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Combinatorial protein engineering identifies potent CRISPR activators with reduced toxicity

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1. scibot 18 Dec 2025
  
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  Addgene_41392
  
  DOI: 10.1038/s41467-025-65986-4
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12706070/
Dec 2025
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The Shigella flexneri effector IpaH1.4 facilitates RNF213 degradation and protects cytosolic bacteria against interferon-induced ubiquitylation

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1. scibot 02 Dec 2025
  
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  DOI: 10.7554/eLife.102714
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12662631/
Nov 2025
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Multiplex neurodegeneration proteotoxicity platform reveals DNAJB6 promotes non-toxic FUS condensate gelation and inhibits neurotoxicity

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1. scibot 24 Nov 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12638947/
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Biallelic antigen escape is a mechanism of resistance to anti-CD38 antibodies in multiple myeloma

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1. scibot 23 Nov 2025
  
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  DOI: 10.1182/blood.2024028107
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12451653/
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The Shigella flexneri effector IpaH1.4 facilitates RNF213 degradation and protects cytosolic bacteria against interferon-induced ubiquitylation

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1. scibot 11 Nov 2025
  
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  DOI: 10.7554/eLife.102714.2
  
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elifesciences.org/reviewed-preprints/102714
Oct 2025
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FEBS Press

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1. scibot 23 Oct 2025
  
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  plasmid_41392
  
  DOI: 10.1002/1878-0261.70146
  
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febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.70146
Sep 2025
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Eradicating Drug Tolerant Persister Cells in EGFR-Mutated Non-Small Cell Lung Cancer by Targeting TROP2 with CAR-T cellular therapy

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1. scibot 07 Sep 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12374242/
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A Potent Inhibitor of Caspase-8 Based on the IL-18 Tetrapeptide Sequence Reveals Shared Specificities between Inflammatory and Apoptotic Initiator Caspases

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1. scibot 06 Sep 2025
  
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  pLEX_307
  
  DOI: 10.1021/acsbiomedchemau.4c00146
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12371506/
Aug 2025
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Dual targeting of BCMA and SLAMF7 with the CARtein system: chimeric antigen receptors with intein-mediated splicing elicit specific T cell activation against multiple myeloma

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1. scibot 16 Aug 2025
  
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  DOI: 10.3389/fimmu.2025.1613222
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12350263/
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Integrated real-time imaging of executioner caspase dynamics, apoptosis-induced proliferation, and immunogenic cell death using a stable fluorescent reporter platform

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1. scibot 10 Aug 2025
  
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  plasmid_41392
  
  DOI: 10.1038/s41420-025-02662-y
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12328661/
Jul 2025
www.biorxiv.org www.biorxiv.org

PRMT5 activity sustains histone production to maintain genome integrity

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1. scibot 23 Jul 2025
  
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  DOI: 10.1101/2025.07.03.663002
  
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biorxiv.org/content/10.1101/2025.07.03.663002v1
Jun 2025
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Phenotypic screens for SIRPA expression reveal RAB21 as a general regulator of macrophage surface identity

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1. scibot 28 Jun 2025
  
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  Plasmid_41392
  
  DOI: 10.1016/j.celrep.2025.115921
  
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sciencedirect.com/science/article/pii/S2211124725006928
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WNK1 signalling regulates amino acid transport and mTORC1 activity to sustain acute myeloid leukaemia growth

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1. scibot 15 Jun 2025
  
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  DOI: 10.1038/s41467-025-59969-8
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12116911/
May 2025
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Stromal Cell Subsets Show Model-Dependent Changes in Experimental Colitis and Affect Epithelial Tissue Repair and Immune Cell Activation

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1. scibot 16 May 2025
  
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  DOI: 10.1093/ibd/izae255
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11985400/
Apr 2025
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Interferon-Inducible ADAR1 p150 Is Essential for the Survival of Oral Squamous Cell Carcinoma

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1. scibot 01 Apr 2025
  
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  DOI: 10.1002/mc.23910
  
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onlinelibrary.wiley.com/doi/10.1002/mc.23910
Feb 2025
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CPSF1 inhibition promotes widespread use of intergenic polyadenylation sites and impairs glycolysis in prostate cancer cells

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1. scibot 24 Feb 2025
  
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  plasmid_41392
  
  DOI: 10.1016/j.celrep.2024.115211
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11831233/
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mTOR-mediated p62/SQSTM1 stabilization confers a robust survival mechanism for ovarian cancer

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1. scibot 20 Feb 2025
  
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  DOI: 10.1016/j.canlet.2025.217565
  
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sciencedirect.com/science/article/pii/S0304383525001296
aacrjournals.org aacrjournals.org

C/EBPa confers dependence to fatty acid anabolic pathways and vulnerability to lipid oxidative stress-induced ferroptosis in FLT3-mutant leukemia

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1. scibot 14 Feb 2025
  
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  RRID:Addgene_41392
  
  DOI: 10.1158/2159-8290.CD-22-0411
  
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aacrjournals.org/cancerdiscovery/article/13/7/1720/727640/C-EBP-Confers-Dependence-to-Fatty-Acid-Anabolic
Jan 2025
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Targeting the mevalonate pathway potentiates NUAK1 inhibition-induced immunogenic cell death and antitumor immunity

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1. scibot 17 Jan 2025
  
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  DOI: 10.1016/j.xcrm.2024.101913
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11866496/
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Development of small molecule non-covalent coronavirus 3CL protease inhibitors from DNA-encoded chemical library screening

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  DOI: 10.1038/s41467-024-55421-5
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11696555/
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SLC7A5 is required for cancer cell growth under arginine-limited conditions

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  AddgeneCat#41392
  
  DOI: 10.1016/j.celrep.2024.115130
  
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sciencedirect.com/science/article/pii/S2211124724014815
Sep 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

MTGR1 is required to maintain small intestinal stem cell populations

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1. scibot 29 Sep 2024
  
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  DOI: 10.1038/s41418-024-01346-x
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11369156/
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The Shigella flexneri effector IpaH1.4 facilitates RNF213 degradation and protects cytosolic bacteria against interferon-induced ubiquitylation

1
1. scibot 25 Sep 2024
  
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  DOI: 10.1101/2024.09.05.611450
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11398459/
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

XRN1 deletion induces PKR-dependent cell lethality in interferon-activated cancer cells

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  DOI: 10.1016/j.celrep.2023.113600
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10989277/
Jul 2024
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ACE2-Decorated Virus-Like Particles Effectively Block SARS-CoV-2 Infection

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  DOI: 10.2147/IJN.S446093
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11246629/
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The hydrophobicity of the CARD8 N-terminus tunes inflammasome activation

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1. scibot 11 Jul 2024
  
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  DOI: 10.1016/j.chembiol.2024.06.004
  
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sciencedirect.com/science/article/pii/S245194562400223X
May 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

PRRX1-TOP2A interaction is a malignancy-promoting factor in human malignant peripheral nerve sheath tumours

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  DOI: 10.1038/s41416-024-02632-8
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11058259/
Mar 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Comprehensive mutational scanning of EGFR reveals TKI sensitivities of extracellular domain mutants

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  DOI: 10.1038/s41467-024-45594-4
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10978866/
Feb 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

RNA m6A modification regulates L1 retrotransposons in human spermatogonial stem cell differentiation in vitro and in vivo

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  41392
  
  DOI: 10.1007/s00018-024-05119-0
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10873452/
journals.plos.org journals.plos.org

CRISPR screen for protein inclusion formation uncovers a role for SRRD in the regulation of intermediate filament dynamics and aggresome assembly

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1. scibot 09 Feb 2024
  
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  DOI: 10.1371/journal.pgen.1011138
  
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journals.plos.org/plosgenetics/article
Jan 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

XRN1 deletion induces PKR-dependent cell lethality in interferon-activated cancer cells

1
1. scibot 23 Jan 2024
  
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  RRID:Addgene_41392
  
  DOI: 10.1016/j.celrep.2023.113600
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10989277/
Oct 2023
www.sciencedirect.com www.sciencedirect.com

SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9

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  Addgene_41392
  
  DOI: 10.1016/j.cell.2023.09.002
  
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sciencedirect.com/science/article/pii/S0092867423009807
Jul 2023
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cd-22-0411-html.html

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  RRID:Addgene_41392
  
  DOI: 10.1158/2159-8290.cd-22-0411
  
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52.53.155.43/453457acda6208aed297e8061921a5c2d2ddddf2/cd-22-0411-html.html
May 2023
aacrjournals.org aacrjournals.org

RASGRF1 Fusions Activate Oncogenic RAS Signaling and Confer Sensitivity to MEK Inhibition

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1. scibot 05 May 2023
  
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  RRID:Addgene_41392
  
  DOI: 10.1158/1078-0432.CCR-21-4291
  
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aacrjournals.org/clincancerres/article/28/14/3091/706867/RASGRF1-Fusions-Activate-Oncogenic-RAS-Signaling
Jan 2023
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Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation

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1. scibot 25 Jan 2023
  
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  Addgene_41392
  
  DOI: 10.1016/j.celrep.2022.111965
  
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sciencedirect.com/science/article/pii/S2211124722018691
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The NLRP1 and CARD8 inflammasomes detect reductive stress

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1. scibot 19 Jan 2023
  
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  Addgene_41392
  
  DOI: 10.1016/j.celrep.2022.111966
  
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sciencedirect.com/science/article/pii/S2211124722018708
Aug 2022
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Cardiac ultrastructure inspired matrix induces advanced metabolic and functional maturation of differentiated human cardiomyocytes

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1. scibot 02 Aug 2022
  
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  plasmid_41392
  
  DOI: 10.1016/j.celrep.2022.111146
  
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sciencedirect.com/science/article/pii/S221112472200955X
May 2022
www.sciencedirect.com www.sciencedirect.com

Interactomic analysis reveals a homeostatic role for the HIV restriction factor TRIM5α in mitophagy

2
1. scibot 11 May 2022
  
  in Public
  
  Addgene41392
  
  DOI: 10.1016/j.celrep.2022.110797
  
  Resource: RRID:Addgene_41392
  
  Curator: @sophiastull
  
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  RRID:Addgene_41392
2. scibot 11 May 2022
  
  in Public
  
  plasmid_41392
  
  DOI: 10.1016/j.celrep.2022.110797
  
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sciencedirect.com/science/article/pii/S2211124722005642
Feb 2022
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Targetable HER3 functions driving tumorigenic signaling in HER2-amplified cancers

2
1. scibot 11 Feb 2022
  
  in Public
  
  RRID:Addgene_41392
  
  DOI: 10.1016/j.celrep.2021.110291
  
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  RRID:Addgene_41392
2. scibot 09 Feb 2022
  
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  RRID:Addgene_41392
  
  DOI: 10.1016/j.celrep.2021.110291
  
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sciencedirect.com/science/article/pii/S2211124721018064
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Sparse dictionary learning recovers pleiotropy from human cell fitness screens

1
1. scibot 02 Feb 2022
  
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  Addgene41392
  
  DOI: 10.1016/j.cels.2021.12.005
  
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sciencedirect.com/science/article/pii/S2405471221004889
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Extensive conformational and physical plasticity protects HER2-HER3 tumorigenic signaling

1
1. scibot 02 Feb 2022
  
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  RRID:Addgene_41392
  
  DOI: 10.1016/j.celrep.2021.110285
  
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sciencedirect.com/science/article/pii/S2211124721018003
Nov 2021
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Deciphering cell signaling networks with massively multiplexed biosensor barcoding

1
1. scibot 30 Nov 2021
  
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  plasmid_41392
  
  DOI: 10.1016/j.cell.2021.11.005
  
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sciencedirect.com/science/article/pii/S0092867421013209
Aug 2021
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Generation of a luciferase-expressing human embryonic stem cell line: NERCe002-A-2

1
1. scibot 12 Aug 2021
  
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  plasmid_41392
  
  DOI: 10.1016/j.scr.2018.02.010
  
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sciencedirect.com/science/article/pii/S1873506118300540
onlinelibrary.wiley.com onlinelibrary.wiley.com

SKAP2 as a new regulator of oligodendroglial migration and myelin sheath formation

1
1. scibot 03 Aug 2021
  
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  RRID:Addgene_41392
  
  DOI: 10.1002/glia.24066
  
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onlinelibrary.wiley.com/doi/10.1002/glia.24066
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Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway

1
1. scibot 01 Aug 2021
  
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  plasmid_41392
  
  DOI: 10.1016/j.ccell.2019.12.006
  
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  RRID:Addgene_41392 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1535610819305768
Jul 2021
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MicroRNA-Mediated Suppression of the TGF-β Pathway Confers Transmissible and Reversible CDK4/6 Inhibitor Resistance

1
1. scibot 28 Jul 2021
  
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  RRID:Addgene_41392
  
  DOI: 10.1016/j.celrep.2019.02.023
  
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  Curator: @ethanbadger
  
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  RRIDCUR:Unrecognized RRID:Addgene_41392
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sciencedirect.com/science/article/pii/S2211124719301937
Apr 2021
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Immunogenomic Landscape of Hematological Malignancies

1
1. scibot 17 Apr 2021
  
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  RRID: Addgene_41392
  
  DOI: 10.1016/j.ccell.2020.06.002
  
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sciencedirect.com/science/article/pii/S1535610820302750
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Donor cell memory confers a metastable state of directly converted cells

1
1. scibot 13 Apr 2021
  
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  Plasmid_41392
  
  DOI: 10.1016/j.stem.2021.02.023
  
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  RRIDCUR:Validated RRID:Addgene_41392
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sciencedirect.com/science/article/pii/S1934590921000746
Feb 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Genome-wide synthetic lethal CRISPR screen identifies FIS1 as a genetic interactor of ALS-linked C9ORF72

2
1. scibot 02 Feb 2021
  
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  RRID:Addgene_41392
  
  DOI: 10.1016/j.brainres.2019.146601
  
  Resource: RRID:Addgene_41392
  
  Curator: @evieth
  
  SciCrunch record: RRID:Addgene_41392
  
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  RRIDCUR:Validated RRID:Addgene_41392
2. scibot 02 Feb 2021
  
  in Public
  
  RRID:Addgene_41392
  
  DOI: 10.1016/j.brainres.2019.146601
  
  Resource: RRID:Addgene_41392
  
  Curator: @evieth
  
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  RRIDCUR:Validated RRID:Addgene_41392
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ncbi.nlm.nih.gov/pmc/articles/PMC7539795/
Oct 2020
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

Activation of the CARD8 Inflammasome Requires a Disordered Region

1
1. scibot 20 Oct 2020
  
  in Public
  
  pLEX_307
  
  DOI: 10.1016/j.celrep.2020.108264
  
  Resource: RRID:Addgene_41392
  
  Curator: @Naa003
  
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  RRIDCUR:Missing RRID:Addgene_41392
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pubmed.ncbi.nlm.nih.gov/33053349/
Sep 2020
genesdev.cshlp.org genesdev.cshlp.org

Competition between maturation and degradation drives human snRNA 3′ end quality control

1
1. scibot 05 Sep 2020
  
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  RRID:Addgene_41392
  
  DOI: 10.1101/gad.336891.120
  
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  RRIDCUR:Validated RRID:Addgene_41392
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genesdev.cshlp.org/content/34/13-14/989.full
Jan 2020
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Untitled document

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1. scibot 13 Jan 2020
  
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  Addgene_41392
  
  DOI: 10.1016/j.cels.2017.10.010
  
  Resource: RRID:Addgene_41392
  
  Curator: @Jmenke
  
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sciencedirect.com/science/article/pii/S2405471217304477