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DSCC1 restrains 53BP1/RIF1 signaling at DNA double-strand breaks to promote homologous recombination repair

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1. scibot 01 Apr 2025
  
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  AddgeneCat#26477
  
  DOI: 10.1016/j.celrep.2025.115452
  
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sciencedirect.com/science/article/pii/S2211124725002232
Mar 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Targeting platinum-resistant ovarian cancer by disrupting histone and RAD51 lactylation

1
1. scibot 23 Mar 2025
  
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  26477
  
  DOI: 10.7150/thno.104858
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11898288/
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Inhibition of Cyclin D1 by Novel Biguanide Derivative YB-004 Increases the Sensitivity of Bladder Cancer to Olaparib via Causing G0 / G1 Arrest

1
1. scibot 23 Mar 2025
  
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  26477
  
  DOI: 10.7150/ijbs.105072
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11900825/
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Targeting FOXP1 phase separation in small cell lung cancer mechanisms of chemotherapy resistance

1
1. scibot 23 Mar 2025
  
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  Addgene_26477
  
  DOI: 10.1038/s42003-025-07804-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11906602/
advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com

Targeting Replication Fork Processing Synergizes with PARP Inhibition to Potentiate Lethality in Homologous Recombination Proficient Ovarian Cancers

1
1. scibot 20 Mar 2025
  
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  RRID:Addgene_26477
  
  DOI: 10.1002/advs.202410718
  
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advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202410718
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Cell Type Specific Suppression of Hyper-Recombination by Human RAD18 Is Linked to Proliferating Cell Nuclear Antigen K164 Ubiquitination

1
1. scibot 11 Mar 2025
  
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  26477
  
  DOI: 10.3390/biom15010150
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11763143/
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Repression of PFKFB3 sensitizes ovarian cancer to PARP inhibitors by impairing homologous recombination repair

1
1. scibot 11 Mar 2025
  
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  26,477
  
  DOI: 10.1186/s12964-025-02056-8
  
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  RRID:Addgene_26477 DOI:10.1186/s12964-025-02056-8
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pmc.ncbi.nlm.nih.gov/articles/PMC11762855/
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The PST repeat region of MDC1 is a tunable multivalent chromatin tethering domain

1
1. scibot 11 Mar 2025
  
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  26477
  
  DOI: 10.1101/2025.01.10.632395
  
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  RRID:Addgene_26477 DOI:10.1101/2025.01.10.632395
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pmc.ncbi.nlm.nih.gov/articles/PMC11761366/
Feb 2025
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Inhibition of GSK3β is synthetic lethal with FHIT loss in lung cancer by blocking homologous recombination repair

1
1. scibot 16 Feb 2025
  
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  plasmid_26477
  
  DOI: 10.1038/s12276-024-01374-0
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11799392/
Jan 2025
www.nature.com www.nature.com

Homologous recombination promotes non-immunogenic mitotic cell death upon DNA damage

1
1. scibot 16 Jan 2025
  
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  RRID:Addgene_26477
  
  DOI: 10.1038/s41556-024-01557-x
  
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nature.com/articles/s41556-024-01557-x
Dec 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

BCAT1 Associates with DNA Repair Proteins KU70 and KU80 and Contributes to Regulate DNA Repair in T-Cell Acute Lymphoblastic Leukemia (T-ALL)

1
1. scibot 29 Dec 2024
  
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  Addgene_26477
  
  DOI: 10.3390/ijms252413571
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11676169/
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Oleanolic Acid Modulates DNA Damage Response to Camptothecin Increasing Cancer Cell Death

1
1. scibot 29 Dec 2024
  
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  plasmid_26477
  
  DOI: 10.3390/ijms252413475
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11676975/
www.cell.com www.cell.com

UBA1 inhibition sensitizes cancer cells to PARP inhibitors

1
1. scibot 05 Dec 2024
  
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  Addgene_26477
  
  DOI: 10.1016/j.xcrm.2024.101834
  
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cell.com/cell-reports-medicine/fulltext/S2666-3791(24)00605-0
Nov 2024
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Distinct effects of sacituzumab govitecan and berzosertib on DNA damage response in ovarian cancer

1
1. scibot 15 Nov 2024
  
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  AddgeneCat #26477
  
  DOI: 10.1016/j.isci.2024.111283
  
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sciencedirect.com/science/article/pii/S2589004224025082
Sep 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Loss of tet methyl cytosine dioxygenase 3 (TET3) enhances cardiac fibrosis via modulating the DNA damage repair response

1
1. scibot 29 Sep 2024
  
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  pCBASceI
  
  DOI: 10.1186/s13148-024-01719-6
  
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  RRID:Addgene_26477 DOI:10.1186/s13148-024-01719-6
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ncbi.nlm.nih.gov/pmc/articles/PMC11350970/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

RAD52 resolves transcription-replication conflicts to mitigate R-loop induced genome instability

1
1. scibot 28 Sep 2024
  
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  26477
  
  DOI: 10.1038/s41467-024-51784-x
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11377823/
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Synergistic Effect of Ubiquitin-Specific Protease 14 and Poly(ADP-Ribose) Glycohydrolase Co-Inhibition in BRCA1-Mutant, Poly(ADP-Ribose) Polymerase Inhibitor-Resistant Triple-Negative Breast Cancer Cells

1
1. scibot 28 Sep 2024
  
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  26477
  
  DOI: 10.2147/OTT.S463217
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11385694/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

NEK6 dampens FOXO3 nuclear translocation to stabilize C-MYC and promotes subsequent de novo purine synthesis to support ovarian cancer chemoresistance

1
1. scibot 27 Sep 2024
  
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  26477
  
  DOI: 10.1038/s41419-024-07045-2
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11387829/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

AXL inhibition prevents RPA2/CHK1-mediated homologous recombination to increase PARP inhibitor sensitivity in hepatocellular carcinoma

1
1. scibot 25 Sep 2024
  
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  pCBA-I-SceI
  
  DOI: 10.1016/j.heliyon.2024.e36283
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11399589/
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Characterization of DNA damage repair pathway utilization in high-grade serous ovarian cancers yields rational therapeutic approaches

1
1. scibot 17 Sep 2024
  
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  RRID:Addgene_26477
  
  DOI: 10.1016/j.tranon.2024.102119
  
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sciencedirect.com/science/article/pii/S1936523324002468
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Synergistic combination of RAD51-SCR7 improves CRISPR-Cas9 genome editing efficiency by preventing R-loop accumulation

1
1. scibot 26 Aug 2024
  
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  26477
  
  DOI: 10.1016/j.omtn.2024.102274
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11331969/
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Involvement of the splicing factor SART1 in the BRCA1-dependent homologous recombination repair of DNA double-strand breaks

1
1. scibot 22 Aug 2024
  
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  Addgene_26477
  
  DOI: 10.1038/s41598-024-68926-2
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11310344/
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PARP inhibitors suppress tumours via centrosome error-induced senescence independent of DNA damage response

1
1. scibot 13 Aug 2024
  
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  26477
  
  DOI: 10.1016/j.ebiom.2024.105129
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11052917/
Jul 2024
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FANCM promotes PARP inhibitor resistance by minimizing ssDNA gap formation and counteracting resection inhibition

1
1. scibot 17 Jul 2024
  
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  AddgeneCat #26477
  
  DOI: 10.1016/j.celrep.2024.114464
  
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sciencedirect.com/science/article/pii/S2211124724007939
www.nature.com www.nature.com

PARG is essential for Polθ-mediated DNA end-joining by removing repressive poly-ADP-ribose marks

4
1. scibot 16 Jul 2024
  
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  plasmid_26477
  
  DOI: 10.1038/s41467-024-50158-7
  
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2. scibot 16 Jul 2024
  
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  RRID:addgene_26477
  
  DOI: 10.1038/s41467-024-50158-7
  
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3. scibot 14 Jul 2024
  
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  plasmid_26477
  
  DOI: 10.1038/s41467-024-50158-7
  
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4. scibot 14 Jul 2024
  
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  RRID:addgene_26477
  
  DOI: 10.1038/s41467-024-50158-7
  
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nature.com/articles/s41467-024-50158-7
www.biorxiv.org www.biorxiv.org

Homologous recombination promotes mitotic death to suppress the innate immune response

1
1. scibot 09 Jul 2024
  
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  RRID:Addgene_26477
  
  DOI: 10.1101/2024.05.04.592546
  
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biorxiv.org/content/10.1101/2024.05.04.592546v1
Jun 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

ATM inhibition exploits checkpoint defects and ATM-dependent double strand break repair in TP53-mutant glioblastoma

1
1. scibot 25 Jun 2024
  
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  plasmid_26477
  
  DOI: 10.1038/s41467-024-49316-8
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11192742/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

UCHL3 induces radiation resistance and acquisition of mesenchymal phenotypes by deubiquitinating POLD4 in glioma stem cells

1
1. scibot 21 Jun 2024
  
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  26477
  
  DOI: 10.1007/s00018-024-05265-5
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11149539/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

ARID1A regulates DNA repair through chromatin organization and its deficiency triggers DNA damage-mediated anti-tumor immune response

1
1. scibot 15 Jun 2024
  
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  26477
  
  DOI: 10.1093/nar/gkae233
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11162808/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The novel SMYD3 inhibitor EM127 impairs DNA repair response to chemotherapy-induced DNA damage and reverses cancer chemoresistance

1
1. scibot 03 Jun 2024
  
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  26477
  
  DOI: 10.1186/s13046-024-03078-9
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11137994/
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Somatic mutations in four novel genes contribute to homologous recombination deficiency in breast cancer: a real‐world clinical tumor sequencing study

1
1. scibot 15 Apr 2024
  
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  26477
  
  DOI: 10.1002/2056-4538.12367
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10951049/
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DNA-PK and ATM drive phosphorylation signatures that antagonistically regulate cytokine responses to herpesvirus infection or DNA damage

2
1. scibot 12 Apr 2024
  
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  Addgene_26477
  
  DOI: 10.1016/j.cels.2024.03.003
  
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2. scibot 12 Apr 2024
  
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  Addgene_26477
  
  DOI: 10.1016/j.cels.2024.03.003
  
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sciencedirect.com/science/article/pii/S2405471224000887
Mar 2024
52.53.155.43 52.53.155.43

The immediate-early protein 1 of human herpesvirus 6B interacts with NBS1 and inhibits ATM signaling

3
1. scibot 19 Mar 2024
  
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  Addgene_26477
  
  DOI: 10.1038/s44319-023-00035-z
  
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2. scibot 19 Mar 2024
  
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  Addgene_26477
  
  DOI: 10.1038/s44319-023-00035-z
  
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3. scibot 01 Mar 2024
  
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  Addgene_26477
  
  DOI: 10.1038/s44319-023-00035-z
  
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52.53.155.43/85f3cfb5ea69a502f1e71c384533cb9dacfc2966/collin-et-al-2024-the-immediate-early-protein-1-of-human-herpesvirus-6b-interacts-with-nbs1-and-inhibits-atm-signaling-html.html
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Repression of the SUMO-conjugating enzyme UBC9 is associated with lowered double minutes and reduced tumor progression

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CDK9-55 guides the anaphase-promoting complex/cyclosome (APC/C) in choosing the DNA repair pathway choice

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  DOI: 10.1038/s41388-024-02982-w
  
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nature.com/articles/s41388-024-02982-w
Jan 2024
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Tolerance to colibactin correlates with homologous recombination proficiency and resistance to irinotecan in colorectal cancer cells

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  DOI: 10.1016/j.xcrm.2023.101376
  
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FAK Drives Resistance to Therapy in HPV-Negative Head and Neck Cancer in a p53-Dependent Manner

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  RRID:Addgene_26477
  
  DOI: 10.1158/1078-0432.CCR-23-0964
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10767302/
Dec 2023
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PRAME induces genomic instability in uveal melanoma

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link.springer.com/article/10.1038/s41388-023-02887-0
Nov 2023
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Widespread BRCA1/2-independent homologous recombination defects are caused by alterations in RNA-binding proteins

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Oct 2023
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Targeting MALAT1 Augments Sensitivity to PARP Inhibition by Impairing Homologous Recombination in Prostate Cancer

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ncbi.nlm.nih.gov/pmc/articles/PMC10561629/
Aug 2023
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Transforming Growth Factor Beta and Epithelial to Mesenchymal Transition Alter Homologous Recombination Repair Gene Expression and Sensitize BRCA Wild-Type Ovarian Cancer Cells to Olaparib

1
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ncbi.nlm.nih.gov/pmc/articles/PMC10417836/
Jul 2023
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The hydrophilic extract from a new tomato genotype (named DHO) kills cancer cell lines through the modulation of the DNA damage response induced by Campthotecin treatment

1
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  plasmid_26477
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10318356/
Jun 2023
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Transforming Growth Factor Beta and Epithelial to Mesenchymal Transition Alter Homologous Recombination Repair Gene Expression and Sensitize BRCA Wild Type Ovarian Cancer Cells to Olaparib

1
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  DOI: 10.20944/preprints202304.0327.v1
  
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52.53.155.43/71ce6d131c64aa7fc9989cc74f4998f83ebdb128/preprints202304.0327.v1-html.html
May 2023
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MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells

2
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  RRID: Addgene_26477
  
  DOI: 10.1016/j.celrep.2023.112484
  
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Apr 2023
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Modular antibodies reveal DNA damage-induced mono-ADP-ribosylation as a second wave of PARP1 signaling

1
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  plasmid_2647767
  
  DOI: 10.1016/j.molcel.2023.03.027
  
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Sep 2022
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Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair

1
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  plasmid_26477
  
  DOI: 10.15252/embr.202154136
  
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embopress.org/doi/10.15252/embr.202154136
Apr 2022
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Loss of Claudin-4 Reduces DNA Damage Repair and Increases Sensitivity to PARP Inhibitors

1
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  RRID:Addgene_26477
  
  DOI: 10.1158/1535-7163.MCT-21-0827
  
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aacrjournals.org/mct/article/21/4/647/689566/Loss-of-Claudin-4-Reduces-DNA-Damage-Repair-and
Dec 2021
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Local non-pituitary growth hormone is induced with aging and facilitates epithelial damage

1
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  RRID:Addgene_26477
  
  DOI: 10.1016/j.celrep.2021.110068
  
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sciencedirect.com/science/article/pii/S2211124721015540
Oct 2021
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Shift in MSL1 alternative polyadenylation in response to DNA damage protects cancer cells from chemotherapeutic agent-induced apoptosis

1
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  Addgene_26477
  
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sciencedirect.com/science/article/pii/S2211124721012791
Aug 2021
cancerres.aacrjournals.org cancerres.aacrjournals.org

SHP2-Mediated Inhibition of DNA Repair Contributes to cGAS–STING Activation and Chemotherapeutic Sensitivity in Colon Cancer

1
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  RRID:Addgene_26477
  
  DOI: 10.1158/0008-5472.CAN-20-3738
  
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cancerres.aacrjournals.org/content/81/12/3215
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Homologous recombination is reduced in female embryonic stem cells by two active X chromosomes

1
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  RRID:Addgene_26477
  
  DOI: 10.15252/embr.202052190
  
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embopress.org/doi/full/10.15252/embr.202052190
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Depletion of the RNA binding protein HNRNPD impairs homologous recombination by inhibiting DNA-end resection and inducing R-loop accumulation

1
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  plasmid_26477
  
  DOI: 10.1093/nar/gkz076
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6486545/
Jul 2021
academic.oup.com academic.oup.com

Untitled document

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  DOI: 10.1093/nar/gkz076
  
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academic.oup.com/nar/advance-article/doi/10.1093/nar/gkz076/5364135
onlinelibrary.wiley.com onlinelibrary.wiley.com

Human RECQL4 represses the RAD52‐mediated single‐strand annealing pathway after ionizing radiation or cisplatin treatment

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  Addgene_26477
  
  DOI: 10.1002/ijc.32670
  
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onlinelibrary.wiley.com/doi/full/10.1002/ijc.32670
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UPF1 promotes the formation of R loops to stimulate DNA double-strand break repair

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  DOI: 10.1038/s41467-021-24201-w
  
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nature.com/articles/s41467-021-24201-w
Jun 2021
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The nuclear kinesin KIF18B promotes 53BP1-mediated DNA double-strand break repair

1
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  Addgene_26477
  
  DOI: 10.1016/j.celrep.2021.109306
  
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sciencedirect.com/science/article/pii/S2211124721006823
May 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Targeting HR Repair as a Synthetic Lethal Approach to Increase DNA Damage Sensitivity by a RAD52 Inhibitor in BRCA2-Deficient Cancer Cells

1
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  RRID:Addgene_26477
  
  DOI: 10.3390/ijms22094422
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8122931/
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miR-1293, a candidate for miRNA-based cancer therapeutics, simultaneously targets BRD4 and the DNA repair pathway

1
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  DOI: 10.1016/j.ymthe.2020.04.001
  
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sciencedirect.com/science/article/pii/S1525001620301829
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Epigenetic Regulation of DNA Repair Pathway Choice by MacroH2A1 Splice Variants Ensures Genome Stability

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  DOI: 10.1016/j.molcel.2020.06.028
  
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sciencedirect.com/science/article/pii/S1097276520304305
Apr 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Elevated CXorf67 Expression in PFA Ependymomas Suppresses DNA Repair and Sensitizes to PARP Inhibitors

1
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  RRID: Addgene_26477
  
  DOI: 10.1016/j.ccell.2020.10.009
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8455074/
Feb 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

RB1 Deletion in Retinoblastoma Protein Pathway-Disrupted Cells Results in DNA Damage and Cancer Progression

1
1. scibot 24 Feb 2021
  
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  RRID:Addgene_26477
  
  DOI: 10.1128/MCB.00105-19
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6664603/
Jan 2021
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Chk1 promotes non-homologous end joining in G1 through direct phosphorylation of ASF1A

1
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  DOI: 10.1016/j.celrep.2020.108680
  
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sciencedirect.com/science/article/pii/S2211124720316697
Dec 2020
www.mdpi.com www.mdpi.com

Global Genome Demethylation Causes Transcription-Associated DNA Double Strand Breaks in HPV-Associated Head and Neck Cancer Cells

1
1. scibot 30 Dec 2020
  
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  RRID:Addgene_26477
  
  DOI: 10.3390/cancers13010021
  
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mdpi.com/2072-6694/13/1/21
Jan 2020
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53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination

1
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  RRID:Addgene_26477
  
  DOI: 10.1016/j.molcel.2019.09.024
  
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sciencedirect.com/science/article/pii/S1097276519307294
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Untitled document

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  DOI: 10.1093/nar/gkz076
  
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academic.oup.com/nar/advance-article/doi/10.1093/nar/gkz076/5364135