89 Matching Annotations
  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Enhancing reprogramming towards induced human expanded pluripotency through substitution of SOX2 with engineered SOX17 transcription factors
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    pmc.ncbi.nlm.nih.gov/articles/PMC13249825/
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    From Natural Compound Screening to Myelin-Associated Effects: Identification of Morusin as a Potent Promoter of Oligodendrocyte Differentiation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12986312/
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Developmental and MAPK-responsive transcription factors regulate distinct malignant cell states and associated genetic dependencies in pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13553295/
  5. Sep 2026
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dynamic neuro-immune regulation of psychiatric risk loci in human neurons
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    pmc.ncbi.nlm.nih.gov/articles/PMC13616973/
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    Directing GABAergic neuronal identity from human iPSCs through developmental patterning
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    sciencedirect.com/science/article/pii/S2213671126002973
  8. Aug 2026
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A universal 6iL/E4 culture system for deriving and maintaining embryonic stem cells across mammalian species
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    pmc.ncbi.nlm.nih.gov/articles/PMC13424318/
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TGFβ-Dependent Epithelial–Mesenchymal Plasticity in Immortalized Human Atrial Epicardial Cells: An mRNA Profiling Study
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    pmc.ncbi.nlm.nih.gov/articles/PMC13406294/
  11. Jul 2026
  12. 54.241.53.176 54.241.53.176
    41419_2026_8660_MOESM1_ESM-html.html
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  13. Apr 2026
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Transcriptomic and phenotypic convergence of neurodevelopmental disorder risk genes in vitro and in vivo
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    pmc.ncbi.nlm.nih.gov/articles/PMC13156037/
  15. www.biorxiv.org www.biorxiv.org
    One-step induction of human GABAergic neurons promotes presynaptic development & synapse maturation
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    biorxiv.org/content/10.1101/2025.06.30.662293v3
  16. Mar 2026
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Early Reprogramming Intermediates Enable Direct Neuronal Conversion Via NGN2
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    pmc.ncbi.nlm.nih.gov/articles/PMC12868028/
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Functional implications of polygenic risk for schizophrenia in human neurons
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    pmc.ncbi.nlm.nih.gov/articles/PMC12877124/
  19. Feb 2026
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    Prevention of transgene silencing during human pluripotent stem cell differentiation
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    sciencedirect.com/science/article/pii/S1934590926000305
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    Non-invasive ovulation tracking enables genetic engineering in wild rodents
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    sciencedirect.com/science/article/pii/S2667237526000111
  22. Jan 2026
  23. 54.241.53.176 54.241.53.176
    2026.01.09.697058v1.full-html.html
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  24. Nov 2025
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ZMYND11 functions in bimodal regulation of latent genes and brain-like splicing to safeguard corticogenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12511308/
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Transcriptomic insights and feeder-free culturing of porcine expanded potential stem cells from cloned embryos
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    pmc.ncbi.nlm.nih.gov/articles/PMC12482889/
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Optimizing the in vitro neuronal microenvironment to mitigate phototoxicity in live-cell imaging
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    pmc.ncbi.nlm.nih.gov/articles/PMC12465337/
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Astrocytic glutamate regulation is shaped by adversity and glucocorticoid signalling
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    pmc.ncbi.nlm.nih.gov/articles/PMC12458319/
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Universal 6iL/E4 Culture System for Deriving and Maintaining Embryonic Stem Cells Across Mammalian Species
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    pmc.ncbi.nlm.nih.gov/articles/PMC12139945/
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CHD7 binds to insulators during neuronal differentiation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11974851/
  31. Sep 2025
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    Protocol for 3D direct reprogramming of human glia into dopaminergic neurons with gene expression and immunocytochemistry validation
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    sciencedirect.com/science/article/pii/S2666166725004940
  33. Aug 2025
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    Anchored screening identifies transcription factor blueprints underlying dendritic cell diversity and subset-specific anti-tumor immunity
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    sciencedirect.com/science/article/pii/S1074761325003358
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Stearoyl-CoA desaturase inhibition normalizes brain lipid saturation, α-synuclein homeostasis, and motor function in mutant Gba1-Parkinson mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC12288896/
  36. 52.53.155.43 52.53.155.43
    2025.07.26.666977v1.full-html.html
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  37. Jul 2025
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Generation of iPSC Lines with Tagged α-Synuclein for Visualization of Endogenous Protein in Human Cellular Models of Neurodegenerative Disorders
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    pmc.ncbi.nlm.nih.gov/articles/PMC12186606/
  39. www.nature.com www.nature.com
    Single-cell transcriptomic and chromatin dynamics of the human brain in PTSD
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    nature.com/articles/s41586-025-09083-y
  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Transcriptional repression of SOX2 by p53 in cancer cells regulates cell identity and migration
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    pmc.ncbi.nlm.nih.gov/articles/PMC12232590/
  41. May 2025
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    Coiled-coil-domain-mediated TRIM E3 protein condensation modulates enzymatic activity and functional specificity
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    sciencedirect.com/science/article/pii/S2211124725005376
  43. elifesciences.org elifesciences.org
    An antisense oligonucleotide-based strategy to ameliorate cognitive dysfunction in the 22q11.2 Deletion Syndrome
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    elifesciences.org/articles/103328
  44. Apr 2025
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    O-GlcNAcylation in Gli1+ Mesenchymal Stem Cells Is Indispensable for Bone Formation and Fracture Healing
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    pmc.ncbi.nlm.nih.gov/articles/PMC11943158/
  46. Mar 2025
  47. elifesciences.org elifesciences.org
    An antisense oligonucleotide-based strategy to ameliorate cognitive dysfunction in the 22q11.2 Deletion Syndrome
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    elifesciences.org/reviewed-preprints/103328
  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Subcellular proteomics and iPSC modeling uncover reversible mechanisms of axonal pathology in Alzheimer’s disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC11922768/
  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SOX9 haploinsufficiency reveals SOX9-Noggin interaction in BMP-SMAD signaling pathway in chondrogenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11872873/
  50. Dec 2024
  51. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Expanding GABAergic Neuronal Diversity in iPSC-Derived Disease Models
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    pmc.ncbi.nlm.nih.gov/articles/PMC11642846/
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    Miltefosine reinvigorates exhausted T cells by targeting their bioenergetic state
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    sciencedirect.com/science/article/pii/S2666379124006402
  53. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Structural and functional alterations of neurons derived from sporadic Alzheimer’s disease hiPSCs are associated with downregulation of the LIMK1-cofilin axis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11660640/
  54. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Aberrant neurodevelopment in human iPS cell‐derived models of Alexander disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC11660530/
  55. Oct 2024
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    3D model for human glia conversion into subtype-specific neurons, including dopamine neurons
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    ncbi.nlm.nih.gov/pmc/articles/PMC11440053/
  57. Sep 2024
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dynamic convergence of autism disorder risk genes across neurodevelopment
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    ncbi.nlm.nih.gov/pmc/articles/PMC11370590/
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    Pharmacological chaperones restore proteostasis of epilepsy-associated GABAA receptor variants
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    sciencedirect.com/science/article/pii/S1043661824003013
  60. Aug 2024
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Distinctive In Vitro Phenotypes in iPSC-Derived Neurons From Patients With Gain- and Loss-of-Function SCN2A Developmental and Epileptic Encephalopathy
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    ncbi.nlm.nih.gov/pmc/articles/PMC10883610/
  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dynamic stress- and inflammatory-based regulation of psychiatric risk loci in human neurons
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    ncbi.nlm.nih.gov/pmc/articles/PMC11257632/
  63. www.cell.com www.cell.com
    SYNGAP1 deficiency disrupts synaptic neoteny in xenotransplanted human cortical neurons in vivo
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    cell.com/neuron/abstract/S0896-6273(24)00529-4
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systematic transcriptome profiling of hPSC-derived osteoblasts unveils CORIN's mastery in governing osteogenesis through CEBPD modulation
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    ncbi.nlm.nih.gov/pmc/articles/PMC11301355/
  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Establishment of porcine embryonic stem cells in simplified serum free media and feeder free expansion
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    ncbi.nlm.nih.gov/pmc/articles/PMC11304784/
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    The divergent effects of G3BP orthologs on human stress granule assembly imply a centric role for the core protein interaction network
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    sciencedirect.com/science/article/pii/S2211124724009677
  67. Jun 2024
  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transcription Factor-Mediated Generation of Dopaminergic Neurons from Human iPSCs—A Comparison of Methods
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    ncbi.nlm.nih.gov/pmc/articles/PMC11201854/
  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Prickle1‐driven basement membrane deposition of the iPSC‐derived embryoid bodies is separable from the establishment of apicobasal polarity
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    ncbi.nlm.nih.gov/pmc/articles/PMC11150132/
  70. May 2024
  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Spatiotemporally resolved colorectal oncogenesis in mini-colons ex vivo
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    ncbi.nlm.nih.gov/pmc/articles/PMC11078756/
  72. Apr 2024
  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ENGINEERED NANOBODIES WITH PROGRAMMABLE TARGET ANTIGEN PROTEOLYSIS (PTAP) FUSIONS REGULATE INTRACELLULAR ALPHA-SYNUCLEIN IN VITRO AND IN VIVO
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    ncbi.nlm.nih.gov/pmc/articles/PMC10996777/
  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation
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    ncbi.nlm.nih.gov/pmc/articles/PMC10959535/
  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BRCA1 and 53BP1 regulate reprogramming efficiency by mediating DNA repair pathway choice at replication-associated double-strand breaks
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    ncbi.nlm.nih.gov/pmc/articles/PMC11272184/
  76. Feb 2024
  77. www.sciencedirect.com www.sciencedirect.com
    Direct reprogramming of non-limb fibroblasts to cells with properties of limb progenitors
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    sciencedirect.com/science/article/pii/S1534580723006901
  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    High-content screening identifies a small molecule that restores AP-4-dependent protein trafficking in neuronal models of AP-4-associated hereditary spastic paraplegia
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    ncbi.nlm.nih.gov/pmc/articles/PMC10794252/
  79. Dec 2023
  80. www.sciencedirect.com www.sciencedirect.com
    ALDH5A1-deficient iPSC-derived excitatory and inhibitory neurons display cell type specific alterations
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    sciencedirect.com/science/article/pii/S0969996123004023
  81. Nov 2023
  82. www.sciencedirect.com www.sciencedirect.com
    An integrated in vitro human iPSCs-derived neuron and in vivo animal approach for preclinical screening of anti-seizure compounds
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    sciencedirect.com/science/article/pii/S2090123223003612
  83. Oct 2023
  84. www.nature.com www.nature.com
    Chromatin-modifying enzymes as modulators of nuclear size during lineage differentiation
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    nature.com/articles/s41420-023-01639-z
  85. Aug 2023
  86. www.sciencedirect.com www.sciencedirect.com
    Multiple genes in a single GWAS risk locus synergistically mediate aberrant synaptic development and function in human neurons
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    sciencedirect.com/science/article/pii/S2666979X23002136
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    Efficient generation of functional neurons from mouse embryonic stem cells via neurogenin-2 expression
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    nature.com/articles/s41596-023-00863-2
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Optimized protocol for the generation of functional human induced-pluripotent-stem-cell-derived dopaminergic neurons
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    ncbi.nlm.nih.gov/pmc/articles/PMC10400954/
  89. Apr 2023
  90. www.biorxiv.org www.biorxiv.org
    Pharmacological chaperones restore proteostasis of epilepsy-associated GABAA receptor variants
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    biorxiv.org/content/10.1101/2023.04.18.537383v1
  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hominoid SVA-lncRNA AK057321 targets human-specific SVA retrotransposons in SCN8A and CDK5RAP2 to initiate neuronal maturation
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    ncbi.nlm.nih.gov/pmc/articles/PMC10063665/
  92. Mar 2023
  93. www.biorxiv.org www.biorxiv.org
    SYNGAP1 deficiency disrupts neoteny in human cortical neurons in vivo
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    biorxiv.org/content/10.1101/2023.01.14.524054v1
  94. Jan 2023
  95. www.sciencedirect.com www.sciencedirect.com
    Neurotransmitter release progressively desynchronizes in induced human neurons during synapse maturation and aging
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    sciencedirect.com/science/article/pii/S2211124723000530
  96. www.sciencedirect.com www.sciencedirect.com
    Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons
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    sciencedirect.com/science/article/pii/S1934590922004945
  97. Nov 2022
  98. www.sciencedirect.com www.sciencedirect.com
    Tip60-mediated H2A.Z acetylation promotes neuronal fate specification and bivalent gene activation
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    sciencedirect.com/science/article/abs/pii/S1097276522010644
  99. www.sciencedirect.com www.sciencedirect.com
    Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies
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    sciencedirect.com/science/article/pii/S2211124722015522
  100. Oct 2022
  101. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CASK loss of function differentially regulates neuronal maturation and synaptic function in human induced cortical excitatory neurons
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    ncbi.nlm.nih.gov/pmc/articles/PMC9574418/
  102. www.cell.com www.cell.com
    In vitro neurons learn and exhibit sentience when embodied in a simulated game-world
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    cell.com/neuron/fulltext/S0896-6273(22)00806-6
  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Induced retinal pigment epithelial cells with anti-epithelial-to-mesenchymal transition ability delay retinal degeneration
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    ncbi.nlm.nih.gov/pmc/articles/PMC9519511/
  104. Jun 2022
  105. www.sciencedirect.com www.sciencedirect.com
    Mapping cis-regulatory elements in human neurons links psychiatric disease heritability and activity-regulated transcriptional programs
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    sciencedirect.com/science/article/pii/S2211124722006520
  106. May 2022
  107. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glioblastoma Embryonic-like Stem Cells Exhibit Immune-Evasive Phenotype
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    ncbi.nlm.nih.gov/pmc/articles/PMC9104850/
  108. Nov 2021
  109. www.sciencedirect.com www.sciencedirect.com
    Rapid generation of murine haploid-induced trophoblast stem cells via a Tet-on system
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    sciencedirect.com/science/article/pii/S2666166721005876
  110. Oct 2021
  111. www.sciencedirect.com www.sciencedirect.com
    A synaptic temperature sensor for body cooling
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    sciencedirect.com/science/article/pii/S0896627321007698
  112. Aug 2021
  113. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    ncbi.nlm.nih.gov/pmc/articles/PMC5679265/
  114. www.sciencedirect.com www.sciencedirect.com
    Interspecies Chimerism with Mammalian Pluripotent Stem Cells
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    sciencedirect.com/science/article/pii/S0092867416317524
  115. Jul 2021
  116. www.sciencedirect.com www.sciencedirect.com
    Neuromodulator Signaling Bidirectionally Controls Vesicle Numbers in Human Synapses
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  117. www.sciencedirect.com www.sciencedirect.com
    Xenotransplanted Human Cortical Neurons Reveal Species-Specific Development and Functional Integration into Mouse Visual Circuits
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    sciencedirect.com/science/article/pii/S0896627319308505
  118. www.sciencedirect.com www.sciencedirect.com
    Sox2 and Klf4 as the Functional Core in Pluripotency Induction without Exogenous Oct4
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    sciencedirect.com/science/article/pii/S2211124719313269
  119. www.sciencedirect.com www.sciencedirect.com
    Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment
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    sciencedirect.com/science/article/pii/S1097276518309985
  120. Jun 2021
  121. www.sciencedirect.com www.sciencedirect.com
    Using the dCas9-KRAB system to repress gene expression in hiPSC-derived NGN2 neurons
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    sciencedirect.com/science/article/pii/S2666166721002872
  122. May 2021
  123. www.nature.com www.nature.com
    Neuron and astrocyte aggregation and sorting in three-dimensional neuronal constructs
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    nature.com/articles/s42003-021-02104-2
  124. www.sciencedirect.com www.sciencedirect.com
    Transformative Network Modeling of Multi-omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer’s Disease
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    sciencedirect.com/science/article/pii/S0896627320308618
  125. Mar 2021
  126. www.sciencedirect.com www.sciencedirect.com
    H3.3-K27M drives neural stem cell-specific gliomagenesis in a human iPSC-derived model
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    sciencedirect.com/science/article/pii/S1535610821000490
  127. Feb 2021
  128. elifesciences.org elifesciences.org
    Dyshomeostatic modulation of Ca2+-activated K+ channels in a human neuronal model of KCNQ2 encephalopathy
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    elifesciences.org/articles/64434
  129. Dec 2020
  130. www.sciencedirect.com www.sciencedirect.com
    Master Regulators and Cofactors of Human Neuronal Cell Fate Specification Identified by CRISPR Gene Activation Screens
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    sciencedirect.com/science/article/pii/S2211124720314492
  131. Oct 2020
  132. www.embopress.org www.embopress.org
    Identification of a dynamic gene regulatory network required for pluripotency factor‐induced reprogramming of mouse fibroblasts and hepatocytes
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    embopress.org/doi/full/10.15252/embj.2019102236
  133. Jan 2020
  134. www.sciencedirect.com www.sciencedirect.com
    Pioneer Factor NeuroD1 Rearranges Transcriptional and Epigenetic Profiles to Execute Microglia-Neuron Conversion
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    sciencedirect.com/science/article/pii/S0896627318310869