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Deep Prior Framework: integrating functional specificity with general plausibility for targeted protein evolution

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1. scibot 09 Oct 2026
  
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  138489
  
  DOI: 10.1093/bib/bbag279
  
  Resource: RRID:Addgene_138489
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13256232/
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Long-term restoration of auditory function in a DFNA2 mouse model by adenine base editing

1
1. scibot 08 Oct 2026
  
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  138489
  
  DOI: 10.1038/s44321-026-00433-5
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13270111/
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Somatic deficiency of the human E3 ubiquitin ligase CBL in leukocytes impairs B cell but not T cell development and function

1
1. scibot 07 Oct 2026
  
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  138489
  
  DOI: 10.1038/s41590-025-02381-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12864045/
Aug 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Guide RNA reprogramming facilitates minimized tracrRNA-dependent off-target and versatile CRISPR/Cas9 engineering

1
1. scibot 07 Aug 2026
  
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  138489
  
  DOI: 10.1038/s41467-026-74520-z
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13434305/
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Deep learning–guided engineering of SpuFz1 and rational miniaturization of ωRNA enables efficient genome editing

1
1. scibot 07 Aug 2026
  
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  plasmid_138489
  
  DOI: 10.1038/s41467-026-74624-6
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13434818/
Jun 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Cleavage of the RNA polymerase II general transcription factor TFIIB tunes transcription during stress

1
1. scibot 18 Jun 2026
  
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  Addgene_138489
  
  DOI: 10.1101/gad.353187.125
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13263058/
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Genome-wide screening reveals producer-cell modifications that improve virus-like particle production and delivery potency

1
1. scibot 06 Jun 2026
  
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  Addgene_138489
  
  DOI: 10.1038/s41467-026-71925-8
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13109392/
May 2026
www.sciencedirect.com www.sciencedirect.com

Genotoxicity profiling reveals distinct platform-and cell type-specific effects in therapeutic gene editing for genetic hyperinflammation

1
1. scibot 14 May 2026
  
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  Addgene_138489
  
  DOI: 10.1016/j.stem.2026.04.014
  
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sciencedirect.com/science/article/pii/S1934590926001542
Apr 2026
advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com

Design of Safe and Efficient Adenine Base Editors via Protein Language Model Screening for Osteoarthritis Treatment

1
1. scibot 30 Apr 2026
  
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  138489
  
  DOI: 10.1002/advs.202519807
  
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advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202519807
Mar 2026
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ABE9 fused to SpRY Cas9 nickase enables precise generation of bystander free mouse models

1
1. scibot 27 Mar 2026
  
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  plasmid_13848923
  
  DOI: 10.1038/s41598-026-40642-z
  
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  Curator: @olekpark
  
  SciCrunch record: RRID:Addgene_138489
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12929607/
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Genome-wide screening reveals producer-cell modifications that improve virus-like particle production and delivery potency

1
1. scibot 18 Mar 2026
  
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  Addgene_138489
  
  DOI: 10.1101/2025.10.07.681010
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12893062/
www.sciencedirect.com www.sciencedirect.com

Precise and efficient DNA base editing restores normal hearing in adult DFNB9 mouse model

1
1. scibot 03 Mar 2026
  
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  Addgene_138489
  
  DOI: 10.1016/j.medj.2026.101001
  
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sciencedirect.com/science/article/pii/S2666634026000048
Jan 2026
www.sciencedirect.com www.sciencedirect.com

AAVLINK: A potent DNA-recombination method for large cargo delivery in gene therapy

1
1. scibot 29 Jan 2026
  
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  plasmid_138489
  
  DOI: 10.1016/j.cell.2025.12.039
  
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sciencedirect.com/science/article/pii/S0092867425014886
Nov 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

A modular strategy for extracellular vesicle-mediated CRISPR-Cas9 delivery through aptamer-based loading and UV-activated cargo release

1
1. scibot 24 Nov 2025
  
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  138489
  
  DOI: 10.1038/s41467-025-65995-3
  
  Resource: RRID:Addgene_138489
  
  Curator: @olekpark
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12639036/
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A motif preferred adenine base editor with minimal bystander and off-targets editing

1
1. scibot 24 Nov 2025
  
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  138489
  
  DOI: 10.1038/s41467-025-64203-6
  
  Resource: RRID:Addgene_138489
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12528748/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Adenine base editing rescues disrupted BCKDH function and reduces BCAAs toxic accumulation in maple syrup urine disease patient iPSC-hepatic organoids

1
1. scibot 23 Nov 2025
  
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  138489
  
  DOI: 10.1186/s13287-025-04630-w
  
  Resource: RRID:Addgene_138489
  
  Curator: @olekpark
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12465149/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Double-stranded DNA deaminase DddAE1347A can increase the efficiency and targeting range of cytidine base editors

1
1. scibot 21 Nov 2025
  
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  138489
  
  DOI: 10.1186/s13059-025-03849-3
  
  Resource: RRID:Addgene_138489
  
  Curator: @olekpark
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12621369/
www.sciencedirect.com www.sciencedirect.com

Megabase-scale loss of heterozygosity provoked by CRISPR-Cas9 DNA double-strand breaks

1
1. scibot 08 Nov 2025
  
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  Addgene_138489
  
  DOI: 10.1016/j.molcel.2025.10.015
  
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sciencedirect.com/science/article/pii/S1097276525008561
Sep 2025
www.sciencedirect.com www.sciencedirect.com

Multiplex base editing of BCL11A regulatory elements to treat sickle cell disease

1
1. scibot 27 Sep 2025
  
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  Addgene_138489
  
  DOI: 10.1016/j.xcrm.2025.102376
  
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sciencedirect.com/science/article/pii/S2666379125004495
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Optimized in vivo base editing restores auditory function in a DFNA15 mouse model

1
1. scibot 22 Sep 2025
  
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  138489
  
  DOI: 10.1038/s41467-025-63613-w
  
  Resource: RRID:Addgene_138489
  
  Curator: @olekpark
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12446455/
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A series of precise and controllable base editors with split-TadA-8e

1
1. scibot 06 Sep 2025
  
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  Addgene_138489
  
  DOI: 10.1016/j.omtn.2025.102672
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12408220/
www.sciencedirect.com www.sciencedirect.com

A base editor facilitates simultaneous purine and pyrimidine substitutions for ex vivo and in vivo mutagenesis screens

1
1. scibot 06 Sep 2025
  
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  Addgene_138489
  
  DOI: 10.1016/j.chembiol.2025.08.003
  
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sciencedirect.com/science/article/pii/S2451945625002491
www.nature.com www.nature.com

A streamlined base editor engineering strategy to reduce bystander editing

1
1. scibot 03 Sep 2025
  
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  RRID:Addgene_138489
  
  DOI: 10.1038/s41467-025-63609-6
  
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nature.com/articles/s41467-025-63609-6
Aug 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

PAM-flexible adenine base editing rescues hearing loss in a humanized MPZL2 mouse model harboring an East Asian founder mutation

1
1. scibot 10 Aug 2025
  
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  138489
  
  DOI: 10.1038/s41467-025-62562-8
  
  Resource: RRID:Addgene_138489
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12325647/
www.biorxiv.org www.biorxiv.org

Cleavage of the RNA polymerase II general transcription factor TFIIB es transcription during stress

1
1. scibot 01 Aug 2025
  
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  Addgene_138489
  
  DOI: 10.1101/2025.07.28.667251
  
  Resource: RRID:Addgene_138489
  
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biorxiv.org/content/10.1101/2025.07.28.667251v1
Jul 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Establishment and rescue of fibroblast cell lines carrying a nonsense mutation of RB1 by CRISPR-based base editing

1
1. scibot 20 Jul 2025
  
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  138489
  
  DOI: 10.1038/s41598-025-10600-2
  
  Resource: RRID:Addgene_138489
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12254293/
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Systematic empirical evaluation of individual base editing targets: Validating therapeutic targets in USH2A and comparison of methods

1
1. scibot 19 May 2025
  
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  Addgene_138489
  
  DOI: 10.1016/j.ymthe.2025.01.042
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11997516/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Predicting adenine base editing efficiencies in different cellular contexts by deep learning

1
1. scibot 17 May 2025
  
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  138489
  
  DOI: 10.1186/s13059-025-03586-7
  
  Resource: RRID:Addgene_138489
  
  Curator: @olekpark
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12060317/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Precision enhancement of CAR-NK cells through non-viral engineering and highly multiplexed base editing

1
1. scibot 17 May 2025
  
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  138489/)
  
  DOI: 10.1136/jitc-2024-009560
  
  Resource: RRID:Addgene_138489
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12067936/
Apr 2025
elifesciences.org elifesciences.org

Transcriptome-wide identification of 5-methylcytosine by deaminase and reader protein-assisted sequencing

1
1. scibot 10 Apr 2025
  
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  RRID:Addgene_138489
  
  DOI: 10.7554/eLife.98166
  
  Resource: RRID:Addgene_138489
  
  Curator: @dhovakimyan1
  
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  DOI:10.7554/eLife.98166 RRID:Addgene_138489
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DOI:10.7554/eLife.98166

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elifesciences.org/articles/98166
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Library‐Assisted Evolution in Eukaryotic Cells Yield Adenine Base Editors with Enhanced Editing Specificity

1
1. scibot 17 Aug 2024
  
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  138489
  
  DOI: 10.1002/advs.202309004
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11321652/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Precision Enhancement of CAR-NK Cells through Non-Viral Engineering and Highly Multiplexed Base Editing

1
1. scibot 13 Aug 2024
  
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  https://www.addgene.org/138489/
  
  DOI: 10.1101/2024.03.05.582637
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10942345/
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Genetic and functional correction of argininosuccinate lyase deficiency using CRISPR adenine base editors

1
1. scibot 05 Apr 2024
  
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  RRID:Addgene_138489
  
  DOI: 10.1016/j.ajhg.2024.03.004
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11023919/
Jun 2023
www.nature.com www.nature.com

Rapid and definitive treatment of phenylketonuria in variant-humanized mice with corrective editing

1
1. scibot 13 Jun 2023
  
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  RRID:Addgene_138489
  
  DOI: 10.1038/s41467-023-39246-2
  
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nature.com/articles/s41467-023-39246-2
Apr 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Precise in vivo functional analysis of DNA variants with base editing using ACEofBASEs target prediction

1
1. scibot 27 Apr 2022
  
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  RRID:Addgene_138489
  
  DOI: 10.7554/eLife.72124
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9033269/