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Jul 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The E3 ubiquitin ligase DTX3L and the deubiquitinase USP28 fine-tune DNA repair through mutual regulation of their protein levels

1
1. scibot 25 Jul 2025
  
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  Addgene_17605
  
  DOI: 10.1016/j.isci.2025.112990
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12283747/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

HDAC6 and USP9X Control Glutamine Metabolism by Stabilizing GS to Promote Glioblastoma Tumorigenesis

1
1. scibot 20 Jul 2025
  
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  pRK5‐HA‐Ubiquitin‐K48
  
  DOI: 10.1002/advs.202501553
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12224959/
Jun 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Reciprocal Regulation Between the SCFFBXO24 Ubiquitin E3 Ligase and FoxP1 Protein

1
1. scibot 25 Jun 2025
  
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  17605
  
  DOI: 10.1101/2025.05.23.653845
  
  Resource: RRID:Addgene_17605
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12154790/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The E3 ubiquitin ligase MARCH2 controls TNF-α mediated inflammation by autoubiquitination

1
1. scibot 15 Jun 2025
  
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  17605
  
  DOI: 10.1186/s12964-025-02260-6
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12126869/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

SDCBP/Syntenin-1 stabilizes BACH1 by disassembling the SCFFBXO22–BACH1 complex in triple-negative breast cancer

1
1. scibot 15 Jun 2025
  
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  17605
  
  DOI: 10.1038/s44318-025-00440-1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12130529/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Exploring Negative Feedback Mechanisms in the PTEN-ACE Axis: Application of Electrosorb Hydrogel-Based Gene Delivery for Intervertebral Disc Regeneration

1
1. scibot 14 Jun 2025
  
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  17605
  
  DOI: 10.7150/ijbs.111898
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12160554/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

NUDT16 enhances the resistance of cancer cells to DNA-damaging agents by regulating replication fork stability via reversing HMGA1 ADP-ribosylation

1
1. scibot 14 Jun 2025
  
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  17605
  
  DOI: 10.1016/j.jbc.2025.108551
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12151214/
May 2025
elifesciences.org elifesciences.org

SIRT2-mediated ACSS2 K271 deacetylation suppresses lipogenesis under nutrient stress

1
1. scibot 22 May 2025
  
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  RRID:Addgene_17605
  
  DOI: 10.7554/eLife.97019
  
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elifesciences.org/articles/97019
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HSPA9 contributes to tumor progression and ferroptosis resistance by enhancing USP14-driven SLC7A11 deubiquitination in multiple myeloma

1
1. scibot 16 May 2025
  
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  AddgeneCat#17605
  
  DOI: 10.1016/j.celrep.2025.115720
  
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sciencedirect.com/science/article/pii/S2211124725004917
Apr 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

CUL1-neddylation contributes to K29-linked ubiquitination on p27 for autophagic degradation in sorafenib-resistant liver cancer

1
1. scibot 07 Apr 2025
  
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  K48
  
  DOI: 10.1007/s10565-025-10008-8
  
  Resource: RRID:Addgene_17605
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11926008/
Feb 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The E3 ubiquitin ligase MAEA promotes macrophage phagocytosis and inhibits gastrointestinal cancer progression by mediating PARP1 ubiquitination and degradation

1
1. scibot 23 Feb 2025
  
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  Ub-K48
  
  DOI: 10.7150/ijbs.102796
  
  Resource: RRID:Addgene_17605
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11844278/
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Deubiquitinase USP9X controls Wnt signaling for CNS vascular formation and barrier maintenance

1
1. scibot 06 Feb 2025
  
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  Plasmid_17605
  
  DOI: 10.1016/j.devcel.2025.01.009
  
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sciencedirect.com/science/article/pii/S1534580725000292
Jan 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Pellino 3 E3 ligase promotes starvation-induced autophagy to prevent hepatic steatosis

1
1. scibot 27 Jan 2025
  
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  17605
  
  DOI: 10.1126/sciadv.adr2450
  
  Resource: RRID:Addgene_17605
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11740972/
Sep 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

USP5 Promotes Ripretinib Resistance in Gastrointestinal Stromal Tumors by MDH2 Deubiquition

1
1. scibot 28 Sep 2024
  
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  The HA‐labeled ubiquitin‐Lys48 (K48)
  
  DOI: 10.1002/advs.202401171
  
  Resource: RRID:Addgene_17605
  
  Curator: @olekpark
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11425886/
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HSV-1-induced N6-methyladenosine reprogramming via ICP0-mediated suppression of METTL14 potentiates oncolytic activity in glioma

1
1. scibot 27 Sep 2024
  
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  Addgene#17605
  
  DOI: 10.1016/j.celrep.2024.114756
  
  Resource: RRID:Addgene_17605
  
  Curator: @vtello
  
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sciencedirect.com/science/article/pii/S2211124724011070
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

PITAR, a DNA damage-inducible cancer/testis long noncoding RNA, inactivates p53 by binding and stabilizing TRIM28 mRNA

1
1. scibot 25 Sep 2024
  
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  17605
  
  DOI: 10.7554/eLife.88256
  
  Resource: RRID:Addgene_17605
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11415074/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Targeting SNRNP200-induced splicing dysregulation offers an immunotherapy opportunity for glycolytic triple-negative breast cancer

1
1. scibot 25 Sep 2024
  
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  17605
  
  DOI: 10.1038/s41421-024-00715-7
  
  Resource: RRID:Addgene_17605
  
  Curator: @olekpark
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11405407/
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Cellular turnover and degradation of the most common missense cystathionine beta‐synthase variants causing homocystinuria

1
1. scibot 26 Aug 2024
  
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  17605
  
  DOI: 10.1002/pro.5123
  
  Resource: RRID:Addgene_17605
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11264351/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Suppression of Skp2 contributes to sepsis-induced acute lung injury by enhancing ferroptosis through the ubiquitination of SLC3A2

1
1. scibot 26 Aug 2024
  
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  17605
  
  DOI: 10.1007/s00018-024-05348-3
  
  Resource: RRID:Addgene_17605
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11335248/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

UBR1 promotes anaplastic thyroid carcinoma progression via stabilizing YAP through monoubiquitylation

1
1. scibot 26 Aug 2024
  
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  HA-K48
  
  DOI: 10.1038/s41598-024-70458-8
  
  Resource: RRID:Addgene_17605
  
  Curator: @olekpark
  
  SciCrunch record: RRID:Addgene_17605
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11341911/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Periodic changes of cyclin D1 mRNA stability are regulated by PC4 modifications in the cell cycle

1
1. scibot 17 Aug 2024
  
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  17605
  
  DOI: 10.1083/jcb.202308066
  
  Resource: RRID:Addgene_17605
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10864110/
52.53.155.43 52.53.155.43

FEBS Press

1
1. scibot 02 Aug 2024
  
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  Plasmid #17605
  
  DOI: 10.1002/1878-0261.13497
  
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52.53.155.43/5ae378afd9ab5ca0cc44c821394ffd9a004fa694/Molecular Oncology - 2023 - Celada-html.html
Jul 2024
www.sciencedirect.com www.sciencedirect.com

PELI2 is a negative regulator of STING signaling that is dynamically repressed during viral infection

1
1. scibot 24 Jul 2024
  
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  RRID:Addgene_17605
  
  DOI: 10.1016/j.molcel.2024.06.001
  
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sciencedirect.com/science/article/pii/S1097276524004799
Jun 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Proximal protein landscapes of the type I interferon signaling cascade reveal negative regulation by PJA2

1
1. scibot 03 Jun 2024
  
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  17605
  
  DOI: 10.1038/s41467-024-48800-5
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11130243/
May 2024
www.sciencedirect.com www.sciencedirect.com

Ubiquitin-mediated regulation of APE2 protein abundance

1
1. scibot 07 May 2024
  
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  RRID:Addgene_17605
  
  DOI: 10.1016/j.jbc.2024.107337
  
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sciencedirect.com/science/article/pii/S0021925824018386
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Oncolytic Newcastle disease virus induced degradation of YAP through E3 ubiquitin ligase PRKN to exacerbate ferroptosis in tumor cells

1
1. scibot 15 Apr 2024
  
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  17605
  
  DOI: 10.1128/jvi.01897-23
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10949840/
Mar 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

RNF166 promotes colorectal cancer progression by recognizing and destabilizing poly-ADP-ribosylated angiomotins

1
1. scibot 17 Mar 2024
  
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  17605
  
  DOI: 10.1038/s41419-024-06595-9
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10937711/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The dePARylase NUDT16 promotes radiation resistance of cancer cells by blocking SETD3 for degradation via reversing its ADP-ribosylation

1
1. scibot 16 Mar 2024
  
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  plasmid_17605
  
  DOI: 10.1016/j.jbc.2024.105671
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10926213/
www.biorxiv.org www.biorxiv.org

SIRT2-Mediated ACSS2 K271 Deacetylation Suppresses Lipogenesis Under Nutrient Stress

1
1. scibot 08 Mar 2024
  
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  RRID:Addgene_17605
  
  DOI: 10.1101/2024.02.27.582293
  
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biorxiv.org/content/10.1101/2024.02.27.582293v1
Feb 2024
www.sciencedirect.com www.sciencedirect.com

The GATOR2 complex maintains lysosomal-autophagic function by inhibiting the protein degradation of MiT/TFEs

1
1. scibot 08 Feb 2024
  
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  Lim et al.72Addgene, Cat# 17605
  
  DOI: 10.1016/j.molcel.2024.01.012
  
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sciencedirect.com/science/article/pii/S1097276524000480
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

An apicoplast-localized deubiquitinase contributes to the cell growth and apicoplast homeostasis of Toxoplasma gondii

1
1. scibot 01 Feb 2024
  
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  17605
  
  DOI: 10.1186/s13567-023-01261-y
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10795397/
Dec 2023
www.sciencedirect.com www.sciencedirect.com

FLOT2 promotes nasopharyngeal carcinoma progression through suppression of TGF-β pathway via facilitating CD109 expression

1
1. scibot 21 Dec 2023
  
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  RRID:Addgene_17605
  
  DOI: 10.1016/j.isci.2023.108580
  
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sciencedirect.com/science/article/pii/S2589004223026573
Nov 2023
link.springer.com link.springer.com

SARS-CoV-2 ORF6 protein targets TRIM25 for proteasomal degradation to diminish K63-linked RIG-I ubiquitination and type-I interferon induction

1
1. scibot 25 Nov 2023
  
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  RRID:Addgene_17605
  
  DOI: 10.1007/s00018-023-05011-3
  
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  Curator: @anisehay
  
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link.springer.com/article/10.1007/s00018-023-05011-3
Sep 2023
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Usp25-Erlin1/2 activity limits cholesterol flux to restrict virus infection

1
1. scibot 08 Sep 2023
  
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  plasmid_17605
  
  DOI: 10.1016/j.devcel.2023.08.013
  
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sciencedirect.com/science/article/pii/S1534580723004094
Jun 2023
www.sciencedirect.com www.sciencedirect.com

KLHL7 promotes hepatocellular carcinoma progression and molecular therapy resistance by degrading RASA2

1
1. scibot 02 Jun 2023
  
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  Plasmid #17605
  
  DOI: 10.1016/j.isci.2023.106914
  
  Resource: RRID:Addgene_17605
  
  Curator: @sofiakhan13
  
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sciencedirect.com/science/article/pii/S2589004223009914
Mar 2023
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Fam72a functions as a cell-cycle-controlled gene during proliferation and antagonizes apoptosis through reprogramming PP2A substrates

1
1. scibot 03 Mar 2023
  
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  RRID:Addgene_17605
  
  DOI: 10.1016/j.devcel.2023.02.006
  
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sciencedirect.com/science/article/pii/S1534580723000485
Dec 2022
www.sciencedirect.com www.sciencedirect.com

Fyn deficiency inhibits oxidative stress by decreasing c-Cbl-mediated ubiquitination of Sirt1 to attenuate diabetic renal fibrosis

1
1. scibot 18 Dec 2022
  
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  RRID:Addgene_17605
  
  DOI: 10.1016/j.metabol.2022.155378
  
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  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_17605
  
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  RRID:Addgene_17605
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sciencedirect.com/science/article/pii/S0026049522002566
Mar 2022
www.sciencedirect.com www.sciencedirect.com

K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy

1
1. scibot 04 Mar 2022
  
  in Public
  
  RRID:Addgene_17605
  
  DOI: 10.1016/j.celrep.2022.110354
  
  Resource: RRID:Addgene_17605
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_17605
  
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  RRID:Addgene_17605
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sciencedirect.com/science/article/pii/S2211124722000705
Jan 2022
www.sciencedirect.com www.sciencedirect.com

Gentiopicroside targets PAQR3 to activate PI3K/AKT signaling pathway and ameliorate glucose and lipid metabolism

1
1. scibot 07 Jan 2022
  
  in Public
  
  RRID:Addgene_17605
  
  DOI: 10.1016/j.apsb.2021.12.023
  
  Resource: RRID:Addgene_17605
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_17605
  
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  RRID:Addgene_17605
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sciencedirect.com/science/article/pii/S2211383521004949
Oct 2021
www.sciencedirect.com www.sciencedirect.com

Peli1 facilitates NLRP3 inflammasome activation by mediating ASC ubiquitination

1
1. scibot 30 Oct 2021
  
  in Public
  
  plasmid_17605
  
  DOI: 10.1016/j.celrep.2021.109904
  
  Resource: RRID:Addgene_17605
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_17605
  
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  RRID:Addgene_17605
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sciencedirect.com/science/article/pii/S2211124721013747
Jul 2021
www.sciencedirect.com www.sciencedirect.com

Untitled document

1
1. scibot 31 Jul 2021
  
  in Public
  
  RRID:Addgene_17605
  
  DOI: 10.1016/j.immuni.2019.01.014
  
  Resource: RRID:Addgene_17605
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:Addgene_17605
  
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  RRID:Addgene_17605 RRIDCUR:Validated
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RRIDCUR:Validated

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sciencedirect.com/science/article/pii/S1074761319300378
Dec 2020
www.mdpi.com www.mdpi.com

Hepatitis B Core Protein Is Post-Translationally Modified through K29-Linked Ubiquitination

1
1. scibot 07 Dec 2020
  
  in Public
  
  pRK5-HA-Ubiquitin-K48
  
  DOI: 10.3390/cells9122547
  
  Resource: RRID:Addgene_17605
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_17605
  
  Curator comments: pRK5-HA-Ubiquitin-K48
  
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  RRID:Addgene_17605 RRIDCUR:Missing
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mdpi.com/2073-4409/9/12/2547/htm
Sep 2020
bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

BPS Publications

1
1. scibot 10 Sep 2020
  
  in Public
  
  RRID:Addgene_17605
  
  DOI: 10.1111/bph.14853
  
  Resource: RRID:Addgene_17605
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_17605
  
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  RRIDCUR:Validated RRID:Addgene_17605
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.14853
www.sciencedirect.com www.sciencedirect.com

L ARP7 Is a BRCA1 Ubiquitinase Substrate and Regulates Genome Stability and Tumorigenesis

1
1. scibot 04 Sep 2020
  
  in Public
  
  RRID:Addgene_17605
  
  DOI: 10.1016/j.celrep.2020.107974
  
  Resource: RRID:Addgene_17605
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_17605
  
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  RRIDCUR:Validated RRID:Addgene_17605
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sciencedirect.com/science/article/pii/S2211124720309554
www.sciencedirect.com www.sciencedirect.com

OTUB1 Is a Key Regulator of RIG-I-Dependent Immune Signaling and Is Targeted for Proteasomal Degradation by Influenza A NS1

1
1. scibot 03 Sep 2020
  
  in Public
  
  Addgene Plasmid 17605
  
  DOI: 10.1016/j.celrep.2020.01.015
  
  Resource: RRID:Addgene_17605
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:Addgene_17605
  
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  RRID:Addgene_17605
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sciencedirect.com/science/article/pii/S2211124720300243
Jan 2020
elifesciences.org elifesciences.org

Nedd4 E3 ligase and beta-arrestins regulate ubiquitination, trafficking, and stability of the mGlu7 receptor

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:Addgene_17605
  
  DOI: 10.7554/eLife.44502
  
  Resource: RRID:Addgene_17605
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_17605
  
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  RRID:Addgene_17605 RRIDCUR:Validated
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elifesciences.org/articles/44502
link.springer.com link.springer.com

β-TrCP-mediated ubiquitination and degradation of Dlg5 regulates hepatocellular carcinoma cell proliferation

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:Addgene_17605
  
  DOI: 10.1186/s12935-019-1029-1
  
  Resource: RRID:Addgene_17605
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_17605
  
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  RRID:Addgene_17605 RRIDCUR:Validated
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link.springer.com/article/10.1186/s12935-019-1029-1
www.sciencedirect.com www.sciencedirect.com

Untitled document

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:Addgene_17605
  
  DOI: 10.1016/j.immuni.2019.01.014
  
  Resource: RRID:Addgene_17605
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:Addgene_17605
  
  What is this?
  
  RRID:Addgene_17605 RRIDCUR:Validated
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RRID:Addgene_17605

RRIDCUR:Validated

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scibot

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sciencedirect.com/science/article/pii/S1074761319300378