152 Matching Annotations
  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TONSL/TONSOKU binding to histone H3.1 is required for DNA repair
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    pmc.ncbi.nlm.nih.gov/articles/PMC13674474/
  3. www.science.org www.science.org
    TONSL/TONSOKU binding to histone H3.1 is required for DNA repair
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    science.org/doi/10.1126/sciadv.aeh3827
  4. www.nature.com www.nature.com
    Role of PER-WDR5 interactions in the mammalian circadian clock
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    nature.com/articles/s41467-026-77583-0
  5. Oct 2026
  6. www.science.org www.science.org
    Citron kinase activity controls alternative splicing events that drive prostate cancer growth
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    science.org/doi/10.1126/sciadv.aee5257
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ERG Orchestrates a Dedifferentiation–Senescence–Inflammation Triad in Prostate Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13631506/
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Citron kinase activity controls alternative splicing events that drive prostate cancer growth
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    pmc.ncbi.nlm.nih.gov/articles/PMC13651888/
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Context-dependent release of HMGB1: cell death mode, cell type and LPS stress drive monomer and heterocomplex formation
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    pmc.ncbi.nlm.nih.gov/articles/PMC13281463/
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A genetic reporter for visualizing nitroreductase activity using magnetic resonance imaging
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    pmc.ncbi.nlm.nih.gov/articles/PMC13271666/
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Divergent pathways of surfactant protein C maturation for disease-associated isoforms
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    pmc.ncbi.nlm.nih.gov/articles/PMC12992958/
  12. Sep 2026
  13. www.sciencedirect.com www.sciencedirect.com
    Functional characterization of the 9q34.13 locus identifies RAPGEF1 as a candidate gene modulating risk for melanoma and nevi via RAS activation
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    sciencedirect.com/science/article/pii/S0002929726003150
  14. Aug 2026
  15. www.sciencedirect.com www.sciencedirect.com
    The CNNM-binding interface drives PRL-3-dependent tumor progression in de novo cancer models
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    sciencedirect.com/science/article/pii/S2589004226027161
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Ligand-independent EPHA2 signaling sustains neural progenitors via ECSIT and NAD+
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    pmc.ncbi.nlm.nih.gov/articles/PMC13503776/
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SARS-CoV-2 nucleocapsid induces hyperinflammation and vascular leakage through the Toll-like receptor signaling axis in macrophages
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    pmc.ncbi.nlm.nih.gov/articles/PMC13440407/
  18. Jul 2026
  19. www.biorxiv.org www.biorxiv.org
    G4 DNA structures induced by UV radiation: a multi-omic approach
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    biorxiv.org/content/10.64898/2026.07.15.738736v1
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Decoding the Mechanism of Action of a Parasite TGFβ Antagonist Inspires the Creation of Cell‐Type‐Specific TGFβ Modulators
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    pmc.ncbi.nlm.nih.gov/articles/PMC13335435/
  21. www.biorxiv.org www.biorxiv.org
    SMAD4 MH2 Mutations Disrupt CREBBP/EP300 Recruitment and TGF-β-Induced Transcription in Colorectal Cancer
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    biorxiv.org/content/10.64898/2026.06.30.735541v1
  22. www.sciencedirect.com www.sciencedirect.com
    Systematic discovery of pathogen effector functions across human pathogens and pathways
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    sciencedirect.com/science/article/pii/S009286742600704X
  23. Jun 2026
  24. www.biorxiv.org www.biorxiv.org
    Decoding the Mechanism of Action of a Parasite TGFβ antagonist Inspires the Creation of Cell-type-specific TGFβ Modulators
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    biorxiv.org/content/10.64898/2026.02.16.706112v1
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    eIF4G2-Dependent Translation Restrains Pancreatic Cancer Progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC13276777/
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Therapeutic vulnerabilities exposed by the 9p21 loss identified through multiparametric drug screening inform rational combination strategies
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    pmc.ncbi.nlm.nih.gov/articles/PMC13276166/
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    GPLD1 is a scavenger carrier mediating lysosomal degradation of extracellular aberrant proteins
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    pmc.ncbi.nlm.nih.gov/articles/PMC13241479/
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Uncovering cancer dependencies in peptide-interacting protein pockets
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    pmc.ncbi.nlm.nih.gov/articles/PMC13061025/
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    mSWI/SNF complex inhibition sensitizes KRAS-mutant lung cancers to targeted therapies via epithelial-mesenchymal subversion
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    pmc.ncbi.nlm.nih.gov/articles/PMC13160128/
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Wnt target gene activation requires β-catenin separation into biomolecular condensates
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    pmc.ncbi.nlm.nih.gov/articles/PMC11460698/
  31. Apr 2026
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SLC33A1 exports oxidized glutathione to maintain endoplasmic reticulum redox homeostasis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12889552/
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    De novo design of Ras isoform selective binders
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    pmc.ncbi.nlm.nih.gov/articles/PMC12982892/
  34. Mar 2026
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Adaptor protein supersaturation drives innate immune signaling and cell fate
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    pmc.ncbi.nlm.nih.gov/articles/PMC13012725/
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Stress-specific NONO interactomes reveal a key role of Hsp70 chaperone activity in regulation of paraspeckle formation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12863303/
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Copper Chaperone ATOX1 Exhibits Differential Protein–Protein Interactions and Contributes to Skeletal Myoblast Differentiation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12983349/
  38. www.sciencedirect.com www.sciencedirect.com
    Sequence-specific RNA recognition drives Restrictor-mediated termination of extragenic transcription
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    sciencedirect.com/science/article/pii/S1097276526001012
  39. Feb 2026
  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Epigenetic and Transcriptional Programs Define Osteosarcoma Subtypes and Establish Targetable Vulnerabilities
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    pmc.ncbi.nlm.nih.gov/articles/PMC12877751/
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    The SWI/SNF-related protein SMARCA3 is a histone H3K23 ubiquitin ligase that regulates H3K9me3 in cancer
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    sciencedirect.com/science/article/pii/S1097276525005507
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Precise control of transcription condensates across S phase balances linker histone expression with DNA replication, ensuring genome stability
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    pmc.ncbi.nlm.nih.gov/articles/PMC12995521/
  43. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Oculopharyngeal muscular dystrophy (OPMD) associated alanine expansion impairs the function of the nuclear polyadenosine RNA binding protein PABPN1 as revealed by proximity labeling and comparative proteomics
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    pmc.ncbi.nlm.nih.gov/articles/PMC12858073/
  44. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DUSP22 dephosphorylates LGALS1 to enhance T cell-driven antitumor immunity
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    pmc.ncbi.nlm.nih.gov/articles/PMC12853559/
  45. Jan 2026
  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MRTF-dependent cytoskeletal dynamics drive efficient cell cycle progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12813672/
  47. www.biorxiv.org www.biorxiv.org
    MYST acetyltransferases are a targetable therapeutic vulnerability in SETBP1-mutant leukemia
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    biorxiv.org/content/10.64898/2026.01.08.697228v1
  48. Nov 2025
  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Autoimmunity-associated DIORA1 binds the MRCK family of serine/threonine kinases and controls cell motility
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    pmc.ncbi.nlm.nih.gov/articles/PMC12519202/
  50. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Novel regulators of heparan sulfate proteoglycans modulate cellular uptake of α-synuclein fibrils
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    pmc.ncbi.nlm.nih.gov/articles/PMC12501064/
  51. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Telomeres control human telomerase (TERT) expression through non-telomeric TRF2
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    pmc.ncbi.nlm.nih.gov/articles/PMC12483519/
  52. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The citrullinating enzyme PADI4 governs progenitor cell proliferation and translation in developing hair follicles
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    pmc.ncbi.nlm.nih.gov/articles/PMC12429026/
  53. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Activation of Kv11.1 potassium channel suppresses non-small cell lung cancer growth by promoting c-Myc degradation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12635092/
  54. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12591322/
  55. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cytidine deaminases APOBEC3C and APOBEC3D promote DNA replication stress resistance in pancreatic cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12557688/
  56. Sep 2025
  57. www.sciencedirect.com www.sciencedirect.com
    Disrupting the interaction between androgen receptor and its coregulator WDR77 delays the growth of treatment-resistant prostate cancer
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    sciencedirect.com/science/article/pii/S221112472501006X
  58. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Ablating UNG activity in a mouse model inhibits colorectal cancer growth by increasing tumor immunogenicity
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    pmc.ncbi.nlm.nih.gov/articles/PMC12406714/
  59. Aug 2025
  60. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.70112
  61. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Multi-selective RAS(ON) Inhibition Targets Oncogenic RAS Mutations and Overcomes RAS/MAPK-Mediated Resistance to FLT3 and BCL2 Inhibitors in Acute Myeloid Leukemia
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    pmc.ncbi.nlm.nih.gov/articles/PMC12259086/
  62. www.sciencedirect.com www.sciencedirect.com
    PALB2 and 53BP1 govern post-resection homologous recombination DNA repair
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    sciencedirect.com/science/article/pii/S1097276525006045
  63. Jul 2025
  64. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Advanced viral genome in vitro Cas9 editing (AdVICE): an overnight method for traceless and limitless manipulation of adenoviral and vector genomes with large transgenes
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    pmc.ncbi.nlm.nih.gov/articles/PMC12172474/
  65. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Adipocyte-specific Zeb1 downregulation remodels the tumor-associated adipose microenvironment to facilitate female breast cancer progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12219764/
  66. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Structural Repetition Detector for multi-scale quantitative mapping of molecular complexes through microscopy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12219329/
  67. www.biorxiv.org www.biorxiv.org
    The copper chaperone ATOX1 exhibits differential protein-protein interactions and contributes to skeletal myoblast differentiation
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    biorxiv.org/content/10.1101/2025.07.08.663731v1
  68. Jun 2025
  69. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A monomeric envelope glycoprotein cytoplasmic tail is sufficient for HIV-1 Gag lattice trapping and incorporation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12090761/
  70. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Phosphatase activity is dispensable for PRL-3-mediated oncogenesis and tumor progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12132575/
  71. May 2025
  72. www.sciencedirect.com www.sciencedirect.com
    Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates
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    sciencedirect.com/science/article/pii/S0092867425005094
  73. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Novel STAT3 Y360C Gain-of-function Variant Underlies Immune Dysregulation and Aberrancy in Mitochondrial Dynamics
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    pmc.ncbi.nlm.nih.gov/articles/PMC12056293/
  74. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PKM splice-switching ASOs induce upregulation of dual-specificity phosphatases and dephosphorylation of ERK1/2 in hepatocellular carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC11982463/
  75. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Suppression of Ovarian Cancer Cell Proliferation Is Associated with Upregulation of Cell-Matrix Adhesion Programs and Integrin-β4-Induced Cell Protection from Cisplatin
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    pmc.ncbi.nlm.nih.gov/articles/PMC12070841/
  76. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    LINE-1 ORF1p Mimics Viral Innate Immune Evasion Mechanisms in Pancreatic Ductal Adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12046326/
  77. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Epstein-Barr virus deubiquitinase BPLF1 regulates stress-induced ribosome UFMylation and reticulophagy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12013442/
  78. Apr 2025
  79. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Metabolic constraint of human telomere length by nucleotide salvage efficiency
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    pmc.ncbi.nlm.nih.gov/articles/PMC11950188/
  80. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Saturation mapping of MUTYH variant effects using DNA repair reporters
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    pmc.ncbi.nlm.nih.gov/articles/PMC11908140/
  81. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Colorectal cancer hot spot mutations attenuate the ASXL-MLL4 interaction
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    pmc.ncbi.nlm.nih.gov/articles/PMC11957774/
  82. www.biorxiv.org www.biorxiv.org
    Inhibition of cytosolic DNA sensing and transposon activity safeguards pluripotency
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    biorxiv.org/content/10.1101/2025.03.26.645264v1
  83. www.cell.com www.cell.com
    SWI/SNF complex-mediated ZNF410 cooperative binding maintains chromatin accessibility and enhancer activity
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    cell.com/cell-reports/fulltext/S2211-1247(25)00247-5
  84. Mar 2025
  85. www.biorxiv.org www.biorxiv.org
    In vivo validation of the palmitoylation cycle as a therapeutic target in NRAS-mutant cancer
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    biorxiv.org/content/10.1101/2025.03.20.644389v1
  86. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    De novo design of Ras isoform selective binders
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    pmc.ncbi.nlm.nih.gov/articles/PMC11838417/
  87. Feb 2025
  88. www.sciencedirect.com www.sciencedirect.com
    Pcf11/Spt5 condensates stall RNA polymerase II to facilitate termination and piRNA-guided heterochromatin formation
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    sciencedirect.com/science/article/pii/S1097276525000577
  89. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Extracellular Histones as Exosome Membrane Proteins Regulated by Cell Stress
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    pmc.ncbi.nlm.nih.gov/articles/PMC11840699/
  90. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dysfunctional mechanotransduction regulates the progression of PIK3CA-driven vascular malformations
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    pmc.ncbi.nlm.nih.gov/articles/PMC11811908/
  91. Jan 2025
  92. www.sciencedirect.com www.sciencedirect.com
    Cytoplasmic mRNA decay controlling inflammatory gene expression is determined by pre-mRNA fate decision
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    sciencedirect.com/science/article/pii/S1097276525000012
  93. www.sciencedirect.com www.sciencedirect.com
    The efflux pump ABCC1/MRP1 constitutively restricts PROTAC sensitivity in cancer cells
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    sciencedirect.com/science/article/pii/S2451945624004896
  94. Dec 2024
  95. elifesciences.org elifesciences.org
    Telomere length sensitive regulation of interleukin receptor 1 type 1 (IL1R1) by the shelterin protein TRF2 modulates immune signalling in the tumour microenvironment
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    elifesciences.org/articles/95106
  96. 52.53.155.43 52.53.155.43
    can-24-2341-html.html
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    52.53.155.43/caa9a81163f3216c96027bd0df03525025321f97/can-24-2341-html.html
  97. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Proximity proteomic analysis of the NRF family reveals the Parkinson's disease protein ZNF746/PARIS as a co-complexed repressor of NRF2
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    pmc.ncbi.nlm.nih.gov/articles/PMC10760916/
  98. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A fully human IgG1 antibody targeting connexin 32 extracellular domain blocks CMTX1 hemichannel dysfunction in an in vitro model
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    pmc.ncbi.nlm.nih.gov/articles/PMC11619691/
  99. Oct 2024
  100. www.sciencedirect.com www.sciencedirect.com
    Disruption of cellular plasticity by repeat RNAs in human pancreatic cancer
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    sciencedirect.com/science/article/pii/S0092867424010729
  101. Sep 2024
  102. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting Grb2 SH3 Domains with Affimer Proteins Provides Novel Insights into Ras Signalling Modulation
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    ncbi.nlm.nih.gov/pmc/articles/PMC11352564/
  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RAS-ON inhibition overcomes clinical resistance to KRAS G12C-OFF covalent blockade
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    ncbi.nlm.nih.gov/pmc/articles/PMC11364849/
  104. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dysfunctional mechanotransduction regulates the progression of PIK3CA-driven vascular malformations
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    ncbi.nlm.nih.gov/pmc/articles/PMC11370454/
  105. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Synergistic Effect of Ubiquitin-Specific Protease 14 and Poly(ADP-Ribose) Glycohydrolase Co-Inhibition in BRCA1-Mutant, Poly(ADP-Ribose) Polymerase Inhibitor-Resistant Triple-Negative Breast Cancer Cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11385694/
  106. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structural and systems characterization of phosphorylation on metabolic enzymes identifies sex-specific metabolic reprogramming in obesity
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    ncbi.nlm.nih.gov/pmc/articles/PMC11383994/
  107. www.sciencedirect.com www.sciencedirect.com
    The ULK1 effector BAG2 regulates autophagy initiation by modulating AMBRA1 localization
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  108. Aug 2024
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  117. Jul 2024
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  120. Jun 2024
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  126. May 2024
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  132. Apr 2024
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  137. Mar 2024
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  142. Feb 2024
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  149. Nov 2023
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  151. Sep 2023
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  153. May 2023
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  163. Aug 2022
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  165. Jul 2022
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  167. Apr 2022
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    Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation
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  173. Mar 2022
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  175. Feb 2022
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  177. Oct 2021
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  180. Sep 2021
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  182. Aug 2021
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  184. Jul 2021
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  187. May 2021
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    RANK links senescence to stemness in the mammary epithelia, delaying tumor onset but increasing tumor aggressiveness
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  190. Apr 2021
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  193. Jan 2021
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    Post-transcriptional Gene Regulation by MicroRNA-194 Promotes Neuroendocrine Transdifferentiation in Prostate Cancer
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  195. Sep 2020
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    Identification of ALPPL2 as a Naive Pluripotent State-Specific Surface Protein Essential for Human Naive Pluripotency Regulation
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    KRAB-zinc finger protein gene expansion in response to active retrotransposons in the murine lineage
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