64 Matching Annotations
  1. Nov 2026
  2. www.sciencedirect.com www.sciencedirect.com
    TRIM2 facilitates macrophage mediated anti-tumor immunity in renal cell carcinoma through enhancing SIRPA ubiquitination and degradation
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    sciencedirect.com/science/article/pii/S1567576926014761
  3. Oct 2026
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    IFI207 promotes antiviral responses by modulating STING ubiquitination and degradation
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    pmc.ncbi.nlm.nih.gov/articles/PMC13251359/
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Ubiquitin-mediated stabilization of KDM5B drives chemoresistance via repression of dual-specificity phosphatase 4 in ovarian cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12979859/
  6. Sep 2026
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PRMT5‐Dependent Stabilization of VPS34 Orchestrates Copper Trafficking to Shield Cancer Cells from Cuproptosis and Radiotherapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC13345692/
  8. Aug 2026
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CYLD-mediated lysine63 deubiquitination regulates synaptic transmission and autophagy to mitigate age-related sequelae
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC13396389/
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    YOD1 drives acute kidney injury by deubiquitinating Bax and promoting apoptosis in tubular epithelial cells
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC13440280/
  11. www.sciencedirect.com www.sciencedirect.com
    Gasdermin E couples viral pyroptosis to lethal hepatic lipid accumulation
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    sciencedirect.com/science/article/pii/S0092867426008093
  12. Apr 2026
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DAPK1-Mediated Parkin Inactivation Enhances Neurotoxicity via MITOL-Dependent Degradation
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    pmc.ncbi.nlm.nih.gov/articles/PMC13053296/
  14. Nov 2025
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    USP9X-triggered ferroptosis mediates follicular atresia via deubiquitinating Beclin1 in chicken
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    pmc.ncbi.nlm.nih.gov/articles/PMC12548185/
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    USP2-mediated PPARγ stabilization promotes hepatocellular carcinoma progression and M2 macrophage polarization via oleic acid
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    pmc.ncbi.nlm.nih.gov/articles/PMC12588028/
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    UBE2O, a host ubiquitin-conjugating enzyme, is a key regulator of hepatitis B virus maturation and egress
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12554184/
  18. Sep 2025
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Novel Role of the Epstein-Barr Virus Encoded Deubiquitinating Enzyme (BPLF1) in mTOR-Mediated Cell Growth and Proliferation Pathways
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    pmc.ncbi.nlm.nih.gov/articles/PMC12390678/
  20. Jul 2025
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The E3 ubiquitin ligase DTX3L and the deubiquitinase USP28 fine-tune DNA repair through mutual regulation of their protein levels
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    pmc.ncbi.nlm.nih.gov/articles/PMC12283747/
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    HDAC6 and USP9X Control Glutamine Metabolism by Stabilizing GS to Promote Glioblastoma Tumorigenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12224959/
  23. Jun 2025
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Reciprocal Regulation Between the SCFFBXO24 Ubiquitin E3 Ligase and FoxP1 Protein
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12154790/
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TRIM21 promotes type I interferon by inhibiting the autophagic degradation of STING via p62/SQSTM1 ubiquitination in systemic lupus erythematosus: TRIM21 promotes IFN-I by inhibiting STING autophagy via p62 in SLE
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12130703/
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The E3 ubiquitin ligase MARCH2 controls TNF-α mediated inflammation by autoubiquitination
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12126869/
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Exploring Negative Feedback Mechanisms in the PTEN-ACE Axis: Application of Electrosorb Hydrogel-Based Gene Delivery for Intervertebral Disc Regeneration
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12160554/
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NUDT16 enhances the resistance of cancer cells to DNA-damaging agents by regulating replication fork stability via reversing HMGA1 ADP-ribosylation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12151214/
  29. May 2025
  30. www.sciencedirect.com www.sciencedirect.com
    HSPA9 contributes to tumor progression and ferroptosis resistance by enhancing USP14-driven SLC7A11 deubiquitination in multiple myeloma
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    sciencedirect.com/science/article/pii/S2211124725004917
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Activity-dependent degradation of Kv4.2 contributes to synaptic plasticity and behavior in Angelman syndrome model mice
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12232208/
  32. Mar 2025
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    OTUD6B regulates KIFC1-dependent centrosome clustering and breast cancer cell survival
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11850729/
  34. Feb 2025
  35. www.sciencedirect.com www.sciencedirect.com
    Deubiquitinase USP9X controls Wnt signaling for CNS vascular formation and barrier maintenance
    1
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    sciencedirect.com/science/article/pii/S1534580725000292
  36. Jan 2025
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pellino 3 E3 ligase promotes starvation-induced autophagy to prevent hepatic steatosis
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11740972/
  38. Sep 2024
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    USP5 Promotes Ripretinib Resistance in Gastrointestinal Stromal Tumors by MDH2 Deubiquition
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    ncbi.nlm.nih.gov/pmc/articles/PMC11425886/
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pseudorabies Virus UL4 protein promotes the ASC-dependent inflammasome activation and pyroptosis to exacerbate inflammation
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11421794/
  41. www.sciencedirect.com www.sciencedirect.com
    HSV-1-induced N6-methyladenosine reprogramming via ICP0-mediated suppression of METTL14 potentiates oncolytic activity in glioma
    1
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    sciencedirect.com/science/article/pii/S2211124724011070
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting SNRNP200-induced splicing dysregulation offers an immunotherapy opportunity for glycolytic triple-negative breast cancer
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11405407/
  43. Aug 2024
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cellular turnover and degradation of the most common missense cystathionine beta‐synthase variants causing homocystinuria
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11264351/
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Suppression of Skp2 contributes to sepsis-induced acute lung injury by enhancing ferroptosis through the ubiquitination of SLC3A2
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11335248/
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    UBR1 promotes anaplastic thyroid carcinoma progression via stabilizing YAP through monoubiquitylation
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    ncbi.nlm.nih.gov/pmc/articles/PMC11341911/
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Periodic changes of cyclin D1 mRNA stability are regulated by PC4 modifications in the cell cycle
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10864110/
  48. 52.53.155.43 52.53.155.43
    FEBS Press
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    52.53.155.43/5ae378afd9ab5ca0cc44c821394ffd9a004fa694/Molecular Oncology - 2023 - Celada-html.html
  49. Jul 2024
  50. www.sciencedirect.com www.sciencedirect.com
    PELI2 is a negative regulator of STING signaling that is dynamically repressed during viral infection
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    sciencedirect.com/science/article/pii/S1097276524004799
  51. Jun 2024
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Proximal protein landscapes of the type I interferon signaling cascade reveal negative regulation by PJA2
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    ncbi.nlm.nih.gov/pmc/articles/PMC11130243/
  53. May 2024
  54. www.sciencedirect.com www.sciencedirect.com
    TBK1 is ubiquitinated by TRIM5α to assemble mitophagy machinery
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    sciencedirect.com/science/article/pii/S2211124724006223
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    N-MYC impairs innate immune signaling in high-grade serous ovarian carcinoma
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11095474/
  56. Apr 2024
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Oncolytic Newcastle disease virus induced degradation of YAP through E3 ubiquitin ligase PRKN to exacerbate ferroptosis in tumor cells
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10949840/
  58. Mar 2024
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RNF166 promotes colorectal cancer progression by recognizing and destabilizing poly-ADP-ribosylated angiomotins
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10937711/
  60. Feb 2024
  61. www.sciencedirect.com www.sciencedirect.com
    DUB3 is a MAGEA3 deubiquitinase and a potential therapeutic target in hepatocellular carcinoma
    1
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    sciencedirect.com/science/article/pii/S2589004224004024
  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An apicoplast-localized deubiquitinase contributes to the cell growth and apicoplast homeostasis of Toxoplasma gondii
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10795397/
  63. Dec 2023
  64. www.sciencedirect.com www.sciencedirect.com
    FLOT2 promotes nasopharyngeal carcinoma progression through suppression of TGF-β pathway via facilitating CD109 expression
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    sciencedirect.com/science/article/pii/S2589004223026573
  65. Nov 2023
  66. link.springer.com link.springer.com
    SARS-CoV-2 ORF6 protein targets TRIM25 for proteasomal degradation to diminish K63-linked RIG-I ubiquitination and type-I interferon induction
    1
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    link.springer.com/article/10.1007/s00018-023-05011-3
  67. Sep 2023
  68. www.sciencedirect.com www.sciencedirect.com
    Usp25-Erlin1/2 activity limits cholesterol flux to restrict virus infection
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    sciencedirect.com/science/article/pii/S1534580723004094
  69. Jun 2023
  70. www.sciencedirect.com www.sciencedirect.com
    KLHL7 promotes hepatocellular carcinoma progression and molecular therapy resistance by degrading RASA2
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    sciencedirect.com/science/article/pii/S2589004223009914
  71. Mar 2023
  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neural mechanism underlies CYLD modulation of morphology and synaptic function of medium spiny neurons in dorsolateral striatum
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC9945542/
  73. Jan 2023
  74. www.sciencedirect.com www.sciencedirect.com
    Fyn deficiency inhibits oxidative stress by decreasing c-Cbl-mediated ubiquitination of Sirt1 to attenuate diabetic renal fibrosis
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    sciencedirect.com/science/article/pii/S0026049522002566
  75. Mar 2022
  76. www.sciencedirect.com www.sciencedirect.com
    K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy
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    sciencedirect.com/science/article/pii/S2211124722000705
  77. Oct 2021
  78. www.sciencedirect.com www.sciencedirect.com
    Peli1 facilitates NLRP3 inflammasome activation by mediating ASC ubiquitination
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    sciencedirect.com/science/article/pii/S2211124721013747
  79. Jul 2021
  80. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    sciencedirect.com/science/article/pii/S1074761319300378
  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    ncbi.nlm.nih.gov/pmc/articles/PMC6372082/
  82. Feb 2021
  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Immune checkpoint protein VISTA regulates antitumor immunity by controlling myeloid cell–mediated inflammation and immunosuppression
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC6726548/
  84. link.springer.com link.springer.com
    FBXL6 governs c-MYC to promote hepatocellular carcinoma through ubiquitination and stabilization of HSP90AA1
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    link.springer.com/article/10.1186/s12964-020-00604-y
  85. Jan 2021
  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RNA binding RING E3-ligase DZIP3/hRUL138 stabilizes Cyclin D1 to drive cell cycle and cancer progression
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC7116596/
  87. Dec 2020
  88. www.mdpi.com www.mdpi.com
    Hepatitis B Core Protein Is Post-Translationally Modified through K29-Linked Ubiquitination
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    mdpi.com/2073-4409/9/12/2547/htm
  89. Sep 2020
  90. link.springer.com link.springer.com
    FBXL6 governs c-MYC to promote hepatocellular carcinoma through ubiquitination and stabilization of HSP90AA1
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    link.springer.com/article/10.1186/s12964-020-00604-y
  91. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.14853
  92. www.sciencedirect.com www.sciencedirect.com
    L ARP7 Is a BRCA1 Ubiquitinase Substrate and Regulates Genome Stability and Tumorigenesis
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    sciencedirect.com/science/article/pii/S2211124720309554
  93. www.sciencedirect.com www.sciencedirect.com
    OTUB1 Is a Key Regulator of RIG-I-Dependent Immune Signaling and Is Targeted for Proteasomal Degradation by Influenza A NS1
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    sciencedirect.com/science/article/pii/S2211124720300243
  94. Jan 2020
  95. www.sciencedirect.com www.sciencedirect.com
    The N-Degron Pathway Mediates ER-phagy
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    sciencedirect.com/science/article/pii/S109727651930485X
  96. elifesciences.org elifesciences.org
    Nedd4 E3 ligase and beta-arrestins regulate ubiquitination, trafficking, and stability of the mGlu7 receptor
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    elifesciences.org/articles/44502
  97. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    sciencedirect.com/science/article/pii/S1097276518309882
  98. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    sciencedirect.com/science/article/pii/S1074761319300378