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Aug 2026
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A universal 6iL/E4 culture system for deriving and maintaining embryonic stem cells across mammalian species

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  FUW-M2rtTA
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13424318/
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TGFβ-Dependent Epithelial–Mesenchymal Plasticity in Immortalized Human Atrial Epicardial Cells: An mRNA Profiling Study

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pmc.ncbi.nlm.nih.gov/articles/PMC13406294/
Jul 2026
54.241.53.176 54.241.53.176

41419_2026_8660_MOESM1_ESM-html.html

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54.241.53.176/f40c43920bf73d30f8d51a6e84410c918e9070af/41419_2026_8660_MOESM1_ESM-html.html
Apr 2026
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Transcriptomic and phenotypic convergence of neurodevelopmental disorder risk genes in vitro and in vivo

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1. scibot 30 Apr 2026
  
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  DOI: 10.1038/s41593-026-02247-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13156037/
www.biorxiv.org www.biorxiv.org

One-step induction of human GABAergic neurons promotes presynaptic development & synapse maturation

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1. scibot 09 Apr 2026
  
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  DOI: 10.1101/2025.06.30.662293
  
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biorxiv.org/content/10.1101/2025.06.30.662293v3
Mar 2026
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Early Reprogramming Intermediates Enable Direct Neuronal Conversion Via NGN2

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1. scibot 18 Mar 2026
  
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  DOI: 10.1007/s12031-025-02460-2
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12868028/
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Functional implications of polygenic risk for schizophrenia in human neurons

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1. scibot 18 Mar 2026
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12877124/
Feb 2026
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Prevention of transgene silencing during human pluripotent stem cell differentiation

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  DOI: 10.1016/j.stem.2026.01.007
  
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sciencedirect.com/science/article/pii/S1934590926000305
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Non-invasive ovulation tracking enables genetic engineering in wild rodents

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1. scibot 19 Feb 2026
  
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  DOI: 10.1016/j.crmeth.2026.101311
  
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sciencedirect.com/science/article/pii/S2667237526000111
Jan 2026
54.241.53.176 54.241.53.176

2026.01.09.697058v1.full-html.html

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1. scibot 13 Jan 2026
  
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  plasmid_20342
  
  DOI: 10.64898/2026.01.09.697058
  
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54.241.53.176/5b0b03ea2cfec8238150047d7e3f6dc3bf5b51c0/2026.01.09.697058v1.full-html.html
Nov 2025
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ZMYND11 functions in bimodal regulation of latent genes and brain-like splicing to safeguard corticogenesis

1
1. scibot 24 Nov 2025
  
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  Addgene_20342
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12511308/
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Transcriptomic insights and feeder-free culturing of porcine expanded potential stem cells from cloned embryos

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1. scibot 23 Nov 2025
  
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  FUW-M2rtTA
  
  DOI: 10.1186/s13287-025-04627-5
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12482889/
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Optimizing the in vitro neuronal microenvironment to mitigate phototoxicity in live-cell imaging

1
1. scibot 23 Nov 2025
  
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  DOI: 10.1186/s13287-025-04591-0
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12465337/
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Astrocytic glutamate regulation is shaped by adversity and glucocorticoid signalling

1
1. scibot 23 Nov 2025
  
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  20342
  
  DOI: 10.1101/2024.06.24.600362
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12458319/
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A Universal 6iL/E4 Culture System for Deriving and Maintaining Embryonic Stem Cells Across Mammalian Species

1
1. scibot 23 Nov 2025
  
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  RRID:Addgene_20342
  
  DOI: 10.1101/2025.05.20.654948
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12139945/
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CHD7 binds to insulators during neuronal differentiation

1
1. scibot 23 Nov 2025
  
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  Addgene_20342
  
  DOI: 10.1101/2025.03.28.646031
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11974851/
Sep 2025
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Protocol for 3D direct reprogramming of human glia into dopaminergic neurons with gene expression and immunocytochemistry validation

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1. scibot 16 Sep 2025
  
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  RRID:Addgene_20342
  
  DOI: 10.1016/j.xpro.2025.104088
  
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sciencedirect.com/science/article/pii/S2666166725004940
Aug 2025
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Anchored screening identifies transcription factor blueprints underlying dendritic cell diversity and subset-specific anti-tumor immunity

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1. scibot 30 Aug 2025
  
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  RRID:Addgene_20342
  
  DOI: 10.1016/j.immuni.2025.08.001
  
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sciencedirect.com/science/article/pii/S1074761325003358
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Stearoyl-CoA desaturase inhibition normalizes brain lipid saturation, α-synuclein homeostasis, and motor function in mutant Gba1-Parkinson mice

1
1. scibot 11 Aug 2025
  
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  20342
  
  DOI: 10.1172/jci.insight.188413
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12288896/
52.53.155.43 52.53.155.43

2025.07.26.666977v1.full-html.html

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1. scibot 05 Aug 2025
  
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  DOI: 10.1101/2025.07.26.666977
  
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52.53.155.43/523aba7c04d08b4157ea984183976bbd000aa86d/2025.07.26.666977v1.full-html.html
Jul 2025
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Generation of iPSC Lines with Tagged α-Synuclein for Visualization of Endogenous Protein in Human Cellular Models of Neurodegenerative Disorders

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  20342
  
  DOI: 10.1523/ENEURO.0093-25.2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12186606/
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Single-cell transcriptomic and chromatin dynamics of the human brain in PTSD

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  20342
  
  DOI: 10.1038/s41586-025-09083-y
  
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nature.com/articles/s41586-025-09083-y
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Transcriptional repression of SOX2 by p53 in cancer cells regulates cell identity and migration

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1. scibot 10 Jul 2025
  
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  DOI: 10.1002/ijc.35490
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12232590/
May 2025
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Coiled-coil-domain-mediated TRIM E3 protein condensation modulates enzymatic activity and functional specificity

1
1. scibot 31 May 2025
  
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  Addgene#20342
  
  DOI: 10.1016/j.celrep.2025.115766
  
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sciencedirect.com/science/article/pii/S2211124725005376
elifesciences.org elifesciences.org

An antisense oligonucleotide-based strategy to ameliorate cognitive dysfunction in the 22q11.2 Deletion Syndrome

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1. scibot 29 May 2025
  
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  DOI: 10.7554/eLife.103328
  
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elifesciences.org/articles/103328
Apr 2025
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O-GlcNAcylation in Gli1+ Mesenchymal Stem Cells Is Indispensable for Bone Formation and Fracture Healing

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1. scibot 07 Apr 2025
  
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  DOI: 10.3390/ijms26062712
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11943158/
Mar 2025
elifesciences.org elifesciences.org

An antisense oligonucleotide-based strategy to ameliorate cognitive dysfunction in the 22q11.2 Deletion Syndrome

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1. scibot 25 Mar 2025
  
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  DOI: 10.7554/eLife.103328.2
  
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elifesciences.org/reviewed-preprints/103328
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Subcellular proteomics and iPSC modeling uncover reversible mechanisms of axonal pathology in Alzheimer’s disease

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  DOI: 10.1038/s43587-025-00823-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11922768/
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SOX9 haploinsufficiency reveals SOX9-Noggin interaction in BMP-SMAD signaling pathway in chondrogenesis

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1. scibot 11 Mar 2025
  
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  plasmid_20342
  
  DOI: 10.1007/s00018-025-05622-y
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11872873/
Dec 2024
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Expanding GABAergic Neuronal Diversity in iPSC-Derived Disease Models

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1. scibot 28 Dec 2024
  
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  DOI: 10.1101/2024.12.03.626438
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11642846/
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Miltefosine reinvigorates exhausted T cells by targeting their bioenergetic state

1
1. scibot 24 Dec 2024
  
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  AddgeneCat#20342
  
  DOI: 10.1016/j.xcrm.2024.101869
  
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sciencedirect.com/science/article/pii/S2666379124006402
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Structural and functional alterations of neurons derived from sporadic Alzheimer’s disease hiPSCs are associated with downregulation of the LIMK1-cofilin axis

1
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  plasmid_20342
  
  DOI: 10.1186/s13195-024-01632-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11660640/
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Aberrant neurodevelopment in human iPS cell‐derived models of Alexander disease

1
1. scibot 24 Dec 2024
  
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  Addgene_20342
  
  DOI: 10.1002/glia.24618
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11660530/
Oct 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

3D model for human glia conversion into subtype-specific neurons, including dopamine neurons

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  DOI: 10.1016/j.crmeth.2024.100845
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11440053/
Sep 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Dynamic convergence of autism disorder risk genes across neurodevelopment

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  Addgene_20342
  
  DOI: 10.1101/2024.08.23.609190
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11370590/
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Pharmacological chaperones restore proteostasis of epilepsy-associated GABAA receptor variants

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  RRID:Addgene_20342
  
  DOI: 10.1016/j.phrs.2024.107356
  
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sciencedirect.com/science/article/pii/S1043661824003013
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Distinctive In Vitro Phenotypes in iPSC-Derived Neurons From Patients With Gain- and Loss-of-Function SCN2A Developmental and Epileptic Encephalopathy

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1. scibot 26 Aug 2024
  
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  20342
  
  DOI: 10.1523/JNEUROSCI.0692-23.2023
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10883610/
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Dynamic stress- and inflammatory-based regulation of psychiatric risk loci in human neurons

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SYNGAP1 deficiency disrupts synaptic neoteny in xenotransplanted human cortical neurons in vivo

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Systematic transcriptome profiling of hPSC-derived osteoblasts unveils CORIN's mastery in governing osteogenesis through CEBPD modulation

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Establishment of porcine embryonic stem cells in simplified serum free media and feeder free expansion

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The divergent effects of G3BP orthologs on human stress granule assembly imply a centric role for the core protein interaction network

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Transcription Factor-Mediated Generation of Dopaminergic Neurons from Human iPSCs—A Comparison of Methods

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Prickle1‐driven basement membrane deposition of the iPSC‐derived embryoid bodies is separable from the establishment of apicobasal polarity

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Spatiotemporally resolved colorectal oncogenesis in mini-colons ex vivo

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ENGINEERED NANOBODIES WITH PROGRAMMABLE TARGET ANTIGEN PROTEOLYSIS (PTAP) FUSIONS REGULATE INTRACELLULAR ALPHA-SYNUCLEIN IN VITRO AND IN VIVO

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Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation

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BRCA1 and 53BP1 regulate reprogramming efficiency by mediating DNA repair pathway choice at replication-associated double-strand breaks

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Feb 2024
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Direct reprogramming of non-limb fibroblasts to cells with properties of limb progenitors

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High-content screening identifies a small molecule that restores AP-4-dependent protein trafficking in neuronal models of AP-4-associated hereditary spastic paraplegia

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Dec 2023
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ALDH5A1-deficient iPSC-derived excitatory and inhibitory neurons display cell type specific alterations

1
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An integrated in vitro human iPSCs-derived neuron and in vivo animal approach for preclinical screening of anti-seizure compounds

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Chromatin-modifying enzymes as modulators of nuclear size during lineage differentiation

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Aug 2023
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Multiple genes in a single GWAS risk locus synergistically mediate aberrant synaptic development and function in human neurons

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Efficient generation of functional neurons from mouse embryonic stem cells via neurogenin-2 expression

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Optimized protocol for the generation of functional human induced-pluripotent-stem-cell-derived dopaminergic neurons

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Apr 2023
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Pharmacological chaperones restore proteostasis of epilepsy-associated GABAA receptor variants

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Hominoid SVA-lncRNA AK057321 targets human-specific SVA retrotransposons in SCN8A and CDK5RAP2 to initiate neuronal maturation

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Mar 2023
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SYNGAP1 deficiency disrupts neoteny in human cortical neurons in vivo

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Neurotransmitter release progressively desynchronizes in induced human neurons during synapse maturation and aging

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Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons

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Nov 2022
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Tip60-mediated H2A.Z acetylation promotes neuronal fate specification and bivalent gene activation

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Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies

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Oct 2022
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CASK loss of function differentially regulates neuronal maturation and synaptic function in human induced cortical excitatory neurons

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In vitro neurons learn and exhibit sentience when embodied in a simulated game-world

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Induced retinal pigment epithelial cells with anti-epithelial-to-mesenchymal transition ability delay retinal degeneration

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Jun 2022
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Mapping cis-regulatory elements in human neurons links psychiatric disease heritability and activity-regulated transcriptional programs

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May 2022
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Glioblastoma Embryonic-like Stem Cells Exhibit Immune-Evasive Phenotype

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ncbi.nlm.nih.gov/pmc/articles/PMC9104850/
Nov 2021
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Rapid generation of murine haploid-induced trophoblast stem cells via a Tet-on system

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Oct 2021
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A synaptic temperature sensor for body cooling

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Aug 2021
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Untitled document

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  DOI: 10.1016/j.cell.2016.12.036
  
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Interspecies Chimerism with Mammalian Pluripotent Stem Cells

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  DOI: 10.1016/j.cell.2016.12.036
  
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Jul 2021
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Neuromodulator Signaling Bidirectionally Controls Vesicle Numbers in Human Synapses

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  FUW-rtTA (lentiviral vector)
  
  DOI: 10.1016/j.cell.2019.09.011
  
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Xenotransplanted Human Cortical Neurons Reveal Species-Specific Development and Functional Integration into Mouse Visual Circuits

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Sox2 and Klf4 as the Functional Core in Pluripotency Induction without Exogenous Oct4

1
1. scibot 29 Jul 2021
  
  in Public
  
  Addgene plasmid Cat# 20342
  
  DOI: 10.1016/j.celrep.2019.10.026
  
  Resource: RRID:Addgene_20342
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:Addgene_20342
  
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  RRID:Addgene_20342 RRIDCUR:Unrecognized
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RRID:Addgene_20342

RRIDCUR:Unrecognized

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scibot

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sciencedirect.com/science/article/pii/S2211124719313269
www.sciencedirect.com www.sciencedirect.com

Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment

1
1. scibot 28 Jul 2021
  
  in Public
  
  FUW-M2rtTA
  
  DOI: 10.1016/j.molcel.2018.11.028
  
  Resource: RRID:Addgene_20342
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_20342
  
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  RRID:Addgene_20342 RRIDCUR:Missing
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RRID:Addgene_20342

RRIDCUR:Missing

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scibot

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sciencedirect.com/science/article/pii/S1097276518309985
Jun 2021
www.sciencedirect.com www.sciencedirect.com

Using the dCas9-KRAB system to repress gene expression in hiPSC-derived NGN2 neurons

1
1. scibot 04 Jun 2021
  
  in Public
  
  Plasmid_20342
  
  DOI: 10.1016/j.xpro.2021.100580
  
  Resource: RRID:Addgene_20342
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_20342
  
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  RRID:Addgene_20342
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RRID:Addgene_20342

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scibot

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sciencedirect.com/science/article/pii/S2666166721002872
May 2021
www.nature.com www.nature.com

Neuron and astrocyte aggregation and sorting in three-dimensional neuronal constructs

1
1. scibot 22 May 2021
  
  in Public
  
  RRID:Addgene_20342
  
  DOI: 10.1038/s42003-021-02104-2
  
  Resource: RRID:Addgene_20342
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_20342
  
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  RRID:Addgene_20342
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RRID:Addgene_20342

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scibot

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nature.com/articles/s42003-021-02104-2
www.sciencedirect.com www.sciencedirect.com

Transformative Network Modeling of Multi-omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer’s Disease

1
1. scibot 08 May 2021
  
  in Public
  
  Addgene_20342
  
  DOI: 10.1016/j.neuron.2020.11.002
  
  Resource: RRID:Addgene_20342
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_20342
  
  What is this?
  
  RRID:Addgene_20342
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RRID:Addgene_20342

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scibot

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sciencedirect.com/science/article/pii/S0896627320308618
Mar 2021
www.sciencedirect.com www.sciencedirect.com

H3.3-K27M drives neural stem cell-specific gliomagenesis in a human iPSC-derived model

1
1. scibot 22 Mar 2021
  
  in Public
  
  RRID:Addgene_20342
  
  DOI: 10.1016/j.ccell.2021.01.005
  
  Resource: RRID:Addgene_20342
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_20342
  
  What is this?
  
  RRID:Addgene_20342
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RRID:Addgene_20342

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scibot

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sciencedirect.com/science/article/pii/S1535610821000490
Feb 2021
elifesciences.org elifesciences.org

Dyshomeostatic modulation of Ca2+-activated K+ channels in a human neuronal model of KCNQ2 encephalopathy

1
1. scibot 11 Feb 2021
  
  in Public
  
  RRID:Addgene_20342
  
  DOI: 10.7554/eLife.64434
  
  Resource: RRID:Addgene_20342
  
  Curator: @evieth
  
  SciCrunch record: RRID:Addgene_20342
  
  What is this?
  
  RRID:Addgene_20342 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:Addgene_20342

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scibot

URL

elifesciences.org/articles/64434
Dec 2020
www.sciencedirect.com www.sciencedirect.com

Master Regulators and Cofactors of Human Neuronal Cell Fate Specification Identified by CRISPR Gene Activation Screens

1
1. scibot 07 Dec 2020
  
  in Public
  
  Addgene_20342
  
  DOI: 10.1016/j.celrep.2020.108460
  
  Resource: RRID:Addgene_20342
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_20342
  
  What is this?
  
  RRIDCUR:Validated RRID:Addgene_20342
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RRIDCUR:Validated

RRID:Addgene_20342

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scibot

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sciencedirect.com/science/article/pii/S2211124720314492
Oct 2020
www.embopress.org www.embopress.org

Identification of a dynamic gene regulatory network required for pluripotency factor‐induced reprogramming of mouse fibroblasts and hepatocytes

1
1. scibot 13 Oct 2020
  
  in Public
  
  RRID:Addgene_20342
  
  DOI: 10.15252/embj.2019102236
  
  Resource: RRID:Addgene_20342
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_20342
  
  What is this?
  
  RRID:Addgene_20342 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:Addgene_20342

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scibot

URL

embopress.org/doi/full/10.15252/embj.2019102236
Jan 2020
www.sciencedirect.com www.sciencedirect.com

Pioneer Factor NeuroD1 Rearranges Transcriptional and Epigenetic Profiles to Execute Microglia-Neuron Conversion

1
1. scibot 13 Jan 2020
  
  in Public
  
  Addgene_20342
  
  DOI: 10.1016/j.neuron.2018.12.010
  
  Resource: RRID:Addgene_20342
  
  Curator: @ethanbadger
  
  SciCrunch record: Addgene_20342
  
  What is this?
  
  RRID:Addgene_20342 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:Addgene_20342

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scibot

URL

sciencedirect.com/science/article/pii/S0896627318310869

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