injury via Hedgehog-independent CREB signaling
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    Short C-terminal Musashi-1 proteins regulate pluripotency states in embryonic stem cells
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  99. www.biorxiv.org www.biorxiv.org
    Mapping ovarian cancer spatial organization uncovers immune evasion drivers at the genetic, cellular, and tissue level
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  100. 52.53.155.43 52.53.155.43
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  101. www.biorxiv.org www.biorxiv.org
    Dicer deficiency in microglia leads to accelerated demyelination and failed remyelination
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    Regulation of STING activity in DNA sensing by ISG15 modification
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    Genome-wide CRISPR/Cas9 screen identifies MAT2A as a critical host factor for BK Polyomavirus
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  104. www.nature.com www.nature.com
    Pentapeptide PYRAE triggers ER stress-mediated apoptosis of breast cancer cells in mice by targeting RHBDF1-BiP interaction
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  105. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Generation of a new Adar1p150−/− mouse demonstrates isoform-specific roles in embryonic development and adult homeostasis
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  106. www.sciencedirect.com www.sciencedirect.com
    Engineered extracellular vesicles efficiently deliver CRISPR-Cas9 ribonucleoprotein (RNP) to inhibit herpes simplex virus1 infection in vitro and in vivo
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    Mitigation of chromosome loss in clinical CRISPR-Cas9-engineered T cells
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  108. www.mdpi.com www.mdpi.com
    In Cerebellar Atrophy of 12-Month-Old ATM-Null Mice, Transcriptome Upregulations Concern Most Neurotransmission and Neuropeptide Pathways, While Downregulations Affect Prominently Itpr1, Usp2 and Non-Coding RNA
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    Vertebrate-class-specific binding modes of the alphavirus receptor MXRA8
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    The mesodermal and myogenic specification of hESCs depend on ZEB1 and are inhibited by ZEB2
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    Evaluation of potential targets to enhance the sensitivity of cholangiocarcinoma cells to anticancer drugs
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    Allosterically inhibited PFKL via prostaglandin E2 withholds glucose metabolism and ovarian cancer invasiveness
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    DNA damage induces nuclear envelope rupture through ATR-mediated phosphorylation of lamin A/C
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  114. www.biorxiv.org www.biorxiv.org
    Linear ubiquitination at damaged lysosomes induces local NF-κB activation and controls cell survival
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    TET3 plays a critical role in white adipose development and diet-induced remodeling
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  116. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Increased degradation of FMRP contributes to neuronal hyperexcitability in tuberous sclerosis complex
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  117. www.cell.com www.cell.com
    Multivalent antigen display on nanoparticle immunogens increases B cell clonotype diversity and neutralization breadth to pneumoviruses
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  118. www.sciencedirect.com www.sciencedirect.com
    TGS1/PIMT regulates pro-inflammatory macrophage mediated paracrine insulin resistance: Crosstalk between macrophages and skeletal muscle cells
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  119. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Optimizing Bioink Composition for Human Chondrocyte Expression of Lubricin
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  120. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR/Cas9-Mediated CtBP1 Gene Editing Enhances Chemosensitivity and Inhibits Metastatic Potential in Esophageal Squamous Cell Carcinoma Cells
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  121. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pyruvate Kinase Activity Regulates Cystine Starvation Induced Ferroptosis through Malic Enzyme 1 in Pancreatic Cancer Cells
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  122. Sep 2023
  123. www.sciencedirect.com www.sciencedirect.com
    Essential role of the amino-terminal region of Drosha for the Microprocessor function
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  124. www.biorxiv.org www.biorxiv.org
    Differential Modulation of Polycomb-Associated Histone Marks by cBAF, pBAF, and gBAF Complexes
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  125. www.sciencedirect.com www.sciencedirect.com
    TGS1/PIMT knockdown reduces lipid accumulation in adipocytes, limits body weight gain and promotes insulin sensitivity in mice
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  126. journals.asm.org journals.asm.org
    Nectin-3 and shed forms of CSPG4 can serve as epithelial cell receptors for Clostridioides difficile TcdB
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  127. www.sciencedirect.com www.sciencedirect.com
    Single-cell epigenome analysis identifies molecular events controlling direct conversion of human fibroblasts to pancreatic ductal-like cells
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  128. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Myeloid leukemia vulnerabilities embedded in long noncoding RNA locus MYNRL15
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  129. www.sciencedirect.com www.sciencedirect.com
    TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal
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  130. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Differential nanoscale organization of excitatory synapses onto excitatory vs inhibitory neurons
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  131. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BAP1 promotes osteoclast function by metabolic reprogramming
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  132. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Generation of mouse models carrying B cell restricted single or multiplexed loss-of-function mutations through CRISPR-Cas9 gene editing
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  133. 52.53.155.43 52.53.155.43
    vdad120-html.html
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  134. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PTEN deficiency exposes a requirement for an ARF GTPase module for integrin‐dependent invasion in ovarian cancer
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  135. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    microRNAs slow translating ribosomes to prevent protein misfolding in eukaryotes
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  136. www.nature.com www.nature.com
    HERC1 deficiency causes osteopenia through transcriptional program dysregulation during bone remodeling
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  137. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lorazepam Stimulates IL6 Production and Is Associated with Poor Survival Outcomes in Pancreatic Cancer
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  138. www.sciencedirect.com www.sciencedirect.com
    CBFA2T3-GLIS2-dependent pediatric acute megakaryoblastic leukemia is driven by GLIS2 and sensitive to navitoclax
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  139. www.sciencedirect.com www.sciencedirect.com
    Mitotic perturbation is a key mechanism of action of decitabine in myeloid tumor treatment
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  140. www.nature.com www.nature.com
    m6A RNA methylation orchestrates transcriptional dormancy during paused pluripotency
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  141. link.springer.com link.springer.com
    Host-derived growth factors drive ERK phosphorylation and MCL1 expression to promote osteosarcoma cell survival during metastatic lung colonization
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  142. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Development of a V5-tag–directed nanobody and its implementation as an intracellular biosensor of GPCR signaling
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  143. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    C9orf72 poly(PR) mediated neurodegeneration is associated with nucleolar stress
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  144. www.sciencedirect.com www.sciencedirect.com
    TMEM127 suppresses tumor development by promoting RET ubiquitination, positioning, and degradation
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  145. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    IGF2BP2 promotes ovarian cancer growth and metastasis by upregulating CKAP2L protein expression in an m6A-dependent manner
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  146. Aug 2023
  147. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SMC3 epigenetic silencing regulates Rab27a expression and drives pancreatic cancer progression
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  148. www.sciencedirect.com www.sciencedirect.com
    Multiple genes in a single GWAS risk locus synergistically mediate aberrant synaptic development and function in human neurons
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  149. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Paralog-dependent isogenic cell assay cascade generates highly selective SLC16A3 inhibitors
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  150. www.sciencedirect.com www.sciencedirect.com
    4-Octyl itaconate restricts STING activation by blocking its palmitoylation
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  151. www.nature.com www.nature.com
    Pyruvate anaplerosis is a targetable vulnerability in persistent leukaemic stem cells
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  152. www.nature.com www.nature.com
    An idiosyncratic zonated stroma encapsulates desmoplastic liver metastases and originates from injured liver
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  153. www.nature.com www.nature.com
    TIGIT can inhibit T cell activation via ligation-induced nanoclusters, independent of CD226 co-stimulation
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  154. link.springer.com link.springer.com
    Primate TRIM34 is a broadly-acting, TRIM5-dependent lentiviral restriction factor
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  155. 52.53.155.43 52.53.155.43
    Deneddylation of ribosomal proteins promotes synergy between MLN4924 and chemotherapy to elicit complete therapeutic responses
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  156. 52.53.155.43 52.53.155.43
    L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab
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  157. www.biorxiv.org www.biorxiv.org
    Culture substrate stiffness impacts human myoblast contractility-dependent proliferation and nuclear envelope wrinkling
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  158. www.nature.com www.nature.com
    Pharmacological perturbation of the phase-separating protein SMNDC1
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  159. 52.53.155.43 52.53.155.43
    A MYC-controlled redox switch protects B lymphoma cells from EGR1-dependent apoptosis
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  160. 52.53.155.43 52.53.155.43
    Targeting TCF19 sensitizes MSI endometrial cancer to anti-PD-1 therapy by alleviating CD8+ T cell exhaustion via TRIM14-IFN-β axis
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  161. 52.53.155.43 52.53.155.43
    2023.08.10.552871v1.full-html.html
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  162. 52.53.155.43 52.53.155.43
    2023.08.14.553170v1.full-html.html
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  163. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Fluid shear stress enhances natural killer cell's cytotoxicity toward circulating tumor cells through NKG2D-mediated mechanosensing
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  164. www.sciencedirect.com www.sciencedirect.com
    METTL3 drives NAFLD-related hepatocellular carcinoma and is a therapeutic target for boosting immunotherapy
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  165. www.biorxiv.org www.biorxiv.org
    Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
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  166. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genetic ablation of ketohexokinase C isoform impairs pancreatic cancer development
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  167. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Reinvestigating the clinical relevance of the m6A writer METTL3 in urothelial carcinoma of the bladder
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  168. 52.53.155.43 52.53.155.43
    mcr-22-0916-html.html
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      RRID:Addgene_12260

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  169. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    β-Catenin Drives Butyrophilin-like Molecule Loss and γδ T-cell Exclusion in Colon Cancer
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    1. scibot 05 Aug 2023
      RRID:Addgene_12260

      DOI: 10.1158/2326-6066.CIR-22-0644

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    ncbi.nlm.nih.gov/pmc/articles/PMC10398359/
  170. www.sciencedirect.com www.sciencedirect.com
    Mapping the dynamic high-density lipoprotein synapse
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      addgene:12260

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    sciencedirect.com/science/article/pii/S0021915023051079
  171. www.sciencedirect.com www.sciencedirect.com
    DPPA3-HIF1α axis controls colorectal cancer chemoresistance by imposing a slow cell-cycle phenotype
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      plasmid_12260

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    sciencedirect.com/science/article/pii/S2211124723009385
  172. www.embopress.org www.embopress.org
    The cell cycle protein MAD2 facilitates endocytosis of the serotonin transporter in the neuronal soma
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  173. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tissue tension permits β-catenin phosphorylation to drive mesoderm specification in human embryonic stem cells
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  174. Jul 2023
  175. www.nature.com www.nature.com
    Collateral lethality between HDAC1 and HDAC2 exploits cancer-specific NuRD complex vulnerabilities
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  176. www.sciencedirect.com www.sciencedirect.com
    Ketolysis drives CD8+ T cell effector function through effects on histone acetylation
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  177. www.embopress.org www.embopress.org
    Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells
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  178. www.sciencedirect.com www.sciencedirect.com
    Small cytosolic double-stranded DNA represses cyclic GMP-AMP synthase activation and induces autophagy
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  179. www.sciencedirect.com www.sciencedirect.com
    Targeting of multiple tumor-associated antigens by individual T cell receptors during successful cancer immunotherapy
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  180. www.biorxiv.org www.biorxiv.org
    Deep mutational scanning of whole SARS-CoV-2 spike in an inverted infection system
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  181. www.sciencedirect.com www.sciencedirect.com
    A spatially defined human Notch receptor interaction network reveals Notch intracellular storage and Ataxin-2-mediated fast recycling
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  182. www.sciencedirect.com www.sciencedirect.com
    Activation of GPR44 decreases severity of myeloid leukemia via specific targeting of leukemia initiating stem cells
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  183. 52.53.155.43 52.53.155.43
    Parallel genome-scale CRISPR screens distinguish pluripotency and self-renewal
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  184. www.biorxiv.org www.biorxiv.org
    Neuronal Activation of the Gαq Protein EGL-30/GNAQ Late in Life Rejuvenates Cognition Across Species
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  185. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Inhibition of CDK1 Overcomes Oxaliplatin Resistance by Regulating ACSL4-mediated Ferroptosis in Colorectal Cancer
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      RRID:Addgene_12

      DOI: 10.1002/advs.202301088

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    onlinelibrary.wiley.com/doi/10.1002/advs.202301088
  186. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Actin nucleators safeguard replication forks by limiting nascent strand degradation
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      Addgene_12260

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  187. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dynamic profiling of medulloblastoma surfaceome
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      RRID:Addgene_12260

      DOI: 10.1186/s40478-023-01609-7

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    ncbi.nlm.nih.gov/pmc/articles/PMC10331972/
  188. www.sciencedirect.com www.sciencedirect.com
    Calcium dysregulation combined with mitochondrial failure and electrophysiological maturity converge in Parkinson’s iPSC-dopamine neurons
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      Addgene_12260

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  189. 52.53.155.43 52.53.155.43
    can-23-0269-html.html
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      Addgene, 12260

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  190. www.nature.com www.nature.com
    Kinome-wide CRISPR-Cas9 knockout screens revealed PLK1 as a therapeutic target for osteosarcoma
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    1. scibot 08 Jul 2023
      RRID:Addgene_12260

      DOI: 10.1038/s41420-023-01526-7

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    nature.com/articles/s41420-023-01526-7
  191. www.sciencedirect.com www.sciencedirect.com
    TMEM106B is a receptor mediating ACE2-independent SARS-CoV-2 cell entry
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      RRID:Addgene_12260

      DOI: 10.1016/j.cell.2023.06.005

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    sciencedirect.com/science/article/pii/S0092867423006451
  192. 52.53.155.43 52.53.155.43
    qiad076-html.html
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      plasmid_12260

      DOI: 10.1093/jleuko/qiad076

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  193. www.sciencedirect.com www.sciencedirect.com
    The anti-SARS-CoV-2 effect and mechanism of Chiehyuan herbal oral protection solution
    1
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      RRID:Addgene_12260

      DOI: 10.1016/j.heliyon.2023.e17701

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  194. www.sciencedirect.com www.sciencedirect.com
    Alpha-tocopherylquinone differentially modulates claudins to enhance intestinal epithelial tight junction barrier via AhR and Nrf2 pathways
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      RRID:Addgene_12260

      DOI: 10.1016/j.celrep.2023.112705

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  195. 52.53.155.43 52.53.155.43
    cd-22-0411-html.html
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      DOI: 10.1158/2159-8290.cd-22-0411

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