139 Matching Annotations
  1. Last 7 days
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    HUWE1 stimulates mTORC1 activity by enhancing Rheb interaction with mTORC1 and supports de novo pyrimidine synthesis
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    sciencedirect.com/science/article/pii/S2211124725011532
  3. Oct 2025
  4. www.biorxiv.org www.biorxiv.org
    Angiopoietin like protein 3 regulates low-density lipoprotein transport through aortic endothelial cells via endothelial lipase
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    biorxiv.org/content/10.1101/2025.09.30.679508v1
  5. Sep 2025
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12420363/
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NCOA6 knockdown enhances RSL3-induced ferroptosis in pancreatic cancer cells and increases the sensitivity to gemcitabine : NCOA6 knockdown and RSL3-induced ferroptosis in pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12368539/
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PBK Expression Promotes the Aggressive Phenotypes of Mesothelioma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12400060/
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    Disrupting mitochondrial dynamics attenuates ferroptosis and chemotoxicity via upregulating NRF2-mediated FSP1 expression
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    sciencedirect.com/science/article/pii/S2211124725010058
  10. Aug 2025
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The HCMV tegument protein UL88 degrades MyD88 and reduces innate immune activation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12363176/
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SGK1 repression by WT1 may confer a survival advantage to leukemic cells under stress conditions
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    pmc.ncbi.nlm.nih.gov/articles/PMC12334445/
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting mitochondrial phosphatidylethanolamine alters mitochondrial metabolism and proliferation in hepatocellular carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12288522/
  14. Jul 2025
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Loss of Predicted Cell Adhesion Molecule MPZL3 Promotes EMT in Ovarian Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12277487/
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A novel β-TrCP1/NRF2 interaction inhibitor for effective anti-inflammatory therapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12247323/
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    BLID is a drug-responsive target of FOXO3a and multi-omics analysis reveals survival mechanisms and therapeutic vulnerabilities in BLID-deficient breast cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12217432/
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Integrated bioinformatics and experimental validation identify ATF3 as a key gene in secondary brain damage after intracerebral hemorrhage
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    pmc.ncbi.nlm.nih.gov/articles/PMC12273966/
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Knockdown of USF1 and USF2 drives prolonged changes in the gene expression response of M12-5B3 cells to DNA damage
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    pmc.ncbi.nlm.nih.gov/articles/PMC12258588/
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    mRNA 3′UTRs chaperone intrinsically disordered regions to control protein activity
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    pmc.ncbi.nlm.nih.gov/articles/PMC12236501/
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sphingolipid synthesis maintains nuclear membrane integrity and genome stability during cell division
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    pmc.ncbi.nlm.nih.gov/articles/PMC12237252/
  22. journals.asm.org journals.asm.org
    The HCMV tegument protein UL88 degrades MyD88 and reduces innate immune activation
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    journals.asm.org/doi/10.1128/jvi.00414-25
  23. www.sciencedirect.com www.sciencedirect.com
    TRIM24 directs replicative stress responses to maintain ALT telomeres via chromatin signaling
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    sciencedirect.com/science/article/pii/S109727652500509X
  24. Jun 2025
  25. www.sciencedirect.com www.sciencedirect.com
    Dynamic decoding of VEGF signaling and coordinated control of multiple phenotypes by the Src-TEM4-YAP pathway
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    sciencedirect.com/science/article/pii/S2405471225001541
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Integrative multi-omics identifies AP-1 transcription factor as a targetable mediator of acquired osimertinib resistance in non-small cell lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12104440/
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Stromal Hedgehog Signaling Is Associated with Favorable Outcomes in Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12154493/
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    Regulation of Rho guanine nucleotide exchange factor 3 by phosphorylation in the PH domain
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    sciencedirect.com/science/article/pii/S2589004225010144
  29. May 2025
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    EYA3 regulation of NF-κB and CCL2 suppresses cytotoxic NK cells in the premetastatic niche to promote TNBC metastasis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12057687/
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The retinoblastoma protein contributes to maintaining the stability of HPV E7 in cervical cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11998531/
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ATF6α inhibits ΔNp63α expression to promote breast cancer metastasis by the GRP78-AKT1-FOXO3a signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC11994819/
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Changes in adrenoceptor expression level contribute to the cellular plasticity of glioblastoma cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12002996/
  34. Apr 2025
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    GATAD2B O-GlcNAcylation Regulates Breast Cancer Stem-like Potential and Drug Resistance
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    pmc.ncbi.nlm.nih.gov/articles/PMC11941746/
  36. www.science.org www.science.org
    Drosophila and human Headcase define a new family of ribonucleotide granule proteins required for stress response
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    science.org/doi/10.1126/sciadv.ads2086
  37. www.sciencedirect.com www.sciencedirect.com
    Versatile roles of annexin A4 in clear cell renal cell carcinoma: Impact on membrane repair, transcriptional signatures, and composition of the tumor microenvironment
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    sciencedirect.com/science/article/pii/S2589004225004596
  38. Mar 2025
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Heat shock protein family D member 1 mediates lung cancer cell‑induced angiogenesis of endothelial cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11904756/
  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Resistance to Radiation Enhances Metastasis by Altering RNA Metabolism
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    pmc.ncbi.nlm.nih.gov/articles/PMC11888214/
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Screening Methods to Discover the FDA-Approved Cancer Drug Encorafenib as Optimally Selective for Metallothionein Gene Loss Ovarian Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11764637/
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    HCMV infection downregulates GPX4 and stimulates lipid peroxidation but does not induce ferroptosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11852782/
  43. www.biorxiv.org www.biorxiv.org
    Cardiolipin deficiency disrupts CoQ-complex III interface in steatohepatitis
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    biorxiv.org/content/10.1101/2024.10.10.617517v3
  44. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ACSS2 drives senescence-associated secretory phenotype by limiting purine biosynthesis through PAICS acetylation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11871226/
  45. Feb 2025
  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    T3SS translocon induces pyroptosis by direct interaction with NLRC4/NAIP inflammasome
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    pmc.ncbi.nlm.nih.gov/articles/PMC11828483/
  47. Jan 2025
  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The oxygen level in air directs airway epithelial cell differentiation by controlling mitochondrial citrate export
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    pmc.ncbi.nlm.nih.gov/articles/PMC11759043/
  49. www.nature.com www.nature.com
    Homologous recombination promotes non-immunogenic mitotic cell death upon DNA damage
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    nature.com/articles/s41556-024-01557-x
  50. Dec 2024
  51. www.sciencedirect.com www.sciencedirect.com
    TurboCas: A method for locus-specific labeling of genomic regions and isolating their associated protein interactome
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    sciencedirect.com/science/article/pii/S1097276524009122
  52. www.sciencedirect.com www.sciencedirect.com
    The Cullin3-Rbx1-KLHL9 E3 ubiquitin ligase complex ubiquitinates Rheb and supports amino acid-induced mTORC1 activation
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    sciencedirect.com/science/article/pii/S2211124724014529
  53. www.sciencedirect.com www.sciencedirect.com
    Lnc-RAINY Regulates Genes Involved in Radiation Susceptibility Through DNA:DNA:RNA triplex-forming Interactions and has Tumor Therapeutic Potential in Lung Cancers
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    sciencedirect.com/science/article/pii/S2468054024001689
  54. Nov 2024
  55. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Ubiquitin C-terminal hydrolase L1 is a regulator of tumor growth and metastasis in double-negative prostate cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11578776/
  56. Sep 2024
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Type I interferon signaling induces melanoma cell-intrinsic PD-1 and its inhibition antagonizes immune checkpoint blockade
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    ncbi.nlm.nih.gov/pmc/articles/PMC11347607/
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Superoxide dismutase 1 mediates adaptation to the tumor microenvironment of glioma cells via mammalian target of rapamycin complex 1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11347576/
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cysteine-rich with EGF-like domains 2 (CRELD2) is an endoplasmic reticulum stress-inducible angiogenic growth factor promoting ischemic heart repair
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    ncbi.nlm.nih.gov/pmc/articles/PMC11358006/
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Altering heparan sulfate suppresses cell abnormalities and neuron loss in Drosophila presenilin model of Alzheimer Disease
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    ncbi.nlm.nih.gov/pmc/articles/PMC11302002/
  61. www.sciencedirect.com www.sciencedirect.com
    mCAUSE: Prioritizing Mitochondrial Targets that Alleviate Pancreatic Cancer Cell Phenotypes
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    sciencedirect.com/science/article/pii/S2589004224021059
  62. Aug 2024
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    De Novo Multi-Omics Pathway Analysis Designed for Prior Data Independent Inference of Cell Signaling Pathways
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    ncbi.nlm.nih.gov/pmc/articles/PMC11259815/
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BMAL1-HIF2α heterodimers contribute to ccRCC
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    ncbi.nlm.nih.gov/pmc/articles/PMC11275985/
  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Valproic acid targets IDH1 mutants through alteration of lipid metabolism
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    ncbi.nlm.nih.gov/pmc/articles/PMC11321993/
  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MARCH2, a T cell specific factor that restricts HIV-1 infection
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    ncbi.nlm.nih.gov/pmc/articles/PMC11309421/
  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RhoGDI1 regulates cell-cell junctions in polarized epithelial cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11288927/
  68. www.sciencedirect.com www.sciencedirect.com
    OPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response
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    sciencedirect.com/science/article/pii/S109727652400618X
  69. www.cell.com www.cell.com
    Slc25a3-dependent copper transport controls flickering-induced Opa1 processing for mitochondrial safeguard
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    cell.com/developmental-cell/fulltext/S1534-5807(24)00386-1
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neuronal autosis is Na+/K+-ATPase alpha 3-dependent and involved in hypoxic-ischemic neuronal death
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    ncbi.nlm.nih.gov/pmc/articles/PMC11127954/
  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Morphological basis of the lung adenocarcinoma subtypes
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    ncbi.nlm.nih.gov/pmc/articles/PMC11066476/
  72. Jul 2024
  73. www.biorxiv.org www.biorxiv.org
    Resistance of estrogen receptor function to BET bromodomain inhibition is mediated by transcriptional coactivator cooperativity
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    biorxiv.org/content/10.1101/2024.07.25.605008v1
  74. www.sciencedirect.com www.sciencedirect.com
    A spatiotemporal molecular atlas of mouse spinal cord injury identifies a distinct astrocyte subpopulation and therapeutic potential of IGFBP2
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    sciencedirect.com/science/article/pii/S1534580724003940
  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HIV-1 Vpr combats the PU.1-driven antiviral response in primary human macrophages
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    ncbi.nlm.nih.gov/pmc/articles/PMC11217462/
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RNASeq highlights ATF6 pathway regulators for CHO cell engineering with different impacts of ATF6β and WFS1 knockdown on fed-batch production of IgG1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11187196/
  77. Jun 2024
  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    METTL3-mediated chromatin contacts promote stress granule phase separation through metabolic reprogramming during senescence
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    ncbi.nlm.nih.gov/pmc/articles/PMC11208586/
  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Notch signaling regulates UNC5B to suppress endothelial proliferation, migration, junction activity, and retinal plexus branching
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    ncbi.nlm.nih.gov/pmc/articles/PMC11169293/
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FOXA3 regulates cholesterol metabolism to compensate for low uptake during the progression of lung adenocarcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC11161053/
  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neratinib, a pan ERBB/HER inhibitor, restores sensitivity of PTEN-null, BRAFV600E melanoma to BRAF/MEK inhibition
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    ncbi.nlm.nih.gov/pmc/articles/PMC11159048/
  82. www.biorxiv.org www.biorxiv.org
    Versatile roles of Annexin A4 in ccRCC: impact on membrane repair, transcriptional signatures, and composition of the tumor microenvironment
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    biorxiv.org/content/10.1101/2024.05.31.596161v1
  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IGSF3 is a homophilic cell adhesion molecule that drives lung metastasis of melanoma by promoting adhesion to vascular endothelium
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    ncbi.nlm.nih.gov/pmc/articles/PMC11145127/
  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Selective and brain-penetrant ACSS2 inhibitors target breast cancer brain metastatic cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11137182/
  85. May 2024
  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Suppression of pancreatic cancer proliferation through TXNIP-mediated inhibition of the MAPK signaling pathway: TXNIP inhibits pancreatic cancer via the MAPK pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC11094629/
  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    mTORC1 regulates cell survival under glucose starvation through 4EBP1/2-mediated translational reprogramming of fatty acid metabolism
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    ncbi.nlm.nih.gov/pmc/articles/PMC11094136/
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CYB561 supports the neuroendocrine phenotype in castration-resistant prostate cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11090301/
  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    AKAP8 promotes ovarian cancer progression and antagonizes PARP inhibitor sensitivity through regulating hnRNPUL1 transcription
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    ncbi.nlm.nih.gov/pmc/articles/PMC11070336/
  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Germline cis variant determines epigenetic regulation of the anti-cancer drug metabolism gene dihydropyrimidine dehydrogenase (DPYD)
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    ncbi.nlm.nih.gov/pmc/articles/PMC11060711/
  91. Apr 2024
  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Chromatin Remodeling in Patient‐Derived Colorectal Cancer Models
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    ncbi.nlm.nih.gov/pmc/articles/PMC11040356/
  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Regulation by the RNA-binding protein Unkempt at its effector interface
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    ncbi.nlm.nih.gov/pmc/articles/PMC11009413/
  94. aacrjournals.org aacrjournals.org
    Sarcoma cells secrete hypoxia-modified collagen VI to weaken the lung endothelial barrier and promote metastasis
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    aacrjournals.org/cancerres/article/84/7/977/742043/Sarcoma-Cells-Secrete-Hypoxia-Modified-Collagen-VI
  95. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Adipose tissue peroxisomal lipid synthesis orchestrates obesity and insulin resistance through LXR-dependent lipogenesis
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    ncbi.nlm.nih.gov/pmc/articles/PMC10950804/
  96. www.nature.com www.nature.com
    Targeting branched N-glycans and fucosylation sensitizes ovarian tumors to immune checkpoint blockade
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    nature.com/articles/s41467-024-47069-y
  97. Mar 2024
  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Knockdown of ANGPTL2 promotes left ventricular systolic dysfunction by upregulation of NOX4 in mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC10902461/
  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    N6-methyladenosine modification is not a general trait of viral RNA genomes
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    ncbi.nlm.nih.gov/pmc/articles/PMC10928186/
  100. Feb 2024
  101. www.sciencedirect.com www.sciencedirect.com
    DUB3 is a MAGEA3 deubiquitinase and a potential therapeutic target in hepatocellular carcinoma
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    sciencedirect.com/science/article/pii/S2589004224004024
  102. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    GPX3 supports ovarian cancer tumor progression in vivo and promotes expression of GDF15
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    ncbi.nlm.nih.gov/pmc/articles/PMC10862694/
  103. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DOT1L stimulates MYC/Mondo transcription factor activity by promoting its degradation cycle on chromatin
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    pmc.ncbi.nlm.nih.gov/articles/PMC10871221/
  104. www.sciencedirect.com www.sciencedirect.com
    SLC25A51 decouples the mitochondrial NAD+/NADH ratio to control proliferation of AML cells
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    sciencedirect.com/science/article/pii/S1550413124000135
  105. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mitofusin 1 silencing decreases the senescent associated secretory phenotype, promotes immune cell recruitment and delays melanoma tumor growth after chemotherapy
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