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A Novel Diagnostic Tool for West Nile Virus Lineage 1a and 2 Using a CRISPR-Cas12a System

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1. scibot 26 Jan 2026
  
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  RRID:Addgene_17452
  
  DOI: 10.3390/bios15120807
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12730693/
Nov 2025
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Small Extracellular Vesicles From Radioresistant H3K27M‐Pediatric Diffuse Midline Glioma Cells Modulate Tumor Phenotypes and Radiation Response

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1. scibot 24 Nov 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12575060/
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A live cell biosensor protocol for high-resolution screening of therapy-resistant cancer cells

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1. scibot 23 Nov 2025
  
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  DOI: 10.1101/2025.09.23.678038
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12485920/
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Expression of intron-containing HIV-1 RNA induces NLRP1 inflammasome activation in myeloid cells

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1. scibot 23 Nov 2025
  
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  Addgene_17452
  
  DOI: 10.1371/journal.pbio.3003320
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12416851/
Aug 2025
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Inactivity-induced NR4A3 downregulation in human skeletal muscle affects glucose metabolism and translation: Insights from in vitro analysis

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1. scibot 11 Aug 2025
  
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  plasmid_17452
  
  DOI: 10.1016/j.molmet.2025.102200
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12275858/
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EphA2 and Ephrin-A1 Utilize the Same Interface for Both in cis and in trans Interactions That Differentially Regulate Cell Signaling and Function

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1. scibot 10 Aug 2025
  
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  DOI: 10.1101/2025.07.31.667925
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12324522/
Jul 2025
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Combining light-induced aggregation and biotin proximity labeling implicates endolysosomal proteins in early α-synuclein oligomerization

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1. scibot 20 Jul 2025
  
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  DOI: 10.1016/j.isci.2025.112823
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12221657/
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Parthenolide disrupts mitosis by inhibiting ZNF207/BUGZ-promoted kinetochore-microtubule attachment

1
1. scibot 20 Jul 2025
  
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  plasmid_17452
  
  DOI: 10.1038/s44318-025-00469-2
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12219771/
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Mechanistic insight into anaphase bridge signaling to the abscission checkpoint

1
1. scibot 20 Jul 2025
  
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  plasmid_17452
  
  DOI: 10.1038/s44318-025-00453-w
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12217976/
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O-GlcNAcylation of FOXK1 co-opts BAP1 to orchestrate the E2F pathway and promotes oncogenesis

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1. scibot 20 Jul 2025
  
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  Addgene_17452
  
  DOI: 10.1038/s41467-025-61022-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12219458/
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Down-regulation of human-specific lncRNA TMEM9B-AS1 in skeletal muscle of people with type 2 diabetes affects ribosomal biogenesis

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1. scibot 15 Jul 2025
  
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  DOI: 10.1126/sciadv.ads4371
  
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science.org/doi/10.1126/sciadv.ads4371
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Down-regulation of human-specific lncRNA TMEM9B-AS1 in skeletal muscle of people with type 2 diabetes affects ribosomal biogenesis

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1. scibot 11 Jul 2025
  
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  DOI: 10.1126/sciadv.ads4371
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12239959/
May 2025
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Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1

1
1. scibot 19 May 2025
  
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  Addgene_17452
  
  DOI: 10.1038/s41467-018-06854-2
  
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pmc.ncbi.nlm.nih.gov/articles/PMC6197237/
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CREB1-BCL2 drives mitochondrial resilience in RAS GAP-dependent breast cancer chemoresistance

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1. scibot 19 May 2025
  
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  Addgene_17452
  
  DOI: 10.1038/s41388-025-03284-5
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11996675/
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Duplexed CeTEAM drug biosensors reveal determinants of PARP inhibitor selectivity in cells

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1. scibot 18 May 2025
  
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  plasmid_17452
  
  DOI: 10.1016/j.jbc.2025.108361
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11986510/
Apr 2025
www.sciencedirect.com www.sciencedirect.com

MLKL activity requires a splicing-regulated, druggable intramolecular interaction

1
1. scibot 10 Apr 2025
  
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  AddgeneCat#17452
  
  DOI: 10.1016/j.molcel.2025.03.015
  
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sciencedirect.com/science/article/pii/S109727652500259X
Mar 2025
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FNDC5/irisin mitigates the cardiotoxic impacts of cancer chemotherapeutics by modulating ROS-dependent and -independent mechanisms

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1. scibot 11 Mar 2025
  
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  pLenti CMV Puro DEST
  
  DOI: 10.1016/j.redox.2025.103527
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11850786/
Feb 2025
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Single-cell sequencing elucidates the mechanism of NUSAP1 in glioma and its diagnostic and prognostic significance

1
1. scibot 23 Feb 2025
  
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  RRID:Addgene_17452
  
  DOI: 10.3389/fimmu.2025.1512867
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11835852/
Sep 2024
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Notch signaling suppresses neuroendocrine differentiation and alters the immune microenvironment in advanced prostate cancer

1
1. scibot 29 Sep 2024
  
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  17452
  
  DOI: 10.1172/JCI175217
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11364388/
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DBT is a metabolic switch for maintenance of proteostasis under proteasomal impairment

1
1. scibot 28 Sep 2024
  
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  pLenti CMV Puro DEST
  
  DOI: 10.7554/eLife.91002
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11386957/
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Light-gated integrator for highlighting kinase activity in living cells

1
1. scibot 28 Sep 2024
  
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  Addgene_17452
  
  DOI: 10.1038/s41467-024-51270-4
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11379911/
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ASCT2 is a major contributor to serine uptake in cancer cells

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1. scibot 25 Sep 2024
  
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  17452
  
  DOI: 10.1016/j.celrep.2024.114552
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11406281/
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Determination of Site-Specific Phosphorylation Occupancy Using Targeted Mass Spectrometry Reveals the Regulation of Human Apical Bile Acid Transporter, ASBT

1
1. scibot 25 Sep 2024
  
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  17452
  
  DOI: 10.1021/acsomega.4c02999
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11411523/
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A spectrum of clinically-identified cysteine mutations in fibulin-3 (EFEMP1) highlight its disulfide bonding complexity and potential to induce stress response activation

1
1. scibot 22 Aug 2024
  
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  plasmid_17452
  
  DOI: 10.1101/2024.07.22.604634
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11291045/
Jul 2024
www.biorxiv.org www.biorxiv.org

An Adipo-Pulmonary Axis Mediated by FABP4 Hormone Defines a Therapeutic Target Against Obesity-Induced Airway Disease

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1. scibot 23 Jul 2024
  
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  RRID:Addgene_17452
  
  DOI: 10.1101/2024.07.15.603433
  
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biorxiv.org/content/10.1101/2024.07.15.603433v1
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DUSP6 inhibition overcomes neuregulin/HER3-driven therapy tolerance in HER2+ breast cancer

1
1. scibot 18 Jul 2024
  
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  RRID:Addgene_17452
  
  DOI: 10.1038/s44321-024-00088-0
  
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embopress.org/doi/10.1038/s44321-024-00088-0
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

DUSP6 inhibition overcomes neuregulin/HER3-driven therapy tolerance in HER2+ breast cancer

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1. scibot 18 Jul 2024
  
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  RRID:Addgene_17452
  
  DOI: 10.1038/s44321-024-00088-0
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11251193/
Jun 2024
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Activation of the IKK2-NF𝜅B pathway in VSMCs inhibits calcified vascular stiffness in CKD

1
1. scibot 13 Jun 2024
  
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  17452
  
  DOI: 10.1172/jci.insight.174977
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11128211/
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Opposing tumor-cell-intrinsic and -extrinsic roles of the IRF1 transcription factor in antitumor immunity

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1. scibot 04 Jun 2024
  
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  Plasmid_17452
  
  DOI: 10.1016/j.celrep.2024.114289
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11315447/
May 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Cancer–stromal cell interactions in breast cancer brain metastases induce glycocalyx-mediated resistance to HER2-targeting therapies

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1. scibot 18 May 2024
  
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  RRID:Addgene_17452
  
  DOI: 10.1073/pnas.2322688121
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11098130/
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Gastric Inhibitory Polypeptide Receptor (GIPR) Overexpression Reduces the Tumorigenic Potential of Retinoblastoma Cells

1
1. scibot 12 May 2024
  
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  17452
  
  DOI: 10.3390/cancers16091656
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11083251/
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

MYADM binds human parechovirus 1 and is essential for viral entry

1
1. scibot 30 Apr 2024
  
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  17452
  
  DOI: 10.1038/s41467-024-47825-0
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11043367/
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The OTX2 Gene Induces Tumor Growth and Triggers Leptomeningeal Metastasis by Regulating the mTORC2 Signaling Pathway in Group 3 Medulloblastomas

1
1. scibot 29 Apr 2024
  
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  17452
  
  DOI: 10.3390/ijms25084416
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11050316/
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Light-gated Integrator for Highlighting Kinase Activity in Living Cells

1
1. scibot 14 Apr 2024
  
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  Addgene_17452
  
  DOI: 10.1101/2024.03.18.585554
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10983958/
Mar 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Comparative analysis of human, rodent and snake deltavirus replication

1
1. scibot 17 Mar 2024
  
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  Addgene_17452
  
  DOI: 10.1371/journal.ppat.1012060
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10942263/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Host E3 ubiquitin ligase ITCH mediates Toxoplasma gondii effector GRA35-triggered NLRP1 inflammasome activation and cell-autonomous immunity

1
1. scibot 15 Mar 2024
  
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  Addgene_17452
  
  DOI: 10.1128/mbio.03302-23
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10936166/
Feb 2024
www.sciencedirect.com www.sciencedirect.com

DUB3 is a MAGEA3 deubiquitinase and a potential therapeutic target in hepatocellular carcinoma

4
1. scibot 29 Feb 2024
  
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  AddgeneCat#17452
  
  DOI: 10.1016/j.isci.2024.109181
  
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p90RSK pathway inhibition synergizes with cisplatin in TMEM16A overexpressing head and neck cancer

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Open-source milligram-scale, four channel, automated protein purification system

1
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Profiling nuclear cysteine ligandability and effects on nuclear localization using proximity labeling-coupled chemoproteomics

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Transcriptional landscape of DTP-DTEP transition reveals DUSP6 as a driver of HER2 inhibitor tolerance via Neuregulin/HER3 axis

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DNA-initiated epigenetic cascades driven by C9orf72 hexanucleotide repeat

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Single-cell heterogeneity of EGFR and CDK4 co-amplification is linked to immune infiltration in glioblastoma

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Fibroblasts secrete fibronectin under lamellipodia in a microtubule- and myosin II–dependent fashion

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rupress.org/jcb/article/222/2/e202204100/213712/Fibroblasts-secrete-fibronectin-under-lamellipodia
Dec 2022
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Serial profiling of circulating tumor DNA identifies dynamic evolution of clinically actionable genomic alterations in high-risk neuroblastoma

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aacrjournals.org/cancerdiscovery/article/12/12/2800/711177/Serial-Profiling-of-Circulating-Tumor-DNA
Nov 2022
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Tumor-intrinsic SIRPA promotes sensitivity to checkpoint inhibition immunotherapy in melanoma

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Structure-function analysis of enterovirus protease 2A in complex with its essential host factor SETD3

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Aug 2022
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A CRISPR-Cas12a-based diagnostic method for multiple genotypes of severe fever with thrombocytopenia syndrome virus

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Intermittent bulk release of human cytomegalovirus

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Mar 2022
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Aberrant induction of a mesenchymal/stem-cell program engages senescence in normal mammary epithelial cells.

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Complex effects of kinase localization revealed by compartment-specific regulation of protein kinase A activity

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Identification of new ETV6 modulators through a high throughput functional screening

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Jan 2022
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STAT3 Enhances Sensitivity of Glioblastoma to Drug-Induced Autophagy-Dependent Cell Death

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Dec 2021
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Antibody-drug conjugate efficacy in neuroblastoma - role of payload, resistance mechanisms, target density, and antibody internalization

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Defective brown adipose tissue thermogenesis and impaired glucose metabolism in mice lacking Letmd1

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RNA-responsive elements for eukaryotic translational control

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  DOI: 10.1038/s41587-021-01068-2
  
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Jul 2021
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Untitled document

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Identification of GPC2 as an Oncoprotein and Candidate Immunotherapeutic Target in High-Risk Neuroblastoma

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  plasmid_17452
  
  DOI: 10.1016/j.ccell.2017.08.003
  
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Untitled document

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A GPC2 antibody-drug conjugate is efficacious against neuroblastoma and small-cell lung cancer via binding a conformational epitope

1
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  DOI: 10.1016/j.xcrm.2021.100344
  
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sciencedirect.com/science/article/pii/S2666379121001932
May 2021
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Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis

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  CAT#17452
  
  DOI: 10.1016/j.cell.2021.04.037
  
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A Membrane-Tethered Ubiquitination Pathway Regulates Hedgehog Signaling and Heart Development

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C9orf72 regulates energy homeostasis by stabilizing mitochondrial complex I assembly

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sciencedirect.com/science/article/pii/S155041312100005X
Mar 2021
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A genome-wide CRISPR screen identifies UFMylation and TRAMP-like complexes as host factors required for hepatitis A virus infection

1
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  Plasmid_17452
  
  DOI: 10.1016/j.celrep.2021.108859
  
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Feb 2021
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A chemical genetic screen identifies Aurora kinases as a therapeutic target in EGFR T790M negative, gefitinib-resistant head and neck squamous cell carcinoma (HNSCC)

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  DOI: 10.1016/j.ebiom.2021.103220
  
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sciencedirect.com/science/article/pii/S235239642100013X
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Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD

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sciencedirect.com/science/article/pii/S1097276520308984
Sep 2020
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Oxysterols provide innate immunity to bacterial infection by mobilizing cell surface accessible cholesterol

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  DOI: 10.1038/s41564-020-0701-5
  
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Kinetic Heterogeneity of Cancer Cell Fractional Killing

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sciencedirect.com/science/article/pii/S2211124720308263
cancerres.aacrjournals.org cancerres.aacrjournals.org

YAP1 mediates resistance to MEK1/2 inhibition in neuroblastomas with hyperactivated RAS signalling

1
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  DOI: 10.1158/0008-5472.CAN-19-1415
  
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cancerres.aacrjournals.org/content/79/24/6204
Jan 2020
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Critical role for Piccolo in synaptic vesicle retrieval

1
1. scibot 13 Jan 2020
  
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  plasmid_17452
  
  DOI: 10.7554/eLife.46629
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6541439/
elifesciences.org elifesciences.org

The ER membrane protein complex is required to ensure correct topology and stable expression of flavivirus polyproteins

1
1. scibot 13 Jan 2020
  
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Genomic and Transcriptomic Determinants of Therapy Resistance and Immune Landscape Evolution during Anti-EGFR Treatment in Colorectal Cancer

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  DOI: 10.1016/j.ccell.2019.05.013
  
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  Curator: @ethanbadger
  
  SciCrunch record: RRID:Addgene_17452
  
  What is this?
  
  RRID:Addgene_17452 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:Addgene_17452

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scibot

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sciencedirect.com/science/article/pii/S1535610819302557
www.sciencedirect.com www.sciencedirect.com

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1. scibot 13 Jan 2020
  
  in Public
  
  RRID:Addgene_17452
  
  DOI: 10.1016/j.celrep.2019.01.043
  
  Resource: RRID:Addgene_17452
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:Addgene_17452
  
  What is this?
  
  RRID:Addgene_17452 RRIDCUR:Validated
Visit annotations in context

Tags

RRIDCUR:Validated

RRID:Addgene_17452

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2211124719300610

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