95 Matching Annotations
  1. Oct 2025
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CRISPR Screen Identifies HDAC3 as a Novel Radiosensitizing Target in Small Cell Lung Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12493205/
  3. Sep 2025
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NSUN2 facilitates DICER cleavage of DNA damage-associated R-loops to promote repair
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    pmc.ncbi.nlm.nih.gov/articles/PMC12374970/
  5. Aug 2025
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Tumor-derived CD84 promotes growth of acute myeloid leukemia cells via regulating nonhomologous DNA end-joining pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC12309267/
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PARP1 and PARP2 are dispensable for DNA repair by microhomology-mediated end-joining during mitosis
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12259053/
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Ivabradine induces RAD51 degradation, potentiating PARP inhibitor efficacy in non-germline BRCA pathogenic variant triple-negative breast cancer
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12323259/
  9. www.biorxiv.org www.biorxiv.org
    Using CCDC6 immunostaining in conjunction with the RAD51 HRD assay as a novel approach to expand PARPi treatment eligibility in HGSOC patients
    1
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    biorxiv.org/content/10.1101/2025.07.29.667411v1
  10. Jul 2025
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The E3 ubiquitin ligase DTX3L and the deubiquitinase USP28 fine-tune DNA repair through mutual regulation of their protein levels
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12283747/
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SIK2 inhibitor SIC-19 enhances the sensitivity of PARP inhibitors in triple-negative breast cancers and pancreatic cancers
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    pmc.ncbi.nlm.nih.gov/articles/PMC12215576/
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    FANCA Deficiency Induces Oncogenic R-Loop Dependent Synthetic Lethality with PARP1 Inhibitors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12236914/
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Steroid‐Modulated Transcription Synergistically Forms DNA Double‐Strand Breaks With Topoisomerase II Inhibitor
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    pmc.ncbi.nlm.nih.gov/articles/PMC12210024/
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12241572/
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PALB2 deficiency may sensitize H3K27M-mutant pediatric HGG cells to BMN673/talazoparib
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    pmc.ncbi.nlm.nih.gov/articles/PMC12256224/
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The human RIF1-Long isoform interacts with BRCA1 to promote recombinational fork repair under DNA replication stress
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    pmc.ncbi.nlm.nih.gov/articles/PMC12214830/
  18. Jun 2025
  19. pubs.acs.org pubs.acs.org
    Exploring the Potential of Homologous Recombination Protein PALB2 in Synthetic Lethal Combinations
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    pubs.acs.org/doi/full/10.1021/acschembio.5c00111
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    POLQ mediated end-joining promotes DNA damage tolerance in neuroblastoma
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12177186/
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Elevated nonhomologous end-joining by AATF enables efficient DNA damage repair and therapeutic resistance in glioblastoma
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12120020/
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Nuclear VPS35 attenuates NHEJ repair by sequestering Ku protein
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12147292/
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Rare SNP in the HELB gene interferes with RPA interaction and cellular function of HELB
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12147029/
  24. May 2025
  25. pubs.acs.org pubs.acs.org
    Exploring the Potential of Homologous Recombination Protein PALB2 in Synthetic Lethal Combinations
    1
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    pubs.acs.org/doi/full/10.1021/acschembio.5c00111
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A first-in-class inhibitor of homologous recombination DNA repair counteracts tumour growth, metastasis and therapeutic resistance in pancreatic cancer
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12020112/
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    LINC01235 Promotes Clonal Evolution through DNA Replication Licensing‐Induced Chromosomal Instability in Breast Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11984920/
  28. Apr 2025
  29. www.sciencedirect.com www.sciencedirect.com
    DSCC1 restrains 53BP1/RIF1 signaling at DNA double-strand breaks to promote homologous recombination repair
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    sciencedirect.com/science/article/pii/S2211124725002232
  30. Mar 2025
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting platinum-resistant ovarian cancer by disrupting histone and RAD51 lactylation
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11898288/
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Inhibition of Cyclin D1 by Novel Biguanide Derivative YB-004 Increases the Sensitivity of Bladder Cancer to Olaparib via Causing G0 / G1 Arrest
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11900825/
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting FOXP1 phase separation in small cell lung cancer mechanisms of chemotherapy resistance
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11906602/
  34. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Targeting Replication Fork Processing Synergizes with PARP Inhibition to Potentiate Lethality in Homologous Recombination Proficient Ovarian Cancers
    1
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202410718
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cell Type Specific Suppression of Hyper-Recombination by Human RAD18 Is Linked to Proliferating Cell Nuclear Antigen K164 Ubiquitination
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11763143/
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Repression of PFKFB3 sensitizes ovarian cancer to PARP inhibitors by impairing homologous recombination repair
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    pmc.ncbi.nlm.nih.gov/articles/PMC11762855/
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The PST repeat region of MDC1 is a tunable multivalent chromatin tethering domain
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11761366/
  38. Feb 2025
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Inhibition of GSK3β is synthetic lethal with FHIT loss in lung cancer by blocking homologous recombination repair
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11799392/
  40. Jan 2025
  41. www.nature.com www.nature.com
    Homologous recombination promotes non-immunogenic mitotic cell death upon DNA damage
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    nature.com/articles/s41556-024-01557-x
  42. Dec 2024
  43. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    BCAT1 Associates with DNA Repair Proteins KU70 and KU80 and Contributes to Regulate DNA Repair in T-Cell Acute Lymphoblastic Leukemia (T-ALL)
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    pmc.ncbi.nlm.nih.gov/articles/PMC11676169/
  44. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Oleanolic Acid Modulates DNA Damage Response to Camptothecin Increasing Cancer Cell Death
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    pmc.ncbi.nlm.nih.gov/articles/PMC11676975/
  45. www.cell.com www.cell.com
    UBA1 inhibition sensitizes cancer cells to PARP inhibitors
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    cell.com/cell-reports-medicine/fulltext/S2666-3791(24)00605-0
  46. Nov 2024
  47. www.sciencedirect.com www.sciencedirect.com
    Distinct effects of sacituzumab govitecan and berzosertib on DNA damage response in ovarian cancer
    1
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    sciencedirect.com/science/article/pii/S2589004224025082
  48. Sep 2024
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Loss of tet methyl cytosine dioxygenase 3 (TET3) enhances cardiac fibrosis via modulating the DNA damage repair response
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11350970/
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RAD52 resolves transcription-replication conflicts to mitigate R-loop induced genome instability
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    ncbi.nlm.nih.gov/pmc/articles/PMC11377823/
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Synergistic Effect of Ubiquitin-Specific Protease 14 and Poly(ADP-Ribose) Glycohydrolase Co-Inhibition in BRCA1-Mutant, Poly(ADP-Ribose) Polymerase Inhibitor-Resistant Triple-Negative Breast Cancer Cells
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11385694/
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NEK6 dampens FOXO3 nuclear translocation to stabilize C-MYC and promotes subsequent de novo purine synthesis to support ovarian cancer chemoresistance
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11387829/
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    AXL inhibition prevents RPA2/CHK1-mediated homologous recombination to increase PARP inhibitor sensitivity in hepatocellular carcinoma
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11399589/
  54. www.sciencedirect.com www.sciencedirect.com
    Characterization of DNA damage repair pathway utilization in high-grade serous ovarian cancers yields rational therapeutic approaches
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    sciencedirect.com/science/article/pii/S1936523324002468
  55. Aug 2024
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Synergistic combination of RAD51-SCR7 improves CRISPR-Cas9 genome editing efficiency by preventing R-loop accumulation
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11331969/
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Involvement of the splicing factor SART1 in the BRCA1-dependent homologous recombination repair of DNA double-strand breaks
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11310344/
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PARP inhibitors suppress tumours via centrosome error-induced senescence independent of DNA damage response
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    ncbi.nlm.nih.gov/pmc/articles/PMC11052917/
  59. Jul 2024
  60. www.sciencedirect.com www.sciencedirect.com
    FANCM promotes PARP inhibitor resistance by minimizing ssDNA gap formation and counteracting resection inhibition
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    sciencedirect.com/science/article/pii/S2211124724007939
  61. www.nature.com www.nature.com
    PARG is essential for Polθ-mediated DNA end-joining by removing repressive poly-ADP-ribose marks
    4
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    nature.com/articles/s41467-024-50158-7
  62. www.biorxiv.org www.biorxiv.org
    Homologous recombination promotes mitotic death to suppress the innate immune response
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    biorxiv.org/content/10.1101/2024.05.04.592546v1
  63. Jun 2024
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ATM inhibition exploits checkpoint defects and ATM-dependent double strand break repair in TP53-mutant glioblastoma
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11192742/
  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    UCHL3 induces radiation resistance and acquisition of mesenchymal phenotypes by deubiquitinating POLD4 in glioma stem cells
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11149539/
  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ARID1A regulates DNA repair through chromatin organization and its deficiency triggers DNA damage-mediated anti-tumor immune response
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11162808/
  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The novel SMYD3 inhibitor EM127 impairs DNA repair response to chemotherapy-induced DNA damage and reverses cancer chemoresistance
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11137994/
  68. Apr 2024
  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Somatic mutations in four novel genes contribute to homologous recombination deficiency in breast cancer: a real‐world clinical tumor sequencing study
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    ncbi.nlm.nih.gov/pmc/articles/PMC10951049/
  70. www.sciencedirect.com www.sciencedirect.com
    DNA-PK and ATM drive phosphorylation signatures that antagonistically regulate cytokine responses to herpesvirus infection or DNA damage
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    sciencedirect.com/science/article/pii/S2405471224000887
  71. Mar 2024
  72. 52.53.155.43 52.53.155.43
    The immediate-early protein 1 of human herpesvirus 6B interacts with NBS1 and inhibits ATM signaling
    3
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    52.53.155.43/85f3cfb5ea69a502f1e71c384533cb9dacfc2966/collin-et-al-2024-the-immediate-early-protein-1-of-human-herpesvirus-6b-interacts-with-nbs1-and-inhibits-atm-signaling-html.html
  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Repression of the SUMO-conjugating enzyme UBC9 is associated with lowered double minutes and reduced tumor progression
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10936631/
  74. www.nature.com www.nature.com
    CDK9-55 guides the anaphase-promoting complex/cyclosome (APC/C) in choosing the DNA repair pathway choice
    1
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    nature.com/articles/s41388-024-02982-w
  75. Jan 2024
  76. www.sciencedirect.com www.sciencedirect.com
    Tolerance to colibactin correlates with homologous recombination proficiency and resistance to irinotecan in colorectal cancer cells
    2
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    sciencedirect.com/science/article/pii/S2666379123006055
  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FAK Drives Resistance to Therapy in HPV-Negative Head and Neck Cancer in a p53-Dependent Manner
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    ncbi.nlm.nih.gov/pmc/articles/PMC10767302/
  78. Dec 2023
  79. link.springer.com link.springer.com
    PRAME induces genomic instability in uveal melanoma
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    link.springer.com/article/10.1038/s41388-023-02887-0
  80. Nov 2023
  81. www.sciencedirect.com www.sciencedirect.com
    Widespread BRCA1/2-independent homologous recombination defects are caused by alterations in RNA-binding proteins
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    sciencedirect.com/science/article/pii/S2666379123004329
  82. Oct 2023
  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting MALAT1 Augments Sensitivity to PARP Inhibition by Impairing Homologous Recombination in Prostate Cancer
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10561629/
  84. Aug 2023
  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transforming Growth Factor Beta and Epithelial to Mesenchymal Transition Alter Homologous Recombination Repair Gene Expression and Sensitize BRCA Wild-Type Ovarian Cancer Cells to Olaparib
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10417836/
  86. Jul 2023
  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The hydrophilic extract from a new tomato genotype (named DHO) kills cancer cell lines through the modulation of the DNA damage response induced by Campthotecin treatment
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10318356/
  88. Jun 2023
  89. 52.53.155.43 52.53.155.43
    Transforming Growth Factor Beta and Epithelial to Mesenchymal Transition Alter Homologous Recombination Repair Gene Expression and Sensitize BRCA Wild Type Ovarian Cancer Cells to Olaparib
    1
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    52.53.155.43/71ce6d131c64aa7fc9989cc74f4998f83ebdb128/preprints202304.0327.v1-html.html
  90. May 2023
  91. www.sciencedirect.com www.sciencedirect.com
    MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells
    2
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    sciencedirect.com/science/article/pii/S2211124723004953
  92. Apr 2023
  93. www.sciencedirect.com www.sciencedirect.com
    Modular antibodies reveal DNA damage-induced mono-ADP-ribosylation as a second wave of PARP1 signaling
    1
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    sciencedirect.com/science/article/pii/S109727652300240X
  94. Sep 2022
  95. www.embopress.org www.embopress.org
    Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair
    1
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    embopress.org/doi/10.15252/embr.202154136
  96. Apr 2022
  97. aacrjournals.org aacrjournals.org
    Loss of Claudin-4 Reduces DNA Damage Repair and Increases Sensitivity to PARP Inhibitors
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    aacrjournals.org/mct/article/21/4/647/689566/Loss-of-Claudin-4-Reduces-DNA-Damage-Repair-and
  98. Dec 2021
  99. www.sciencedirect.com www.sciencedirect.com
    Local non-pituitary growth hormone is induced with aging and facilitates epithelial damage
    1
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    sciencedirect.com/science/article/pii/S2211124721015540
  100. Oct 2021
  101. www.sciencedirect.com www.sciencedirect.com
    Shift in MSL1 alternative polyadenylation in response to DNA damage protects cancer cells from chemotherapeutic agent-induced apoptosis
    1
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    sciencedirect.com/science/article/pii/S2211124721012791
  102. Aug 2021
  103. cancerres.aacrjournals.org cancerres.aacrjournals.org
    SHP2-Mediated Inhibition of DNA Repair Contributes to cGAS–STING Activation and Chemotherapeutic Sensitivity in Colon Cancer
    1
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    cancerres.aacrjournals.org/content/81/12/3215
  104. www.embopress.org www.embopress.org
    Homologous recombination is reduced in female embryonic stem cells by two active X chromosomes
    1
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    embopress.org/doi/full/10.15252/embr.202052190
  105. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Depletion of the RNA binding protein HNRNPD impairs homologous recombination by inhibiting DNA-end resection and inducing R-loop accumulation
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC6486545/
  106. Jul 2021
  107. academic.oup.com academic.oup.com
    Untitled document
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    academic.oup.com/nar/advance-article/doi/10.1093/nar/gkz076/5364135
  108. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Human RECQL4 represses the RAD52‐mediated single‐strand annealing pathway after ionizing radiation or cisplatin treatment
    1
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    onlinelibrary.wiley.com/doi/full/10.1002/ijc.32670
  109. www.nature.com www.nature.com
    UPF1 promotes the formation of R loops to stimulate DNA double-strand break repair
    1
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    nature.com/articles/s41467-021-24201-w
  110. Jun 2021
  111. www.sciencedirect.com www.sciencedirect.com
    The nuclear kinesin KIF18B promotes 53BP1-mediated DNA double-strand break repair
    1
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    sciencedirect.com/science/article/pii/S2211124721006823
  112. May 2021
  113. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting HR Repair as a Synthetic Lethal Approach to Increase DNA Damage Sensitivity by a RAD52 Inhibitor in BRCA2-Deficient Cancer Cells
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC8122931/
  114. www.sciencedirect.com www.sciencedirect.com
    miR-1293, a candidate for miRNA-based cancer therapeutics, simultaneously targets BRD4 and the DNA repair pathway
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    sciencedirect.com/science/article/pii/S1525001620301829
  115. www.sciencedirect.com www.sciencedirect.com
    Epigenetic Regulation of DNA Repair Pathway Choice by MacroH2A1 Splice Variants Ensures Genome Stability
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    sciencedirect.com/science/article/pii/S1097276520304305
  116. Apr 2021
  117. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Elevated CXorf67 Expression in PFA Ependymomas Suppresses DNA Repair and Sensitizes to PARP Inhibitors
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    ncbi.nlm.nih.gov/pmc/articles/PMC8455074/
  118. Feb 2021
  119. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RB1 Deletion in Retinoblastoma Protein Pathway-Disrupted Cells Results in DNA Damage and Cancer Progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC6664603/
  120. Jan 2021
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    Chk1 promotes non-homologous end joining in G1 through direct phosphorylation of ASF1A
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    sciencedirect.com/science/article/pii/S2211124720316697
  122. Dec 2020
  123. www.mdpi.com www.mdpi.com
    Global Genome Demethylation Causes Transcription-Associated DNA Double Strand Breaks in HPV-Associated Head and Neck Cancer Cells
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    mdpi.com/2072-6694/13/1/21
  124. Jan 2020
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    53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination
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    sciencedirect.com/science/article/pii/S1097276519307294
  126. academic.oup.com academic.oup.com
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    academic.oup.com/nar/advance-article/doi/10.1093/nar/gkz076/5364135