47 Matching Annotations
  1. Nov 2025
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Prime editing for the investigation of aberrant splicing defect associated with a pathogenic PRPH2 variant
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    pmc.ncbi.nlm.nih.gov/articles/PMC12594906/
  3. Aug 2025
  4. www.science.org www.science.org
    Diverse oncogenes use common mechanisms to drive growth of major forms of human cancer
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    science.org/doi/10.1126/sciadv.adt1798
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Detecting Methylation Changes Induced by Prime Editing
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    pmc.ncbi.nlm.nih.gov/articles/PMC12294443/
  6. www.sciencedirect.com www.sciencedirect.com
    AI-generated MLH1 small binder improves prime editing efficiency
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    sciencedirect.com/science/article/pii/S0092867425007998
  7. Jul 2025
  8. www.science.org www.science.org
    High-resolution spatial mapping of cell state and lineage dynamics in vivo with PEtracer
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    science.org/doi/10.1126/science.adx3800
  9. www.cell.com www.cell.com
    In vivo prime editing rescues alternating hemiplegia of childhood in mice
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    cell.com/cell/fulltext/S0092-8674(25)00740-8
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Precise Correction of the Pde6b-L659P Mutation Causing Retinal Degeneration with Minimum Bystander Editing by Advanced Genome Editing Tools
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    pmc.ncbi.nlm.nih.gov/articles/PMC12220932/
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    In Vitro Correction of Point Mutations in the DYSF Gene Using Prime Editing
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    pmc.ncbi.nlm.nih.gov/articles/PMC12193300/
  12. Jun 2025
  13. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.70097
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Circular RNA-mediated inverse prime editing in human cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12125189/
  15. May 2025
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Universal Prime Editing Therapeutic Strategy for RyR1-Related Myopathies: A Protective Mutation Rescues Leaky RyR1 Channel
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    pmc.ncbi.nlm.nih.gov/articles/PMC11988564/
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Systematic optimization of prime editing for enhanced efficiency and versatility in genome engineering across diverse cell types
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    pmc.ncbi.nlm.nih.gov/articles/PMC12069386/
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Enhancing Prime Editing Efficiency Through Modulation of Methylation on the Newly Synthesized DNA Strand and Prolonged Expression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12061241/
  19. Mar 2025
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SunTag-PE: a modular prime editing system enables versatile and efficient genome editing
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    pmc.ncbi.nlm.nih.gov/articles/PMC11914589/
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Proceedings of the 27th Annual Meeting of the Portuguese Society of Human Genetics (SPGH – Sociedade Portuguesa de Genética Humana) Lisbon, 23 -25 November 2023
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    pmc.ncbi.nlm.nih.gov/articles/PMC11771725/
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    AMPK phosphosite profiling by label-free mass spectrometry reveals a multitude of mTORC1-regulated substrates
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    pmc.ncbi.nlm.nih.gov/articles/PMC11879883/
  23. www.nature.com www.nature.com
    Comparative characterization of human accelerated regions in neurons
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    nature.com/articles/s41586-025-08622-x
  24. Feb 2025
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    EXPERT expands prime editing efficiency and range of large fragment edits
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    pmc.ncbi.nlm.nih.gov/articles/PMC11822059/
  26. Jan 2025
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    In Vivo Prime Editing by Lipid Nanoparticle Co-delivery of Chemically Modified pegRNA and Prime Editor mRNA
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    pmc.ncbi.nlm.nih.gov/articles/PMC11756591/
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Delivery of Prime editing in human stem cells using pseudoviral NanoScribes particles
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    pmc.ncbi.nlm.nih.gov/articles/PMC11700204/
  29. www.sciencedirect.com www.sciencedirect.com
    Improved split prime editors enable efficient in vivo genome editing
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    sciencedirect.com/science/article/pii/S2211124724014955
  30. Sep 2024
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    T4 DNA polymerase prevents deleterious on-target DNA damage and enhances precise CRISPR editing
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    ncbi.nlm.nih.gov/pmc/articles/PMC11377749/
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Precise Insertion of AttB Sequences in Goat Genome Using Enhanced Prime Editor
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    ncbi.nlm.nih.gov/pmc/articles/PMC11395042/
  33. Jun 2024
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Development and testing of a versatile genome editing application reporter (V-GEAR) system
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    ncbi.nlm.nih.gov/pmc/articles/PMC11101715/
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Application of prime editing system to introduce TP53 R248Q hotspot mutation in acute lymphoblastic leukemia cell line
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    ncbi.nlm.nih.gov/pmc/articles/PMC11145152/
  36. May 2024
  37. www.biorxiv.org www.biorxiv.org
    Enrichment of allelic editing outcomes by Prime Editing in iPS cells
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    biorxiv.org/content/10.1101/2024.03.19.585665v1
  38. www.sciencedirect.com www.sciencedirect.com
    Prime editing functionally corrects cystic fibrosis-causing CFTR mutations in human organoids and airway epithelial cells
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    sciencedirect.com/science/article/pii/S2666379124002349
  39. Apr 2024
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Enhancing prime editor flexibility with coiled-coil heterodimers
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    ncbi.nlm.nih.gov/pmc/articles/PMC11046888/
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Improving prime editing with an endogenous small RNA-binding protein
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    ncbi.nlm.nih.gov/pmc/articles/PMC11023932/
  42. Mar 2024
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Enhancing prime editor activity by directed protein evolution in yeast
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    ncbi.nlm.nih.gov/pmc/articles/PMC10920827/
  44. Feb 2024
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Generation of Human Isogenic Induced Pluripotent Stem Cell Lines with CRISPR Prime Editing
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    ncbi.nlm.nih.gov/pmc/articles/PMC10880268/
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Profiling of RNA-binding protein binding sites by in situ reverse transcription-based sequencing
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    ncbi.nlm.nih.gov/pmc/articles/PMC10864177/
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide in-locus epitope tagging of Arabidopsis proteins using prime editors
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    ncbi.nlm.nih.gov/pmc/articles/PMC10828436/
  48. Jan 2024
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Fluorescent Reporter Mouse for In Vivo Assessment of Genome Editing with Diverse Cas Nucleases and Prime Editors
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    ncbi.nlm.nih.gov/pmc/articles/PMC10753986/
  50. Dec 2023
  51. www.sciencedirect.com www.sciencedirect.com
    High-throughput PRIME-editing screens identify functional DNA variants in the human genome
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    sciencedirect.com/science/article/pii/S1097276523009668
  52. Aug 2023
  53. www.sciencedirect.com www.sciencedirect.com
    Quantitative proteomics and phosphoproteomics of PP2A-PPP2R5D variants reveal deregulation of RPS6 phosphorylation via converging signaling cascades
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    sciencedirect.com/science/article/pii/S0021925823021828
  54. May 2023
  55. www.mdpi.com www.mdpi.com
    Comparison of In-Frame Deletion, Homology-Directed Repair, and Prime Editing-Based Correction of Duchenne Muscular Dystrophy Mutations
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    mdpi.com/2218-273X/13/5/870
  56. www.sciencedirect.com www.sciencedirect.com
    Systematic characterization of regulatory variants of blood pressure genes
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    sciencedirect.com/science/article/pii/S2666979X23000988
  57. www.sciencedirect.com www.sciencedirect.com
    Generation of three CRISPR/Cas9 edited human induced pluripotent stem cell lines (DHMi005-A-5, DHMi005-A-6 and DHMi005-A-7) carrying a Holt-Oram Syndrome patient-specific TBX5 mutation with known cardiac phenotype and a FLAG-tag after exon 9 of the TBX5 gene
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    sciencedirect.com/science/article/pii/S1873506123001095
  58. academic.oup.com academic.oup.com
    Position-dependent sequence motif preferences of SpCas9 are largely determined by scaffold-complementary spacer motifs
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    academic.oup.com/nar/advance-article/doi/10.1093/nar/gkad323/7151351
  59. Apr 2023
  60. www.biorxiv.org www.biorxiv.org
    Quantitative proteomics and phosphoproteomics of PPP2R5D variants reveal deregulation of RPS6 phosphorylation through converging signaling cascades
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    biorxiv.org/content/10.1101/2023.03.27.534397v1
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An OMA1 redox site controls mitochondrial homeostasis, sarcoma growth, and immunogenicity
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    ncbi.nlm.nih.gov/pmc/articles/PMC10078952/
  62. Oct 2022
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Highly efficient generation of isogenic pluripotent stem cell models using prime editing
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    ncbi.nlm.nih.gov/pmc/articles/PMC9584603/
  64. www.sciencedirect.com www.sciencedirect.com
    Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas
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    sciencedirect.com/science/article/pii/S1097276522008966
  65. May 2022
  66. www.nature.com www.nature.com
    Saturation variant interpretation using CRISPR prime editing
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    nature.com/articles/s41587-021-01201-1
  67. Jan 2022
  68. www.sciencedirect.com www.sciencedirect.com
    Generation of a CRISPR/Cas edited human induced pluripotent stem cell line DHMi005-A-1 carrying a patient-specific disease-causing point mutation in the TBX5 gene
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    sciencedirect.com/science/article/pii/S187350612200040X
  69. May 2021
  70. www.sciencedirect.com www.sciencedirect.com
    Adenine base editing and prime editing of chemically derived hepatic progenitors rescue genetic liver disease
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    sciencedirect.com/science/article/pii/S1934590921001673