95 Matching Annotations
  1. Jul 2025
  2. www.biorxiv.org www.biorxiv.org
    A novel, high-density CRISPR activation platform for mapping cancer dependencies and resistance pathways ex vivo and in vivo
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    biorxiv.org/content/10.1101/2025.07.22.666069v1
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The role of gene duplication and paralog specialisation in the evolution of the mammalian PRPS complex
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    pmc.ncbi.nlm.nih.gov/articles/PMC12238573/
  4. Jun 2025
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PRPS activity tunes redox homeostasis in Myc-driven lymphoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12166406/
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Phosphorylation-induced SUMOylation promotes Ulk4 condensation at the ciliary tip to transduce Hedgehog signal
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    pmc.ncbi.nlm.nih.gov/articles/PMC12148026/
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Harnessing endogenous miRNA targeting ZIKV: A cutting-edge strategy to inhibit virus infection
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    pmc.ncbi.nlm.nih.gov/articles/PMC12155756/
  8. May 2025
  9. www.sciencedirect.com www.sciencedirect.com
    Two waves of adipogenesis in developing avian skin and dermal plasticity
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    sciencedirect.com/science/article/pii/S0012160625001423
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Lineage-specific CDK activity dynamics characterize early mammalian development
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    pmc.ncbi.nlm.nih.gov/articles/PMC12070373/
  11. Mar 2025
  12. www.sciencedirect.com www.sciencedirect.com
    m6A deficiency impairs hypothalamic neurogenesis of feeding-related neurons in mice and human organoids and leads to adult obesity in mice
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    sciencedirect.com/science/article/pii/S1934590925000797
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The PST repeat region of MDC1 is a tunable multivalent chromatin tethering domain
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    pmc.ncbi.nlm.nih.gov/articles/PMC11761366/
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    UM171 glues asymmetric CRL3–HDAC1/2 assembly to degrade CoREST corepressors
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    pmc.ncbi.nlm.nih.gov/articles/PMC11882444/
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The essential clathrin adapter protein complex-2 is tumor suppressive specifically in vivo
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    pmc.ncbi.nlm.nih.gov/articles/PMC11885535/
  16. Feb 2025
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    GEVSod2 Powder: A Modified Product Based on Biovesicles Functioned in Air Pollution PM2.5-Induced Cardiopulmonary Injury
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    pmc.ncbi.nlm.nih.gov/articles/PMC11822167/
  18. Jan 2025
  19. www.nature.com www.nature.com
    Advancing the genetic engineering toolbox by combining AsCas12a knock-in mice with ultra-compact screening
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    nature.com/articles/s41467-025-56282-2
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Proximity based proteomics reveals Git1 as a regulator of Smoothened signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC11741329/
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    OSMOTIC STRESS INFLUENCES MICROTUBULE DRUG RESPONSE VIA WNK1 KINASE SIGNALING
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    sciencedirect.com/science/article/pii/S1368764625000032
  22. Dec 2024
  23. 52.53.155.43 52.53.155.43
    PDF-html.html
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  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Identification and development of TRPM4 antagonists to counteract neuronal excitotoxicity
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    pmc.ncbi.nlm.nih.gov/articles/PMC11648915/
  25. Nov 2024
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Regulation of synapse density by Pumilio RNA-binding proteins
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    pmc.ncbi.nlm.nih.gov/articles/PMC11544588/
  27. www.biorxiv.org www.biorxiv.org
    Human adipose-derived mesenchymal stromal cells improved wound healing in enterocutaneous fistulizing disease mouse model
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    biorxiv.org/content/10.1101/2024.11.07.622127v1
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Manipulation of DHPS activity affects dendritic morphology and expression of synaptic proteins in primary rat cortical neurons
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    pmc.ncbi.nlm.nih.gov/articles/PMC11513877/
  29. Sep 2024
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Light-gated integrator for highlighting kinase activity in living cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11379911/
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    New ZNHIT3 Variants Disrupting snoRNP Assembly Cause Prenatal PEHO Syndrome with Isolated Hydrops
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    ncbi.nlm.nih.gov/pmc/articles/PMC11383450/
  32. Aug 2024
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Deafness causing neuroplastin missense variants fail to promote plasma membrane Ca2+-ATPase levels and Ca2+ transient regulation in brain neurons
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    ncbi.nlm.nih.gov/pmc/articles/PMC11264175/
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Alzheimer’s disease–linked protease BACE2 cleaves VEGFR3 and modulates its signaling
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    ncbi.nlm.nih.gov/pmc/articles/PMC11324312/
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Arl2 GTPase associates with the centrosomal protein Cdk5rap2 to regulate cortical development via microtubule organization
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    ncbi.nlm.nih.gov/pmc/articles/PMC11321591/
  36. Jul 2024
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TRPV4 disrupts mitochondrial transport and causes axonal degeneration via a CaMKII-dependent elevation of intracellular Ca2+
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    ncbi.nlm.nih.gov/pmc/articles/PMC7260201/
  38. www.biorxiv.org www.biorxiv.org
    Osmotic Stress Influences Microtubule Drug Response Via WNK1 Kinase Signaling
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    biorxiv.org/content/10.1101/2024.07.08.602030v1
  39. Jun 2024
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MYCT1 controls environmental sensing in human haematopoietic stem cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11168926/
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A dynamic in vitro model of Down syndrome neurogenesis with trisomy 21 gene dosage correction
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    ncbi.nlm.nih.gov/pmc/articles/PMC11160455/
  42. www.biorxiv.org www.biorxiv.org
    Advancing the genetic engineering toolbox by combining AsCas12a knock-in mice with ultra-compact screening
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    biorxiv.org/content/10.1101/2024.05.30.596755v1
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Aplp1 interacts with Lag3 to facilitate transmission of pathologic α-synuclein
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    ncbi.nlm.nih.gov/pmc/articles/PMC11143359/
  44. May 2024
  45. www.biorxiv.org www.biorxiv.org
    Spatiotemporal proteomics reveals the biosynthetic lysosomal membrane protein interactome in neurons
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    biorxiv.org/content/10.1101/2024.05.16.594502v1
  46. www.sciencedirect.com www.sciencedirect.com
    Modeling blood-brain barrier formation and cerebral cavernous malformations in human PSC-derived organoids
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    sciencedirect.com/science/article/pii/S1934590924001462
  47. Apr 2024
  48. www.sciencedirect.com www.sciencedirect.com
    Transcription factor Tox2 is required for metabolic adaptation and tissue residency of ILC3 in the gut
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    sciencedirect.com/science/article/pii/S1074761324002061
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    Hematopoietic stem cell niche generation and maintenance are distinguishable by an epitranscriptomic program
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    sciencedirect.com/science/article/pii/S0092867424003489
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The response of Dual-leucine zipper kinase (DLK) to nocodazole: Evidence for a homeostatic cytoskeletal repair mechanism
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    ncbi.nlm.nih.gov/pmc/articles/PMC10994325/
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Light-gated Integrator for Highlighting Kinase Activity in Living Cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10983958/
  52. www.sciencedirect.com www.sciencedirect.com
    Human iPSC 4R tauopathy model uncovers modifiers of tau propagation
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    sciencedirect.com/science/article/pii/S0092867424003064
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Viral Epitope Scanning Reveals Correlation between Seasonal HCoVs and SARS-CoV-2 Antibody Responses among Cancer and Non-Cancer Patients
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    ncbi.nlm.nih.gov/pmc/articles/PMC10975915/
  54. Feb 2024
  55. www.sciencedirect.com www.sciencedirect.com
    Protocol for the isolation of GFP-expressing ferroptosis-dependent extracellular vesicles in in vitro cell culture models
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    sciencedirect.com/science/article/pii/S2666166724000571
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sequential CRISPR screening reveals partial NatB inhibition as a strategy to mitigate alpha-synuclein levels in human neurons
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    ncbi.nlm.nih.gov/pmc/articles/PMC10857481/
  57. www.sciencedirect.com www.sciencedirect.com
    In vivo imaging in transgenic songbirds reveals superdiffusive neuron migration in the adult brain
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    sciencedirect.com/science/article/pii/S221112472400086X
  58. www.sciencedirect.com www.sciencedirect.com
    Glia trigger endocytic clearance of axonal proteins to promote rodent myelination
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    sciencedirect.com/science/article/pii/S1534580724000285
  59. Jan 2024
  60. www.jneurosci.org www.jneurosci.org
    Synaptotagmin 9 Modulates Spontaneous Neurotransmitter Release in Striatal Neurons by Regulating Substance P Secretion
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    jneurosci.org/content/43/9/1475
  61. www.nature.com www.nature.com
    The juxtamembrane linker of synaptotagmin 1 regulates Ca2+ binding via liquid-liquid phase separation
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    nature.com/articles/s41467-023-44414-5
  62. www.sciencedirect.com www.sciencedirect.com
    A TCF4-dependent gene regulatory network confers resistance to immunotherapy in melanoma
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    sciencedirect.com/science/article/pii/S0092867423013223
  63. Nov 2023
  64. www.sciencedirect.com www.sciencedirect.com
    Chimeric autoantibody receptor T cells deplete NMDA receptor-specific B cells
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    sciencedirect.com/science/article/pii/S0092867423010838
  65. Oct 2023
  66. www.sciencedirect.com www.sciencedirect.com
    Abl2 repairs microtubules and phase separates with tubulin to promote microtubule nucleation
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    sciencedirect.com/science/article/pii/S0960982223012344
  67. www.sciencedirect.com www.sciencedirect.com
    Human pallial MGE-type GABAergic interneuron cell therapy for chronic focal epilepsy
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    sciencedirect.com/science/article/pii/S1934590923002965
  68. Aug 2023
  69. 52.53.155.43 52.53.155.43
    2023.08.11.551903v1.full-html.html
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    Neuronal γ-secretase regulates lipid metabolism, linking cholesterol to synaptic dysfunction in Alzheimer’s disease
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    sciencedirect.com/science/article/pii/S0896627323005135
  71. May 2023
  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mitofusin 2 sustains the axonal mitochondrial network to support presynaptic Ca2+ homeostasis and the synaptic vesicle cycle in rat hippocampal axons
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    ncbi.nlm.nih.gov/pmc/articles/PMC10175236/
  73. Feb 2023
  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Synaptic vesicle proteins are selectively delivered to axons in mammalian neurons
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    ncbi.nlm.nih.gov/pmc/articles/PMC9894587/
  75. Nov 2022
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Niraparib-induced STAT3 inhibition increases its antitumor effects
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    ncbi.nlm.nih.gov/pmc/articles/PMC9618811/
  77. Oct 2022
  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Fast generation of forebrain oligodendrocyte spheroids from human embryonic stem cells by transcription factors
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    ncbi.nlm.nih.gov/pmc/articles/PMC9547302/
  79. May 2022
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Zfp580 Regulates Paracrine and Endocrine Igf1 and Igfbp3 Differently in the Brain and Blood After a Murine Stroke
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    ncbi.nlm.nih.gov/pmc/articles/PMC9089756/
  81. Feb 2022
  82. www.nature.com www.nature.com
    Characterization of the canine CD20 as a therapeutic target for comparative passive immunotherapy
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    nature.com/articles/s41598-022-06549-1
  83. Nov 2021
  84. www.sciencedirect.com www.sciencedirect.com
    Transcriptomic taxonomy and neurogenic trajectories of adult human, macaque, and pig hippocampal and entorhinal cells
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    sciencedirect.com/science/article/pii/S0896627321008667
  85. www.sciencedirect.com www.sciencedirect.com
    Fetal growth restriction impairs hippocampal neurogenesis and cognition via Tet1 in offspring
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    sciencedirect.com/science/article/pii/S2211124721013851
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    RTN4/NoGo-receptor binding to BAI adhesion-GPCRs regulates neuronal development
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    sciencedirect.com/science/article/pii/S0092867421012320
  87. Oct 2021
  88. www.sciencedirect.com www.sciencedirect.com
    Multiomics of synaptic junctions reveals altered lipid metabolism and signaling following environmental enrichment
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    sciencedirect.com/science/article/pii/S2211124721012572
  89. Sep 2021
  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Synaptotagmin 7 is targeted to the axonal plasma membrane through γ-secretase processing to promote synaptic vesicle docking in mouse hippocampal neurons
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    ncbi.nlm.nih.gov/pmc/articles/PMC8452306/
  91. Aug 2021
  92. www.nature.com www.nature.com
    The endosomal Q-SNARE, Syntaxin 7, defines a rapidly replenishing synaptic vesicle recycling pool in hippocampal neurons
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    nature.com/articles/s42003-021-02512-4
  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Overlapping roles of JIP3 and JIP4 in promoting axonal transport of lysosomes in human iPSC-derived neurons
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    ncbi.nlm.nih.gov/pmc/articles/PMC8351540/
  94. www.sciencedirect.com www.sciencedirect.com
    A subthreshold synaptic mechanism regulating BDNF expression and resting synaptic strength
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    sciencedirect.com/science/article/pii/S2211124721008901
  95. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    ncbi.nlm.nih.gov/pmc/articles/PMC6384025/
  96. www.sciencedirect.com www.sciencedirect.com
    Activation of a hippocampal CREB-pCREB-miRNA-MEF2 axis modulates individual variation of spatial learning and memory capability
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    sciencedirect.com/science/article/pii/S2211124721009049
  97. Jul 2021
  98. europepmc.org europepmc.org
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    europepmc.org/articles/PMC6302549/
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    Untitled document
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    sciencedirect.com/science/article/pii/S2211124718318424
  100. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    ncbi.nlm.nih.gov/pmc/articles/PMC6224479/
  101. May 2021
  102. www.sciencedirect.com www.sciencedirect.com
    Nuclear isoform of FGF13 regulates post-natal neurogenesis in the hippocampus through an epigenomic mechanism
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    sciencedirect.com/science/article/pii/S2211124721004666
  103. link.springer.com link.springer.com
    An Intronic Variant of CHD7 Identified in Autism Patients Interferes with Neuronal Differentiation and Development
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    link.springer.com/article/10.1007/s12264-021-00685-w
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    Dcaf11 activates Zscan4-mediated alternative telomere lengthening in early embryos and embryonic stem cells
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    sciencedirect.com/science/article/pii/S1934590920305828
  105. www.sciencedirect.com www.sciencedirect.com
    Interneuronal exchange and functional integration of synaptobrevin via extracellular vesicles
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    sciencedirect.com/science/article/pii/S0896627321000076
  106. www.sciencedirect.com www.sciencedirect.com
    Presynaptic store-operated Ca2+ entry drives excitatory spontaneous neurotransmission and augments endoplasmic reticulum stress
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    sciencedirect.com/science/article/pii/S0896627321001239
  107. www.sciencedirect.com www.sciencedirect.com
    SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration
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    sciencedirect.com/science/article/pii/S0896627321000830
  108. Apr 2021
  109. www.sciencedirect.com www.sciencedirect.com
    Tumor Reliance on Cytosolic versus Mitochondrial One-Carbon Flux Depends on Folate Availability
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    sciencedirect.com/science/article/pii/S1550413120306574
  110. Feb 2021
  111. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Synapse type-specific proteomic dissection identifies IgSF8 as a hippocampal CA3 microcircuit organizer
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    ncbi.nlm.nih.gov/pmc/articles/PMC7560607/
  112. www.cell.com www.cell.com
    Importin α5 Regulates Anxiety through MeCP2 and Sphingosine Kinase 1
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    cell.com/cell-reports/abstract/S2211-1247(18)31842-4
  113. Jan 2021
  114. www.sciencedirect.com www.sciencedirect.com
    Tonic GABAergic Inhibition Is Essential for Nerve Injury-Induced Afferent Remodeling in the Somatosensory Thalamus and Ectopic Sensations
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    sciencedirect.com/science/article/pii/S2211124720307786
  115. Dec 2020
  116. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The palmitoyl acyltransferase ZDHHC14 controls Kv1-family potassium channel clustering at the axon initial segment
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    ncbi.nlm.nih.gov/pmc/articles/PMC7685708/
  117. www.sciencedirect.com www.sciencedirect.com
    Multiple Alternative Promoters and Alternative Splicing Enable Universal Transcription-Based Logic Computation in Mammalian Cells
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    sciencedirect.com/science/article/pii/S2211124720314261
  118. Nov 2020
  119. www.sciencedirect.com www.sciencedirect.com
    PICK1 Controls Activity-Dependent Synaptic Vesicle Cargo Retrieval
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    sciencedirect.com/science/article/pii/S2211124720313012
  120. Oct 2020
  121. link.springer.com link.springer.com
    In Vivo Gene Delivery of STC2 Promotes Axon Regeneration in Sciatic Nerves
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    link.springer.com/article/10.1007/s12035-020-02155-2
  122. Sep 2020
  123. elifesciences.org elifesciences.org
    Acute disruption of the synaptic vesicle membrane protein synaptotagmin 1 using knockoff in mouse hippocampal neurons
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    elifesciences.org/articles/56469
  124. www.jneurosci.org www.jneurosci.org
    Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease Risk
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    jneurosci.org/content/39/37/7408
  125. Jan 2020
  126. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Increased expression of heme-binding protein 1 early in Alzheimer's disease is linked to neurotoxicity
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    ncbi.nlm.nih.gov/pmc/articles/PMC6739868/
  127. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Semaphorin4D Induces Inhibitory Synapse Formation by Rapid Stabilization of Presynaptic Boutons via MET Coactivation
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    ncbi.nlm.nih.gov/pmc/articles/PMC6538862/
  128. www.sciencedirect.com www.sciencedirect.com
    Shank Proteins Couple the Endocytic Zone to the Postsynaptic Density to Control Trafficking and Signaling of Metabotropic Glutamate Receptor 5
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    sciencedirect.com/science/article/pii/S2211124719311647
  129. www.sciencedirect.com www.sciencedirect.com
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    sciencedirect.com/science/article/pii/S2211124718318424
  130. www.sciencedirect.com www.sciencedirect.com
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    sciencedirect.com/science/article/pii/S0960982218311448
  131. www.sciencedirect.com www.sciencedirect.com
    Polarity Acquisition in Cortical Neurons Is Driven by Synergistic Action of Sox9-Regulated Wwp1 and Wwp2 E3 Ubiquitin Ligases and Intronic miR-140
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    sciencedirect.com/science/article/pii/S0896627318308961
  132. europepmc.org europepmc.org
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    europepmc.org/articles/PMC6302549/