59 Matching Annotations
  1. Sep 2024
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Notch signaling suppresses neuroendocrine differentiation and alters the immune microenvironment in advanced prostate cancer
    1
    1. scibot 29 Sep 2024
      17452

      DOI: 10.1172/JCI175217

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    ncbi.nlm.nih.gov/pmc/articles/PMC11364388/
  3. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DBT is a metabolic switch for maintenance of proteostasis under proteasomal impairment
    1
    1. scibot 28 Sep 2024
      pLenti CMV Puro DEST

      DOI: 10.7554/eLife.91002

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    ncbi.nlm.nih.gov/pmc/articles/PMC11386957/
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Light-gated integrator for highlighting kinase activity in living cells
    1
    1. scibot 28 Sep 2024
      Addgene_17452

      DOI: 10.1038/s41467-024-51270-4

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    ncbi.nlm.nih.gov/pmc/articles/PMC11379911/
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ASCT2 is a major contributor to serine uptake in cancer cells
    1
    1. scibot 25 Sep 2024
      17452

      DOI: 10.1016/j.celrep.2024.114552

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    ncbi.nlm.nih.gov/pmc/articles/PMC11406281/
  6. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Determination of Site-Specific Phosphorylation Occupancy Using Targeted Mass Spectrometry Reveals the Regulation of Human Apical Bile Acid Transporter, ASBT
    1
    1. scibot 25 Sep 2024
      17452

      DOI: 10.1021/acsomega.4c02999

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    ncbi.nlm.nih.gov/pmc/articles/PMC11411523/
  7. Aug 2024
  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A spectrum of clinically-identified cysteine mutations in fibulin-3 (EFEMP1) highlight its disulfide bonding complexity and potential to induce stress response activation
    1
    1. scibot 22 Aug 2024
      plasmid_17452

      DOI: 10.1101/2024.07.22.604634

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    ncbi.nlm.nih.gov/pmc/articles/PMC11291045/
  9. Jul 2024
  10. www.biorxiv.org www.biorxiv.org
    An Adipo-Pulmonary Axis Mediated by FABP4 Hormone Defines a Therapeutic Target Against Obesity-Induced Airway Disease
    1
    1. scibot 23 Jul 2024
      RRID:Addgene_17452

      DOI: 10.1101/2024.07.15.603433

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    biorxiv.org/content/10.1101/2024.07.15.603433v1
  11. www.embopress.org www.embopress.org
    DUSP6 inhibition overcomes neuregulin/HER3-driven therapy tolerance in HER2+ breast cancer
    1
    1. scibot 18 Jul 2024
      RRID:Addgene_17452

      DOI: 10.1038/s44321-024-00088-0

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    embopress.org/doi/10.1038/s44321-024-00088-0
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DUSP6 inhibition overcomes neuregulin/HER3-driven therapy tolerance in HER2+ breast cancer
    1
    1. scibot 18 Jul 2024
      RRID:Addgene_17452

      DOI: 10.1038/s44321-024-00088-0

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    ncbi.nlm.nih.gov/pmc/articles/PMC11251193/
  13. Jun 2024
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Activation of the IKK2-NF𝜅B pathway in VSMCs inhibits calcified vascular stiffness in CKD
    1
    1. scibot 13 Jun 2024
      17452

      DOI: 10.1172/jci.insight.174977

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    pmc.ncbi.nlm.nih.gov/articles/PMC11128211/
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Opposing tumor-cell-intrinsic and -extrinsic roles of the IRF1 transcription factor in antitumor immunity
    1
    1. scibot 04 Jun 2024
      Plasmid_17452

      DOI: 10.1016/j.celrep.2024.114289

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    ncbi.nlm.nih.gov/pmc/articles/PMC11315447/
  16. May 2024
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cancer–stromal cell interactions in breast cancer brain metastases induce glycocalyx-mediated resistance to HER2-targeting therapies
    1
    1. scibot 18 May 2024
      RRID:Addgene_17452

      DOI: 10.1073/pnas.2322688121

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    ncbi.nlm.nih.gov/pmc/articles/PMC11098130/
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Gastric Inhibitory Polypeptide Receptor (GIPR) Overexpression Reduces the Tumorigenic Potential of Retinoblastoma Cells
    1
    1. scibot 12 May 2024
      17452

      DOI: 10.3390/cancers16091656

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    ncbi.nlm.nih.gov/pmc/articles/PMC11083251/
  19. Apr 2024
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MYADM binds human parechovirus 1 and is essential for viral entry
    1
    1. scibot 30 Apr 2024
      17452

      DOI: 10.1038/s41467-024-47825-0

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    ncbi.nlm.nih.gov/pmc/articles/PMC11043367/
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The OTX2 Gene Induces Tumor Growth and Triggers Leptomeningeal Metastasis by Regulating the mTORC2 Signaling Pathway in Group 3 Medulloblastomas
    1
    1. scibot 29 Apr 2024
      17452

      DOI: 10.3390/ijms25084416

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    ncbi.nlm.nih.gov/pmc/articles/PMC11050316/
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Light-gated Integrator for Highlighting Kinase Activity in Living Cells
    1
    1. scibot 14 Apr 2024
      Addgene_17452

      DOI: 10.1101/2024.03.18.585554

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    ncbi.nlm.nih.gov/pmc/articles/PMC10983958/
  23. Mar 2024
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Comparative analysis of human, rodent and snake deltavirus replication
    1
    1. scibot 17 Mar 2024
      Addgene_17452

      DOI: 10.1371/journal.ppat.1012060

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    ncbi.nlm.nih.gov/pmc/articles/PMC10942263/
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Host E3 ubiquitin ligase ITCH mediates Toxoplasma gondii effector GRA35-triggered NLRP1 inflammasome activation and cell-autonomous immunity
    1
    1. scibot 15 Mar 2024
      Addgene_17452

      DOI: 10.1128/mbio.03302-23

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    ncbi.nlm.nih.gov/pmc/articles/PMC10936166/
  26. Feb 2024
  27. www.sciencedirect.com www.sciencedirect.com
    DUB3 is a MAGEA3 deubiquitinase and a potential therapeutic target in hepatocellular carcinoma
    4
    1. scibot 29 Feb 2024
      AddgeneCat#17452

      DOI: 10.1016/j.isci.2024.109181

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    2. scibot 29 Feb 2024
      Addgene_17452

      DOI: 10.1016/j.isci.2024.109181

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    3. scibot 29 Feb 2024
      Addgene_17452

      DOI: 10.1016/j.isci.2024.109181

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    4. scibot 29 Feb 2024
      Addgene_17452

      DOI: 10.1016/j.isci.2024.109181

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    sciencedirect.com/science/article/pii/S2589004224004024
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    p90RSK pathway inhibition synergizes with cisplatin in TMEM16A overexpressing head and neck cancer
    1
    1. scibot 29 Feb 2024
      17,452

      DOI: 10.1186/s12885-024-11892-9

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    ncbi.nlm.nih.gov/pmc/articles/PMC10875868/
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Open-source milligram-scale, four channel, automated protein purification system
    1
    1. scibot 29 Feb 2024
      17452

      DOI: 10.1371/journal.pone.0297879

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    ncbi.nlm.nih.gov/pmc/articles/PMC10889886/
  30. Dec 2023
  31. www.sciencedirect.com www.sciencedirect.com
    Profiling nuclear cysteine ligandability and effects on nuclear localization using proximity labeling-coupled chemoproteomics
    1
    1. scibot 17 Dec 2023
      RRID:Addgene_17452

      DOI: 10.1016/j.chembiol.2023.11.010

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    sciencedirect.com/science/article/pii/S2451945623004257
  32. Jun 2023
  33. www.biorxiv.org www.biorxiv.org
    Transcriptional landscape of DTP-DTEP transition reveals DUSP6 as a driver of HER2 inhibitor tolerance via Neuregulin/HER3 axis
    1
    1. scibot 22 Jun 2023
      RRID:Addgene_17452

      DOI: 10.1101/2023.06.14.544493

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    biorxiv.org/content/10.1101/2023.06.14.544493v1
  34. Apr 2023
  35. www.sciencedirect.com www.sciencedirect.com
    DNA-initiated epigenetic cascades driven by C9orf72 hexanucleotide repeat
    1
    1. scibot 27 Apr 2023
      plasmid_17452

      DOI: 10.1016/j.neuron.2023.01.022

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    sciencedirect.com/science/article/pii/S0896627323000727
  36. Mar 2023
  37. www.sciencedirect.com www.sciencedirect.com
    Single-cell heterogeneity of EGFR and CDK4 co-amplification is linked to immune infiltration in glioblastoma
    1
    1. scibot 16 Mar 2023
      Plasmid_17452

      DOI: 10.1016/j.celrep.2023.112235

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    sciencedirect.com/science/article/pii/S2211124723002462
  38. Jan 2023
  39. rupress.org rupress.org
    Fibroblasts secrete fibronectin under lamellipodia in a microtubule- and myosin II–dependent fashion
    1
    1. scibot 12 Jan 2023
      RRID:Addgene_17452

      DOI: 10.1083/jcb.202204100

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    rupress.org/jcb/article/222/2/e202204100/213712/Fibroblasts-secrete-fibronectin-under-lamellipodia
  40. Dec 2022
  41. aacrjournals.org aacrjournals.org
    Serial profiling of circulating tumor DNA identifies dynamic evolution of clinically actionable genomic alterations in high-risk neuroblastoma
    1
    1. scibot 03 Dec 2022
      RRID:Addgene_17452

      DOI: 10.1158/2159-8290.CD-22-0287

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    aacrjournals.org/cancerdiscovery/article/12/12/2800/711177/Serial-Profiling-of-Circulating-Tumor-DNA
  42. Nov 2022
  43. www.sciencedirect.com www.sciencedirect.com
    Tumor-intrinsic SIRPA promotes sensitivity to checkpoint inhibition immunotherapy in melanoma
    1
    1. scibot 04 Nov 2022
      RRID:Addgene_17452

      DOI: 10.1016/j.ccell.2022.10.012

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    sciencedirect.com/science/article/pii/S1535610822005037
  44. Sep 2022
  45. www.nature.com www.nature.com
    Structure-function analysis of enterovirus protease 2A in complex with its essential host factor SETD3
    1
    1. scibot 10 Sep 2022
      RRID:Addgene_17452

      DOI: 10.1038/s41467-022-32758-3

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    nature.com/articles/s41467-022-32758-3
  46. Aug 2022
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A CRISPR-Cas12a-based diagnostic method for multiple genotypes of severe fever with thrombocytopenia syndrome virus
    1
    1. scibot 06 Aug 2022
      Addgene_17452

      DOI: 10.1371/journal.pntd.0010666

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    ncbi.nlm.nih.gov/pmc/articles/PMC9345333/
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Intermittent bulk release of human cytomegalovirus
    1
    1. scibot 06 Aug 2022
      RRID:Addgene_17452

      DOI: 10.1371/journal.ppat.1010575

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    ncbi.nlm.nih.gov/pmc/articles/PMC9352052/
  49. Mar 2022
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Aberrant induction of a mesenchymal/stem-cell program engages senescence in normal mammary epithelial cells.
    1
    1. scibot 04 Mar 2022
      plasmid_17452

      DOI: 10.1158/1541-7786.MCR-19-1181

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    ncbi.nlm.nih.gov/pmc/articles/PMC8867383/
  51. elifesciences.org elifesciences.org
    Complex effects of kinase localization revealed by compartment-specific regulation of protein kinase A activity
    1
    1. scibot 03 Mar 2022
      plasmid_17452

      DOI: 10.7554/eLife.66869

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    elifesciences.org/articles/66869
  52. www.sciencedirect.com www.sciencedirect.com
    Identification of new ETV6 modulators through a high throughput functional screening
    1
    1. scibot 02 Mar 2022
      RRID:Addgene_17452

      DOI: 10.1016/j.isci.2022.103858

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    sciencedirect.com/science/article/pii/S2589004222001286
  53. Jan 2022
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    STAT3 Enhances Sensitivity of Glioblastoma to Drug-Induced Autophagy-Dependent Cell Death
    1
    1. scibot 22 Jan 2022
      RRID:Addgene_17452

      DOI: 10.3390/cancers14020339

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    ncbi.nlm.nih.gov/pmc/articles/PMC8773829/
  55. Dec 2021
  56. mct.aacrjournals.org mct.aacrjournals.org
    Antibody-drug conjugate efficacy in neuroblastoma - role of payload, resistance mechanisms, target density, and antibody internalization
    1
    1. scibot 22 Dec 2021
      plasmid_17452

      DOI: 10.1158/1535-7163.MCT-20-1034

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    mct.aacrjournals.org/content/20/11/2228
  57. www.sciencedirect.com www.sciencedirect.com
    Defective brown adipose tissue thermogenesis and impaired glucose metabolism in mice lacking Letmd1
    1
    1. scibot 15 Dec 2021
      Plasmid_17452

      DOI: 10.1016/j.celrep.2021.110104

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    sciencedirect.com/science/article/pii/S2211124721015989
  58. Nov 2021
  59. www.nature.com www.nature.com
    RNA-responsive elements for eukaryotic translational control
    1
    1. scibot 06 Nov 2021
      RRID:Addgene_17452

      DOI: 10.1038/s41587-021-01068-2

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    nature.com/articles/s41587-021-01068-2
  60. Jul 2021
  61. www.sciencedirect.com www.sciencedirect.com
    Untitled document
    1
    1. scibot 31 Jul 2021
      RRID:Addgene_17452

      DOI: 10.1016/j.celrep.2019.01.043

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    sciencedirect.com/science/article/pii/S2211124719300610
  62. www.sciencedirect.com www.sciencedirect.com
    Identification of GPC2 as an Oncoprotein and Candidate Immunotherapeutic Target in High-Risk Neuroblastoma
    2
    1. scibot 29 Jul 2021
      plasmid_17452

      DOI: 10.1016/j.ccell.2017.08.003

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    2. scibot 27 Jul 2021
      plasmid_17452

      DOI: 10.1016/j.ccell.2017.08.003

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  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  64. www.sciencedirect.com www.sciencedirect.com
    A GPC2 antibody-drug conjugate is efficacious against neuroblastoma and small-cell lung cancer via binding a conformational epitope
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      DOI: 10.1016/j.xcrm.2021.100344

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  65. May 2021
  66. www.sciencedirect.com www.sciencedirect.com
    Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis
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      CAT#17452

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    A Membrane-Tethered Ubiquitination Pathway Regulates Hedgehog Signaling and Heart Development
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      Addgene_17452

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    C9orf72 regulates energy homeostasis by stabilizing mitochondrial complex I assembly
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  69. Mar 2021
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    A genome-wide CRISPR screen identifies UFMylation and TRAMP-like complexes as host factors required for hepatitis A virus infection
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      Plasmid_17452

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  71. Feb 2021
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    A chemical genetic screen identifies Aurora kinases as a therapeutic target in EGFR T790M negative, gefitinib-resistant head and neck squamous cell carcinoma (HNSCC)
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      RRID:Addgene_17452

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  73. Dec 2020
  74. www.sciencedirect.com www.sciencedirect.com
    Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD
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      Addgene_17452

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  75. Sep 2020
  76. www.nature.com www.nature.com
    Oxysterols provide innate immunity to bacterial infection by mobilizing cell surface accessible cholesterol
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  77. www.sciencedirect.com www.sciencedirect.com
    Kinetic Heterogeneity of Cancer Cell Fractional Killing
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      RRID:Addgene_17452

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    sciencedirect.com/science/article/pii/S2211124720308263
  78. cancerres.aacrjournals.org cancerres.aacrjournals.org
    YAP1 mediates resistance to MEK1/2 inhibition in neuroblastomas with hyperactivated RAS signalling
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      RRID:Addgene_17452

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  79. Jan 2020
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Critical role for Piccolo in synaptic vesicle retrieval
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    The ER membrane protein complex is required to ensure correct topology and stable expression of flavivirus polyproteins
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    Genomic and Transcriptomic Determinants of Therapy Resistance and Immune Landscape Evolution during Anti-EGFR Treatment in Colorectal Cancer
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      RRID:Addgene_17452

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      RRID:Addgene_17452

      DOI: 10.1016/j.celrep.2019.01.043

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