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A Hotspot Phosphorylation Site on SHP2 Drives Oncoprotein Activation and Drug Resistance

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1. scibot 07 Sep 2025
  
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  RRID:Addgene_25890
  
  DOI: 10.21203/rs.3.rs-7032881/v1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12340909/
Aug 2025
www.sciencedirect.com www.sciencedirect.com

ER-phagy and proteostasis defects prime pancreatic epithelial state changes in KRAS-mediated oncogenesis

1
1. scibot 19 Aug 2025
  
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  Plasmid_25890
  
  DOI: 10.1016/j.devcel.2025.07.016
  
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sciencedirect.com/science/article/pii/S1534580725004733
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Membrane-wide screening identifies potential tissue-specific determinants of SARS-CoV-2 tropism

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1. scibot 11 Aug 2025
  
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  25890
  
  DOI: 10.1371/journal.ppat.1013157
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12286382/
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A Hotspot Phosphorylation Site on SHP2 Drives Oncoprotein Activation and Drug Resistance

1
1. scibot 11 Aug 2025
  
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  RRID:Addgene_25890
  
  DOI: 10.1101/2025.06.11.659120
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12262427/
Jul 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Mechanism and Structure-Guided Optimization of SLC1A1/EAAT3-Selective Inhibitors in Kidney Cancer

1
1. scibot 23 Jul 2025
  
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  DOI: 10.1101/2025.07.03.663021
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12265667/
Jun 2025
www.nature.com www.nature.com

DMXL1 promotes recruitment of V1-ATPase to lysosomes upon TRPML1 activation

2
1. scibot 18 Jun 2025
  
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  Addgene, cat. no. 25890
  
  DOI: 10.1038/s41594-025-01581-x
  
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2. scibot 18 Jun 2025
  
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  Addgene, cat. no. 25890
  
  DOI: 10.1038/s41594-025-01581-x
  
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nature.com/articles/s41594-025-01581-x
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SWI/SNF ATPase silenced HLF potentiates lung metastasis in solid cancers

1
1. scibot 14 Jun 2025
  
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  25890
  
  DOI: 10.1038/s41467-025-60329-9
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12141477/
Apr 2025
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Radiotherapy promotes cuproptosis and synergizes with cuproptosis inducers to overcome tumor radioresistance

1
1. scibot 11 Apr 2025
  
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  AddgeneCat# 25890
  
  DOI: 10.1016/j.ccell.2025.03.031
  
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sciencedirect.com/science/article/pii/S1535610825001321
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Influenza virus antagonizes self sensing by RIG-I to enhance viral replication

1
1. scibot 07 Apr 2025
  
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  25890
  
  DOI: 10.1101/2025.03.12.642847
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11952396/
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PCSK5M452I is a recessive hypomorph exclusive to MCF10DCIS.com cells

1
1. scibot 07 Apr 2025
  
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  25890
  
  DOI: 10.1101/2025.03.03.641323
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11908202/
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Metabolic constraint of human telomere length by nucleotide salvage efficiency

1
1. scibot 07 Apr 2025
  
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  25890
  
  DOI: 10.1038/s41467-025-58221-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11950188/
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VIPAS39 confers ferroptosis resistance in epithelial ovarian cancer through exporting ACSL4

1
1. scibot 05 Apr 2025
  
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  25890
  
  DOI: 10.1016/j.ebiom.2025.105646
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11957506/
Mar 2025
www.sciencedirect.com www.sciencedirect.com

SOD2 is a regulator of proteasomal degradation promoting an adaptive cellular starvation response

1
1. scibot 29 Mar 2025
  
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  plasmid_25890
  
  DOI: 10.1016/j.celrep.2025.115434
  
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sciencedirect.com/science/article/pii/S2211124725002050
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1-s2.0-S2589004225001324-main-html.html

1
1. scibot 11 Mar 2025
  
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  25890
  
  DOI: 10.1016/j.isci.2025.111872
  
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sciencedirect.com/science/article/pii/S2589004225001324
Feb 2025
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TRIP13 protects pancreatic cancer cells against intrinsic and therapy-induced DNA replication stress

1
1. scibot 23 Feb 2025
  
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  Addgene_25890
  
  DOI: 10.1101/2025.01.26.634889
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11838190/
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Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer

1
1. scibot 16 Feb 2025
  
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  25890
  
  DOI: 10.1038/s41588-024-02058-1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11821538/
Jan 2025
www.sciencedirect.com www.sciencedirect.com

SLC7A5 is required for cancer cell growth under arginine-limited conditions

1
1. scibot 07 Jan 2025
  
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  Addgene_25890
  
  DOI: 10.1016/j.celrep.2024.115130
  
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sciencedirect.com/science/article/pii/S2211124724014815
Dec 2024
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MRGPRX4 mediates phospho-drug associated pruritus in a humanized mouse model

1
1. scibot 29 Dec 2024
  
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  pLX304
  
  DOI: 10.1126/scitranslmed.adk8198
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11645656/
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Suppression of ADP-ribosylation reversal triggers cell vulnerability to alkylating agents

1
1. scibot 27 Dec 2024
  
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  Addgene_25890
  
  DOI: 10.1016/j.neo.2024.101092
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11648251/
Sep 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

PDCD10 Is a Key Player in TMZ-Resistance and Tumor Cell Regrowth: Insights into Its Underlying Mechanism in Glioblastoma Cells

1
1. scibot 26 Sep 2024
  
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  plasmid_25890
  
  DOI: 10.3390/cells13171442
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11394141/
Jul 2024
www.biorxiv.org www.biorxiv.org

Regulation of cell–nanoparticle interactions through mechanobiology

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1. scibot 12 Jul 2024
  
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  RRID:Addgene_25890
  
  DOI: 10.1101/2024.07.07.599665
  
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biorxiv.org/content/10.1101/2024.07.07.599665v1
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SLC7A5 is required for citrulline-dependent growth in arginine limited conditions

1
1. scibot 03 Jul 2024
  
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  Addgene_25890
  
  DOI: 10.1101/2024.06.27.600869
  
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biorxiv.org/content/10.1101/2024.06.27.600869v1
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Testis-specific serine kinase 6 (TSSK6) is abnormally expressed in colorectal cancer and promotes oncogenic behaviors

1
1. scibot 01 Jul 2024
  
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  25890
  
  DOI: 10.1016/j.jbc.2024.107380
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11214309/
Jun 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

In Vivo Genome-Wide CRISPR Screening Identifies CITED2 as a Driver of Prostate Cancer Bone Metastasis

1
1. scibot 21 Jun 2024
  
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  Addgene_25890
  
  DOI: 10.1038/s41388-024-02995-5
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11101692/
May 2024
www.cell.com www.cell.com

ALK inhibitors suppress HCC and synergize with anti-PD-1 therapy and ABT-263 in preclinical models

1
1. scibot 10 May 2024
  
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  RRID:Addgene_25890
  
  DOI: 10.1016/j.isci.2024.109800
  
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cell.com/iscience/abstract/S2589-0042(24)01022-8
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Ligand-based virtual-screening identified a novel CFTR ligand which improves the defective cell surface expression of misfolded ABC transporters

1
1. scibot 30 Apr 2024
  
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  25890
  
  DOI: 10.3389/fphar.2024.1370676
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11043560/
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A Novel Class of Human ADAM8 Inhibitory Antibodies for Treatment of Triple-Negative Breast Cancer

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1. scibot 29 Apr 2024
  
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  25890
  
  DOI: 10.3390/pharmaceutics16040536
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11054802/
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Lysyl Oxidase Regulates Epithelial Differentiation and Barrier Integrity in Eosinophilic Esophagitis

1
1. scibot 23 Apr 2024
  
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  25890
  
  DOI: 10.1016/j.jcmgh.2024.01.025
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11026689/
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Adipose triglyceride lipase is a therapeutic target in advanced prostate cancer that promotes metabolic plasticity

1
1. scibot 19 Apr 2024
  
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  RRID:Addgene_25890
  
  DOI: 10.1158/0008-5472.CAN-23-0555
  
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aacrjournals.org/cancerres/article/84/5/703/734936/Adipose-Triglyceride-Lipase-Is-a-Therapeutic
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Context-dependent roles for ubiquitous mitochondrial creatine kinase CKMT1 in breast cancer progression

1
1. scibot 19 Apr 2024
  
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  RRID:Addgene_25890
  
  DOI: 10.1016/j.celrep.2024.114121
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11100297/
Mar 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Targeting Tryptophan Catabolism in Ovarian Cancer to Attenuate Macrophage Infiltration and PD-L1 Expression

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1. scibot 20 Mar 2024
  
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  RRID:Addgene_25890
  
  DOI: 10.1158/2767-9764.CRC-23-0513
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10946310/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

An engineered biosensor enables dynamic aspartate measurements in living cells

1
1. scibot 17 Mar 2024
  
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  25890
  
  DOI: 10.7554/eLife.90024
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10942590/
Feb 2024
52.53.155.43 52.53.155.43

HERC3 E3 ligase provides an ERAD branch eliminating select membrane proteins

1
1. scibot 23 Feb 2024
  
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  Addgene_25890
  
  DOI: 10.1101/2023.10.16.562477
  
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52.53.155.43/893a986f25098b75e101f0b7cb970068940c81b3/2023.10.16.562477v2.full-html.html
52.53.155.43 52.53.155.43

can-23-0555-html.html

3
1. scibot 23 Feb 2024
  
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  RRID:Addgene_25890
  
  DOI: 10.1158/0008-5472.can-23-0555
  
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2. scibot 23 Feb 2024
  
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  RRID:Addgene_25890
  
  DOI: 10.1158/0008-5472.can-23-0555
  
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3. scibot 23 Feb 2024
  
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  RRID:Addgene_25890
  
  DOI: 10.1158/0008-5472.can-23-0555
  
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52.53.155.43/e8db3efafb8a8253e8641e16f59e9a4a6a668dad/can-23-0555-html.html
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Combined BET and MEK Inhibition synergistically suppresses melanoma by targeting YAP1

1
1. scibot 13 Feb 2024
  
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  Addgene_25890
  
  DOI: 10.7150/thno.85437
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10758063/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

c-Fos regulated by TMPO/ERK axis promotes 5-FU resistance via inducing NANOG transcription in colon cancer

1
1. scibot 01 Feb 2024
  
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  25890
  
  DOI: 10.1038/s41419-024-06451-w
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10794174/
Sep 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Inhibition of Abelson Tyrosine-Protein Kinase 2 Suppresses the Development of Alcohol-Associated Liver Disease by Decreasing PPARgamma Expression

2
1. scibot 29 Sep 2023
  
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  RRID:Addgene_25890
  
  DOI: 10.1016/j.jcmgh.2023.07.006
  
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  DOI: 10.1016/j.jcmgh.2023.07.006
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10520367/
Aug 2023
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TIGIT can inhibit T cell activation via ligation-induced nanoclusters, independent of CD226 co-stimulation

1
1. scibot 24 Aug 2023
  
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  Plasmid_25890
  
  DOI: 10.1038/s41467-023-40755-3
  
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nature.com/articles/s41467-023-40755-3
Jun 2023
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Role of Nudt2 in Anchorage-Independent Growth and Cell Migration of Human Melanoma

1
1. scibot 27 Jun 2023
  
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  RRID:Addgene_25890
  
  DOI: 10.3390/ijms241310513
  
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mdpi.com/1422-0067/24/13/10513
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Intracellular pH dynamics regulates intestinal stem cell lineage specification

1
1. scibot 24 Jun 2023
  
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  Addgene_25890
  
  DOI: 10.1038/s41467-023-39312-9
  
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nature.com/articles/s41467-023-39312-9
May 2023
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Vangl-dependent Wnt/planar cell polarity signaling mediates collective breast carcinoma motility and distant metastasis

1
1. scibot 06 May 2023
  
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  RRID:Addgene_25890
  
  DOI: 10.1186/s13058-023-01651-2
  
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link.springer.com/article/10.1186/s13058-023-01651-2
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A Mesenchymal Tumor Cell State Confers Increased Dependency on the BCL-XL Anti-apoptotic Protein in Kidney Cancer

1
1. scibot 04 May 2023
  
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  RRID:Addgene_25890
  
  DOI: 10.1158/1078-0432.CCR-22-0669
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9633392/
Mar 2023
www.biorxiv.org www.biorxiv.org

YAP signaling regulates the cellular uptake and therapeutic effect of nanoparticles

1
1. scibot 16 Mar 2023
  
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  RRID:Addgene_25890
  
  DOI: 10.1101/2023.03.10.532035
  
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biorxiv.org/content/10.1101/2023.03.10.532035v1
Feb 2023
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Distinct but interchangeable subpopulations of colorectal cancer cells with different growth fates and drug sensitivity

1
1. scibot 01 Feb 2023
  
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  Addgene_25890
  
  DOI: 10.1016/j.isci.2023.105962
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9883198/
Sep 2022
journals.biologists.com journals.biologists.com

TGFBR3 supports anoikis through suppressing ATF4 signaling

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1. scibot 22 Sep 2022
  
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  DOI: 10.1242/jcs.258396
  
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journals.biologists.com/jcs/article/135/17/jcs258396/276460/TGFBR3-supports-anoikis-through-suppressing-ATF4
Jun 2022
www.sciencedirect.com www.sciencedirect.com

Supramolecular assembly of GSK3α as a cellular response to amino acid starvation

1
1. scibot 22 Jun 2022
  
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  plasmid_25890
  
  DOI: 10.1016/j.molcel.2022.05.025
  
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sciencedirect.com/science/article/pii/S1097276522004920
May 2022
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The AMPK-related kinase NUAK2 suppresses glutathione peroxidase 4 expression and promotes ferroptotic cell death in breast cancer cells

1
1. scibot 10 May 2022
  
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  RRID:Addgene_25890
  
  DOI: 10.1038/s41420-022-01044-y
  
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nature.com/articles/s41420-022-01044-y
Jan 2022
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Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion

1
1. scibot 26 Jan 2022
  
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  RRID:Addgene_25890
  
  DOI: 10.1016/j.celrep.2021.110227
  
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sciencedirect.com/science/article/pii/S2211124721017319
Oct 2021
www.jneurosci.org www.jneurosci.org

Metabolic control of sensory neuron survival by the p75 neurotrophin receptor in Schwann cells

1
1. scibot 27 Oct 2021
  
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  DOI: 10.1523/JNEUROSCI.3243-20.2021
  
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jneurosci.org/content/41/42/8710
Jul 2021
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Low-Level Saturated Fatty Acid Palmitate Benefits Liver Cells by Boosting Mitochondrial Metabolism via CDK1-SIRT3-CPT2 Cascade

1
1. scibot 30 Jul 2021
  
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  RRID: Addgene_25890
  
  DOI: 10.1016/j.devcel.2019.11.012
  
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sciencedirect.com/science/article/pii/S1534580719309438
Jun 2021
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Co-occurring gain-of-function mutations in HER2 and HER3 modulate HER2/HER3 activation, oncogenesis, and HER2 inhibitor sensitivity

1
1. scibot 25 Jun 2021
  
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sciencedirect.com/science/article/pii/S1535610821002841
May 2021
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Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease

2
1. scibot 21 May 2021
  
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  Cat# 25890
  
  DOI: 10.1016/j.molcel.2021.04.028
  
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2. scibot 21 May 2021
  
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  Addgene_25890
  
  DOI: 10.1016/j.molcel.2021.04.028
  
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sciencedirect.com/science/article/pii/S1097276521003579
clincancerres.aacrjournals.org clincancerres.aacrjournals.org

YAP1 Mediates Trametinib Resistance in Head and Neck Squamous Cell Carcinomas

1
1. scibot 10 May 2021
  
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  RRID:Addgene_25890
  
  DOI: 10.1158/1078-0432.CCR-19-4179
  
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clincancerres.aacrjournals.org/content/27/8/2326
Apr 2021
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MAX Functions as a Tumor Suppressor and Rewires Metabolism in Small Cell Lung Cancer

1
1. scibot 17 Apr 2021
  
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  Cat# 25890
  
  DOI: 10.1016/j.ccell.2020.04.016
  
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sciencedirect.com/science/article/pii/S1535610820302154
Feb 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

PCK1 and DHODH drive colorectal cancer liver metastatic colonization and hypoxic growth by promoting nucleotide synthesis

1
1. scibot 25 Feb 2021
  
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  RRID:Addgene_25890
  
  DOI: 10.7554/eLife.52135
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7299340/
www.cell.com www.cell.com

TMEM41B IS A PAN-FLAVIVIRUS HOST FACTOR

1
1. scibot 24 Feb 2021
  
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  RRID:Addgene_25890
  
  DOI: 10.1016/j.cell.2020.12.005
  
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cell.com/cell/abstract/S0092-8674(20)31627-5
Jan 2021
www.sciencedirect.com www.sciencedirect.com

NAD+ boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle

1
1. scibot 20 Jan 2021
  
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  Plasmid_25890
  
  DOI: 10.1016/j.celrep.2020.108660
  
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sciencedirect.com/science/article/pii/S2211124720316491
Sep 2020
www.jneurosci.org www.jneurosci.org

Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease Risk

1
1. scibot 26 Sep 2020
  
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  plasmid_25890
  
  DOI: 10.1523/JNEUROSCI.2994-18.2019
  
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jneurosci.org/content/39/37/7408
Jan 2020
www.sciencedirect.com www.sciencedirect.com

Genomic and Transcriptomic Determinants of Therapy Resistance and Immune Landscape Evolution during Anti-EGFR Treatment in Colorectal Cancer

1
1. scibot 13 Jan 2020
  
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  RRID:Addgene_25890
  
  DOI: 10.1016/j.ccell.2019.05.013
  
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sciencedirect.com/science/article/pii/S1535610819302557