Hypothesis

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Nov 2025
www.sciencedirect.com www.sciencedirect.com

Lactylation of mTOR enhances autophagy in skeletal muscle during exercise

1
1. scibot 13 Nov 2025
  
  in Public
  
  RRID:Addgene_26603
  
  DOI: 10.1016/j.chembiol.2025.10.007
  
  Resource: RRID:Addgene_26603
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_26603
  
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  RRID:Addgene_26603
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RRID:Addgene_26603

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scibot

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sciencedirect.com/science/article/pii/S2451945625003447
Sep 2025
link.springer.com link.springer.com

p62/SQSTM1 signaling nexus and orchestration of ERK and mTOR pathways are crucial for Bacoside A- induced autophagy-mediated apoptosis in chronic myelogenous leukemia

1
1. scibot 18 Sep 2025
  
  in Public
  
  RRID:Addgene_26603
  
  DOI: 10.1007/s12272-025-01565-x
  
  Resource: RRID:Addgene_26603
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_26603
  
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  RRID:Addgene_26603
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RRID:Addgene_26603

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scibot

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link.springer.com/article/10.1007/s12272-025-01565-x
www.biorxiv.org www.biorxiv.org

The tumor suppressor CYLD acts as a deubiquitinase for mTOR to constrain its activity

1
1. scibot 09 Sep 2025
  
  in Public
  
  plasmid_26603
  
  DOI: 10.1101/2025.09.01.673523
  
  Resource: RRID:Addgene_26603
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_26603
  
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  RRID:Addgene_26603
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RRID:Addgene_26603

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scibot

URL

biorxiv.org/content/10.1101/2025.09.01.673523v1
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Novel Role of the Epstein-Barr Virus Encoded Deubiquitinating Enzyme (BPLF1) in mTOR-Mediated Cell Growth and Proliferation Pathways

1
1. scibot 07 Sep 2025
  
  in Public
  
  Plasmid_26603
  
  DOI: 10.3390/v17081139
  
  Resource: RRID:Addgene_26603
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_26603
  
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  RRID:Addgene_26603
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scibot

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pmc.ncbi.nlm.nih.gov/articles/PMC12390678/
Mar 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Pifithrin-μ sensitizes mTOR-activated liver cancer to sorafenib treatment

1
1. scibot 11 Mar 2025
  
  in Public
  
  26603
  
  DOI: 10.1038/s41419-025-07332-6
  
  Resource: RRID:Addgene_26603
  
  Curator: @olekpark
  
  SciCrunch record: RRID:Addgene_26603
  
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  RRID:Addgene_26603 DOI:10.1038/s41419-025-07332-6
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DOI:10.1038/s41419-025-07332-6

RRID:Addgene_26603

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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC11762308/
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Clinical and functional studies of MTOR variants in Smith-Kingsmore syndrome reveal deficits of circadian rhythm and sleep-wake behavior

1
1. scibot 26 Aug 2024
  
  in Public
  
  Addgene_26603
  
  DOI: 10.1016/j.xhgg.2024.100333
  
  Resource: RRID:Addgene_26603
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_26603
  
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  RRID:Addgene_26603
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ncbi.nlm.nih.gov/pmc/articles/PMC11342114/
Aug 2023
www.nature.com www.nature.com

Malonyl-CoA is a conserved endogenous ATP-competitive mTORC1 inhibitor

1
1. scibot 17 Aug 2023
  
  in Public
  
  RRID:Addgene_26603
  
  DOI: 10.1038/s41556-023-01198-6
  
  Resource: RRID:Addgene_26603
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_26603
  
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  RRID:Addgene_26603
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nature.com/articles/s41556-023-01198-6
Sep 2021
www.sciencedirect.com www.sciencedirect.com

KARATE: PKA-induced KRAS4B-RHOA-mTORC2 supercomplex phosphorylates AKT in insulin signaling and glucose homeostasis

1
1. scibot 22 Sep 2021
  
  in Public
  
  Addgene_26603
  
  DOI: 10.1016/j.molcel.2021.09.001
  
  Resource: RRID:Addgene_26603
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_26603
  
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  RRID:Addgene_26603
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RRID:Addgene_26603

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scibot

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sciencedirect.com/science/article/pii/S1097276521007358
Aug 2021
www.sciencedirect.com www.sciencedirect.com

Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation

1
1. scibot 09 Aug 2021
  
  in Public
  
  Plasmid_26603
  
  DOI: 10.1016/j.cmet.2018.07.019
  
  Resource: RRID:Addgene_26603
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_26603
  
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  RRID:Addgene_26603
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RRID:Addgene_26603

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scibot

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sciencedirect.com/science/article/pii/S1550413118304625
Jul 2021
www.sciencedirect.com www.sciencedirect.com

An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress

1
1. scibot 10 Jul 2021
  
  in Public
  
  plasmid_26603
  
  DOI: 10.1016/j.molcel.2021.06.017
  
  Resource: RRID:Addgene_26603
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_26603
  
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  RRID:Addgene_26603
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RRID:Addgene_26603

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scibot

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sciencedirect.com/science/article/pii/S1097276521004974
Jan 2021
www.sciencedirect.com www.sciencedirect.com

Rheb1-Independent Activation of mTORC1 in Mammary Tumors Occurs through Activating Mutations in mTOR

1
1. scibot 27 Jan 2021
  
  in Public
  
  Plasmid_26603
  
  DOI: 10.1016/j.celrep.2020.107571
  
  Resource: RRID:Addgene_26603
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:Addgene_26603
  
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  RRIDCUR:Validated RRID:Addgene_26603
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RRIDCUR:Validated

RRID:Addgene_26603

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scibot

URL

sciencedirect.com/science/article/pii/S2211124720305209
Jan 2020
www.frontiersin.org www.frontiersin.org

Pentapeptide Protects INS-1 Cells From hIAPP-Mediated Apoptosis by Enhancing Autophagy Through mTOR Pathway

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:Addgene_26603
  
  DOI: 10.3389/fphar.2019.00896
  
  Resource: RRID:Addgene_26603
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_26603
  
  What is this?
  
  RRID:Addgene_26603 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:Addgene_26603

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scibot

URL

frontiersin.org/articles/10.3389/fphar.2019.00896/full