79 Matching Annotations
  1. Last 7 days
  2. dx.doi.org dx.doi.org
    UBQLN2 is necessary for UBE3A-mediated proteasomal degradation of the domesticated retroelement PEG10
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    dx.doi.org/10.1242/jcs.264105
  3. Feb 2026
  4. www.sciencedirect.com www.sciencedirect.com
    The SWI/SNF-related protein SMARCA3 is a histone H3K23 ubiquitin ligase that regulates H3K9me3 in cancer
    1
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    sciencedirect.com/science/article/pii/S1097276525005507
  5. Nov 2025
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    USP2-mediated PPARγ stabilization promotes hepatocellular carcinoma progression and M2 macrophage polarization via oleic acid
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    pmc.ncbi.nlm.nih.gov/articles/PMC12588028/
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NDR1 enhances USP9X-mediated AR deubiquitination and promotes enzalutamide resistance in castration-resistant prostate cancer
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12509700/
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Deciphering the unique autoregulatory mechanisms and substrate specificity of the understudied DCLK3 kinase linked to neurodegenerative diseases
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    pmc.ncbi.nlm.nih.gov/articles/PMC12509982/
  9. Oct 2025
  10. www.sciencedirect.com www.sciencedirect.com
    HUWE1 stimulates mTORC1 activity by enhancing Rheb interaction with mTORC1 and supports de novo pyrimidine synthesis
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    sciencedirect.com/science/article/pii/S2211124725011532
  11. Sep 2025
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Ubiquitin specific protease 7 deubiquitinates and regulates Aurora B-mediated cytokinesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12402693/
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Novel Role of the Epstein-Barr Virus Encoded Deubiquitinating Enzyme (BPLF1) in mTOR-Mediated Cell Growth and Proliferation Pathways
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    pmc.ncbi.nlm.nih.gov/articles/PMC12390678/
  14. Jun 2025
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Downregulated TRAF3IP2-AS1 promotes hepatocellular carcinoma progression through the miR-374a-5p/SEL1L1/RPL6 axis to enhance DNA damage repair
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    pmc.ncbi.nlm.nih.gov/articles/PMC12082530/
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Development of MDM2‐Targeting PROTAC for Advancing Bone Regeneration
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    pmc.ncbi.nlm.nih.gov/articles/PMC12097015/
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Exploring Negative Feedback Mechanisms in the PTEN-ACE Axis: Application of Electrosorb Hydrogel-Based Gene Delivery for Intervertebral Disc Regeneration
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    pmc.ncbi.nlm.nih.gov/articles/PMC12160554/
  18. Mar 2025
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Protein phosphatase EYA1 regulates the dephosphorylation and turnover of BCL2L12 to promote glioma development
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    pmc.ncbi.nlm.nih.gov/articles/PMC11781168/
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Uncovering the rewired IAP-JAK regulatory axis as an immune-dependent vulnerability of LKB1-mutant lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11890758/
  21. Feb 2025
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The O-glycosyltransferase C1GALT1 promotes EWSR1::FLI1 expression and is a therapeutic target for Ewing sarcoma
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11788431/
  23. Jan 2025
  24. www.sciencedirect.com www.sciencedirect.com
    PDE4 inhibitor rolipram represses hedgehog signaling via ubiquitin-mediated proteolysis of GLI transcription factors to regress breast cancer
    1
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    sciencedirect.com/science/article/pii/S0021925825000869
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pellino 3 E3 ligase promotes starvation-induced autophagy to prevent hepatic steatosis
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11740972/
  26. Dec 2024
  27. www.sciencedirect.com www.sciencedirect.com
    The ATAC complex represses the transcriptional program of the autophagy-lysosome pathway via its E3 ubiquitin ligase activity
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    sciencedirect.com/science/article/pii/S2211124724013846
  28. www.nature.com www.nature.com
    USP39 regulates pyruvate handling in non-small cell lung cancer
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    nature.com/articles/s41420-024-02264-0
  29. www.sciencedirect.com www.sciencedirect.com
    The Cullin3-Rbx1-KLHL9 E3 ubiquitin ligase complex ubiquitinates Rheb and supports amino acid-induced mTORC1 activation
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    sciencedirect.com/science/article/pii/S2211124724014529
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Phosphorylation of Optineurin by protein kinase D regulates Parkin-dependent mitophagy
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    pmc.ncbi.nlm.nih.gov/articles/PMC11634986/
  31. Sep 2024
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Furin Egress from the TGN is Regulated by Membrane‐Associated RING‐CH Finger (MARCHF) Proteins and Ubiquitin‐Specific Protease 32 (USP32) via Nondegradable K33‐Polyubiquitination
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11425283/
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NDR1/FBXO11 promotes phosphorylation-mediated ubiquitination of β-catenin to suppress metastasis in prostate cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11414387/
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Deubiquitinase JOSD1 tempers hepatic proteotoxicity
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    ncbi.nlm.nih.gov/pmc/articles/PMC11405666/
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Orientia tsutsugamushi Ank5 promotes NLRC5 cytoplasmic retention and degradation to inhibit MHC class I expression
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    ncbi.nlm.nih.gov/pmc/articles/PMC11401901/
  36. Aug 2024
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Kumujan B suppresses TNF-α-induced inflammatory response and alleviates experimental colitis in mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC11324439/
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    UBR1 promotes anaplastic thyroid carcinoma progression via stabilizing YAP through monoubiquitylation
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    ncbi.nlm.nih.gov/pmc/articles/PMC11341911/
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of IRP2-dependent reprogramming of iron metabolism suppresses tumor growth in colorectal cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11342626/
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FBXO24 deletion causes abnormal accumulation of membraneless electron-dense granules in sperm flagella and male infertility
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    ncbi.nlm.nih.gov/pmc/articles/PMC11335345/
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MARCH2, a T cell specific factor that restricts HIV-1 infection
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    ncbi.nlm.nih.gov/pmc/articles/PMC11309421/
  42. www.nature.com www.nature.com
    Deubiquitinase USP9x regulates the proline biosynthesis pathway in non-small cell lung cancer
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    nature.com/articles/s41420-024-02111-2
  43. Jun 2024
  44. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    FAK loss reduces BRAFV600E-induced ERK phosphorylation to promote intestinal stemness and cecal tumor formation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11208045/
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Proteinase 3 depletion attenuates leukemia by promoting myeloid differentiation
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    ncbi.nlm.nih.gov/pmc/articles/PMC11165011/
  46. May 2024
  47. www.sciencedirect.com www.sciencedirect.com
    TBK1 is ubiquitinated by TRIM5α to assemble mitophagy machinery
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    sciencedirect.com/science/article/pii/S2211124724006223
  48. www.sciencedirect.com www.sciencedirect.com
    Oncogenic fatty acid oxidation senses circadian disruption in sleep-deficiency-enhanced tumorigenesis
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    sciencedirect.com/science/article/pii/S1550413124001384
  49. www.sciencedirect.com www.sciencedirect.com
    Ubiquitin-mediated regulation of APE2 protein abundance
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    sciencedirect.com/science/article/pii/S0021925824018386
  50. Apr 2024
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    USP28 promotes tumorigenesis and cisplatin resistance by deubiquitinating MAST1 protein in cancer cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10948558/
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Depletion of proteasome subunit PSMD1 induces cancer cell death via protein ubiquitination and DNA damage, irrespective of p53 status
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    ncbi.nlm.nih.gov/pmc/articles/PMC10997673/
  53. Mar 2024
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The CRL5–SPSB3 ubiquitin ligase targets nuclear cGAS for degradation
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    ncbi.nlm.nih.gov/pmc/articles/PMC10972748/
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MARCH2, a novel oncogene-regulated SNAIL E3 ligase, suppresses triple negative breast cancer metastases
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    ncbi.nlm.nih.gov/pmc/articles/PMC10977041/
  56. www.biorxiv.org www.biorxiv.org
    PDE4 inhibitor Rolipram represses hedgehog signaling via ubiquitin-mediated proteolysis of GLI transcription factors to regress breast cancer
    1
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    biorxiv.org/content/10.1101/2024.03.03.583221v1
  57. www.sciencedirect.com www.sciencedirect.com
    MOF-mediated acetylation of UHRF1 enhances UHRF1 E3 ligase activity to facilitate DNA methylation maintenance
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    sciencedirect.com/science/article/pii/S2211124724002365
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Disease-associated polyalanine expansion mutations impair UBA6-dependent ubiquitination
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    ncbi.nlm.nih.gov/pmc/articles/PMC10897158/
  59. Feb 2024
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SARS-CoV-2 ORF7a Mutation Found in BF.5 and BF.7 Sublineages Impacts Its Functions
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    ncbi.nlm.nih.gov/pmc/articles/PMC10889720/
  61. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    FAK loss reduces BRAFV600E-induced ERK phosphorylation to promote intestinal stemness and cecal tumor formation
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    pmc.ncbi.nlm.nih.gov/articles/PMC9915899/
  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Activation of Ca2+ phosphatase Calcineurin regulates Parkin translocation to mitochondria and mitophagy in flies
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    ncbi.nlm.nih.gov/pmc/articles/PMC10850161/
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ZDHHC5-mediated S-palmitoylation of FAK promotes its membrane localization and epithelial-mesenchymal transition in glioma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10795333/
  64. Jan 2024
  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ubiquitin-specific Protease 35 Promotes Gastric Cancer Metastasis by Increasing the Stability of Snail1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10797686/
  66. Sep 2023
  67. www.sciencedirect.com www.sciencedirect.com
    USP13 deubiquitinates p62/SQSTM1 to induce autophagy and Nrf2 release for activating antioxidant response genes
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    sciencedirect.com/science/article/pii/S0891584923006482
  68. www.sciencedirect.com www.sciencedirect.com
    Usp25-Erlin1/2 activity limits cholesterol flux to restrict virus infection
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    sciencedirect.com/science/article/pii/S1534580723004094
  69. Aug 2023
  70. 52.53.155.43 52.53.155.43
    FEBS Press
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    52.53.155.43/5ae378afd9ab5ca0cc44c821394ffd9a004fa694/Molecular Oncology - 2023 - Celada-html.html
  71. Jul 2023
  72. www.nature.com www.nature.com
    E3 ligase MG53 suppresses tumor growth by degrading cyclin D1
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    nature.com/articles/s41392-023-01458-9
  73. Jun 2023
  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The pro-tumorigenic cytokine IL-32 has a high turnover in multiple myeloma cells due to proteolysis regulated by oxygen-sensing cysteine dioxygenase and deubiquitinating enzymes
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    ncbi.nlm.nih.gov/pmc/articles/PMC10258340/
  75. Dec 2022
  76. link.springer.com link.springer.com
    USP13 regulates HMGB1 stability and secretion through its deubiquitinase activity
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    link.springer.com/article/10.1186/s10020-022-00596-0
  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Heat shock protein Hspa13 regulates endoplasmic reticulum and cytosolic proteostasis through modulation of protein translocation
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    ncbi.nlm.nih.gov/pmc/articles/PMC9691929/
  78. Nov 2022
  79. www.nature.com www.nature.com
    Tautomycin and enzalutamide combination yields synergistic effects on castration-resistant prostate cancer
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    nature.com/articles/s41420-022-01257-1
  80. Oct 2022
  81. www.cell.com www.cell.com
    X-linked ubiquitin-specific peptidase 11 increases tauopathy vulnerability in women
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    cell.com/cell/fulltext/S0092-8674(22)01124-2
  82. Sep 2022
  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    APE1 redox function is required for activation of Yes-associated protein 1 under reflux conditions in Barrett’s-associated esophageal adenocarcinomas
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    ncbi.nlm.nih.gov/pmc/articles/PMC9434868/
  84. Aug 2022
  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of the NRF2 transcriptional network as a therapeutic target for trigeminal neuropathic pain
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    ncbi.nlm.nih.gov/pmc/articles/PMC9348805/
  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Antibody for Serine 65 Phosphorylated Ubiquitin Identifies PLK1-Mediated Phosphorylation of Mitotic Proteins and APC1
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    ncbi.nlm.nih.gov/pmc/articles/PMC9369648/
  87. Apr 2022
  88. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15763
  89. Mar 2022
  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IBtkα Activates the β-Catenin-Dependent Transcription of MYC through Ubiquitylation and Proteasomal Degradation of GSK3β in Cancerous B Cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC8875111/
  91. Dec 2021
  92. www.sciencedirect.com www.sciencedirect.com
    Drp1 SUMO/deSUMOylation by Senp5 isoforms influences ER tubulation and mitochondrial dynamics to regulate brain development
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    sciencedirect.com/science/article/pii/S2589004221014553
  93. www.sciencedirect.com www.sciencedirect.com
    CD95/Fas suppresses NF-κB activation through recruitment of KPC2 in a CD95L/FasL-independent mechanism
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    sciencedirect.com/science/article/pii/S2589004221015091
  94. Sep 2021
  95. www.sciencedirect.com www.sciencedirect.com
    PKCλ/ι inhibition activates an ULK2-mediated interferon response to repress tumorigenesis
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    sciencedirect.com/science/article/pii/S1097276521007292
  96. Aug 2021
  97. academic.oup.com academic.oup.com
    Rpsa Signaling Regulates Cortical Neuronal Morphogenesis via Its Ligand, PEDF, and Plasma Membrane Interaction Partner, Itga6
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    academic.oup.com/cercor/advance-article-abstract/doi/10.1093/cercor/bhab242/6338536
  98. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    sciencedirect.com/science/article/pii/S2211124718317716
  99. www.sciencedirect.com www.sciencedirect.com
    O-GlcNAc Transferase Links Glucose Metabolism to MAVS-Mediated Antiviral Innate Immunity
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    sciencedirect.com/science/article/pii/S1931312818305584
  100. Jul 2021
  101. www.sciencedirect.com www.sciencedirect.com
    Vaccinia Virus Ankyrin-Repeat/F-Box Protein Targets Interferon-Induced IFITs for Proteasomal Degradation
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    sciencedirect.com/science/article/pii/S2211124719312276
  102. www.sciencedirect.com www.sciencedirect.com
    Plasticity of the Cullin-RING Ligase Repertoire Shapes Sensitivity to Ligand-Induced Protein Degradation
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    sciencedirect.com/science/article/pii/S109727651930543X
  103. rupress.org rupress.org
    TRIM37 prevents formation of condensate-organized ectopic spindle poles to ensure mitotic fidelity
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    rupress.org/jcb/article/220/7/e202010180/212098/TRIM37-prevents-formation-of-condensate-organized
  104. May 2021
  105. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    EGFR phosphorylates HDAC1 to regulate its expression and anti-apoptotic function
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    ncbi.nlm.nih.gov/pmc/articles/PMC8113371/
  106. www.sciencedirect.com www.sciencedirect.com
    Amino Acids Enhance Polyubiquitination of Rheb and Its Binding to mTORC1 by Blocking Lysosomal ATXN3 Deubiquitinase Activity
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    sciencedirect.com/science/article/pii/S1097276520306870
  107. Feb 2021
  108. www.sciencedirect.com www.sciencedirect.com
    mTORC2 Assembly Is Regulated by USP9X-Mediated Deubiquitination of RICTOR
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    sciencedirect.com/science/article/pii/S2211124720315539
  109. Jan 2021
  110. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RNA binding RING E3-ligase DZIP3/hRUL138 stabilizes Cyclin D1 to drive cell cycle and cancer progression
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    ncbi.nlm.nih.gov/pmc/articles/PMC7116596/
  111. Sep 2020
  112. www.nature.com www.nature.com
    TRIM37 controls cancer-specific vulnerability to PLK4 inhibition
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    nature.com/articles/s41586-020-2710-1
  113. www.sciencedirect.com www.sciencedirect.com
    OTUB1 Is a Key Regulator of RIG-I-Dependent Immune Signaling and Is Targeted for Proteasomal Degradation by Influenza A NS1
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    sciencedirect.com/science/article/pii/S2211124720300243
  114. Jan 2020
  115. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Histone Deacetylase SIRT1 Targets Plk2 to Regulate Centriole Duplication
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    ncbi.nlm.nih.gov/pmc/articles/PMC6814291/