44 Matching Annotations
  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Tryptophan–kynurenine metabolic reprogramming along the gut–brain axis alleviates Alzheimer’s pathology
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    pmc.ncbi.nlm.nih.gov/articles/PMC13248358/
  3. Aug 2026
  4. www.biorxiv.org www.biorxiv.org
    INTS6 loss of function disrupts transcriptional regulation in mild intellectual disability
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    biorxiv.org/content/10.64898/2026.07.17.737701v1
  5. Apr 2026
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Tracking tau and cellular responses in human iPSC‐microglia: from uptake to seedable secretion, including in extracellular vesicles
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    pmc.ncbi.nlm.nih.gov/articles/PMC13053939/
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    APOE3 astrocytes can rescue lipid abnormalities and dystrophic neurites of APOE4 human neurons
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    pmc.ncbi.nlm.nih.gov/articles/PMC13003211/
  8. Mar 2026
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Uncovering NMDA receptor-mediated high firing activity in excitatory human neurons
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    pmc.ncbi.nlm.nih.gov/articles/PMC12997311/
  10. Nov 2025
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genetic and proteomic analysis identifies BAG3 as an amyloid-responsive regulator of neuronal proteostasis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12521299/
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases
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    pmc.ncbi.nlm.nih.gov/articles/PMC12552125/
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SARS-CoV-2 infection in hiPSC-derived neurons is cathepsin-dependent and causes differential accumulation of HIF1ɑ and phosphorylated tau
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    pmc.ncbi.nlm.nih.gov/articles/PMC12597281/
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Neuronal activity-dependent mechanisms of small cell lung cancer pathogenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12571889/
  15. Oct 2025
  16. www.sciencedirect.com www.sciencedirect.com
    Protocol for generating a human iPSC-derived tri-culture model to study interactions between neurons, astrocytes, and microglia
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    sciencedirect.com/science/article/pii/S2666166725005581
  17. Sep 2025
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Neuronal activity-dependent mechanisms of small cell lung cancer pathogenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12571889/
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Optineurin deficiency disrupts phosphorylated tau proteostasis and clusterin expression in human neurons
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    pmc.ncbi.nlm.nih.gov/articles/PMC12406597/
  20. Jul 2025
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    An improved immunoassay detects Aβ oligomers in human biofluids: their CSF levels rise with tau and phosphotau levels
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    pmc.ncbi.nlm.nih.gov/articles/PMC12255133/
  22. Jun 2025
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Experimental evidence that readily diffusible forms of Aβ from Alzheimer’s disease brain have seeding activity
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    pmc.ncbi.nlm.nih.gov/articles/PMC12102860/
  24. www.sciencedirect.com www.sciencedirect.com
    Astrocyte induction of disease-associated microglia is suppressed by acute exposure to fAD neurons in human iPSC triple cultures
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    sciencedirect.com/science/article/pii/S2211124725005480
  25. May 2025
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Ubiquitous MEIS transcription factors actuate lineage-specific transcription to establish cell fate
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    pmc.ncbi.nlm.nih.gov/articles/PMC12000411/
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CLU alleviates Alzheimer’s disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density
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    pmc.ncbi.nlm.nih.gov/articles/PMC12181066/
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    HAND1 level controls the specification of multipotent cardiac and extraembryonic progenitors from human pluripotent stem cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12048643/
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Contributions of Genetic Variation in Astrocytes to Cell and Molecular Mechanisms of Risk and Resilience to Late‐Onset Alzheimer's Disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC12012329/
  30. Mar 2025
  31. www.biorxiv.org www.biorxiv.org
    Protective ApoE variants support neuronal function by extracting peroxidated lipids
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    biorxiv.org/content/10.1101/2025.03.05.641722v1
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Development and characterization of in vitro inducible immortalization of a murine microglia cell line for high throughput studies
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    pmc.ncbi.nlm.nih.gov/articles/PMC11762310/
  33. Feb 2025
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Regulation of ER stress-induced apoptotic and inflammatory responses via YAP/TAZ-mediated control of the TRAIL-R2/DR5 signaling pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC11794427/
  35. www.sciencedirect.com www.sciencedirect.com
    Imaging lipid rafts reveals the principle of ApoE4-induced Aβ upregulation in human neurons
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    sciencedirect.com/science/article/pii/S2589004225001531
  36. Dec 2024
  37. www.sciencedirect.com www.sciencedirect.com
    KIF5A regulates axonal repair and time-dependent axonal transport of SFPQ granules and mitochondria in human motor neurons
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    sciencedirect.com/science/article/pii/S0969996124003619
  38. Sep 2024
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    KIF5A regulates axonal repair and time-dependent axonal transport of SFPQ granules and mitochondria in human motor neurons
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    ncbi.nlm.nih.gov/pmc/articles/PMC11418931/
  40. www.nature.com www.nature.com
    A single-cell transcriptomic dataset of pluripotent stem cell-derived astrocytes via NFIB/SOX9 overexpression
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    nature.com/articles/s41597-024-03823-x
  41. Aug 2024
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Protocol for neurogenin-2-mediated induction of human stem cell-derived neural progenitor cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10865475/
  43. Jun 2024
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    KDM5-mediated transcriptional activation of ribosomal protein genes alters translation efficiency to regulate mitochondrial metabolism in neurons
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    ncbi.nlm.nih.gov/pmc/articles/PMC11194071/
  45. Apr 2024
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mutations in the postsynaptic density signaling hub TNIK disrupt PSD signaling in human models of neurodevelopmental disorders
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    ncbi.nlm.nih.gov/pmc/articles/PMC11024424/
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Insulin signalling regulates Pink1 mRNA localization via modulation of AMPK activity to support PINK1 function in neurons
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    ncbi.nlm.nih.gov/pmc/articles/PMC10963278/
  48. Mar 2024
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Defined co-cultures of glutamatergic and GABAergic neurons with a mutation in DISC1 reveal aberrant phenotypes in GABAergic neurons
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    ncbi.nlm.nih.gov/pmc/articles/PMC10910844/
  50. Feb 2024
  51. www.sciencedirect.com www.sciencedirect.com
    Proline restores mitochondrial function and reverses aging hallmarks in senescent cells
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    sciencedirect.com/science/article/pii/S2211124724000664
  52. Oct 2023
  53. www.mdpi.com www.mdpi.com
    Role of the YAP/TAZ-TEAD Transcriptional Complex in the Metabolic Control of TRAIL Sensitivity by the Mevalonate Pathway in Cancer Cells
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    mdpi.com/2073-4409/12/19/2370
  54. Aug 2023
  55. www.sciencedirect.com www.sciencedirect.com
    Cell-type-specific regulation of APOE and CLU levels in human neurons by the Alzheimer’s disease risk gene SORL1
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    sciencedirect.com/science/article/pii/S2211124723010057
  56. Jun 2023
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    APOE expression and secretion are modulated by mitochondrial dysfunction
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    ncbi.nlm.nih.gov/pmc/articles/PMC10231934/
  58. May 2023
  59. www.biorxiv.org www.biorxiv.org
    Upregulated GIRK2 counteracts ethanol-induced changes in excitability and respiration in human neurons
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    biorxiv.org/content/10.1101/2023.03.22.533236v2
  60. Mar 2022
  61. www.nature.com www.nature.com
    APP and DYRK1A regulate axonal and synaptic vesicle protein networks and mediate Alzheimer’s pathology in trisomy 21 neurons
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    nature.com/articles/s41380-022-01454-5
  62. Sep 2021
  63. www.sciencedirect.com www.sciencedirect.com
    Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors
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    sciencedirect.com/science/article/pii/S089662732100578X
  64. Jun 2021
  65. currentprotocols.onlinelibrary.wiley.com currentprotocols.onlinelibrary.wiley.com
    Efficient Derivation of Excitatory and Inhibitory Neurons from Human Pluripotent Stem Cells Stably Expressing Direct Reprogramming Factors
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    currentprotocols.onlinelibrary.wiley.com/doi/10.1002/cpz1.141
  66. Dec 2020
  67. www.sciencedirect.com www.sciencedirect.com
    Protocol for Tri-culture of hiPSC-Derived Neurons, Astrocytes, and Microglia
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    sciencedirect.com/science/article/pii/S2666166720301775
  68. Sep 2020
  69. www.sciencedirect.com www.sciencedirect.com
    A Susceptibility Locus on Chromosome 13 Profoundly Impacts the Stability of Genomic Imprinting in Mouse Pluripotent Stem Cells
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    sciencedirect.com/science/article/pii/S2211124720302424
  70. Jan 2020
  71. www.sciencedirect.com www.sciencedirect.com
    Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment
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    sciencedirect.com/science/article/pii/S1097276518309985