87 Matching Annotations
  1. Oct 2025
  2. www.sciencedirect.com www.sciencedirect.com
    Limited activation interdependence and differing patterns of the in vivo effects of IKK1 and IKK2 downstream of NIK
    1
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    sciencedirect.com/science/article/pii/S2211124725011751
  3. Sep 2025
  4. www.sciencedirect.com www.sciencedirect.com
    PDE7A inhibition suppresses triple-negative breast cancer by attenuating de novo pyrimidine biosynthesis
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    sciencedirect.com/science/article/pii/S266637912500429X
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Pan-RAS Inhibitor with a Unique Mechanism of Action Blocks Tumor Growth and Induces Antitumor Immunity in Gastrointestinal Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11875992/
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ACTL6A depletion induces KLF4-mediated anti-tumorigenic effects in colorectal cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12394641/
  7. Aug 2025
  8. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Improved Methods for the Stable Generation of Human Papillomavirus-Driven Head and Neck Cancer Cell Lines
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    onlinelibrary.wiley.com/doi/10.1002/mc.70025
  9. Jul 2025
  10. www.biorxiv.org www.biorxiv.org
    An Iron-regulated Signalling Pathway Controls Adipose Browning and Cancer Cachexia
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    biorxiv.org/content/10.1101/2025.07.16.664180v1
  11. 52.53.155.43 52.53.155.43
    MyoD is Essential in Rhabdomyosarcoma by Promoting Survival Through Differentiation and CYLD
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    52.53.155.43/383127a3ba30f18153ba559aaeac9e14b54b55e6/1-s2.0-S2589004225014105-main-html.html
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Nuclear deformability increases PARPi sensitivity in BRCA1-deficient cells by increasing microtubule-dependent DNA break mobility
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    pmc.ncbi.nlm.nih.gov/articles/PMC12174318/
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Deletion of AMP-activated protein kinase impairs metastasis and is rescued by ROS scavenging or ectopic CD36 expression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12180712/
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The cancer-associated SF3B1K700E spliceosome mutation confers enhanced sensitivity to BV-6-induced cytotoxicity
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    pmc.ncbi.nlm.nih.gov/articles/PMC12216663/
  15. Jun 2025
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PDF-html.html
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    pmc.ncbi.nlm.nih.gov/articles/PMC12270665/
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genomic Locus Tagged by Lung Function GWAS SNV rs12477314 (2q37.3) Acts as a Regulatory Region for a Systemic Inflammatory Phenotype
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    pmc.ncbi.nlm.nih.gov/articles/PMC12164972/
  18. May 2025
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    High Antigenicity for Treg Cells Confers Resistance to PD‐1 Blockade Therapy via High PD‐1 Expression in Treg Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12044662/
  20. Mar 2025
  21. www.mdpi.com www.mdpi.com
    HTLV-1 p13 Protein Hijacks Macrophage Polarization and Promotes T-Cell Recruitment
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    mdpi.com/1999-4915/17/4/471
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Suppression of stress granule formation is a vulnerability imposed by mutant p53
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    pmc.ncbi.nlm.nih.gov/articles/PMC11894096/
  23. Feb 2025
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MTCH2 controls energy demand and expenditure to fuel anabolism during adipogenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11832942/
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Histone H3E50K remodels chromatin to confer oncogenic activity and support an EMT phenotype
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    pmc.ncbi.nlm.nih.gov/articles/PMC11788928/
  26. www.nature.com www.nature.com
    Immune evasion through mitochondrial transfer in the tumour microenvironment
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    nature.com/articles/s41586-024-08439-0
  27. Nov 2024
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Chromatin protein complexes involved in gene repression in lamina-associated domains
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    pmc.ncbi.nlm.nih.gov/articles/PMC11535540/
  29. Sep 2024
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The interaction between RIPK1 and FADD controls perinatal lethality and inflammation
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    ncbi.nlm.nih.gov/pmc/articles/PMC11256114/
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Elevated GRHL2 Imparts Plasticity in ER-Positive Breast Cancer Cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11353109/
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Role of TIM-1 and CD300a in Zika Virus Infection Investigated with Cell-Based Electrical Impedance
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    ncbi.nlm.nih.gov/pmc/articles/PMC11352571/
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The ABA/LANCL1-2 Hormone/Receptors System Controls ROS Production in Cardiomyocytes through ERRα
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    ncbi.nlm.nih.gov/pmc/articles/PMC11428665/
  34. Aug 2024
  35. www.sciencedirect.com www.sciencedirect.com
    Histone chaperone HIRA, promyelocytic leukemia protein, and p62/SQSTM1 coordinate to regulate inflammation during cell senescence
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    sciencedirect.com/science/article/pii/S1097276524006609
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The IRE1α/XBP1 signaling axis drives myoblast fusion in adult skeletal muscle
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    ncbi.nlm.nih.gov/pmc/articles/PMC11316051/
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The SEMA3F-NRP1/NRP2 axis is a key factor in the acquisition of invasive traits in in situ breast ductal carcinoma
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11320849/
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Prostate Cancer-Specific Lysine 53 Acetylation of Cytochrome c Drives Metabolic Reprogramming and Protects from Apoptosis in Intact Cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11201891/
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    VISTA promotes the metabolism and differentiation of myeloid-derived suppressor cells by STAT3 and polyamine-dependent mechanisms
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    ncbi.nlm.nih.gov/pmc/articles/PMC10851928/
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    GRB2 is a BECN1 interacting protein that regulates autophagy.
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    ncbi.nlm.nih.gov/pmc/articles/PMC10770341/
  41. Jun 2024
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    METTL3-mediated chromatin contacts promote stress granule phase separation through metabolic reprogramming during senescence
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    ncbi.nlm.nih.gov/pmc/articles/PMC11208586/
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PML restrains p53 activity and cellular senescence in clear cell renal cell carcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC11178789/
  44. May 2024
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ERLIN1/2 scaffolds bridge TMUB1 and RNF170 and restrict cholesterol esterification to regulate the secretory pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC11116810/
  46. link.springer.com link.springer.com
    Brusatol attenuated proliferation and invasion induced by KRAS in differentiated thyroid cancer through inhibiting Nrf2
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    link.springer.com/article/10.1007/s40618-023-02248-4
  47. www.biorxiv.org www.biorxiv.org
    ERLIN1/2 scaffolds bridge TMUB1 and RNF170 and restrict cholesterol esterification to regulate the secretory pathway
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    biorxiv.org/content/10.1101/2024.01.17.576039v1
  48. www.mdpi.com www.mdpi.com
    TurboID-Based IRE1 Interactome Reveals Participants of the Endoplasmic Reticulum-Associated Protein Degradation Machinery in the Human Mast Cell Leukemia Cell Line HMC-1.2
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    mdpi.com/2073-4409/13/9/747
  49. Apr 2024
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Epithelial Expressed B7-H4 Drives Differential Immunotherapy Response in Murine and Human Breast Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11041871/
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Three Modes of Viral Adaption by the Heart
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    ncbi.nlm.nih.gov/pmc/articles/PMC10996681/
  52. Mar 2024
  53. www.sciencedirect.com www.sciencedirect.com
    Housekeeping U1 snRNA facilitates antiviral innate immunity by promoting TRIM25-mediated RIG-I activation
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    sciencedirect.com/science/article/pii/S2211124724002730
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Recurrent UBE3C-LRP5 translocations in head and neck cancer with therapeutic implications
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    ncbi.nlm.nih.gov/pmc/articles/PMC10912599/
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    VISTA promotes the metabolism and differentiation of myeloid-derived suppressor cells by STAT3 and polyamine-dependent mechanisms
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10851928/
  56. Feb 2024
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cooperativity of c-MYC with Krüppel-Like Factor 6 Splice Variant 1 induces phenotypic plasticity and promotes prostate cancer progression and metastasis
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10862900/
  58. www.biorxiv.org www.biorxiv.org
    KDM6A Regulates Immune Response Genes in Multiple Myeloma
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    biorxiv.org/content/10.1101/2024.02.12.579179v1
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Oncoprotein SET-associated transcription factor ZBTB11 triggers lung cancer metastasis
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    ncbi.nlm.nih.gov/pmc/articles/PMC10867109/
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pim kinase inhibitors increase gilteritinib cytotoxicity in FLT3-ITD acute myeloid leukemia through GSK-3β activation and c-Myc and Mcl-1 proteasomal degradation
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    ncbi.nlm.nih.gov/pmc/articles/PMC10870818/
  61. www.sciencedirect.com www.sciencedirect.com
    Stem-like progenitor and terminally differentiated TFH-like CD4+ T cell exhaustion in the tumor microenvironment
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    sciencedirect.com/science/article/pii/S2211124724001256
  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Akt enhances the vulnerability of cancer cells to VCP/p97 inhibition-mediated paraptosis
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    ncbi.nlm.nih.gov/pmc/articles/PMC10787777/
  63. Jan 2024
  64. www.nature.com www.nature.com
    CD8+ T cell metabolic flexibility elicited by CD28-ARS2 axis-driven alternative splicing of PKM supports antitumor immunity
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    nature.com/articles/s41423-024-01124-2
  65. Nov 2023
  66. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Oncogenic KRAS, Mucin 4, and Activin A-Mediated Fibroblast Activation Cooperate for Panin Initiation
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    onlinelibrary.wiley.com/doi/10.1002/advs.202301240
  67. www.sciencedirect.com www.sciencedirect.com
    LPGAT1 controls MEGDEL syndrome by coupling phosphatidylglycerol remodeling with mitochondrial transport
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    sciencedirect.com/science/article/pii/S2211124723012263
  68. Oct 2023
  69. www.cell.com www.cell.com
    CD36 maintains lipid homeostasis via selective uptake of monounsaturated fatty acids during matrix detachment and tumor progression
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    cell.com/cell-metabolism/fulltext/S1550-4131(23)00368-6
  70. Sep 2023
  71. dx.doi.org dx.doi.org
    Seryl-tRNA synthetase promotes translational readthrough by mRNA binding and involvement of the selenocysteine incorporation machinery
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    dx.doi.org/10.1093/nar/gkad773
  72. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Low frequency of intracranial progression in advanced NSCLC patients treated with cancer immunotherapies
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    onlinelibrary.wiley.com/doi/10.1002/ijc.34700
  73. Jun 2023
  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Induction by rapamycin and proliferation‑promoting activity of Hspb1 in a <em>Tsc2</em>‑deficient cell line
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    ncbi.nlm.nih.gov/pmc/articles/PMC10236050/
  75. Apr 2023
  76. www.sciencedirect.com www.sciencedirect.com
    Escape from oncogene-induced senescence is controlled by POU2F2 and memorized by chromatin scars
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    sciencedirect.com/science/article/pii/S2666979X23000599
  77. Mar 2023
  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sustained oncogenic signaling in the cytostatic state enables targeting of non-proliferating persistent cancer cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC9444958/
  79. www.sciencedirect.com www.sciencedirect.com
    COP I and II dependent trafficking controls ER-associated degradation in mammalian cells
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    sciencedirect.com/science/article/pii/S2589004223003097
  80. Jan 2023
  81. www.mdpi.com www.mdpi.com
    BCL2L11 Induction Mediates Sensitivity to Src and MEK1/2 Inhibition in Thyroid Cancer
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    mdpi.com/2072-6694/15/2/378
  82. Dec 2022
  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CEACAM1 is a direct SOX10 target and inhibits melanoma immune infiltration and stemness
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    ncbi.nlm.nih.gov/pmc/articles/PMC9682343/
  84. Nov 2022
  85. www.science.org www.science.org
    Intronic enhancers of the human SNCA gene predominantly regulate its expression in brain in vivo
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    science.org/doi/10.1126/sciadv.abq6324
  86. Aug 2022
  87. 52.53.155.43 52.53.155.43
    can-21-2908-html.html
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  88. Jun 2022
  89. www.sciencedirect.com www.sciencedirect.com
    Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis
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    sciencedirect.com/science/article/pii/S109727652200541X
  90. www.sciencedirect.com www.sciencedirect.com
    MacroH2As regulate enhancer-promoter contacts affecting enhancer activity and sensitivity to inflammatory cytokines
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    sciencedirect.com/science/article/pii/S2211124722007744
  91. Feb 2022
  92. www.sciencedirect.com www.sciencedirect.com
    Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments
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    sciencedirect.com/science/article/pii/S1535610822000034
  93. Dec 2021
  94. www.nature.com www.nature.com
    Clonal dynamics of BRAF-driven drug resistance in EGFR-mutant lung cancer
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    nature.com/articles/s41698-021-00241-9
  95. www.sciencedirect.com www.sciencedirect.com
    ERK1/2 inhibition promotes robust myotube growth via CaMKII activation resulting in myoblast-to-myotube fusion
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    sciencedirect.com/science/article/pii/S1534580721009461
  96. Oct 2021
  97. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Zyxin Mediates Vascular Repair via Endothelial Migration Promoted by Forskolin in Mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC8531502/
  98. www.sciencedirect.com www.sciencedirect.com
    Regulation of CYLD activity and specificity by phosphorylation and ubiquitin-binding CAP-Gly domains
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    sciencedirect.com/science/article/pii/S2211124721012316
  99. Aug 2021
  100. www.sciencedirect.com www.sciencedirect.com
    Exocyst protein subnetworks integrate Hippo and mTOR signaling to promote virus detection and cancer
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    sciencedirect.com/science/article/pii/S2211124721009189
  101. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    ncbi.nlm.nih.gov/pmc/articles/PMC5446411/
  102. Jul 2021
  103. www.sciencedirect.com www.sciencedirect.com
    MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation
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    sciencedirect.com/science/article/pii/S1074761317302285
  104. Apr 2021
  105. www.sciencedirect.com www.sciencedirect.com
    Cholesterol Pathway Inhibition Induces TGF-β Signaling to Promote Basal Differentiation in Pancreatic Cancer
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    sciencedirect.com/science/article/pii/S1535610820304268
  106. Jan 2021
  107. www.sciencedirect.com www.sciencedirect.com
    Inhibition of Tumor VEGFR2 Induces Serine 897 EphA2-Dependent Tumor Cell Invasion and Metastasis in NSCLC
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    sciencedirect.com/science/article/pii/S2211124720305179
  108. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Re-expression of SMARCA4/BRG1 in small cell carcinoma of ovary, hypercalcemic type (SCCOHT) promotes an epithelial-like gene signature through an AP-1-dependent mechanism
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    ncbi.nlm.nih.gov/pmc/articles/PMC7813545/
  109. Nov 2020
  110. www.sciencedirect.com www.sciencedirect.com
    ARID1A Mutations Promote P300-Dependent Endometrial Invasion through Super-Enhancer Hyperacetylation
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    sciencedirect.com/science/article/pii/S2211124720313553
  111. www.sciencedirect.com www.sciencedirect.com
    G9a Promotes Breast Cancer Recurrence through Repression of a Pro-inflammatory Program
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    sciencedirect.com/science/article/pii/S2211124720313309
  112. Oct 2020
  113. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Respiratory Supercomplexes Promote Mitochondrial Efficiency and Growth in Severely Hypoxic Pancreatic Cancer
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    pubmed.ncbi.nlm.nih.gov/33027658/
  114. Sep 2020
  115. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Replication-Competent Vesicular Stomatitis Virus for Studies of SARS-CoV-2 Spike-Mediated Cell Entry and Its Inhibition
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    ncbi.nlm.nih.gov/pmc/articles/PMC7332447/
  116. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PCK1 and DHODH drive colorectal cancer liver metastatic colonization and hypoxic growth by promoting nucleotide synthesis
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    ncbi.nlm.nih.gov/pmc/articles/PMC7299340/
  117. www.sciencedirect.com www.sciencedirect.com
    Dissecting the Regulatory Strategies of NF-κB RelA Target Genes in the Inflammatory Response Reveals Differential Transactivation Logics
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    sciencedirect.com/science/article/pii/S2211124720301522
  118. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    DNA Structure-Specific Cleavage of DNA-Protein Crosslinks by the SPRTN Protease
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    pubmed.ncbi.nlm.nih.gov/32853547/
  119. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Malignant Transformation Involving CXXC4 Mutations Identified in a Leukemic Progression Model of Severe Congenital Neutropenia
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    pubmed.ncbi.nlm.nih.gov/33205068/
  120. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PTEN and DNA-PK determine sensitivity and recovery in response to WEE1 inhibition in human breast cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC7338058/
  121. rupress.org rupress.org
    Genetic manipulation of LKB1 elicits lethal metastatic prostate cancer
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    Senescence, Necrosis, and Apoptosis Govern Circulating Cell-free DNA Release Kinetics
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    Bmal1 integrates mitochondrial metabolism and macrophage activation
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    ncbi.nlm.nih.gov/pmc/articles/PMC7259948/
  124. Jan 2020
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    sciencedirect.com/science/article/pii/S0092867418308560