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CRISPR associated enzymes are mislocalized to the cytoplasm in iPSC-derived neurons resulting in KRAB(KOX1)-specific degradation

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1. scibot 22 Oct 2026
  
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  127458
  
  DOI: 10.1016/j.cels.2026.101737
  
  Resource: RRID:Addgene_127458
  
  Curator: @dhovakimyan1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13682918/
Sep 2026
www.sciencedirect.com www.sciencedirect.com

Live-cell transcriptomics with engineered virus-like particles

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1. scibot 03 Sep 2026
  
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  Plasmid_127458
  
  DOI: 10.1016/j.cell.2026.08.005
  
  Resource: RRID:Addgene_127458
  
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sciencedirect.com/science/article/pii/S0092867426009323
Jun 2026
www.sciencedirect.com www.sciencedirect.com

Deep learning of functional perturbations from condensate morphology

1
1. scibot 05 Jun 2026
  
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  plasmid_127458
  
  DOI: 10.1016/j.cell.2026.05.010
  
  Resource: RRID:Addgene_127458
  
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sciencedirect.com/science/article/pii/S0092867426005696
Feb 2026
www.biorxiv.org www.biorxiv.org

X-CODE: a dual RNA barcoding system for multi-platform clonal tracking and spatial phenotyping

1
1. scibot 26 Feb 2026
  
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  Addgene; #127458
  
  DOI: 10.64898/2026.02.10.705126
  
  Resource: RRID:Addgene_127458
  
  Curator: @dhovakimyan1
  
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biorxiv.org/content/10.64898/2026.02.10.705126v1
Nov 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Temporal Clonal Tracing Reveals Tumor-Intrinsic IFNγ-Dependencies Driving Niche Adaptation and Early Metastatic Colonization

1
1. scibot 24 Nov 2025
  
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  Addgene_127458
  
  DOI: 10.1101/2025.08.13.669778
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12363968/
Jul 2025
www.nature.com www.nature.com

Single-cell image-based screens identify host regulators of Ebola virus infection dynamics

1
1. scibot 30 Jul 2025
  
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  Addgene, 127458
  
  DOI: 10.1038/s41564-025-02034-3
  
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  Curator: @dhovakimyan1
  
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nature.com/articles/s41564-025-02034-3
Jun 2025
www.sciencedirect.com www.sciencedirect.com

High-content image-based pooled screens reveal regulators of synaptogenesis

1
1. scibot 25 Jun 2025
  
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  Addgene_127458
  
  DOI: 10.1016/j.celrep.2025.115889
  
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sciencedirect.com/science/article/pii/S2211124725006606
Mar 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Optical Pooled Screening for the Discovery of Regulators of the Alternative Lengthening of Telomeres Pathway

1
1. scibot 11 Mar 2025
  
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  127458
  
  DOI: 10.1101/2025.02.15.638448
  
  Resource: RRID:Addgene_127458
  
  Curator: @olekpark
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11844499/
Dec 2024
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Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening

2
1. scibot 24 Dec 2024
  
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  AddgeneCat# 127458
  
  DOI: 10.1016/j.cels.2024.11.004
  
  Resource: RRID:Addgene_127458
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:Addgene_127458
  
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  RRID:Addgene_127458
2. scibot 10 Dec 2024
  
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  Addgene_127458
  
  DOI: 10.1016/j.cels.2024.11.004
  
  Resource: RRID:Addgene_127458
  
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sciencedirect.com/science/article/pii/S2405471224003375
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening

1
1. scibot 28 Apr 2024
  
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  Addgene_127458
  
  DOI: 10.1101/2024.04.07.588166
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11030420/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Single-cell image-based genetic screens systematically identify regulators of Ebola virus subcellular infection dynamics

1
1. scibot 23 Apr 2024
  
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  Addgene_127458
  
  DOI: 10.1101/2024.04.06.588168
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11014611/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

CROPseq-multi: a versatile solution for multiplexed perturbation and decoding in pooled CRISPR screens

1
1. scibot 15 Apr 2024
  
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  Plasmid_127458
  
  DOI: 10.1101/2024.03.17.585235
  
  Resource: RRID:Addgene_127458
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10979941/
Feb 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Sequential CRISPR screening reveals partial NatB inhibition as a strategy to mitigate alpha-synuclein levels in human neurons

1
1. scibot 15 Feb 2024
  
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  Addgene_127458
  
  DOI: 10.1126/sciadv.adj4767
  
  Resource: RRID:Addgene_127458
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10857481/
May 2023
www.pnas.org www.pnas.org

A genome-wide optical pooled screen reveals regulators of cellular antiviral responses

1
1. scibot 18 May 2023
  
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  Addgene_127458
  
  DOI: 10.1073/pnas.2210623120
  
  Resource: RRID:Addgene_127458
  
  Curator: @scibot
  
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pnas.org/doi/abs/10.1073/pnas.2210623120
Nov 2022
www.sciencedirect.com www.sciencedirect.com

The phenotypic landscape of essential human genes

2
1. scibot 09 Nov 2022
  
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  127458
  
  DOI: 10.1016/j.cell.2022.10.017
  
  Resource: RRID:Addgene_127458
  
  Curator: @a5munoz
  
  SciCrunch record: RRID:Addgene_127458
  
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  RRID:Addgene_127458
2. scibot 08 Nov 2022
  
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  Addgene_127458
  
  DOI: 10.1016/j.cell.2022.10.017
  
  Resource: RRID:Addgene_127458
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_127458
  
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  RRID:Addgene_127458
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sciencedirect.com/science/article/pii/S0092867422013599