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Simvastatin overcomes the pPCK1‐pLDHA‐SPRINGlac axis‐mediated ferroptosis and chemo‐immunotherapy resistance in AKT‐hyperactivated intrahepatic cholangiocarcinoma

1
1. scibot 07 Sep 2025
  
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  132777
  
  DOI: 10.1002/cac2.70036
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12365544/
Sep 2025
www.nature.com www.nature.com

A streamlined base editor engineering strategy to reduce bystander editing

1
1. scibot 03 Sep 2025
  
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  RRID:Addgene_132777
  
  DOI: 10.1038/s41467-025-63609-6
  
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nature.com/articles/s41467-025-63609-6
Aug 2025
www.science.org www.science.org

Diverse oncogenes use common mechanisms to drive growth of major forms of human cancer

1
1. scibot 27 Aug 2025
  
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  132777
  
  DOI: 10.1126/sciadv.adt1798
  
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science.org/doi/10.1126/sciadv.adt1798
Jul 2025
www.cell.com www.cell.com

In vivo prime editing rescues alternating hemiplegia of childhood in mice

1
1. scibot 25 Jul 2025
  
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  #132777
  
  DOI: 10.1016/j.cell.2025.06.038
  
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cell.com/cell/fulltext/S0092-8674(25)00740-8
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Modulating Collagen I Expression in Fibroblasts by CRISPR-Cas9 Base Editing of the Collagen 1A1 Promoter

1
1. scibot 17 May 2025
  
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  132777
  
  DOI: 10.3390/ijms26073041
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11989027/
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Enhancing Prime Editing Efficiency Through Modulation of Methylation on the Newly Synthesized DNA Strand and Prolonged Expression

1
1. scibot 17 May 2025
  
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  132 777
  
  DOI: 10.1002/advs.202417790
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12061241/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

A dual-fluorescence assay for gene delivery vehicle screening in macrophages with an inflammation-inducible reporter construct

1
1. scibot 17 May 2025
  
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  Addgene_132
  
  DOI: 10.1186/s44330-025-00030-x
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12062070/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

High-throughput screening of human genetic variants by pooled prime editing

1
1. scibot 16 May 2025
  
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  132777
  
  DOI: 10.1016/j.xgen.2025.100814
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12008803/
Mar 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

In vivo prime editing rescues photoreceptor degeneration in nonsense mutant retinitis pigmentosa

1
1. scibot 23 Mar 2025
  
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  Addgene_132777
  
  DOI: 10.1038/s41467-025-57628-6
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11893901/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Precise Generation of Human Induced Pluripotent Stem Cell–derived Cell Lines Harboring Disease-relevant Single Nucleotide Variants Using a Prime Editing System

1
1. scibot 11 Mar 2025
  
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  132777
  
  DOI: 10.21769/BioProtoc.5191
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11865833/
Feb 2025
www.sciencedirect.com www.sciencedirect.com

Variability in proliferative and migratory defects in Hirschsprung disease-associated RET pathogenic variants

1
1. scibot 27 Feb 2025
  
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  Addgene (cat. #132777)
  
  DOI: 10.1016/j.ajhg.2025.02.004
  
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sciencedirect.com/science/article/pii/S0002929725000515
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The integrated stress response drives MET oncogene overexpression in cancers

1
1. scibot 23 Feb 2025
  
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  132777
  
  DOI: 10.1038/s44318-024-00338-4
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11832788/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

A molecular proximity sensor based on an engineered, dual-component guide RNA

1
1. scibot 16 Feb 2025
  
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  132777
  
  DOI: 10.7554/eLife.98110
  
  Resource: RRID:Addgene_132777
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11820115/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

EXPERT expands prime editing efficiency and range of large fragment edits

1
1. scibot 16 Feb 2025
  
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  132777
  
  DOI: 10.1038/s41467-025-56734-9
  
  Resource: RRID:Addgene_132777
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11822059/
Jan 2025
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ATRX silences Cartpt expression in osteoblastic cells during skeletal development

1
1. scibot 27 Jan 2025
  
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  132777
  
  DOI: 10.1172/JCI163587
  
  Resource: RRID:Addgene_132777
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11684799/
Dec 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Identification of a novel nuclease activity in human DDX49 helicase

1
1. scibot 27 Dec 2024
  
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  132777
  
  DOI: 10.1098/rsos.241891
  
  Resource: RRID:Addgene_132777
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11651898/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Prime Editor Gene Therapy and TREX1 Mosaicism in Retinal Vasculopathy with Cerebral Leukoencephalopathy

1
1. scibot 27 Dec 2024
  
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  132777
  
  DOI: 10.1007/s10875-024-01846-y
  
  Resource: RRID:Addgene_132777
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11645301/
www.nature.com www.nature.com

Precise kilobase-scale genomic insertions in mammalian cells using PASTE

2
1. scibot 17 Dec 2024
  
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  Addgene ID: 132777
  
  DOI: 10.1038/s41596-024-01090-z
  
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  Curator: @inessasarian
  
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  RRID:Addgene_132777
2. scibot 17 Dec 2024
  
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  Addgene_132777
  
  DOI: 10.1038/s41596-024-01090-z
  
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nature.com/articles/s41596-024-01090-z
Sep 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

ISGylation enhances dsRNA-induced interferon response and NFκB signaling in fallopian tube epithelial cells

1
1. scibot 27 Sep 2024
  
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  132777
  
  DOI: 10.1016/j.jbc.2024.107686
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11418117/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Engineering Oncogenic Hotspot Mutations on SF3B1 via CRISPR-Directed PRECIS Mutagenesis

1
1. scibot 27 Sep 2024
  
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  132777
  
  DOI: 10.1158/2767-9764.CRC-24-0145
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11421219/
www.sciencedirect.com www.sciencedirect.com

Modeling the atrioventricular conduction axis using human pluripotent stem cell-derived cardiac assembloids

1
1. scibot 11 Sep 2024
  
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  RRID:Addgene_132777
  
  DOI: 10.1016/j.stem.2024.08.008
  
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sciencedirect.com/science/article/pii/S1934590924002947
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Directed evolution of hyperactive integrases for site specific insertion of transgenes

1
1. scibot 22 Aug 2024
  
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  Addgene_132777
  
  DOI: 10.1093/nar/gkae534
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11317131/
Jun 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Precise editing of pathogenic nucleotide repeat expansions in iPSCs using paired prime editor

1
1. scibot 15 Jun 2024
  
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  plasmid_132777
  
  DOI: 10.1093/nar/gkae310
  
  Resource: RRID:Addgene_132777
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11162781/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Application of prime editing system to introduce TP53 R248Q hotspot mutation in acute lymphoblastic leukemia cell line

1
1. scibot 06 Jun 2024
  
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  132777
  
  DOI: 10.1111/cas.16162
  
  Resource: RRID:Addgene_132777
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11145152/
May 2024
www.biorxiv.org www.biorxiv.org

Enrichment of allelic editing outcomes by Prime Editing in iPS cells

1
1. scibot 29 May 2024
  
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  RRID; Addgene_132777
  
  DOI: 10.1101/2024.03.19.585665
  
  Resource: RRID:Addgene_132777
  
  Curator: @abever99
  
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  DOI:10.1101/2024.03.19.585665 RRID:Addgene_132777
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DOI:10.1101/2024.03.19.585665

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biorxiv.org/content/10.1101/2024.03.19.585665v1
analyticalsciencejournals.onlinelibrary.wiley.com analyticalsciencejournals.onlinelibrary.wiley.com

Prime editing-mediated correction of the leptin receptor in muscle cells of db/db mice

1
1. scibot 16 May 2024
  
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  RRID:Addgene_132777
  
  DOI: 10.1002/biot.202300676
  
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analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/biot.202300676
www.sciencedirect.com www.sciencedirect.com

Prime editing functionally corrects cystic fibrosis-causing CFTR mutations in human organoids and airway epithelial cells

1
1. scibot 02 May 2024
  
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  Addgene: 132777
  
  DOI: 10.1016/j.xcrm.2024.101544
  
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sciencedirect.com/science/article/pii/S2666379124002349
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Improving prime editing with an endogenous small RNA-binding protein

1
1. scibot 23 Apr 2024
  
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  132777
  
  DOI: 10.1038/s41586-024-07259-6
  
  Resource: RRID:Addgene_132777
  
  Curator: @olekpark
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11023932/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Massively parallel screen uncovers many rare 3′ UTR variants regulating mRNA abundance of cancer driver genes

1
1. scibot 23 Apr 2024
  
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  Plasmid_132777
  
  DOI: 10.1038/s41467-024-46795-7
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11026479/
Feb 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Generation of Human Isogenic Induced Pluripotent Stem Cell Lines with CRISPR Prime Editing

1
1. scibot 29 Feb 2024
  
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  Addgene_132777
  
  DOI: 10.1089/crispr.2023.0066
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10880268/
www.biorxiv.org www.biorxiv.org

iSCORE-PD: an isogenic stem cell collection to research Parkinson’s Disease

1
1. scibot 22 Feb 2024
  
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  RRID:Addgene_132777
  
  DOI: 10.1101/2024.02.12.579917
  
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biorxiv.org/content/10.1101/2024.02.12.579917v1
Sep 2023
www.nature.com www.nature.com

CRISPR prime editing for unconstrained correction of oncogenic KRAS variants

1
1. scibot 20 Sep 2023
  
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  132777
  
  DOI: 10.1038/s42003-023-05052-1
  
  Resource: RRID:Addgene_132777
  
  Curator: @bandrow
  
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  RRID:Addgene_132777
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nature.com/articles/s42003-023-05052-1
May 2023
www.sciencedirect.com www.sciencedirect.com

Generation of three CRISPR/Cas9 edited human induced pluripotent stem cell lines (DHMi005-A-5, DHMi005-A-6 and DHMi005-A-7) carrying a Holt-Oram Syndrome patient-specific TBX5 mutation with known cardiac phenotype and a FLAG-tag after exon 9 of the TBX5 gene

1
1. scibot 17 May 2023
  
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  Addgene_132777
  
  DOI: 10.1016/j.scr.2023.103123
  
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sciencedirect.com/science/article/pii/S1873506123001095
Apr 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

An OMA1 redox site controls mitochondrial homeostasis, sarcoma growth, and immunogenicity

1
1. scibot 08 Apr 2023
  
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  RRID:Addgene_132777
  
  DOI: 10.26508/lsa.202201767
  
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  Curator: @scibot
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10078952/
Oct 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Highly efficient generation of isogenic pluripotent stem cell models using prime editing

1
1. scibot 25 Oct 2022
  
  in Public
  
  RRID:Addgene_132777
  
  DOI: 10.7554/eLife.79208
  
  Resource: RRID:Addgene_132777
  
  Curator: @scibot
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9584603/
www.sciencedirect.com www.sciencedirect.com

Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas

1
1. scibot 07 Oct 2022
  
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  Cat#132777
  
  DOI: 10.1016/j.molcel.2022.09.007
  
  Resource: RRID:Addgene_132777
  
  Curator: @a5munoz
  
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sciencedirect.com/science/article/pii/S1097276522008966
May 2022
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A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination

1
1. scibot 25 May 2022
  
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  AddgeneCat#132777
  
  DOI: 10.1016/j.molcel.2022.04.031
  
  Resource: RRID:Addgene_132777
  
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sciencedirect.com/science/article/pii/S109727652200394X
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Saturation variant interpretation using CRISPR prime editing

1
1. scibot 05 May 2022
  
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  RRID:Addgene_132777
  
  DOI: 10.1038/s41587-021-01201-1
  
  Resource: RRID:Addgene_132777
  
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nature.com/articles/s41587-021-01201-1
Jan 2022
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Generation of a CRISPR/Cas edited human induced pluripotent stem cell line DHMi005-A-1 carrying a patient-specific disease-causing point mutation in the TBX5 gene

2
1. scibot 28 Jan 2022
  
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  Addgene #132777
  
  DOI: 10.1016/j.scr.2022.102691
  
  Resource: RRID:Addgene_132777
  
  Curator: @sophiastull
  
  SciCrunch record: RRID:Addgene_132777
  
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  RRID:Addgene_132777
2. scibot 28 Jan 2022
  
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  RRID:Addgene_132777
  
  DOI: 10.1016/j.scr.2022.102691
  
  Resource: RRID:Addgene_132777
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S187350612200040X
May 2021
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Adenine base editing and prime editing of chemically derived hepatic progenitors rescue genetic liver disease

1
1. scibot 05 May 2021
  
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  Addgene_132777
  
  DOI: 10.1016/j.stem.2021.04.010
  
  Resource: RRID:Addgene_132777
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_132777
  
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  RRID:Addgene_132777
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sciencedirect.com/science/article/pii/S1934590921001673