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A glycan-based adjuvant expands the breadth and duration of protection of mRNA-based vaccines

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1. scibot 10 Jun 2026
  
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  17477
  
  DOI: 10.1038/s41590-026-02517-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13226070/
Jun 2026
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Immunogenicity and Protection of mRNA Vaccine Encoding Spike Protein of SARS-CoV-2 Omicron-XEC Subvariant

1
1. scibot 06 Jun 2026
  
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  pLenti-CMV-LUC
  
  DOI: 10.3390/ijms27104218
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13207987/
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Modeling the role of urokinase-type plasminogen activator, uPA, and circulating cancer-associated fibroblasts (cCAFs) in breast cancer cell extravasation

1
1. scibot 06 Jun 2026
  
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  plasmid_17477
  
  DOI: 10.1007/s10585-026-10411-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13233632/
Feb 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Liver metastases dampen IL18-driven γδ T cell activity and immunotherapy responsiveness in colorectal cancer

1
1. scibot 24 Feb 2026
  
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  Plasmid_17477
  
  DOI: 10.1016/j.xcrm.2025.102579
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12923965/
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DDX6 undergoes phase separation to modulate metabolic plasticity and chemoresistance

1
1. scibot 01 Feb 2026
  
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  17477
  
  DOI: 10.1038/s41467-025-66966-4
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12783633/
Jan 2026
www.sciencedirect.com www.sciencedirect.com

Affinity maturation and light-chain-mediated paratope diversification anticipates viral evolution

1
1. scibot 06 Jan 2026
  
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  AddgeneCat#17477
  
  DOI: 10.1016/j.celrep.2025.116800
  
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sciencedirect.com/science/article/pii/S2211124725015724
Dec 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

D3-GPC2-directed CAR T cells are safe and efficacious in preclinical models of neuroblastoma and small cell lung cancer

1
1. scibot 19 Dec 2025
  
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  RRID:Addgene_17477
  
  DOI: 10.1158/1078-0432.CCR-25-0089
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12699724/
Nov 2025
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MEX3A is a diagnostic, independent prognostic biomarker and a promising therapeutic target in glioblastoma

1
1. scibot 23 Nov 2025
  
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  pLenti CMV Puro Luc w168-1
  
  DOI: 10.3389/fonc.2025.1585592
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12433882/
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Mesenchymal Stem Cells Expressing CES1 and Soluble TRAIL Activate CPT-11 and Induce Apoptosis in Lung Cancer Brain Metastatic Lesions

1
1. scibot 23 Nov 2025
  
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  plasmid_17477
  
  DOI: 10.1158/2767-9764.CRC-25-0209
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12417980/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Disruption of Microhomology-mediated End-joining in Ewing Sarcoma

1
1. scibot 23 Nov 2025
  
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  plasmid_17477
  
  DOI: 10.1101/2025.05.06.651696
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12191234/
Oct 2025
www.science.org www.science.org

Enhancing mRNA therapy through iterative delivery

1
1. scibot 08 Oct 2025
  
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  RRID:Addgene_17477
  
  DOI: 10.1126/sciadv.adx0916
  
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science.org/doi/10.1126/sciadv.adx0916
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Enhancing mRNA therapy through iterative delivery

1
1. scibot 03 Oct 2025
  
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  RRID:Addgene_17477
  
  DOI: 10.1126/sciadv.adx0916
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12487881/
Aug 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Assessment of Feasibility of the M2 Macrophage-Based Adoptive Gene Transfer Strategy for Osteoarthritis with a Mouse Model

1
1. scibot 11 Aug 2025
  
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  17477
  
  DOI: 10.3390/cells14141067
  
  Resource: RRID:Addgene_17477
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12293217/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Modeling the role of urokinase plasminogen activator, uPA, and circulating Cancer-Associated Fibroblasts (cCAFS) in breast cancer cell extravasation

1
1. scibot 11 Aug 2025
  
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  plasmid_17477
  
  DOI: 10.1101/2025.06.11.659108
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12262346/
52.53.155.43 52.53.155.43

ssrn-5367706-html.html

1
1. scibot 05 Aug 2025
  
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  RRID:Addgene_17477
  
  DOI: 10.2139/ssrn.5367706
  
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52.53.155.43/d4ac87e5901810967bc62a763150192c57d079f9/ssrn-5367706-html.html
Jul 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Establishing preclinical models for clear cell sarcoma of soft tissue

1
1. scibot 20 Jul 2025
  
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  pLenti CMV Puro Luc
  
  DOI: 10.3389/fonc.2025.1589773
  
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  Curator: @olekpark
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12213553/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Env from EIAV vaccine delicately regulates NLRP3 activation via attenuating NLRP3-NEK7 interaction

1
1. scibot 20 Jul 2025
  
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  Plenti-CMV Puro-Luc
  
  DOI: 10.1371/journal.ppat.1012772
  
  Resource: RRID:Addgene_17477
  
  Curator: @olekpark
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12187018/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

CCNY-mediated phosphorylation and TET2-BACH1-driven DNA demethylation activate PRC1 to augment NSCLC progression

1
1. scibot 20 Jul 2025
  
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  17477
  
  DOI: 10.1186/s13046-025-03472-x
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12261648/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Modeling the role of urokinase plasminogen activator, uPA, and circulating Cancer-Associated Fibroblasts (cCAFS) in breast cancer cell extravasation

1
1. scibot 12 Jul 2025
  
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  plasmid_17477
  
  DOI: 10.1101/2025.06.11.659108
  
  Resource: RRID:Addgene_17477
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12262346/
www.sciencedirect.com www.sciencedirect.com

Early innate immune response and evolution of a SARS-CoV-2 furin cleavage site inactive variant in bat cells

1
1. scibot 02 Jul 2025
  
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  Addgene_17477
  
  DOI: 10.1016/j.celrep.2025.115929
  
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sciencedirect.com/science/article/pii/S2211124725007004
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

On-patient medical record and mRNA therapeutics using intradermal microneedles

1
1. scibot 17 May 2025
  
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  pLenti-CMV Puro-Luc
  
  DOI: 10.1038/s41563-024-02115-4
  
  Resource: RRID:Addgene_17477
  
  Curator: @olekpark
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12048341/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Memory-promoting function of miR-379-5p attenuates CD8+ T cell exhaustion by targeting immune checkpoints

1
1. scibot 16 May 2025
  
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  pLenti CMV Puro LUC
  
  DOI: 10.1136/jitc-2024-010363
  
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  Curator: @olekpark
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11997822/
Apr 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Glycosylated Receptor-Binding-Domain-Targeting Mucosal Vaccines Protect Against SARS-CoV-2 Omicron and MERS-CoV

1
1. scibot 07 Apr 2025
  
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  pLenti-CMV-LUC
  
  DOI: 10.3390/vaccines13030293
  
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  Curator: @olekpark
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11946235/
Mar 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Generation of RNA aptamers against chikungunya virus E2 envelope protein

1
1. scibot 23 Mar 2025
  
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  17477
  
  DOI: 10.1128/jvi.02095-24
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11915788/
Feb 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

5‐hydroxymethylcytosine features of portal venous blood predict metachronous liver metastases of colorectal cancer and reveal phosphodiesterase 4 as a therapeutic target

1
1. scibot 24 Feb 2025
  
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  plasmid_17477
  
  DOI: 10.1002/ctm2.70189
  
  Resource: RRID:Addgene_17477
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11830572/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Protocol for evaluating humoral immune responses in mice following SARS-CoV-2 vaccination

1
1. scibot 18 Feb 2025
  
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  17477
  
  DOI: 10.1016/j.xpro.2024.103548
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11786727/
Jan 2025
www.sciencedirect.com www.sciencedirect.com

Nonhuman primate antigenic cartography of SARS-CoV-2

1
1. scibot 07 Jan 2025
  
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  RRID:Addgene_17477
  
  DOI: 10.1016/j.celrep.2024.115140
  
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sciencedirect.com/science/article/pii/S2211124724014918
Sep 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

miR-10a/b-5p-NCOR2 Regulates Insulin-Resistant Diabetes in Female Mice

1
1. scibot 29 Sep 2024
  
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  pLenti-CMV-Luc-Puro
  
  DOI: 10.3390/ijms251810147
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11432729/
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Immunogen characterization reveals an intrinsic hindrance in eliciting neutralizing antibodies against JN.1 variant

1
1. scibot 26 Sep 2024
  
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  17477
  
  DOI: 10.1016/j.isci.2024.110405
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11300904/
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

CAR T-cell-mediated delivery of bispecific innate immune cell engagers for neuroblastoma

1
1. scibot 26 Aug 2024
  
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  pLenti-CMV-puro-Luc (w168-1)
  
  DOI: 10.1038/s41467-024-51337-2
  
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  Curator: @olekpark
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11336212/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Cell-specific cross-talk proteomics reveals cathepsin B signaling as a driver of glioblastoma malignancy near the subventricular zone

1
1. scibot 21 Aug 2024
  
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  RRID:Addgene_17477
  
  DOI: 10.1126/sciadv.adn1607
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11305394/
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

B cell somatic hypermutation following COVID-19 vaccination with Ad26.COV2.S

1
1. scibot 30 Apr 2024
  
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  17477
  
  DOI: 10.1016/j.isci.2024.109716
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11035370/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

BET inhibitors drive Natural Killer activation in non-small cell lung cancer via BRD4 and SMAD3

1
1. scibot 15 Apr 2024
  
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  Addgene_17477
  
  DOI: 10.1038/s41467-024-46778-8
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10960013/
Feb 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Waning immunity and IgG4 responses following bivalent mRNA boosting

1
1. scibot 29 Feb 2024
  
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  pLenti-CMV Puro-Luc
  
  DOI: 10.1126/sciadv.adj9945
  
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  Curator: @olekpark
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10889350/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Therapeutic targeting Tudor domains in leukemia via CRISPR-Scan Assisted Drug Discovery

1
1. scibot 29 Feb 2024
  
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  17477
  
  DOI: 10.1126/sciadv.adk3127
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10889360/
www.biorxiv.org www.biorxiv.org

A novel, RAS-independent role for NF1 in microtubular dynamics and damage repair dictates sensitivity to T-DM1 in HER2-positive breast cancer

1
1. scibot 09 Feb 2024
  
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  Addgene (#17477
  
  DOI: 10.1101/2023.12.06.569572
  
  Resource: RRID:Addgene_17477
  
  Curator: @abever99
  
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biorxiv.org/content/10.1101/2023.12.06.569572v1
onlinelibrary.wiley.com onlinelibrary.wiley.com

Genetic engineering employing MPB70 and its promoter enables efficient secretion and expression of foreign antigen in bacillus Calmette Guérin (BCG) Tokyo

1
1. scibot 07 Feb 2024
  
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  RRID:Addgene_17477
  
  DOI: 10.1111/1348-0421.13116
  
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onlinelibrary.wiley.com/doi/10.1111/1348-0421.13116
Sep 2023
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TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal

1
1. scibot 29 Sep 2023
  
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  RRID:Addgene_17477
  
  DOI: 10.1016/j.stem.2023.07.001
  
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sciencedirect.com/science/article/pii/S1934590923002461
Aug 2023
www.biorxiv.org www.biorxiv.org

Cell-specific crosstalk proteomics reveals cathepsin B signaling as a driver of glioblastoma malignancy near the subventricular zone

1
1. scibot 28 Aug 2023
  
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  RRID:Addgene_17477
  
  DOI: 10.1101/2023.08.19.553966
  
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biorxiv.org/content/10.1101/2023.08.19.553966v1
Jun 2023
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Taxanes trigger cancer cell killing in vivo by inducing non-canonical T cell cytotoxicity

1
1. scibot 16 Jun 2023
  
  in Public
  
  Plasmid_17477
  
  DOI: 10.1016/j.ccell.2023.05.009
  
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sciencedirect.com/science/article/pii/S1535610823001769
May 2023
www.nature.com www.nature.com

Identification of acquired Notch3 dependency in metastatic Head and Neck Cancer

1
1. scibot 20 May 2023
  
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  plasmid_17477
  
  DOI: 10.1038/s42003-023-04828-9
  
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nature.com/articles/s42003-023-04828-9
Jan 2023
www.sciencedirect.com www.sciencedirect.com

METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism

1
1. scibot 06 Jan 2023
  
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  RRID:Addgene_17477
  
  DOI: 10.1016/j.stem.2022.12.006
  
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sciencedirect.com/science/article/pii/S1934590922004908
Dec 2022
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Lipid-laden lung mesenchymal cells foster breast cancer metastasis via metabolic reprogramming of tumor cells and natural killer cells

1
1. scibot 08 Dec 2022
  
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  Addgene_17477
  
  DOI: 10.1016/j.cmet.2022.11.003
  
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sciencedirect.com/science/article/pii/S1550413122004946
Sep 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Original research: Development of GPC2-directed chimeric antigen receptors using mRNA for pediatric brain tumors

1
1. scibot 30 Sep 2022
  
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  RRID:Addgene_17477
  
  DOI: 10.1136/jitc-2021-004450
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9516314/
www.nature.com www.nature.com

A RUNX-targeted gene switch-off approach modulates the BIRC5/PIF1-p21 pathway and reduces glioblastoma growth in mice

1
1. scibot 10 Sep 2022
  
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  plasmid_17477
  
  DOI: 10.1038/s42003-022-03917-5
  
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nature.com/articles/s42003-022-03917-5
www.sciencedirect.com www.sciencedirect.com

All-trans retinoic acid enhanced the antileukemic efficacy of ABT-199 in acute myeloid leukemia by downregulating the expression of S100A8

1
1. scibot 03 Sep 2022
  
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  RRID:Addgene_17477
  
  DOI: 10.1016/j.intimp.2022.109182
  
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sciencedirect.com/science/article/pii/S156757692200666X
Aug 2022
www.sciencedirect.com www.sciencedirect.com

Lung fibroblasts facilitate pre-metastatic niche formation by remodeling the local immune microenvironment

1
1. scibot 02 Aug 2022
  
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  Addgene_17477
  
  DOI: 10.1016/j.immuni.2022.07.001
  
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sciencedirect.com/science/article/pii/S107476132200334X
Apr 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Vaccine protection against the SARS-CoV-2 Omicron variant in macaques

1
1. scibot 15 Apr 2022
  
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  AddgeneCat# 17477
  
  DOI: 10.1016/j.cell.2022.03.024
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8926910/
Nov 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Synergistic effect of chidamide and venetoclax on apoptosis in acute myeloid leukemia cells and its mechanism

1
1. scibot 19 Nov 2021
  
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  RRID:Addgene_17477
  
  DOI: 10.21037/atm-21-5066
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8576699/
Jul 2021
www.sciencedirect.com www.sciencedirect.com

A GPC2 antibody-drug conjugate is efficacious against neuroblastoma and small-cell lung cancer via binding a conformational epitope

1
1. scibot 22 Jul 2021
  
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  plasmid_17477
  
  DOI: 10.1016/j.xcrm.2021.100344
  
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sciencedirect.com/science/article/pii/S2666379121001932
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Ovarian Cells Have Increased Proliferation in Response to Heparin-Binding Epidermal Growth Factor as Collagen Density Increases

1
1. scibot 03 Jul 2021
  
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  RRID:Addgene_17477
  
  DOI: 10.1089/ten.tea.2020.0001
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7398436/
May 2021
www.sciencedirect.com www.sciencedirect.com

Gut vascular barrier impairment leads to intestinal bacteria dissemination and colorectal cancer metastasis to liver

1
1. scibot 11 May 2021
  
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  RRID:Addgene_17477
  
  DOI: 10.1016/j.ccell.2021.03.004
  
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sciencedirect.com/science/article/pii/S1535610821001628
Apr 2021
www.sciencedirect.com www.sciencedirect.com

Local Mitochondrial ATP Production Regulates Endothelial Fatty Acid Uptake and Transport

2
1. scibot 29 Apr 2021
  
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  Cat#17477
  
  DOI: 10.1016/j.cmet.2020.05.018
  
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  Curator: @Naa003
  
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2. scibot 29 Apr 2021
  
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  addgene_17477
  
  DOI: 10.1016/j.cmet.2020.05.018
  
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sciencedirect.com/science/article/pii/S1550413120302576
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Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion

1
1. scibot 17 Apr 2021
  
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  RRID:Addgene_17477
  
  DOI: 10.1016/j.ccell.2020.04.017
  
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sciencedirect.com/science/article/pii/S1535610820302166
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Pharmacological Regulation of Tumor Hypoxia in Model Murine Tumors and Spontaneous Canine Tumors

1
1. scibot 13 Apr 2021
  
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  Addgene_17477
  
  DOI: 10.3390/cancers13071696
  
  Resource: RRID:Addgene_17477
  
  Curator: @evieth
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8038388/
Feb 2021
www.sciencedirect.com www.sciencedirect.com

R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m6A/PFKP/LDHB axis

1
1. scibot 28 Feb 2021
  
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  RRID:Addgene_17477
  
  DOI: 10.1016/j.molcel.2020.12.026
  
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sciencedirect.com/science/article/pii/S1097276520309473
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microRNA-induced translational control of antiviral immunity by the cap-binding protein 4EHP

1
1. scibot 28 Feb 2021
  
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  RRID:Addgene_17477
  
  DOI: 10.1016/j.molcel.2021.01.030
  
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sciencedirect.com/science/article/pii/S1097276521000502
Sep 2020
link.springer.com link.springer.com

Using Bioengineered Bioluminescence to Track Stem Cell Transplantation In Vivo

1
1. scibot 15 Sep 2020
  
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  RRID:Addgene_17477
  
  DOI: 10.1007/978-1-0716-0364-2_1
  
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link.springer.com/protocol/10.1007/978-1-0716-0364-2_1
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

Co-culture Systems of Drug-Treated Acute Myeloid Leukemia Cells and T Cells for In Vitro and In Vivo Study

1
1. scibot 03 Sep 2020
  
  in Public
  
  pLenti CMV Puro LUC (w168-1)
  
  DOI: 10.1016/j.xpro.2020.100097
  
  Resource: RRID:Addgene_17477
  
  Curator: @Naa003
  
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pubmed.ncbi.nlm.nih.gov/32995754/
Jan 2020
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Genomic and Transcriptomic Determinants of Therapy Resistance and Immune Landscape Evolution during Anti-EGFR Treatment in Colorectal Cancer

1
1. scibot 13 Jan 2020
  
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  RRID:Addgene_17477
  
  DOI: 10.1016/j.ccell.2019.05.013
  
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  Curator: @ethanbadger
  
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  RRID:Addgene_17477 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1535610819302557