80 Matching Annotations
  1. Jun 2026
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-wide CRISPR screen identifies a cytokine-enhancer circuit driving HIF-2α activation in renal cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13178659/
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Structure-guided optimization of SLC1A1/EAAT3-selective inhibitors targeting renal cancer metabolism
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC13226657/
  4. Apr 2026
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RHOV is a Detachment-Responsive Rho GTPase Necessary for Ovarian Cancer Peritoneal Metastasis
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC13089303/
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A hotspot phosphorylation site on SHP2 drives oncoprotein activation and drug resistance
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    pmc.ncbi.nlm.nih.gov/articles/PMC13066003/
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Integrative analysis of mRNA stability regulation uncovers a metastasis-suppressive program in breast cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12978252/
  8. Mar 2026
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Three-dimensional reconstruction of a biliary system in a bioengineered liver using decellularized scaffold
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    pmc.ncbi.nlm.nih.gov/articles/PMC12960976/
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A simple method for analyzing competitive growth of multiple cell types in xenograft tumors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12873974/
  11. Feb 2026
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Regulation of LRRK2 mRNA stability by ATIC and its substrate AICAR through ARE‐mediated mRNA decay in Parkinson's disease
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC10390876/
  13. Jan 2026
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TDP‐43 and APOE: A complex interaction
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    pmc.ncbi.nlm.nih.gov/articles/PMC12737955/
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Loss of EHMT2 enhances NK cell-driven anti-tumor immunity through TGF-β1 suppression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12808752/
  16. academic.oup.com academic.oup.com
    Androgen Receptors Promote Oxidative Phosphorylation and Resistance to Palmitate Lipotoxicity in ER-Mutant Breast Cancer
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    academic.oup.com/endo/article/167/1/bqaf168/8320418
  17. Dec 2025
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PCSK5M452I is a recessive hypomorph exclusive to MCF10DCIS.com cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12671455/
  19. Nov 2025
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The SLC1A1/EAAT3 dicarboxylic amino acid transporter is an epigenetically dysregulated nutrient carrier that sustains oncogenic metabolic programs
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12618888/
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The lipid droplet protein DHRS3 is a regulator of melanoma cell state
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12244328/
  22. Sep 2025
  23. www.sciencedirect.com www.sciencedirect.com
    PDE7A inhibition suppresses triple-negative breast cancer by attenuating de novo pyrimidine biosynthesis
    1
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    sciencedirect.com/science/article/pii/S266637912500429X
  24. www.sciencedirect.com www.sciencedirect.com
    NNMT-driven metabolic reprogramming creates a NAMPT druggable vulnerability and reveals liquid biopsy biomarkers for TKI resistance in EGFR-mutant NSCLC
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    sciencedirect.com/science/article/pii/S0304383525006020
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Hotspot Phosphorylation Site on SHP2 Drives Oncoprotein Activation and Drug Resistance
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    pmc.ncbi.nlm.nih.gov/articles/PMC12340909/
  26. Aug 2025
  27. www.sciencedirect.com www.sciencedirect.com
    ER-phagy and proteostasis defects prime pancreatic epithelial state changes in KRAS-mediated oncogenesis
    1
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    sciencedirect.com/science/article/pii/S1534580725004733
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Membrane-wide screening identifies potential tissue-specific determinants of SARS-CoV-2 tropism
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    pmc.ncbi.nlm.nih.gov/articles/PMC12286382/
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Hotspot Phosphorylation Site on SHP2 Drives Oncoprotein Activation and Drug Resistance
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    pmc.ncbi.nlm.nih.gov/articles/PMC12262427/
  30. Jul 2025
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mechanism and Structure-Guided Optimization of SLC1A1/EAAT3-Selective Inhibitors in Kidney Cancer
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12265667/
  32. Jun 2025
  33. www.nature.com www.nature.com
    DMXL1 promotes recruitment of V1-ATPase to lysosomes upon TRPML1 activation
    2
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    nature.com/articles/s41594-025-01581-x
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SWI/SNF ATPase silenced HLF potentiates lung metastasis in solid cancers
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    pmc.ncbi.nlm.nih.gov/articles/PMC12141477/
  35. Apr 2025
  36. www.sciencedirect.com www.sciencedirect.com
    Radiotherapy promotes cuproptosis and synergizes with cuproptosis inducers to overcome tumor radioresistance
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    sciencedirect.com/science/article/pii/S1535610825001321
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Influenza virus antagonizes self sensing by RIG-I to enhance viral replication
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    pmc.ncbi.nlm.nih.gov/articles/PMC11952396/
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PCSK5M452I is a recessive hypomorph exclusive to MCF10DCIS.com cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11908202/
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Metabolic constraint of human telomere length by nucleotide salvage efficiency
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    pmc.ncbi.nlm.nih.gov/articles/PMC11950188/
  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    VIPAS39 confers ferroptosis resistance in epithelial ovarian cancer through exporting ACSL4
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    pmc.ncbi.nlm.nih.gov/articles/PMC11957506/
  41. Mar 2025
  42. www.sciencedirect.com www.sciencedirect.com
    SOD2 is a regulator of proteasomal degradation promoting an adaptive cellular starvation response
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    sciencedirect.com/science/article/pii/S2211124725002050
  43. www.sciencedirect.com www.sciencedirect.com
    1-s2.0-S2589004225001324-main-html.html
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    sciencedirect.com/science/article/pii/S2589004225001324
  44. Feb 2025
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TRIP13 protects pancreatic cancer cells against intrinsic and therapy-induced DNA replication stress
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    pmc.ncbi.nlm.nih.gov/articles/PMC11838190/
  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11821538/
  47. Jan 2025
  48. www.sciencedirect.com www.sciencedirect.com
    SLC7A5 is required for cancer cell growth under arginine-limited conditions
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    sciencedirect.com/science/article/pii/S2211124724014815
  49. Dec 2024
  50. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MRGPRX4 mediates phospho-drug associated pruritus in a humanized mouse model
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    pmc.ncbi.nlm.nih.gov/articles/PMC11645656/
  51. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Suppression of ADP-ribosylation reversal triggers cell vulnerability to alkylating agents
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    pmc.ncbi.nlm.nih.gov/articles/PMC11648251/
  52. Sep 2024
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PDCD10 Is a Key Player in TMZ-Resistance and Tumor Cell Regrowth: Insights into Its Underlying Mechanism in Glioblastoma Cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11394141/
  54. Jul 2024
  55. www.biorxiv.org www.biorxiv.org
    Regulation of cell–nanoparticle interactions through mechanobiology
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    biorxiv.org/content/10.1101/2024.07.07.599665v1
  56. www.biorxiv.org www.biorxiv.org
    SLC7A5 is required for citrulline-dependent growth in arginine limited conditions
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    biorxiv.org/content/10.1101/2024.06.27.600869v1
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Testis-specific serine kinase 6 (TSSK6) is abnormally expressed in colorectal cancer and promotes oncogenic behaviors
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11214309/
  58. Jun 2024
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In Vivo Genome-Wide CRISPR Screening Identifies CITED2 as a Driver of Prostate Cancer Bone Metastasis
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    ncbi.nlm.nih.gov/pmc/articles/PMC11101692/
  60. May 2024
  61. www.cell.com www.cell.com
    ALK inhibitors suppress HCC and synergize with anti-PD-1 therapy and ABT-263 in preclinical models
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    cell.com/iscience/abstract/S2589-0042(24)01022-8
  62. Apr 2024
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ligand-based virtual-screening identified a novel CFTR ligand which improves the defective cell surface expression of misfolded ABC transporters
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11043560/
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Novel Class of Human ADAM8 Inhibitory Antibodies for Treatment of Triple-Negative Breast Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11054802/
  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lysyl Oxidase Regulates Epithelial Differentiation and Barrier Integrity in Eosinophilic Esophagitis
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    ncbi.nlm.nih.gov/pmc/articles/PMC11026689/
  66. aacrjournals.org aacrjournals.org
    Adipose triglyceride lipase is a therapeutic target in advanced prostate cancer that promotes metabolic plasticity
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    aacrjournals.org/cancerres/article/84/5/703/734936/Adipose-Triglyceride-Lipase-Is-a-Therapeutic
  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Context-dependent roles for ubiquitous mitochondrial creatine kinase CKMT1 in breast cancer progression
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    ncbi.nlm.nih.gov/pmc/articles/PMC11100297/
  68. Mar 2024
  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting Tryptophan Catabolism in Ovarian Cancer to Attenuate Macrophage Infiltration and PD-L1 Expression
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    ncbi.nlm.nih.gov/pmc/articles/PMC10946310/
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An engineered biosensor enables dynamic aspartate measurements in living cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10942590/
  71. Feb 2024
  72. 52.53.155.43 52.53.155.43
    HERC3 E3 ligase provides an ERAD branch eliminating select membrane proteins
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    52.53.155.43/893a986f25098b75e101f0b7cb970068940c81b3/2023.10.16.562477v2.full-html.html
  73. 52.53.155.43 52.53.155.43
    can-23-0555-html.html
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    52.53.155.43/e8db3efafb8a8253e8641e16f59e9a4a6a668dad/can-23-0555-html.html
  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Combined BET and MEK Inhibition synergistically suppresses melanoma by targeting YAP1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10758063/
  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    c-Fos regulated by TMPO/ERK axis promotes 5-FU resistance via inducing NANOG transcription in colon cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10794174/
  76. Sep 2023
  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of Abelson Tyrosine-Protein Kinase 2 Suppresses the Development of Alcohol-Associated Liver Disease by Decreasing PPARgamma Expression
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    ncbi.nlm.nih.gov/pmc/articles/PMC10520367/
  78. Aug 2023
  79. www.nature.com www.nature.com
    TIGIT can inhibit T cell activation via ligation-induced nanoclusters, independent of CD226 co-stimulation
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    nature.com/articles/s41467-023-40755-3
  80. Jun 2023
  81. www.mdpi.com www.mdpi.com
    Role of Nudt2 in Anchorage-Independent Growth and Cell Migration of Human Melanoma
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    mdpi.com/1422-0067/24/13/10513
  82. www.nature.com www.nature.com
    Intracellular pH dynamics regulates intestinal stem cell lineage specification
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    nature.com/articles/s41467-023-39312-9
  83. May 2023
  84. link.springer.com link.springer.com
    Vangl-dependent Wnt/planar cell polarity signaling mediates collective breast carcinoma motility and distant metastasis
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    link.springer.com/article/10.1186/s13058-023-01651-2
  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Mesenchymal Tumor Cell State Confers Increased Dependency on the BCL-XL Anti-apoptotic Protein in Kidney Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC9633392/
  86. Mar 2023
  87. www.biorxiv.org www.biorxiv.org
    YAP signaling regulates the cellular uptake and therapeutic effect of nanoparticles
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    biorxiv.org/content/10.1101/2023.03.10.532035v1
  88. Feb 2023
  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Distinct but interchangeable subpopulations of colorectal cancer cells with different growth fates and drug sensitivity
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    ncbi.nlm.nih.gov/pmc/articles/PMC9883198/
  90. Sep 2022
  91. journals.biologists.com journals.biologists.com
    TGFBR3 supports anoikis through suppressing ATF4 signaling
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    journals.biologists.com/jcs/article/135/17/jcs258396/276460/TGFBR3-supports-anoikis-through-suppressing-ATF4
  92. Jun 2022
  93. www.sciencedirect.com www.sciencedirect.com
    Supramolecular assembly of GSK3α as a cellular response to amino acid starvation
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    sciencedirect.com/science/article/pii/S1097276522004920
  94. May 2022
  95. www.nature.com www.nature.com
    The AMPK-related kinase NUAK2 suppresses glutathione peroxidase 4 expression and promotes ferroptotic cell death in breast cancer cells
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    nature.com/articles/s41420-022-01044-y
  96. Jan 2022
  97. www.sciencedirect.com www.sciencedirect.com
    Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion
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    sciencedirect.com/science/article/pii/S2211124721017319
  98. Oct 2021
  99. www.jneurosci.org www.jneurosci.org
    Metabolic control of sensory neuron survival by the p75 neurotrophin receptor in Schwann cells
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    jneurosci.org/content/41/42/8710
  100. Jul 2021
  101. www.sciencedirect.com www.sciencedirect.com
    Low-Level Saturated Fatty Acid Palmitate Benefits Liver Cells by Boosting Mitochondrial Metabolism via CDK1-SIRT3-CPT2 Cascade
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    sciencedirect.com/science/article/pii/S1534580719309438
  102. Jun 2021
  103. www.sciencedirect.com www.sciencedirect.com
    Co-occurring gain-of-function mutations in HER2 and HER3 modulate HER2/HER3 activation, oncogenesis, and HER2 inhibitor sensitivity
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    sciencedirect.com/science/article/pii/S1535610821002841
  104. May 2021
  105. www.sciencedirect.com www.sciencedirect.com
    Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease
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    sciencedirect.com/science/article/pii/S1097276521003579
  106. clincancerres.aacrjournals.org clincancerres.aacrjournals.org
    YAP1 Mediates Trametinib Resistance in Head and Neck Squamous Cell Carcinomas
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    clincancerres.aacrjournals.org/content/27/8/2326
  107. Apr 2021
  108. www.sciencedirect.com www.sciencedirect.com
    MAX Functions as a Tumor Suppressor and Rewires Metabolism in Small Cell Lung Cancer
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    sciencedirect.com/science/article/pii/S1535610820302154
  109. Feb 2021
  110. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PCK1 and DHODH drive colorectal cancer liver metastatic colonization and hypoxic growth by promoting nucleotide synthesis
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    ncbi.nlm.nih.gov/pmc/articles/PMC7299340/
  111. www.cell.com www.cell.com
    TMEM41B IS A PAN-FLAVIVIRUS HOST FACTOR
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    cell.com/cell/abstract/S0092-8674(20)31627-5
  112. Jan 2021
  113. www.sciencedirect.com www.sciencedirect.com
    NAD+ boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle
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    sciencedirect.com/science/article/pii/S2211124720316491
  114. Sep 2020
  115. www.jneurosci.org www.jneurosci.org
    Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease Risk
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    jneurosci.org/content/39/37/7408
  116. Jan 2020
  117. www.sciencedirect.com www.sciencedirect.com
    Genomic and Transcriptomic Determinants of Therapy Resistance and Immune Landscape Evolution during Anti-EGFR Treatment in Colorectal Cancer
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    sciencedirect.com/science/article/pii/S1535610819302557