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Nov 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

PICALM Alzheimer’s risk allele causes aberrant lipid droplets in microglia

1
1. scibot 23 Nov 2025
  
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  167981
  
  DOI: 10.1038/s41586-025-09486-x
  
  Resource: RRID:Addgene_167981
  
  Curator: @olekpark
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12571902/
Sep 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

dFLASH; dual FLuorescent transcription factor activity sensor for histone integrated live-cell reporting and high-content screening

1
1. scibot 25 Sep 2025
  
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  Addgene_167981
  
  DOI: 10.1038/s41467-025-58488-w
  
  Resource: RRID:Addgene_167981
  
  Curator: @scibot
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11977238/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Programmable epigenome editing by transient delivery of CRISPR epigenome editor ribonucleoproteins

1
1. scibot 06 Sep 2025
  
  in Public
  
  Addgene_167981
  
  DOI: 10.1038/s41467-025-63167-x
  
  Resource: RRID:Addgene_167981
  
  Curator: @scibot
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12381050/
Aug 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Removal of promoter CpG methylation by epigenome editing reverses HBG silencing

1
1. scibot 11 Aug 2025
  
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  plasmid_167981
  
  DOI: 10.1038/s41467-025-62177-z
  
  Resource: RRID:Addgene_167981
  
  Curator: @scibot
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12297318/
Jul 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Epigenetic editing and epi-drugs: a combination strategy to simultaneously target KDM4 as a novel anticancer approach

1
1. scibot 20 Jul 2025
  
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  167981
  
  DOI: 10.1186/s13148-025-01913-0
  
  Resource: RRID:Addgene_167981
  
  Curator: @olekpark
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12177974/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Epigenetic editing at individual age-associated CpGs affects the genome-wide epigenetic aging landscape

1
1. scibot 20 Jul 2025
  
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  167981
  
  DOI: 10.1038/s43587-025-00841-1
  
  Resource: RRID:Addgene_167981
  
  Curator: @olekpark
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12176646/
Jun 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Elucidating the genetic mechanisms governing cytosine base editing outcomes through CRISPRi screens

1
1. scibot 15 Jun 2025
  
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  167981
  
  DOI: 10.1038/s41467-025-59948-z
  
  Resource: RRID:Addgene_167981
  
  Curator: @olekpark
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12092667/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Durable HTT silencing using non-evolved dCas9 epigenome editors in patient-derived cells

1
1. scibot 15 Jun 2025
  
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  167981
  
  DOI: 10.1016/j.omtn.2025.102561
  
  Resource: RRID:Addgene_167981
  
  Curator: @olekpark
  
  SciCrunch record: RRID:Addgene_167981
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12163160/
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

CRISPRoff epigenome editing for programmable gene silencing in human cell lines and primary T cells

1
1. scibot 17 May 2025
  
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  Addgene_167981
  
  DOI: 10.1016/bs.mie.2025.01.010
  
  Resource: RRID:Addgene_167981
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_167981
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12052198/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The ZBTB24-CDCA7-HELLS axis suppresses the totipotent 2C-like reprogramming by maintaining Dux methylation and repression

1
1. scibot 16 May 2025
  
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  167981
  
  DOI: 10.1093/nar/gkaf302
  
  Resource: RRID:Addgene_167981
  
  Curator: @olekpark
  
  SciCrunch record: RRID:Addgene_167981
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11995263/
Jun 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Alzheimer’s disease risk allele of PICALM causes detrimental lipid droplets in microglia

1
1. scibot 21 Jun 2024
  
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  Addgene_167981
  
  DOI: 10.21203/rs.3.rs-4407146/v1
  
  Resource: RRID:Addgene_167981
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_167981
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11142308/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Epigenome editing revealed the role of DNA methylation of T-DMR/CpG island shore on Runx2 transcription

1
1. scibot 06 Jun 2024
  
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  167981
  
  DOI: 10.1016/j.bbrep.2024.101733
  
  Resource: RRID:Addgene_167981
  
  Curator: @olekpark
  
  SciCrunch record: RRID:Addgene_167981
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11127475/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Epigenetic editing of BRCA1 promoter increases cisplatin and olaparib sensitivity of ovarian cancer cells

1
1. scibot 03 Jun 2024
  
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  Addgene_167981
  
  DOI: 10.1080/15592294.2024.2357518
  
  Resource: RRID:Addgene_167981
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_167981
  
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  RRID:Addgene_167981
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ncbi.nlm.nih.gov/pmc/articles/PMC11135871/
Apr 2024
www.sciencedirect.com www.sciencedirect.com

Chromatin context-dependent regulation and epigenetic manipulation of prime editing

1
1. scibot 12 Apr 2024
  
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  Addgene: 167981
  
  DOI: 10.1016/j.cell.2024.03.020
  
  Resource: RRID:Addgene_167981
  
  Curator: @abever99
  
  SciCrunch record: RRID:Addgene_167981
  
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  RRID:Addgene_167981
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sciencedirect.com/science/article/pii/S0092867424003118
Feb 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Epigenetic modification and characterization of the MGMT promoter region using CRISPRoff in glioblastoma cells

1
1. scibot 21 Feb 2024
  
  in Public
  
  plasmid_167981
  
  DOI: 10.3389/fonc.2024.1342114
  
  Resource: Addgene_167981
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_167981
  
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  RRID:Addgene_167981
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URL

ncbi.nlm.nih.gov/pmc/articles/PMC10864556/