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Deltex and RING-UIM E3 ligases cooperate to create a ubiquitin-ADP-ribose hybrid mark on tankyrase, promoting its stabilization

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1. scibot 06 Sep 2025
  
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  17608
  
  DOI: 10.1126/sciadv.adx7172
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12407064/
Aug 2025
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Ubiquitination Regulates Reorganization of the Membrane System During Cytomegalovirus Infection

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1. scibot 05 Aug 2025
  
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  RRID:Addgene_17608
  
  DOI: 10.3390/life15081212
  
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mdpi.com/2075-1729/15/8/1212
Jul 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The E3 ubiquitin ligase DTX3L and the deubiquitinase USP28 fine-tune DNA repair through mutual regulation of their protein levels

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1. scibot 25 Jul 2025
  
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  Addgene_17608
  
  DOI: 10.1016/j.isci.2025.112990
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12283747/
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HDAC6 and USP9X Control Glutamine Metabolism by Stabilizing GS to Promote Glioblastoma Tumorigenesis

1
1. scibot 20 Jul 2025
  
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  p‐RK5‐HA‐Ub
  
  DOI: 10.1002/advs.202501553
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12224959/
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Endosomal RFFL ubiquitin ligase regulates mitochondrial morphology by targeting mitofusin 2

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1. scibot 20 Jul 2025
  
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  plasmid_17608
  
  DOI: 10.1242/jcs.263830
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12211564/
Jun 2025
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The E3 ubiquitin ligase MARCH2 controls TNF-α mediated inflammation by autoubiquitination

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1. scibot 15 Jun 2025
  
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  17608
  
  DOI: 10.1186/s12964-025-02260-6
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12126869/
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SDCBP/Syntenin-1 stabilizes BACH1 by disassembling the SCFFBXO22–BACH1 complex in triple-negative breast cancer

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1. scibot 15 Jun 2025
  
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  DOI: 10.1038/s44318-025-00440-1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12130529/
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cIAP2-mediated IGF2BP2 ubiquitination and degradation regulate cardiomyocyte apoptosis via stabilizing m6A-modified BAX mRNA in myocardial infarction

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1. scibot 15 Jun 2025
  
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  17608
  
  DOI: 10.1007/s10565-025-10045-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12125055/
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CCDC50 mediates the clearance of protein aggregates to prevent cellular proteotoxicity

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1. scibot 14 Jun 2025
  
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  17,608
  
  DOI: 10.1080/15548627.2024.2367183
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11572255/
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Inhibiting Infectious Bronchitis Virus PLpro Using Ubiquitin Variants

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1. scibot 13 Jun 2025
  
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  RRID:Addgene_17608
  
  DOI: 10.3390/ijms26115254
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12155308/
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Mitochondrial fumarate inhibits Parkin-mediated mitophagy

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1. scibot 11 Jun 2025
  
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  Addgene#17608
  
  DOI: 10.1016/j.molcel.2025.05.021
  
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sciencedirect.com/science/article/pii/S1097276525004605
May 2025
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HSPA9 contributes to tumor progression and ferroptosis resistance by enhancing USP14-driven SLC7A11 deubiquitination in multiple myeloma

1
1. scibot 16 May 2025
  
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  AddgeneCat#17608
  
  DOI: 10.1016/j.celrep.2025.115720
  
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sciencedirect.com/science/article/pii/S2211124725004917
Apr 2025
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GATAD2B O-GlcNAcylation Regulates Breast Cancer Stem-like Potential and Drug Resistance

1
1. scibot 07 Apr 2025
  
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  pRK5-HA-Ub
  
  DOI: 10.3390/cells14060398
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11941746/
www.biorxiv.org www.biorxiv.org

The E3 ubiquitin ligase MGRN1 targets melanocortin receptors MC1R and MC4R via interactions with transmembrane adapters

1
1. scibot 03 Apr 2025
  
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  Addgene (Cat #17608)
  
  DOI: 10.1101/2025.03.25.645338
  
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biorxiv.org/content/10.1101/2025.03.25.645338v1
Mar 2025
rupress.org rupress.org

The deubiquitinase USP45 inhibits autophagy through actin regulation by Coronin 1B

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1. scibot 23 Mar 2025
  
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  17608
  
  DOI: 10.1083/jcb.202407014
  
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rupress.org/jcb/article/224/5/e202407014/277317/The-deubiquitinase-USP45-inhibits-autophagy
Feb 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

TRIM32 regulates insulin sensitivity by controlling insulin receptor degradation in the liver

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1. scibot 16 Feb 2025
  
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  17608
  
  DOI: 10.1038/s44319-024-00348-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11811033/
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Enhanced secretion of the amyotrophic lateral sclerosis ALS-associated misfolded TDP-43 mediated by the ER-ubiquitin specific peptidase USP19

1
1. scibot 16 Feb 2025
  
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  plasmid_17608
  
  DOI: 10.1007/s00018-025-05589-w
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11825969/
Jan 2025
www.biorxiv.org www.biorxiv.org

Avoidance of pyroptosis accounts for the relatively high metastatic potential observed in early hybrid EMT states

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1. scibot 31 Jan 2025
  
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  Cat:17608
  
  DOI: 10.1101/2025.01.26.634904
  
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biorxiv.org/content/10.1101/2025.01.26.634904v1
Sep 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Retinoic acid-induced protein 14 links mechanical forces to Hippo signaling

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1. scibot 27 Sep 2024
  
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  17608
  
  DOI: 10.1038/s44319-024-00228-0
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11387738/
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HSV-1-induced N6-methyladenosine reprogramming via ICP0-mediated suppression of METTL14 potentiates oncolytic activity in glioma

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1. scibot 27 Sep 2024
  
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  Addgene_17608
  
  DOI: 10.1016/j.celrep.2024.114756
  
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sciencedirect.com/science/article/pii/S2211124724011070
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Proteostasis perturbation of N-Myc leveraging HSP70 mediated protein turnover improves treatment of neuroendocrine prostate cancer

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1. scibot 26 Sep 2024
  
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  DOI: 10.1038/s41467-024-50459-x
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11300456/
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Targeting SNRNP200-induced splicing dysregulation offers an immunotherapy opportunity for glycolytic triple-negative breast cancer

2
1. scibot 25 Sep 2024
  
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  DOI: 10.1038/s41421-024-00715-7
  
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  17608
  
  DOI: 10.1038/s41421-024-00715-7
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11405407/
Aug 2024
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Cellular turnover and degradation of the most common missense cystathionine beta‐synthase variants causing homocystinuria

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1. scibot 26 Aug 2024
  
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  17608
  
  DOI: 10.1002/pro.5123
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11264351/
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Suppression of Skp2 contributes to sepsis-induced acute lung injury by enhancing ferroptosis through the ubiquitination of SLC3A2

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1. scibot 26 Aug 2024
  
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  17608
  
  DOI: 10.1007/s00018-024-05348-3
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11335248/
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Periodic changes of cyclin D1 mRNA stability are regulated by PC4 modifications in the cell cycle

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1. scibot 17 Aug 2024
  
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  17608
  
  DOI: 10.1083/jcb.202308066
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10864110/
Jul 2024
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A fine balance between Prpf19 and Exoc7 in achieving degradation of aggregated protein and suppression of cell death in spinocerebellar ataxia type 3

1
1. scibot 25 Jul 2024
  
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  plasmid_17608
  
  DOI: 10.1038/s41419-021-03444-x
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7862454/
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PELI2 is a negative regulator of STING signaling that is dynamically repressed during viral infection

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1. scibot 24 Jul 2024
  
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  RRID:Addgene_17608
  
  DOI: 10.1016/j.molcel.2024.06.001
  
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sciencedirect.com/science/article/pii/S1097276524004799
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ZNF598 co-translationally titrates poly(GR) protein implicated in the pathogenesis of C9ORF72-associated ALS/FTD

1
1. scibot 24 Jul 2024
  
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  plasmid_17608
  
  DOI: 10.1093/nar/gkab834
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8565315/
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Hsp47 promotes biogenesis of multi-subunit neuroreceptors in the endoplasmic reticulum

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1. scibot 20 Jul 2024
  
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  RRID:Addgene_17608
  
  DOI: 10.7554/eLife.84798
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11257679/
Jun 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Proximal protein landscapes of the type I interferon signaling cascade reveal negative regulation by PJA2

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1. scibot 03 Jun 2024
  
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  17608
  
  DOI: 10.1038/s41467-024-48800-5
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11130243/
May 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

OTULIN-related conditions: Report of a new case and review of the literature using GenIA

1
1. scibot 19 May 2024
  
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  Addgene_17608
  
  DOI: 10.21203/rs.3.rs-3950863/v2
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11071612/
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

SCFFBXW11 Complex Targets Interleukin-17 Receptor A for Ubiquitin–Proteasome-Mediated Degradation

1
1. scibot 29 Apr 2024
  
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  17608
  
  DOI: 10.3390/biomedicines12040755
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11047997/
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Oncolytic Newcastle disease virus induced degradation of YAP through E3 ubiquitin ligase PRKN to exacerbate ferroptosis in tumor cells

1
1. scibot 15 Apr 2024
  
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  17608
  
  DOI: 10.1128/jvi.01897-23
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10949840/
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Casein kinase 2 phosphorylates and induces the SALL2 tumor suppressor degradation in colon cancer cells

1
1. scibot 15 Apr 2024
  
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  plasmid_17608
  
  DOI: 10.1038/s41419-024-06591-z
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10944491/
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Deubiquitinating activity of SARS-CoV-2 papain-like protease does not influence virus replication or innate immune responses in vivo

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1. scibot 14 Apr 2024
  
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  17608
  
  DOI: 10.1371/journal.ppat.1012100
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10994560/
Mar 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

RNF166 promotes colorectal cancer progression by recognizing and destabilizing poly-ADP-ribosylated angiomotins

1
1. scibot 17 Mar 2024
  
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  17608
  
  DOI: 10.1038/s41419-024-06595-9
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10937711/
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Multi-monoubiquitylation controls VASP-mediated actin dynamics

1
1. scibot 08 Mar 2024
  
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  plasmid_17608
  
  DOI: 10.1242/jcs.261527
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10917064/
Feb 2024
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DUB3 is a MAGEA3 deubiquitinase and a potential therapeutic target in hepatocellular carcinoma

1
1. scibot 29 Feb 2024
  
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  Addgene17608
  
  DOI: 10.1016/j.isci.2024.109181
  
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The GATOR2 complex maintains lysosomal-autophagic function by inhibiting the protein degradation of MiT/TFEs

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  Lim et al.72Addgene, Cat# 17608
  
  DOI: 10.1016/j.molcel.2024.01.012
  
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Diabetic sensory neuropathy and insulin resistance are induced by loss of UCHL1 in Drosophila

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  17608
  
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An apicoplast-localized deubiquitinase contributes to the cell growth and apicoplast homeostasis of Toxoplasma gondii

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  17608
  
  DOI: 10.1186/s13567-023-01261-y
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10795397/
Jan 2024
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Inhibition of VHL by VH298 Accelerates Pexophagy by Activation of HIF-1α in HeLa Cells

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1. scibot 29 Jan 2024
  
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  17608
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10819186/
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The unusual gene architecture of polyubiquitin is created by dual-specific splice sites

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  plasmid_17
  
  DOI: 10.1186/s13059-023-03157-8
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10809524/
Dec 2023
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FLOT2 promotes nasopharyngeal carcinoma progression through suppression of TGF-β pathway via facilitating CD109 expression

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  RRID:Addgene_17608
  
  DOI: 10.1016/j.isci.2023.108580
  
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sciencedirect.com/science/article/pii/S2589004223026573
Aug 2023
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Multi-monoubiquitination controls VASP-mediated actin dynamics

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  RRID:Addgene_17608
  
  DOI: 10.1101/2023.07.16.549237
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10370145/
Jul 2023
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Generation of host-directed and virus-specific antivirals using targeted protein degradation promoted by small molecules and viral RNA mimics

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  RRID:Addgene_17608
  
  DOI: 10.1016/j.chom.2023.05.030
  
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sciencedirect.com/science/article/pii/S1931312823002238
Apr 2023
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USP9X mediates an acute adaptive response to MAPK suppression in pancreatic cancer but creates multiple actionable therapeutic vulnerabilities

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  RRID:Addgene_17608
  
  DOI: 10.1016/j.xcrm.2023.101007
  
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sciencedirect.com/science/article/pii/S2666379123001179
Mar 2023
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Lysosomal trafficking of the glucose transporter GLUT1 requires sequential regulation by TXNIP and ubiquitin

1
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  RRID:Addgene_17608
  
  DOI: 10.1016/j.isci.2023.106150
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9986520/
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Fam72a functions as a cell-cycle-controlled gene during proliferation and antagonizes apoptosis through reprogramming PP2A substrates

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  RRID:Addgene_17608
  
  DOI: 10.1016/j.devcel.2023.02.006
  
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sciencedirect.com/science/article/pii/S1534580723000485
Dec 2022
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Fyn deficiency inhibits oxidative stress by decreasing c-Cbl-mediated ubiquitination of Sirt1 to attenuate diabetic renal fibrosis

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  RRID:Addgene_17608
  
  DOI: 10.1016/j.metabol.2022.155378
  
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sciencedirect.com/science/article/pii/S0026049522002566
Jul 2022
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Ubiquitination and deubiquitination of 4E-T regulate neural progenitor cell maintenance and neurogenesis by controlling P-body formation

1
1. scibot 13 Jul 2022
  
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  AddgeneCat# 17608
  
  DOI: 10.1016/j.celrep.2022.111070
  
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sciencedirect.com/science/article/pii/S2211124722008683
Jun 2022
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Stub1 maintains proteostasis of master transcription factors in embryonic stem cells

1
1. scibot 09 Jun 2022
  
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  AddgeneCat#17608
  
  DOI: 10.1016/j.celrep.2022.110919
  
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sciencedirect.com/science/article/pii/S2211124722006969
Mar 2022
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The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its localization, degradation, and toxicity

1
1. scibot 18 Mar 2022
  
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  plasmid_17608
  
  DOI: 10.1083/jcb.202010065
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8919618/
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K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy

1
1. scibot 04 Mar 2022
  
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  RRID:Addgene_17608
  
  DOI: 10.1016/j.celrep.2022.110354
  
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sciencedirect.com/science/article/pii/S2211124722000705
Jan 2022
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Gentiopicroside targets PAQR3 to activate PI3K/AKT signaling pathway and ameliorate glucose and lipid metabolism

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1. scibot 07 Jan 2022
  
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  RRID:Addgene_17608
  
  DOI: 10.1016/j.apsb.2021.12.023
  
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sciencedirect.com/science/article/pii/S2211383521004949
Oct 2021
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Peli1 facilitates NLRP3 inflammasome activation by mediating ASC ubiquitination

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1. scibot 30 Oct 2021
  
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  plasmid_17608
  
  DOI: 10.1016/j.celrep.2021.109904
  
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Mitophagy antagonism by ZIKV reveals Ajuba as a regulator of PINK1 signaling, PKR-dependent inflammation, and viral invasion of tissues

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1. scibot 27 Oct 2021
  
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  Addgene_17608
  
  DOI: 10.1016/j.celrep.2021.109888
  
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sciencedirect.com/science/article/pii/S2211124721013589
Jul 2021
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Untitled document

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1. scibot 31 Jul 2021
  
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  RRID:Addgene_17608
  
  DOI: 10.1016/j.immuni.2019.01.014
  
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sciencedirect.com/science/article/pii/S1074761319300378
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Vps11 and Vps18 of Vps-C membrane traffic complexes are E3 ubiquitin ligases and fine-tune signalling

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1. scibot 28 Jul 2021
  
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  pRK5-HA-Ubiquitin
  
  DOI: 10.1038/s41467-019-09800-y
  
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nature.com/articles/s41467-019-09800-y
Jun 2021
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TRIM7 inhibits enterovirus replication and promotes emergence of a viral variant with increased pathogenicity

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1. scibot 02 Jun 2021
  
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  Addgene_17608
  
  DOI: 10.1016/j.cell.2021.04.047
  
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sciencedirect.com/science/article/pii/S0092867421005821
May 2021
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A Membrane-Tethered Ubiquitination Pathway Regulates Hedgehog Signaling and Heart Development

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1. scibot 05 May 2021
  
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  Addgene_17608
  
  DOI: 10.1016/j.devcel.2020.08.012
  
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sciencedirect.com/science/article/pii/S1534580720306705
Jan 2021
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DNA and RNA Cleavage Complexes and Repair Pathway for TOP3B RNA- and DNA-Protein Crosslinks

1
1. scibot 05 Jan 2021
  
  in Public
  
  pRK5-HA-Ubiquitin-WT
  
  DOI: 10.1016/j.celrep.2020.108569
  
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sciencedirect.com/science/article/pii/S2211124720315588
Dec 2020
www.mdpi.com www.mdpi.com

Hepatitis B Core Protein Is Post-Translationally Modified through K29-Linked Ubiquitination

1
1. scibot 07 Dec 2020
  
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  pRK5-HA-Ubiquitin-WT
  
  DOI: 10.3390/cells9122547
  
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mdpi.com/2073-4409/9/12/2547/htm
Sep 2020
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A pair of E3 ubiquitin ligases compete to regulate filopodial dynamics and axon guidance

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1. scibot 11 Sep 2020
  
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  RRID:Addgene_17608
  
  DOI: 10.1083/jcb.201902088
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7039193/
bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

BPS Publications

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1. scibot 10 Sep 2020
  
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  RRID:Addgene_17608
  
  DOI: 10.1111/bph.14853
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.14853
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L ARP7 Is a BRCA1 Ubiquitinase Substrate and Regulates Genome Stability and Tumorigenesis

1
1. scibot 04 Sep 2020
  
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  RRID:Addgene_17608
  
  DOI: 10.1016/j.celrep.2020.107974
  
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sciencedirect.com/science/article/pii/S2211124720309554
Jan 2020
elifesciences.org elifesciences.org

Nedd4 E3 ligase and beta-arrestins regulate ubiquitination, trafficking, and stability of the mGlu7 receptor

1
1. scibot 13 Jan 2020
  
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  RRID:Addgene_17608
  
  DOI: 10.7554/eLife.44502
  
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elifesciences.org/articles/44502
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Untitled document

1
1. scibot 13 Jan 2020
  
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  RRID:Addgene_17608
  
  DOI: 10.1016/j.immuni.2019.01.014
  
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sciencedirect.com/science/article/pii/S1074761319300378

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