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Anchored screening identifies transcription factor blueprints underlying dendritic cell diversity and subset-specific anti-tumor immunity

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sciencedirect.com/science/article/pii/S1074761325003358
Aug 2025
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Stearoyl-CoA desaturase inhibition normalizes brain lipid saturation, α-synuclein homeostasis, and motor function in mutant Gba1-Parkinson mice

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2025.07.26.666977v1.full-html.html

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52.53.155.43/523aba7c04d08b4157ea984183976bbd000aa86d/2025.07.26.666977v1.full-html.html
Jul 2025
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Generation of iPSC Lines with Tagged α-Synuclein for Visualization of Endogenous Protein in Human Cellular Models of Neurodegenerative Disorders

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pmc.ncbi.nlm.nih.gov/articles/PMC12186606/
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Single-cell transcriptomic and chromatin dynamics of the human brain in PTSD

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pmc.ncbi.nlm.nih.gov/articles/PMC12267058/
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Transcriptional repression of SOX2 by p53 in cancer cells regulates cell identity and migration

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pmc.ncbi.nlm.nih.gov/articles/PMC12232590/
May 2025
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Coiled-coil-domain-mediated TRIM E3 protein condensation modulates enzymatic activity and functional specificity

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sciencedirect.com/science/article/pii/S2211124725005376
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An antisense oligonucleotide-based strategy to ameliorate cognitive dysfunction in the 22q11.2 Deletion Syndrome

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  DOI: 10.7554/eLife.103328
  
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elifesciences.org/articles/103328
Apr 2025
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O-GlcNAcylation in Gli1+ Mesenchymal Stem Cells Is Indispensable for Bone Formation and Fracture Healing

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pmc.ncbi.nlm.nih.gov/articles/PMC11943158/
Mar 2025
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An antisense oligonucleotide-based strategy to ameliorate cognitive dysfunction in the 22q11.2 Deletion Syndrome

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1. scibot 25 Mar 2025
  
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elifesciences.org/reviewed-preprints/103328
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Subcellular proteomics and iPSC modeling uncover reversible mechanisms of axonal pathology in Alzheimer’s disease

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pmc.ncbi.nlm.nih.gov/articles/PMC11922768/
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SOX9 haploinsufficiency reveals SOX9-Noggin interaction in BMP-SMAD signaling pathway in chondrogenesis

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  plasmid_20342
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11872873/
Dec 2024
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Expanding GABAergic Neuronal Diversity in iPSC-Derived Disease Models

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1. scibot 28 Dec 2024
  
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  DOI: 10.1101/2024.12.03.626438
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11642846/
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Miltefosine reinvigorates exhausted T cells by targeting their bioenergetic state

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1. scibot 24 Dec 2024
  
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  DOI: 10.1016/j.xcrm.2024.101869
  
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sciencedirect.com/science/article/pii/S2666379124006402
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Structural and functional alterations of neurons derived from sporadic Alzheimer’s disease hiPSCs are associated with downregulation of the LIMK1-cofilin axis

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1. scibot 24 Dec 2024
  
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  plasmid_20342
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11660640/
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Aberrant neurodevelopment in human iPS cell‐derived models of Alexander disease

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1. scibot 24 Dec 2024
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11660530/
Oct 2024
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3D model for human glia conversion into subtype-specific neurons, including dopamine neurons

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1. scibot 03 Oct 2024
  
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  DOI: 10.1016/j.crmeth.2024.100845
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11440053/
Sep 2024
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Dynamic convergence of autism disorder risk genes across neurodevelopment

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1. scibot 29 Sep 2024
  
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  Addgene_20342
  
  DOI: 10.1101/2024.08.23.609190
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11370590/
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Pharmacological chaperones restore proteostasis of epilepsy-associated GABAA receptor variants

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  DOI: 10.1016/j.phrs.2024.107356
  
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sciencedirect.com/science/article/pii/S1043661824003013
Aug 2024
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Distinctive In Vitro Phenotypes in iPSC-Derived Neurons From Patients With Gain- and Loss-of-Function SCN2A Developmental and Epileptic Encephalopathy

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1. scibot 26 Aug 2024
  
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  DOI: 10.1523/JNEUROSCI.0692-23.2023
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10883610/
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Dynamic stress- and inflammatory-based regulation of psychiatric risk loci in human neurons

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1. scibot 26 Aug 2024
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11257632/
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SYNGAP1 deficiency disrupts synaptic neoteny in xenotransplanted human cortical neurons in vivo

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  DOI: 10.1016/j.neuron.2024.07.007
  
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cell.com/neuron/abstract/S0896-6273(24)00529-4
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Systematic transcriptome profiling of hPSC-derived osteoblasts unveils CORIN's mastery in governing osteogenesis through CEBPD modulation

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  DOI: 10.1016/j.jbc.2024.107494
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11301355/
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Establishment of porcine embryonic stem cells in simplified serum free media and feeder free expansion

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1. scibot 18 Aug 2024
  
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  FUW-M2rtTA
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11304784/
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The divergent effects of G3BP orthologs on human stress granule assembly imply a centric role for the core protein interaction network

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sciencedirect.com/science/article/pii/S2211124724009677
Jun 2024
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Transcription Factor-Mediated Generation of Dopaminergic Neurons from Human iPSCs—A Comparison of Methods

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ncbi.nlm.nih.gov/pmc/articles/PMC11201854/
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Prickle1‐driven basement membrane deposition of the iPSC‐derived embryoid bodies is separable from the establishment of apicobasal polarity

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1. scibot 09 Jun 2024
  
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  https://www.addgene.org/20342/
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11150132/
May 2024
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Spatiotemporally resolved colorectal oncogenesis in mini-colons ex vivo

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  DOI: 10.1038/s41586-024-07330-2
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11078756/
Apr 2024
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ENGINEERED NANOBODIES WITH PROGRAMMABLE TARGET ANTIGEN PROTEOLYSIS (PTAP) FUSIONS REGULATE INTRACELLULAR ALPHA-SYNUCLEIN IN VITRO AND IN VIVO

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  DOI: 10.21203/rs.3.rs-4088206/v1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10996777/
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Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation

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ncbi.nlm.nih.gov/pmc/articles/PMC10959535/
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BRCA1 and 53BP1 regulate reprogramming efficiency by mediating DNA repair pathway choice at replication-associated double-strand breaks

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  AddgeneCat# 20342
  
  DOI: 10.1016/j.celrep.2024.114006
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11272184/
Feb 2024
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Direct reprogramming of non-limb fibroblasts to cells with properties of limb progenitors

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  Addgene#20342
  
  DOI: 10.1016/j.devcel.2023.12.010
  
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sciencedirect.com/science/article/pii/S1534580723006901
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High-content screening identifies a small molecule that restores AP-4-dependent protein trafficking in neuronal models of AP-4-associated hereditary spastic paraplegia

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1. scibot 01 Feb 2024
  
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  Addgene_20342
  
  DOI: 10.1038/s41467-023-44264-1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10794252/
Dec 2023
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ALDH5A1-deficient iPSC-derived excitatory and inhibitory neurons display cell type specific alterations

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  addgene_20342
  
  DOI: 10.1016/j.nbd.2023.106386
  
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sciencedirect.com/science/article/pii/S0969996123004023
Nov 2023
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An integrated in vitro human iPSCs-derived neuron and in vivo animal approach for preclinical screening of anti-seizure compounds

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1. scibot 28 Nov 2023
  
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  DOI: 10.1016/j.jare.2023.11.022
  
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sciencedirect.com/science/article/pii/S2090123223003612
Oct 2023
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Chromatin-modifying enzymes as modulators of nuclear size during lineage differentiation

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1. scibot 21 Oct 2023
  
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  RRID:Addgene_20342
  
  DOI: 10.1038/s41420-023-01639-z
  
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nature.com/articles/s41420-023-01639-z
Aug 2023
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Multiple genes in a single GWAS risk locus synergistically mediate aberrant synaptic development and function in human neurons

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1. scibot 30 Aug 2023
  
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  DOI: 10.1016/j.xgen.2023.100399
  
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sciencedirect.com/science/article/pii/S2666979X23002136
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Efficient generation of functional neurons from mouse embryonic stem cells via neurogenin-2 expression

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Optimized protocol for the generation of functional human induced-pluripotent-stem-cell-derived dopaminergic neurons

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Pharmacological chaperones restore proteostasis of epilepsy-associated GABAA receptor variants

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Hominoid SVA-lncRNA AK057321 targets human-specific SVA retrotransposons in SCN8A and CDK5RAP2 to initiate neuronal maturation

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Mar 2023
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SYNGAP1 deficiency disrupts neoteny in human cortical neurons in vivo

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Neurotransmitter release progressively desynchronizes in induced human neurons during synapse maturation and aging

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Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons

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Tip60-mediated H2A.Z acetylation promotes neuronal fate specification and bivalent gene activation

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Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies

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CASK loss of function differentially regulates neuronal maturation and synaptic function in human induced cortical excitatory neurons

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  Addgene_20342
  
  DOI: 10.1016/j.isci.2022.105187
  
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In vitro neurons learn and exhibit sentience when embodied in a simulated game-world

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Induced retinal pigment epithelial cells with anti-epithelial-to-mesenchymal transition ability delay retinal degeneration

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Jun 2022
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Mapping cis-regulatory elements in human neurons links psychiatric disease heritability and activity-regulated transcriptional programs

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May 2022
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Glioblastoma Embryonic-like Stem Cells Exhibit Immune-Evasive Phenotype

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ncbi.nlm.nih.gov/pmc/articles/PMC9104850/
Nov 2021
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Rapid generation of murine haploid-induced trophoblast stem cells via a Tet-on system

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Oct 2021
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A synaptic temperature sensor for body cooling

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  DOI: 10.1016/j.neuron.2021.10.001
  
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Untitled document

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  DOI: 10.1016/j.cell.2016.12.036
  
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Interspecies Chimerism with Mammalian Pluripotent Stem Cells

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  DOI: 10.1016/j.cell.2016.12.036
  
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Neuromodulator Signaling Bidirectionally Controls Vesicle Numbers in Human Synapses

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  FUW-rtTA (lentiviral vector)
  
  DOI: 10.1016/j.cell.2019.09.011
  
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Xenotransplanted Human Cortical Neurons Reveal Species-Specific Development and Functional Integration into Mouse Visual Circuits

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Sox2 and Klf4 as the Functional Core in Pluripotency Induction without Exogenous Oct4

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Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment

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Using the dCas9-KRAB system to repress gene expression in hiPSC-derived NGN2 neurons

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Neuron and astrocyte aggregation and sorting in three-dimensional neuronal constructs

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Transformative Network Modeling of Multi-omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer’s Disease

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Mar 2021
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H3.3-K27M drives neural stem cell-specific gliomagenesis in a human iPSC-derived model

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Feb 2021
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Dyshomeostatic modulation of Ca2+-activated K+ channels in a human neuronal model of KCNQ2 encephalopathy

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  DOI: 10.7554/eLife.64434
  
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elifesciences.org/articles/64434
Dec 2020
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Master Regulators and Cofactors of Human Neuronal Cell Fate Specification Identified by CRISPR Gene Activation Screens

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Oct 2020
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Identification of a dynamic gene regulatory network required for pluripotency factor‐induced reprogramming of mouse fibroblasts and hepatocytes

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  DOI: 10.15252/embj.2019102236
  
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embopress.org/doi/full/10.15252/embj.2019102236
Jan 2020
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Pioneer Factor NeuroD1 Rearranges Transcriptional and Epigenetic Profiles to Execute Microglia-Neuron Conversion

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sciencedirect.com/science/article/pii/S0896627318310869

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