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43 Matching Annotations

Nov 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Systematic Engineering of TROP2-Targeted CAR T-Cell Therapy Overcomes Resistance Pathways in Solid Tumors

1
1. scibot 24 Nov 2025
  
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  17446
  
  DOI: 10.1158/2326-6066.CIR-25-0527
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12580781/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Modeling and addressing on-target/off-tumor toxicity of claudin 18.2 targeted immunotherapies

1
1. scibot 24 Nov 2025
  
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  17446
  
  DOI: 10.1038/s41467-025-65148-6
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12579598/
Sep 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Eradicating Drug Tolerant Persister Cells in EGFR-Mutated Non-Small Cell Lung Cancer by Targeting TROP2 with CAR-T cellular therapy

1
1. scibot 07 Sep 2025
  
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  RRID:Addgene_17446
  
  DOI: 10.1158/2159-8290.CD-24-1515
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12374242/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

PIN1 prolyl isomerase promotes initiation and progression of bladder cancer through the SREBP2-mediated cholesterol biosynthesis pathway

1
1. scibot 07 Sep 2025
  
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  RRID:Addgene_17446
  
  DOI: 10.1158/2159-8290.CD-24-0866
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11875963/
Aug 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Analysis of astrocyte progenitors derived from human induced pluripotent stem cells in vitro and following transplantation into the intact spinal cord

1
1. scibot 11 Aug 2025
  
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  plasmid_17446
  
  DOI: 10.1101/2025.06.27.661961
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12262438/
52.53.155.43 52.53.155.43

ssrn-5367706-html.html

1
1. scibot 05 Aug 2025
  
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  RRID:Addgene_17446
  
  DOI: 10.2139/ssrn.5367706
  
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52.53.155.43/d4ac87e5901810967bc62a763150192c57d079f9/ssrn-5367706-html.html
Jul 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Engineering of CD63 Enables Selective Extracellular Vesicle Cargo Loading and Enhanced Payload Delivery

1
1. scibot 20 Jul 2025
  
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  addgene_17446
  
  DOI: 10.1002/jev2.70094
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12173531/
www.biorxiv.org www.biorxiv.org

Active Merlin Binds RalB to Regulate Exocytosis

1
1. scibot 12 Jul 2025
  
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  plasmid_17446
  
  DOI: 10.1101/2025.06.13.659557
  
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biorxiv.org/content/10.1101/2025.06.13.659557v1
Jun 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

A Potential Role for c-MYC in the Regulation of Meibocyte Cell Stress

1
1. scibot 15 Jun 2025
  
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  plasmid_17446
  
  DOI: 10.3390/cells14100709
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12109776/
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Cross-talks between Metabolic and Translational Controls during Beige Adipocyte Differentiation

1
1. scibot 16 May 2025
  
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  17446
  
  DOI: 10.1038/s41467-025-58665-x
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11982337/
Mar 2025
www.sciencedirect.com www.sciencedirect.com

The transcription factor MEF2C restrains microglial overactivation by inhibiting kinase CDK2

1
1. scibot 29 Mar 2025
  
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  AddgeneCat#656-4
  
  DOI: 10.1016/j.immuni.2025.02.026
  
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  Curator: @areedewitt04
  
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sciencedirect.com/science/article/pii/S1074761325000937
Feb 2025
www.sciencedirect.com www.sciencedirect.com

PSPC1 exerts an oncogenic role in AML by regulating a leukemic transcription program in cooperation with PU.1

1
1. scibot 20 Feb 2025
  
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  RRID:Addgene_17446
  
  DOI: 10.1016/j.stem.2025.01.010
  
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sciencedirect.com/science/article/pii/S1934590925000104
Jan 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Human ACE2 transgenic pigs are susceptible to SARS-CoV-2 and develop COVID-19-like disease

1
1. scibot 23 Jan 2025
  
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  plasmid_17446
  
  DOI: 10.1038/s41467-024-54615-1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11742018/
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TRMT1L-catalyzed m22G27 on tyrosine tRNA is required for efficient mRNA translation and cell survival under oxidative stress

1
1. scibot 16 Jan 2025
  
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  RRID:Addgene_17446
  
  DOI: 10.1016/j.celrep.2024.115167
  
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sciencedirect.com/science/article/pii/S2211124724015183
Dec 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Development of Liver-Targeting αVβ5+ Exosomes as Anti-TGF-β Nanocarriers for the Treatment of the Pre-Metastatic Niche

1
1. scibot 29 Dec 2024
  
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  Addgene_17446
  
  DOI: 10.3390/biology13121066
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11673512/
Nov 2024
www.biorxiv.org www.biorxiv.org

Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability in cancer

1
1. scibot 22 Nov 2024
  
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  Addgene_17446
  
  DOI: 10.1101/2022.04.11.487892
  
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biorxiv.org/content/10.1101/2022.04.11.487892v1
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer

1
1. scibot 21 Aug 2024
  
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  Plasmid_17446
  
  DOI: 10.1126/science.adk0850
  
  Resource: RRID:Addgene_17446
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11301400/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Histone H3.1 is a chromatin-embedded redox sensor triggered by tumor cells developing adaptive phenotypic plasticity and multidrug resistance

1
1. scibot 13 Aug 2024
  
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  RRID: Addgene_17446
  
  DOI: 10.1016/j.celrep.2024.113897
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11209755/
Jul 2024
www.science.org www.science.org

Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer

1
1. scibot 18 Jul 2024
  
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  Plasmid_17446
  
  DOI: 10.1126/science.adk0850
  
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science.org/doi/10.1126/science.adk0850
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Down-regulation of SLC14A1 in prostate cancer activates CDK1/CCNB1 and mTOR pathways and promotes tumor progression

1
1. scibot 01 Jul 2024
  
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  pLenti CMV GFP Hygro
  
  DOI: 10.1038/s41598-024-66020-1
  
  Resource: RRID:Addgene_17446
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11213927/
Jun 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Mitochondrial respiratory function is preserved under cysteine starvation via glutathione catabolism in NSCLC

1
1. scibot 07 Jun 2024
  
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  17446
  
  DOI: 10.1038/s41467-024-48695-2
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11102494/
May 2024
www.sciencedirect.com www.sciencedirect.com

Identification of WNK1 as a therapeutic target to suppress IgH/MYC expression in multiple myeloma

2
1. scibot 09 May 2024
  
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  Addgene Cat# 17446
  
  DOI: 10.1016/j.celrep.2024.114211
  
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2. scibot 09 May 2024
  
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  plasmid_17446
  
  DOI: 10.1016/j.celrep.2024.114211
  
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sciencedirect.com/science/article/pii/S2211124724005394
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A Scaffold-Assisted 3D Cancer Cell Model for Surface-Enhanced Raman Scattering-Based Real-Time Sensing and Imaging

1
1. scibot 05 May 2024
  
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  pLenti CMV GFP Hygro
  
  DOI: 10.1021/acsnano.4c00543
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11064228/
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Antibody-independent protection against heterologous SARS-CoV-2 challenge conferred by prior infection or vaccination

1
1. scibot 13 Apr 2024
  
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  17446
  
  DOI: 10.1038/s41590-024-01787-z
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11003867/
Mar 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Histone H3.1 is a chromatin-embedded redox sensor triggered by tumor cells developing adaptive phenotypic plasticity and multidrug resistance

1
1. scibot 19 Mar 2024
  
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  RRID:Addgene_17446
  
  DOI: 10.1016/j.celrep.2024.113897
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11209755/
Feb 2024
link.springer.com link.springer.com

Flotillin-1 palmitoylation is essential for its stability and subsequent tumor promoting capabilities

1
1. scibot 22 Feb 2024
  
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  Addgene_17446
  
  DOI: 10.1038/s41388-024-02946-0
  
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link.springer.com/article/10.1038/s41388-024-02946-0
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Experimental evidence for cancer resistance in a bat species

1
1. scibot 21 Feb 2024
  
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  Addgene_17446
  
  DOI: 10.1038/s41467-024-45767-1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10869793/
Jan 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Isolation and Characterization of Neutralizing Monoclonal Antibodies from a Large Panel of Murine Antibodies against RBD of the SARS-CoV-2 Spike Protein

1
1. scibot 29 Jan 2024
  
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  Addgene_17446
  
  DOI: 10.3390/antib13010005
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10801580/
Dec 2023
www.nature.com www.nature.com

The function of ER-phagy receptors is regulated through phosphorylation-dependent ubiquitination pathways

1
1. scibot 16 Dec 2023
  
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  RRID:Addgene_17446
  
  DOI: 10.1038/s41467-023-44101-5
  
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nature.com/articles/s41467-023-44101-5
Jul 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

GSK-3 Inhibitor Elraglusib Enhances Tumor-Infiltrating Immune Cell Activation in Tumor Biopsies and Synergizes with Anti-PD-L1 in a Murine Model of Colorectal Cancer

1
1. scibot 15 Jul 2023
  
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  RRID:Addgene_17446
  
  DOI: 10.3390/ijms241310870
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10342141/
Mar 2023
www.biorxiv.org www.biorxiv.org

Function of ERphagy receptors is regulated via phosphorylation-dependent ubiquitination pathways

1
1. scibot 31 Mar 2023
  
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  RRID:Addgene_17446
  
  DOI: 10.1101/2023.02.27.530364
  
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biorxiv.org/content/10.1101/2023.02.27.530364v1
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

GSK-3 inhibitor elraglusib enhances tumor-infiltrating immune cell activation in tumor biopsies and synergizes with anti-PD-L1 in a murine model of colorectal cancer

1
1. scibot 10 Mar 2023
  
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  RRID:Addgene_17446
  
  DOI: 10.1101/2023.02.07.527499
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9934544/
Jan 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

SAYSD1 senses UFMylated ribosome to safeguard co-translational protein translocation at the endoplasmic reticulum

1
1. scibot 24 Jan 2023
  
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  Addgene_17446
  
  DOI: 10.1016/j.celrep.2023.112028
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10010011/
May 2022
www.sciencedirect.com www.sciencedirect.com

Synthetic Carbohydrate Binding Agents neutralize SARS-CoV-2 by inhibiting binding of the spike protein to ACE2.

2
1. scibot 10 May 2022
  
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  Addgene_17446
  
  DOI: 10.1016/j.isci.2022.104239
  
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2. scibot 10 May 2022
  
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  Addgene_17446
  
  DOI: 10.1016/j.isci.2022.104239
  
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sciencedirect.com/science/article/pii/S2589004222005090
Apr 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

YAP1 activation by human papillomavirus E7 promotes basal cell identity in squamous epithelia

1
1. scibot 01 Apr 2022
  
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  plasmid_17446
  
  DOI: 10.7554/eLife.75466
  
  Resource: RRID:Addgene_17446
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8959598/
Jan 2022
www.sciencedirect.com www.sciencedirect.com

C2cd6-encoded CatSperτ targets sperm calcium channel to Ca2+ signaling domains in the flagellar membrane

1
1. scibot 08 Jan 2022
  
  in Public
  
  plasmid_17
  
  DOI: 10.1016/j.celrep.2021.110226
  
  Resource: RRID:Addgene_17446
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_17446
  
  Curator comments: pLenti CMV GFP Hygro (656-4)
  
  What is this?
  
  RRID:Addgene_17446 RRIDCUR:Unresolved RRIDCUR:Incorrect
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Tags

RRIDCUR:Incorrect

RRIDCUR:Unresolved

RRID:Addgene_17446

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2211124721017307
Apr 2021
www.sciencedirect.com www.sciencedirect.com

Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis

1
1. scibot 30 Apr 2021
  
  in Public
  
  Cat#: 17446
  
  DOI: 10.1016/j.cmet.2020.12.007
  
  Resource: RRID:Addgene_17446
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_17446
  
  What is this?
  
  RRID:Addgene_17446 RRIDCUR:Missing
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Tags

RRIDCUR:Missing

RRID:Addgene_17446

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S1550413120306628
www.sciencedirect.com www.sciencedirect.com

Physiological hypoxia restrains the senescence-associated secretory phenotype via AMPK-mediated mTOR suppression

1
1. scibot 13 Apr 2021
  
  in Public
  
  plasmid_17446
  
  DOI: 10.1016/j.molcel.2021.03.018
  
  Resource: RRID:Addgene_17446
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_17446
  
  What is this?
  
  RRID:Addgene_17446 RRIDCUR:Validated
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Tags

RRIDCUR:Validated

RRID:Addgene_17446

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S1097276521002136
www.sciencedirect.com www.sciencedirect.com

Declining lamin B1 expression mediates age-dependent decreases of hippocampal stem cell activity

1
1. scibot 12 Apr 2021
  
  in Public
  
  RRID:Addgene_17446
  
  DOI: 10.1016/j.stem.2021.01.015
  
  Resource: RRID:Addgene_17446
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_17446
  
  What is this?
  
  RRID:Addgene_17446
Visit annotations in context

Tags

RRID:Addgene_17446

Annotators

scibot

URL

sciencedirect.com/science/article/abs/pii/S1934590921000151
Jan 2021
www.sciencedirect.com www.sciencedirect.com

hGBP1 Coordinates Chlamydia Restriction and Inflammasome Activation through Sequential GTP Hydrolysis

1
1. scibot 16 Jan 2021
  
  in Public
  
  Addgene_17446
  
  DOI: 10.1016/j.celrep.2020.107667
  
  Resource: RRID:Addgene_17446
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:Addgene_17446
  
  What is this?
  
  RRIDCUR:Validated RRID:Addgene_17446
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Tags

RRIDCUR:Validated

RRID:Addgene_17446

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2211124720306203
Sep 2020
www.sciencedirect.com www.sciencedirect.com

hGBP1 Coordinates Chlamydia Restriction and Inflammasome Activation through Sequential GTP Hydrolysis

1
1. scibot 03 Sep 2020
  
  in Public
  
  Addgene # 17446
  
  DOI: 10.1016/j.celrep.2020.107667
  
  Resource: RRID:Addgene_17446
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:Addgene_17446
  
  What is this?
  
  RRID:Addgene_17446
Visit annotations in context

Tags

RRID:Addgene_17446

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2211124720306203