69 Matching Annotations
  1. Last 7 days
  2. www.sciencedirect.com www.sciencedirect.com
    A genome-scale adaptation map identifies the FANCM-RMI1/2 complex as an opposing modulator of cell fitness upon BRCA1 or BRCA2 loss
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    sciencedirect.com/science/article/pii/S109727652600660X
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    G-quadruplex structures are key regulators of mammalian spermatogenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12865992/
  4. Sep 2026
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting LDHA Palmitoylation Sensitizes GBM to Chemoradiotherapy via Suppressing Palmitic Acid Induced Glycolytic Reprogramming
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    pmc.ncbi.nlm.nih.gov/articles/PMC13618168/
  6. Jul 2026
  7. aacrjournals.org aacrjournals.org
    A Peptide-Based PROTAC Degrader of BRCA2 Sensitizes Metastatic Castration-Resistant Prostate Cancer to PARP Inhibition
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    aacrjournals.org/cancerres/article/85/18/3490/764450/A-Peptide-Based-PROTAC-Degrader-of-BRCA2
  8. Dec 2025
  9. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    Serotonin-licensed macrophages potentiate chemoresistance via inositol metabolic crosstalk in ovarian cancer
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    sciencedirect.com:5037/science/article/pii/S1550413125004954
  10. Nov 2025
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cisplatin-mediated activation of NF-κB promotes lung cancer stem cell formation via DNA repair pathways
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    pmc.ncbi.nlm.nih.gov/articles/PMC12639660/
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting RAD52 overcomes PARP inhibitor resistance in preclinical Brca2-deficient ovarian cancer model
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    pmc.ncbi.nlm.nih.gov/articles/PMC12485677/
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A novel biguanide-derivative promotes NEDD4-mediated FGFR1 ubiquitination through BMI1 to overcome osimertinib resistance in NSCLC
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    pmc.ncbi.nlm.nih.gov/articles/PMC12624813/
  14. Oct 2025
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CRISPR Screen Identifies HDAC3 as a Novel Radiosensitizing Target in Small Cell Lung Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12493205/
  16. Aug 2025
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Ivabradine induces RAD51 degradation, potentiating PARP inhibitor efficacy in non-germline BRCA pathogenic variant triple-negative breast cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12323259/
  18. Jul 2025
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SIK2 inhibitor SIC-19 enhances the sensitivity of PARP inhibitors in triple-negative breast cancers and pancreatic cancers
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    pmc.ncbi.nlm.nih.gov/articles/PMC12215576/
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    FANCA Deficiency Induces Oncogenic R-Loop Dependent Synthetic Lethality with PARP1 Inhibitors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12236914/
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    G6PC3 promotes genome maintenance and is a candidate mammary tumor suppressor
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    pmc.ncbi.nlm.nih.gov/articles/PMC12220951/
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Steroid‐Modulated Transcription Synergistically Forms DNA Double‐Strand Breaks With Topoisomerase II Inhibitor
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    pmc.ncbi.nlm.nih.gov/articles/PMC12210024/
  23. Jun 2025
  24. pubs.acs.org pubs.acs.org
    Exploring the Potential of Homologous Recombination Protein PALB2 in Synthetic Lethal Combinations
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    pubs.acs.org/doi/full/10.1021/acschembio.5c00111
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Nuclear VPS35 attenuates NHEJ repair by sequestering Ku protein
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    pmc.ncbi.nlm.nih.gov/articles/PMC12147292/
  26. May 2025
  27. 52.53.155.43 52.53.155.43
    PDF-html.html
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    52.53.155.43/934070a9a2d77450bd4205d4f9ad5da4d7cdf39e/PDF-html.html
  28. pubs.acs.org pubs.acs.org
    Exploring the Potential of Homologous Recombination Protein PALB2 in Synthetic Lethal Combinations
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    pubs.acs.org/doi/full/10.1021/acschembio.5c00111
  29. Apr 2025
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Interleukin-33 (IL-33) promotes DNA damage-resistance in lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11992107/
  31. www.sciencedirect.com www.sciencedirect.com
    DSCC1 restrains 53BP1/RIF1 signaling at DNA double-strand breaks to promote homologous recombination repair
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    sciencedirect.com/science/article/pii/S2211124725002232
  32. Mar 2025
  33. academic.oup.com academic.oup.com
    Homeodomain protein PRRX1 anchors the Ku heterodimers at DNA double-strand breaks to promote nonhomologous end-joining
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    academic.oup.com/nar/article/53/6/gkaf200/8089753
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting platinum-resistant ovarian cancer by disrupting histone and RAD51 lactylation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11898288/
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Inhibition of Cyclin D1 by Novel Biguanide Derivative YB-004 Increases the Sensitivity of Bladder Cancer to Olaparib via Causing G0 / G1 Arrest
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    pmc.ncbi.nlm.nih.gov/articles/PMC11900825/
  36. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Targeting Replication Fork Processing Synergizes with PARP Inhibition to Potentiate Lethality in Homologous Recombination Proficient Ovarian Cancers
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202410718
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cell Type Specific Suppression of Hyper-Recombination by Human RAD18 Is Linked to Proliferating Cell Nuclear Antigen K164 Ubiquitination
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    pmc.ncbi.nlm.nih.gov/articles/PMC11763143/
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Repression of PFKFB3 sensitizes ovarian cancer to PARP inhibitors by impairing homologous recombination repair
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    pmc.ncbi.nlm.nih.gov/articles/PMC11762855/
  39. Jan 2025
  40. www.nature.com www.nature.com
    Homologous recombination promotes non-immunogenic mitotic cell death upon DNA damage
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    nature.com/articles/s41556-024-01557-x
  41. Dec 2024
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Oleanolic Acid Modulates DNA Damage Response to Camptothecin Increasing Cancer Cell Death
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    pmc.ncbi.nlm.nih.gov/articles/PMC11676975/
  43. Nov 2024
  44. www.sciencedirect.com www.sciencedirect.com
    Distinct effects of sacituzumab govitecan and berzosertib on DNA damage response in ovarian cancer
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    sciencedirect.com/science/article/pii/S2589004224025082
  45. Sep 2024
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance
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    ncbi.nlm.nih.gov/pmc/articles/PMC11254748/
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Loss of tet methyl cytosine dioxygenase 3 (TET3) enhances cardiac fibrosis via modulating the DNA damage repair response
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    ncbi.nlm.nih.gov/pmc/articles/PMC11350970/
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    L3MBTL1, a polycomb protein, promotes Osimertinib acquired resistance through epigenetic regulation of DNA damage response in lung adenocarcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC11374981/
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RAD52 resolves transcription-replication conflicts to mitigate R-loop induced genome instability
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    ncbi.nlm.nih.gov/pmc/articles/PMC11377823/
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Synergistic Effect of Ubiquitin-Specific Protease 14 and Poly(ADP-Ribose) Glycohydrolase Co-Inhibition in BRCA1-Mutant, Poly(ADP-Ribose) Polymerase Inhibitor-Resistant Triple-Negative Breast Cancer Cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11385694/
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NEK6 dampens FOXO3 nuclear translocation to stabilize C-MYC and promotes subsequent de novo purine synthesis to support ovarian cancer chemoresistance
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    ncbi.nlm.nih.gov/pmc/articles/PMC11387829/
  52. www.sciencedirect.com www.sciencedirect.com
    Characterization of DNA damage repair pathway utilization in high-grade serous ovarian cancers yields rational therapeutic approaches
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    sciencedirect.com/science/article/pii/S1936523324002468
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of Aberrantly Overexpressed Polo-like Kinase 4 Is a Potential Effective Treatment for DNA Damage Repair–Deficient Uterine Leiomyosarcoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC11369621/
  54. Aug 2024
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Synergistic combination of RAD51-SCR7 improves CRISPR-Cas9 genome editing efficiency by preventing R-loop accumulation
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    ncbi.nlm.nih.gov/pmc/articles/PMC11331969/
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PARP inhibitors suppress tumours via centrosome error-induced senescence independent of DNA damage response
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    ncbi.nlm.nih.gov/pmc/articles/PMC11052917/
  57. Jul 2024
  58. www.biorxiv.org www.biorxiv.org
    Homologous recombination promotes mitotic death to suppress the innate immune response
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    biorxiv.org/content/10.1101/2024.05.04.592546v1
  59. Jun 2024
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HELLS regulates transcription in T-cell lymphomas by reducing unscheduled R-loops and by facilitating RNAPII progression
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    ncbi.nlm.nih.gov/pmc/articles/PMC11194065/
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    UCHL3 induces radiation resistance and acquisition of mesenchymal phenotypes by deubiquitinating POLD4 in glioma stem cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11149539/
  62. Apr 2024
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Somatic mutations in four novel genes contribute to homologous recombination deficiency in breast cancer: a real‐world clinical tumor sequencing study
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    ncbi.nlm.nih.gov/pmc/articles/PMC10951049/
  64. Mar 2024
  65. www.nature.com www.nature.com
    CDK9-55 guides the anaphase-promoting complex/cyclosome (APC/C) in choosing the DNA repair pathway choice
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    nature.com/articles/s41388-024-02982-w
  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PRMT5-mediated homologous recombination repair is essential to maintain genomic integrity of neural progenitor cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10923982/
  67. Jan 2024
  68. www.sciencedirect.com www.sciencedirect.com
    Tolerance to colibactin correlates with homologous recombination proficiency and resistance to irinotecan in colorectal cancer cells
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    sciencedirect.com/science/article/pii/S2666379123006055
  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FAK Drives Resistance to Therapy in HPV-Negative Head and Neck Cancer in a p53-Dependent Manner
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    ncbi.nlm.nih.gov/pmc/articles/PMC10767302/
  70. Dec 2023
  71. link.springer.com link.springer.com
    PRAME induces genomic instability in uveal melanoma
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    link.springer.com/article/10.1038/s41388-023-02887-0
  72. Nov 2023
  73. www.nature.com www.nature.com
    Repression of LSD1 potentiates homologous recombination-proficient ovarian cancer to PARP inhibitors through down-regulation of BRCA1/2 and RAD51
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    nature.com/articles/s41467-023-42850-x
  74. Oct 2023
  75. www.sciencedirect.com www.sciencedirect.com
    Tyrosine catabolism enhances genotoxic chemotherapy by suppressing translesion DNA synthesis in epithelial ovarian cancer
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    sciencedirect.com/science/article/pii/S1550413123003716
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting MALAT1 Augments Sensitivity to PARP Inhibition by Impairing Homologous Recombination in Prostate Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10561629/
  77. Sep 2023
  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TLK1-mediated RAD54 phosphorylation spatio-temporally regulates Homologous Recombination Repair
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    ncbi.nlm.nih.gov/pmc/articles/PMC10484734/
  79. Jul 2023
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The hydrophilic extract from a new tomato genotype (named DHO) kills cancer cell lines through the modulation of the DNA damage response induced by Campthotecin treatment
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    ncbi.nlm.nih.gov/pmc/articles/PMC10318356/
  81. May 2023
  82. www.mdpi.com www.mdpi.com
    Global Genome Demethylation Causes Transcription-Associated DNA Double Strand Breaks in HPV-Associated Head and Neck Cancer Cells
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    mdpi.com/2072-6694/13/1/21
  83. Apr 2023
  84. link.springer.com link.springer.com
    SARS-CoV-2 viral protein Nsp2 stimulates translation under normal and hypoxic conditions
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    link.springer.com/article/10.1186/s12985-023-02021-2
  85. Aug 2022
  86. molecular-cancer.biomedcentral.com molecular-cancer.biomedcentral.com
    BTApep-TAT peptide inhibits ADP-ribosylation of BORIS to induce DNA damage in cancer
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    molecular-cancer.biomedcentral.com/articles/10.1186/s12943-022-01621-w
  87. May 2022
  88. www.sciencedirect.com www.sciencedirect.com
    A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination
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    sciencedirect.com/science/article/pii/S109727652200394X
  89. Apr 2022
  90. aacrjournals.org aacrjournals.org
    Loss of Claudin-4 Reduces DNA Damage Repair and Increases Sensitivity to PARP Inhibitors
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    aacrjournals.org/mct/article/21/4/647/689566/Loss-of-Claudin-4-Reduces-DNA-Damage-Repair-and
  91. Aug 2021
  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Depletion of the RNA binding protein HNRNPD impairs homologous recombination by inhibiting DNA-end resection and inducing R-loop accumulation
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    ncbi.nlm.nih.gov/pmc/articles/PMC6486545/
  93. cancerres.aacrjournals.org cancerres.aacrjournals.org
    SHP2-Mediated Inhibition of DNA Repair Contributes to cGAS–STING Activation and Chemotherapeutic Sensitivity in Colon Cancer
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    cancerres.aacrjournals.org/content/81/12/3215
  94. Jul 2021
  95. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Human RECQL4 represses the RAD52‐mediated single‐strand annealing pathway after ionizing radiation or cisplatin treatment
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    onlinelibrary.wiley.com/doi/full/10.1002/ijc.32670
  96. May 2021
  97. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting HR Repair as a Synthetic Lethal Approach to Increase DNA Damage Sensitivity by a RAD52 Inhibitor in BRCA2-Deficient Cancer Cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC8122931/
  98. Dec 2020
  99. www.mdpi.com www.mdpi.com
    Global Genome Demethylation Causes Transcription-Associated DNA Double Strand Breaks in HPV-Associated Head and Neck Cancer Cells
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    mdpi.com/2072-6694/13/1/21
  100. Oct 2020
  101. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    TGFβR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment
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    pubmed.ncbi.nlm.nih.gov/33027668/
  102. Sep 2020
  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiates the DNA damage response and repair in humans and mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC7324161/
  104. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FOXL2 directs DNA double-strand break repair pathways by differentially interacting with Ku
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    ncbi.nlm.nih.gov/pmc/articles/PMC7181608/
  105. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RB1 Deletion in Retinoblastoma Protein Pathway-Disrupted Cells Results in DNA Damage and Cancer Progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC6664603/
  106. Jan 2020
  107. academic.oup.com academic.oup.com
    Untitled document
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    academic.oup.com/nar/advance-article/doi/10.1093/nar/gkz076/5364135