Hypothesis

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Aug 2025
52.53.155.43 52.53.155.43

preprints202508.0115.v1-html.html

1
1. scibot 14 Aug 2025
  
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  Addgene_22418
  
  DOI: 10.20944/preprints202508.0115.v1
  
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52.53.155.43/404097c13a1856caf19c4b99d86ab0e9a3c47028/preprints202508.0115.v1-html.html
Jul 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

CAMKKβ supports growth and viability of epithelial ovarian cancer in vitro and in vivo

1
1. scibot 22 Jul 2025
  
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  RRID:Addgene_22418
  
  DOI: 10.1038/s41598-025-11584-9
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12271461/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Tetrandrine augments melanoma cell immunogenicity via dual inhibition of autophagic flux and proteasomal activity enhancing MHC-I presentation

1
1. scibot 20 Jul 2025
  
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  22418
  
  DOI: 10.1038/s41401-025-01507-9
  
  Resource: RRID:Addgene_22418
  
  Curator: @olekpark
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12205077/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Impaired Autophagic Flux in Skeletal Muscle of Plectin‐Related Epidermolysis Bullosa Simplex With Muscular Dystrophy

1
1. scibot 20 Jul 2025
  
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  22418
  
  DOI: 10.1002/jcsm.70001
  
  Resource: RRID:Addgene_22418
  
  Curator: @olekpark
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12246382/
Jun 2025
www.sciencedirect.com www.sciencedirect.com

The evolutionarily conserved PRP4K-CHMP4B/vps32 splicing circuit regulates autophagy

1
1. scibot 18 Jun 2025
  
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  Addgene_22418
  
  DOI: 10.1016/j.celrep.2025.115870
  
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sciencedirect.com/science/article/pii/S2211124725006412
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Autophagy-enhancing strategies to promote intestinal viral resistance and mucosal barrier function in SARS-CoV-2 infection

1
1. scibot 14 Jun 2025
  
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  22,418
  
  DOI: 10.1080/27694127.2025.2514232
  
  Resource: RRID:Addgene_22418
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12153388/
Oct 2024
link.springer.com link.springer.com

Apache is a neuronal player in autophagy required for retrograde axonal transport of autophagosomes

1
1. scibot 08 Oct 2024
  
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  RRID:Addgene_22418
  
  DOI: 10.1007/s00018-024-05441-7
  
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link.springer.com/article/10.1007/s00018-024-05441-7
Sep 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Inhibition of ULK1/2 and KRASG12C controls tumor growth in preclinical models of lung cancer

1
1. scibot 29 Sep 2024
  
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  22418
  
  DOI: 10.7554/eLife.96992
  
  Resource: RRID:Addgene_22418
  
  Curator: @olekpark
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11364435/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Inhibition of Autophagy by Berbamine Hydrochloride Mitigates Tumor Immune Escape by Elevating MHC-I in Melanoma Cells

1
1. scibot 29 Sep 2024
  
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  22418
  
  DOI: 10.3390/cells13181537
  
  Resource: RRID:Addgene_22418
  
  Curator: @olekpark
  
  SciCrunch record: RRID:Addgene_22418
  
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  DOI:10.3390/cells13181537 RRID:Addgene_22418
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ncbi.nlm.nih.gov/pmc/articles/PMC11430705/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

All-trans retinoic acid induces lipophagy by reducing Rubicon in Hepa1c1c7 cells

1
1. scibot 28 Sep 2024
  
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  22418
  
  DOI: 10.1016/j.jlr.2024.100598
  
  Resource: RRID:Addgene_22418
  
  Curator: @olekpark
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11381443/
Jun 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Dengue virus exploits autophagy vesicles and secretory pathways to promote transmission by human dendritic cells

1
1. scibot 15 Jun 2024
  
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  22418
  
  DOI: 10.3389/fimmu.2024.1260439
  
  Resource: RRID:Addgene_22418
  
  Curator: @olekpark
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11165123/
May 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The gluconeogenesis enzyme PCK2 has a non-enzymatic role in proteostasis in endothelial cells

1
1. scibot 30 May 2024
  
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  RRID:Addgene_22418
  
  DOI: 10.1038/s42003-024-06186-6
  
  Resource: RRID:Addgene_22418
  
  Curator: @scibot
  
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  RRID:Addgene_22418
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ncbi.nlm.nih.gov/pmc/articles/PMC11116505/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Lysosomal dysfunction and overload of nucleosides in thymidine phosphorylase deficiency of MNGIE

1
1. scibot 19 May 2024
  
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  plasmid_22
  
  DOI: 10.1186/s12967-024-05275-8
  
  Resource: RRID:Addgene_22418
  
  Curator: @olekpark
  
  SciCrunch record: RRID:Addgene_22418
  
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  RRID:Addgene_22418 RRIDCUR:Incorrect RRIDCUR:Unresolved
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RRIDCUR:Incorrect

RRIDCUR:Unresolved

RRID:Addgene_22418

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ncbi.nlm.nih.gov/pmc/articles/PMC11089807/
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

High glucose-induced p66Shc mitochondrial translocation regulates autophagy initiation and autophagosome formation in syncytiotrophoblast and extravillous trophoblast

1
1. scibot 30 Apr 2024
  
  in Public
  
  pBABE-puro-mCherry-EGFP-LC3B
  
  DOI: 10.1186/s12964-024-01621-x
  
  Resource: RRID:Addgene_22418
  
  Curator: @olekpark
  
  SciCrunch record: RRID:Addgene_22418
  
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  RRID:Addgene_22418
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ncbi.nlm.nih.gov/pmc/articles/PMC11031965/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Transcription factor Nrf1 regulates proteotoxic stress-induced autophagy

1
1. scibot 30 Apr 2024
  
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  plasmid_22418
  
  DOI: 10.1083/jcb.202306150
  
  Resource: RRID:Addgene_22418
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_22418
  
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  RRID:Addgene_22418
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ncbi.nlm.nih.gov/pmc/articles/PMC11040505/
Mar 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Autophagy-enhancing ATG16L1 polymorphism is associated with improved clinical outcome and T-cell immunity in chronic HIV-1 infection

1
1. scibot 31 Mar 2024
  
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  22418
  
  DOI: 10.1038/s41467-024-46606-z
  
  Resource: RRID:Addgene_22418
  
  Curator: @olekpark
  
  SciCrunch record: RRID:Addgene_22418
  
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  RRID:Addgene_22418
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RRID:Addgene_22418

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ncbi.nlm.nih.gov/pmc/articles/PMC10979031/
Feb 2024
www.sciencedirect.com www.sciencedirect.com

In vivo CRISPR knockout screen identifies p47 as a suppressor of HER2+ breast cancer metastasis by regulating NEMO trafficking and autophagy flux

1
1. scibot 22 Feb 2024
  
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  Addgene Cat # 22418
  
  DOI: 10.1016/j.celrep.2024.113780
  
  Resource: RRID:Addgene_22418
  
  Curator: @abever99
  
  SciCrunch record: RRID:Addgene_22418
  
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  RRID:Addgene_22418
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sciencedirect.com/science/article/pii/S2211124724001086
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

NSD1 supports cell growth and regulates autophagy in HPV-negative head and neck squamous cell carcinoma

1
1. scibot 15 Feb 2024
  
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  22418
  
  DOI: 10.1038/s41420-024-01842-6
  
  Resource: RRID:Addgene_22418
  
  Curator: @olekpark
  
  SciCrunch record: RRID:Addgene_22418
  
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  RRID:Addgene_22418
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RRID:Addgene_22418

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ncbi.nlm.nih.gov/pmc/articles/PMC10861597/
Jul 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Combination Therapies with CDK4/6 Inhibitors to Treat KRAS-mutant Pancreatic Cancer

1
1. scibot 06 Jul 2023
  
  in Public
  
  RRID:Addgene_22418
  
  DOI: 10.1158/0008-5472.CAN-22-0391
  
  Resource: RRID:Addgene_22418
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_22418
  
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  RRID:Addgene_22418
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ncbi.nlm.nih.gov/pmc/articles/PMC9812941/
Jun 2023
www.sciencedirect.com www.sciencedirect.com

LC3B is lipidated to large lipid droplets during prolonged starvation for noncanonical autophagy

1
1. scibot 23 Jun 2023
  
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  RRID:Addgene_22418
  
  DOI: 10.1016/j.devcel.2023.05.009
  
  Resource: RRID:Addgene_22418
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_22418
  
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  RRID:Addgene_22418
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sciencedirect.com/science/article/pii/S1534580723002423
aacrjournals.org aacrjournals.org

Dysregulation of mitochondrial translation caused by CBFB deficiency cooperates with mutant PIK3CA and is a vulnerability in breast cancer

1
1. scibot 03 Jun 2023
  
  in Public
  
  RRID:Addgene_22418
  
  DOI: 10.1158/0008-5472.CAN-22-2525
  
  Resource: RRID:Addgene_22418
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_22418
  
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  RRID:Addgene_22418
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aacrjournals.org/cancerres/article/83/8/1280/725099/Dysregulation-of-Mitochondrial-Translation-Caused
Mar 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

VCP/p97, a pleiotropic protein regulator of the DNA damage response and proteostasis, is a potential therapeutic target in KRAS-mutant pancreatic cancer

1
1. scibot 16 Mar 2023
  
  in Public
  
  RRID:Addgene_22418
  
  DOI: 10.18632/genesandcancer.231
  
  Resource: RRID:Addgene_22418
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_22418
  
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  RRID:Addgene_22418
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RRID:Addgene_22418

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC10010283/
Feb 2023
www.nature.com www.nature.com

CTB-targeted protocells enhance ability of lanthionine ketenamine analogs to induce autophagy in motor neuron-like cells

1
1. scibot 15 Feb 2023
  
  in Public
  
  RRID:Addgene_22418
  
  DOI: 10.1038/s41598-023-29437-8
  
  Resource: RRID:Addgene_22418
  
  Curator: @a5munoz
  
  SciCrunch record: RRID:Addgene_22418
  
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  RRID:Addgene_22418
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nature.com/articles/s41598-023-29437-8
Dec 2022
www.sciencedirect.com www.sciencedirect.com

Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis

1
1. scibot 24 Dec 2022
  
  in Public
  
  RRID:Addgene_22418
  
  DOI: 10.1016/j.celrep.2022.111834
  
  Resource: RRID:Addgene_22418
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_22418
  
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  RRID:Addgene_22418
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sciencedirect.com/science/article/pii/S2211124722017260
Aug 2022
www.science.org www.science.org

Functional and biological heterogeneity of KRASQ61 mutations

1
1. scibot 23 Aug 2022
  
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  plasmid_22418
  
  DOI: 10.1126/scisignal.abn2694
  
  Resource: RRID:Addgene_22418
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_22418
  
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  RRID:Addgene_22418
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science.org/doi/10.1126/scisignal.abn2694
Dec 2021
www.sciencedirect.com www.sciencedirect.com

Undescribed polyether ionophores from Streptomyces cacaoi and their antibacterial and antiproliferative activities

1
1. scibot 16 Dec 2021
  
  in Public
  
  RRID:Addgene_22
  
  DOI: 10.1016/j.phytochem.2021.113038
  
  Resource: RRID:Addgene_22418
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_22418
  
  Curator comments: pBABE-puro mCherry-EGFP-LC3B
  
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  RRID:Addgene_22418 RRIDCUR:Unresolved RRIDCUR:SyntaxError
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RRIDCUR:SyntaxError

RRIDCUR:Unresolved

RRID:Addgene_22418

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URL

sciencedirect.com/science/article/pii/S0031942221003873
Oct 2021
journals.biologists.com journals.biologists.com

GRASP55 restricts early-stage autophagy and regulates spatial organization of the early secretory network

1
1. scibot 18 Oct 2021
  
  in Public
  
  RRID:Addgene_22418
  
  DOI: 10.1242/bio.058736
  
  Resource: RRID:Addgene_22418
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_22418
  
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  RRID:Addgene_22418
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journals.biologists.com/bio/article/10/10/bio058736/272440/GRASP55-restricts-early-stage-autophagy-and
Sep 2021
www.sciencedirect.com www.sciencedirect.com

PKCλ/ι inhibition activates an ULK2-mediated interferon response to repress tumorigenesis

1
1. scibot 24 Sep 2021
  
  in Public
  
  22418
  
  DOI: 10.1016/j.molcel.2021.08.039
  
  Resource: RRID:Addgene_22418
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_22418
  
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  RRIDCUR:Missing RRID:Addgene_22418
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RRIDCUR:Missing

RRID:Addgene_22418

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scibot

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sciencedirect.com/science/article/pii/S1097276521007292
Aug 2021
www.sciencedirect.com www.sciencedirect.com

RalA and PLD1 promote lipid droplet growth in response to nutrient withdrawal

1
1. scibot 14 Aug 2021
  
  in Public
  
  Addgene_22418
  
  DOI: 10.1016/j.celrep.2021.109451
  
  Resource: RRID:Addgene_22418
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_22418
  
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  RRID:Addgene_22418
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sciencedirect.com/science/article/pii/S2211124721008688
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer

1
1. scibot 14 Aug 2021
  
  in Public
  
  RRID:Addgene_22418
  
  DOI: 10.1038/s41591-019-0368-8
  
  Resource: RRID:Addgene_22418
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_22418
  
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  RRID:Addgene_22418
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ncbi.nlm.nih.gov/pmc/articles/PMC6484853/
Jul 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis

1
1. scibot 31 Jul 2021
  
  in Public
  
  RRID:Addgene_22418
  
  DOI: 10.7554/eLife.40811
  
  Resource: RRID:Addgene_22418
  
  Curator: @evieth
  
  SciCrunch record: RRID:Addgene_22418
  
  What is this?
  
  RRIDCUR:Validated RRID:Addgene_22418
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RRIDCUR:Validated

RRID:Addgene_22418

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ncbi.nlm.nih.gov/pmc/articles/PMC6389288/
May 2021
clincancerres.aacrjournals.org clincancerres.aacrjournals.org

G9a Inhibition Enhances Checkpoint Inhibitor Blockade Response in Melanoma

1
1. scibot 10 May 2021
  
  in Public
  
  RRID:Addgene_22418
  
  DOI: 10.1158/1078-0432.CCR-20-3463
  
  Resource: RRID:Addgene_22418
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_22418
  
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  RRID:Addgene_22418
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scibot

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clincancerres.aacrjournals.org/content/27/9/2624
Apr 2021
www.sciencedirect.com www.sciencedirect.com

PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression

1
1. scibot 17 Apr 2021
  
  in Public
  
  Cat# 22418
  
  DOI: 10.1016/j.ccell.2020.05.018
  
  Resource: RRID:Addgene_22418
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_22418
  
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  RRID:Addgene_22418 RRIDCUR:Missing
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RRIDCUR:Missing

RRID:Addgene_22418

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scibot

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sciencedirect.com/science/article/pii/S1535610820302683
Sep 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Adipocyte-specific Beclin1 deletion impairs lipolysis and mitochondrial integrity in adipose tissue

1
1. scibot 16 Sep 2020
  
  in Public
  
  RRID:Addgene_22418
  
  DOI: 10.1016/j.molmet.2020.101005
  
  Resource: RRID:Addgene_22418
  
  Curator: @evieth
  
  SciCrunch record: RRID:Addgene_22418
  
  What is this?
  
  RRIDCUR:Validated RRID:Addgene_22418
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RRIDCUR:Validated

RRID:Addgene_22418

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC7235646/
Jan 2020
www.sciencedirect.com www.sciencedirect.com

Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:Addgene_22418
  
  DOI: 10.1016/j.ebiom.2019.06.049
  
  Resource: RRID:Addgene_22418
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:Addgene_22418
  
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  RRID:Addgene_22418 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:Addgene_22418

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scibot

URL

sciencedirect.com/science/article/pii/S235239641930430X
www.nature.com www.nature.com

Untitled document

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:Addgene_22418
  
  DOI: 10.1038/s41591-019-0368-8
  
  Resource: RRID:Addgene_22418
  
  Curator: @evieth
  
  SciCrunch record: RRID:Addgene_22418
  
  What is this?
  
  RRID:Addgene_22418 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:Addgene_22418

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scibot

URL

nature.com/articles/s41591-019-0368-8
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:Addgene_22418
  
  DOI: 10.7554/eLife.40811
  
  Resource: RRID:Addgene_22418
  
  Curator: @evieth
  
  SciCrunch record: RRID:Addgene_22418
  
  What is this?
  
  RRID:Addgene_22418 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:Addgene_22418

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC6389288/