108 Matching Annotations
  1. Sep 2025
  2. www.sciencedirect.com www.sciencedirect.com
    Disrupting the interaction between androgen receptor and its coregulator WDR77 delays the growth of treatment-resistant prostate cancer
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    sciencedirect.com/science/article/pii/S221112472501006X
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Ablating UNG activity in a mouse model inhibits colorectal cancer growth by increasing tumor immunogenicity
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    pmc.ncbi.nlm.nih.gov/articles/PMC12406714/
  4. Aug 2025
  5. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.70112
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Multi-selective RAS(ON) Inhibition Targets Oncogenic RAS Mutations and Overcomes RAS/MAPK-Mediated Resistance to FLT3 and BCL2 Inhibitors in Acute Myeloid Leukemia
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    pmc.ncbi.nlm.nih.gov/articles/PMC12259086/
  7. www.sciencedirect.com www.sciencedirect.com
    PALB2 and 53BP1 govern post-resection homologous recombination DNA repair
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    sciencedirect.com/science/article/pii/S1097276525006045
  8. Jul 2025
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Advanced viral genome in vitro Cas9 editing (AdVICE): an overnight method for traceless and limitless manipulation of adenoviral and vector genomes with large transgenes
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    pmc.ncbi.nlm.nih.gov/articles/PMC12172474/
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Adipocyte-specific Zeb1 downregulation remodels the tumor-associated adipose microenvironment to facilitate female breast cancer progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12219764/
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Structural Repetition Detector for multi-scale quantitative mapping of molecular complexes through microscopy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12219329/
  12. www.biorxiv.org www.biorxiv.org
    The copper chaperone ATOX1 exhibits differential protein-protein interactions and contributes to skeletal myoblast differentiation
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    biorxiv.org/content/10.1101/2025.07.08.663731v1
  13. Jun 2025
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A monomeric envelope glycoprotein cytoplasmic tail is sufficient for HIV-1 Gag lattice trapping and incorporation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12090761/
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Phosphatase activity is dispensable for PRL-3-mediated oncogenesis and tumor progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12132575/
  16. May 2025
  17. www.sciencedirect.com www.sciencedirect.com
    Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates
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    sciencedirect.com/science/article/pii/S0092867425005094
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Novel STAT3 Y360C Gain-of-function Variant Underlies Immune Dysregulation and Aberrancy in Mitochondrial Dynamics
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    pmc.ncbi.nlm.nih.gov/articles/PMC12056293/
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PKM splice-switching ASOs induce upregulation of dual-specificity phosphatases and dephosphorylation of ERK1/2 in hepatocellular carcinoma
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11982463/
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Suppression of Ovarian Cancer Cell Proliferation Is Associated with Upregulation of Cell-Matrix Adhesion Programs and Integrin-β4-Induced Cell Protection from Cisplatin
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    pmc.ncbi.nlm.nih.gov/articles/PMC12070841/
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    LINE-1 ORF1p Mimics Viral Innate Immune Evasion Mechanisms in Pancreatic Ductal Adenocarcinoma
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12046326/
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Epstein-Barr virus deubiquitinase BPLF1 regulates stress-induced ribosome UFMylation and reticulophagy
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12013442/
  23. Apr 2025
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Metabolic constraint of human telomere length by nucleotide salvage efficiency
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    pmc.ncbi.nlm.nih.gov/articles/PMC11950188/
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Saturation mapping of MUTYH variant effects using DNA repair reporters
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    pmc.ncbi.nlm.nih.gov/articles/PMC11908140/
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Colorectal cancer hot spot mutations attenuate the ASXL-MLL4 interaction
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    pmc.ncbi.nlm.nih.gov/articles/PMC11957774/
  27. www.biorxiv.org www.biorxiv.org
    Inhibition of cytosolic DNA sensing and transposon activity safeguards pluripotency
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    biorxiv.org/content/10.1101/2025.03.26.645264v1
  28. www.cell.com www.cell.com
    SWI/SNF complex-mediated ZNF410 cooperative binding maintains chromatin accessibility and enhancer activity
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    cell.com/cell-reports/fulltext/S2211-1247(25)00247-5
  29. Mar 2025
  30. www.biorxiv.org www.biorxiv.org
    In vivo validation of the palmitoylation cycle as a therapeutic target in NRAS-mutant cancer
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    biorxiv.org/content/10.1101/2025.03.20.644389v1
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    De novo design of Ras isoform selective binders
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    pmc.ncbi.nlm.nih.gov/articles/PMC11838417/
  32. Feb 2025
  33. www.sciencedirect.com www.sciencedirect.com
    Pcf11/Spt5 condensates stall RNA polymerase II to facilitate termination and piRNA-guided heterochromatin formation
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    sciencedirect.com/science/article/pii/S1097276525000577
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Extracellular Histones as Exosome Membrane Proteins Regulated by Cell Stress
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    pmc.ncbi.nlm.nih.gov/articles/PMC11840699/
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dysfunctional mechanotransduction regulates the progression of PIK3CA-driven vascular malformations
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    pmc.ncbi.nlm.nih.gov/articles/PMC11811908/
  36. Jan 2025
  37. www.sciencedirect.com www.sciencedirect.com
    Cytoplasmic mRNA decay controlling inflammatory gene expression is determined by pre-mRNA fate decision
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    sciencedirect.com/science/article/pii/S1097276525000012
  38. www.sciencedirect.com www.sciencedirect.com
    The efflux pump ABCC1/MRP1 constitutively restricts PROTAC sensitivity in cancer cells
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    sciencedirect.com/science/article/pii/S2451945624004896
  39. Dec 2024
  40. elifesciences.org elifesciences.org
    Telomere length sensitive regulation of interleukin receptor 1 type 1 (IL1R1) by the shelterin protein TRF2 modulates immune signalling in the tumour microenvironment
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    elifesciences.org/articles/95106
  41. 52.53.155.43 52.53.155.43
    can-24-2341-html.html
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  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Proximity proteomic analysis of the NRF family reveals the Parkinson's disease protein ZNF746/PARIS as a co-complexed repressor of NRF2
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    pmc.ncbi.nlm.nih.gov/articles/PMC10760916/
  43. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A fully human IgG1 antibody targeting connexin 32 extracellular domain blocks CMTX1 hemichannel dysfunction in an in vitro model
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    pmc.ncbi.nlm.nih.gov/articles/PMC11619691/
  44. Oct 2024
  45. www.sciencedirect.com www.sciencedirect.com
    Disruption of cellular plasticity by repeat RNAs in human pancreatic cancer
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    sciencedirect.com/science/article/pii/S0092867424010729
  46. Sep 2024
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting Grb2 SH3 Domains with Affimer Proteins Provides Novel Insights into Ras Signalling Modulation
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    ncbi.nlm.nih.gov/pmc/articles/PMC11352564/
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RAS-ON inhibition overcomes clinical resistance to KRAS G12C-OFF covalent blockade
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    ncbi.nlm.nih.gov/pmc/articles/PMC11364849/
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dysfunctional mechanotransduction regulates the progression of PIK3CA-driven vascular malformations
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    ncbi.nlm.nih.gov/pmc/articles/PMC11370454/
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Synergistic Effect of Ubiquitin-Specific Protease 14 and Poly(ADP-Ribose) Glycohydrolase Co-Inhibition in BRCA1-Mutant, Poly(ADP-Ribose) Polymerase Inhibitor-Resistant Triple-Negative Breast Cancer Cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11385694/
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structural and systems characterization of phosphorylation on metabolic enzymes identifies sex-specific metabolic reprogramming in obesity
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    ncbi.nlm.nih.gov/pmc/articles/PMC11383994/
  52. www.sciencedirect.com www.sciencedirect.com
    The ULK1 effector BAG2 regulates autophagy initiation by modulating AMBRA1 localization
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    sciencedirect.com/science/article/pii/S2211124724010404
  53. Aug 2024
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tumoral Interferon Beta Induces an Immune-Stimulatory Phenotype in Tumor-Associated Macrophages in Melanoma Brain Metastases
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    ncbi.nlm.nih.gov/pmc/articles/PMC11337092/
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human stem cell–derived neurons and astrocytes to detect novel auto-reactive IgG response in immune-mediated neurological diseases
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    ncbi.nlm.nih.gov/pmc/articles/PMC11303155/
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Involvement of the splicing factor SART1 in the BRCA1-dependent homologous recombination repair of DNA double-strand breaks
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    ncbi.nlm.nih.gov/pmc/articles/PMC11310344/
  57. www.sciencedirect.com www.sciencedirect.com
    Sugar-mediated non-canonical ubiquitination impairs Nrf1/NFE2L1 activation
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    sciencedirect.com/science/article/pii/S1097276524005896
  58. www.sciencedirect.com www.sciencedirect.com
    A High-Throughput Screening Identifies MCM Chromatin loading Inhibitors Targeting Cells with increased Replication Origins
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    sciencedirect.com/science/article/pii/S2589004224017929
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cyclin F–EXO1 axis controls cell cycle–dependent execution of double-strand break repair
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    ncbi.nlm.nih.gov/pmc/articles/PMC11313846/
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Leukemic stem cells activate lineage inappropriate signalling pathways to promote their growth
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    ncbi.nlm.nih.gov/pmc/articles/PMC10867020/
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Opa1 and Drp1 reciprocally regulate cristae morphology, ETC function, and NAD+ regeneration in KRas-mutant lung adenocarcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10265649/
  62. Jul 2024
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Highlights from MBoC Selection: A methodology for specific disruption of microtubule polymerization into dendritic spines
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    ncbi.nlm.nih.gov/pmc/articles/PMC11238079/
  64. elifesciences.org elifesciences.org
    Novel autophagy inducers by accelerating lysosomal clustering against Parkinson’s disease
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    elifesciences.org/articles/98649
  65. Jun 2024
  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ASXLs binding to the PHD2/3 fingers of MLL4 provides a mechanism for the recruitment of BAP1 to active enhancers
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    ncbi.nlm.nih.gov/pmc/articles/PMC11161652/
  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dynamic label-free analysis of SARS-CoV-2 infection reveals virus-induced subcellular remodeling
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    ncbi.nlm.nih.gov/pmc/articles/PMC11166935/
  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeted sequencing for hereditary breast and ovarian cancer in BRCA1/2-negative families from the Lynch Memorial Biobank reveals complex genetic architecture and phenocopies
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    ncbi.nlm.nih.gov/pmc/articles/PMC11166883/
  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dynamic control of gene expression by ISGF3 and IRF1 during IFNβ and IFNγ signaling
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    ncbi.nlm.nih.gov/pmc/articles/PMC11148166/
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TCF7L1 regulates colorectal cancer cell migration by repressing GAS1 expression
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    ncbi.nlm.nih.gov/pmc/articles/PMC11139868/
  71. May 2024
  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Herpes simplex encephalitis due to a mutation in an E3 ubiquitin ligase
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    ncbi.nlm.nih.gov/pmc/articles/PMC11087577/
  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Downregulation of HNF4A enables transcriptomic reprogramming during the hepatic acute-phase response
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    ncbi.nlm.nih.gov/pmc/articles/PMC11099168/
  74. www.biorxiv.org www.biorxiv.org
    Context dependent activity of p63-bound gene regulatory elements
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    biorxiv.org/content/10.1101/2024.05.09.593326v1
  75. www.science.org www.science.org
    p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol
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    science.org/doi/10.1126/sciadv.adl6082
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol
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    ncbi.nlm.nih.gov/pmc/articles/PMC11068011/
  77. Apr 2024
  78. www.pnas.org www.pnas.org
    NOVA1 acts as an oncogenic RNA-binding protein to regulate cholesterol homeostasis in human glioblastoma cells
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    pnas.org/doi/abs/10.1073/pnas.2314695121
  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tumor Cell-Associated IL-1α Affects Breast Cancer Progression and Metastasis in Mice through Manipulation of the Tumor Immune Microenvironment
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    ncbi.nlm.nih.gov/pmc/articles/PMC11011794/
  80. www.sciencedirect.com www.sciencedirect.com
    SHIP inhibition mediates select TREM2-induced microglial functions
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    sciencedirect.com/science/article/pii/S0161589024000725
  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Thymidine nucleotide metabolism controls human telomere length
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    ncbi.nlm.nih.gov/pmc/articles/PMC11000509/
  82. Mar 2024
  83. link.springer.com link.springer.com
    Altered vacuole membrane protein 1 (VMP1) expression is associated with increased NLRP3 inflammasome activation and mitochondrial dysfunction
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    link.springer.com/article/10.1007/s00011-024-01856-x
  84. www.biorxiv.org www.biorxiv.org
    A Methodology for Specific Disruption of Microtubules in Dendritic Spines
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    biorxiv.org/content/10.1101/2024.03.04.583370v1
  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Protein supersaturation powers innate immune signaling
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    ncbi.nlm.nih.gov/pmc/articles/PMC10055258/
  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A model of human neural networks reveals NPTX2 pathology in ALS and FTLD
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    ncbi.nlm.nih.gov/pmc/articles/PMC10901740/
  87. Feb 2024
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Downregulation of praja2 restrains endocytosis and boosts tyrosine kinase receptors in kidney cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10879500/
  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DUX4-r exerts a neomorphic activity that depends on GTF2I in acute lymphoblastic leukemia
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    ncbi.nlm.nih.gov/pmc/articles/PMC10881058/
  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Chromatin targeting of the RNF12/RLIM E3 ubiquitin ligase controls transcriptional responses
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    ncbi.nlm.nih.gov/pmc/articles/PMC10781586/
  91. Jan 2024
  92. www.sciencedirect.com www.sciencedirect.com
    EXO1 protects BRCA1-deficient cells against toxic DNA lesions
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    sciencedirect.com/science/article/pii/S1097276523010857
  93. www.sciencedirect.com www.sciencedirect.com
    The male pachynema-specific protein MAPS drives phase separation in vitro and regulates sex body formation and chromatin behaviors in vivo
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    sciencedirect.com/science/article/pii/S2211124723016625
  94. Nov 2023
  95. www.sciencedirect.com www.sciencedirect.com
    Allosteric SHP2 inhibition increases apoptotic dependency on BCL2 and synergizes with venetoclax in FLT3- and KIT-mutant AML
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    sciencedirect.com/science/article/pii/S2666379123004846
  96. Sep 2023
  97. www.sciencedirect.com www.sciencedirect.com
    CBFA2T3-GLIS2-dependent pediatric acute megakaryoblastic leukemia is driven by GLIS2 and sensitive to navitoclax
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    sciencedirect.com/science/article/pii/S2211124723010951
  98. May 2023
  99. elifesciences.org elifesciences.org
    Human DUX4 and mouse Dux interact with STAT1 and broadly inhibit interferon-stimulated gene induction
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    elifesciences.org/articles/82057
  100. www.sciencedirect.com www.sciencedirect.com
    Glioblastoma cell fate is differentially regulated by the microenvironments of the tumor bulk and infiltrative margin
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    sciencedirect.com/science/article/pii/S2211124723004837
  101. Mar 2023
  102. 52.53.155.43 52.53.155.43
    Remodeling of the Ribosomal Quality Control and Protein Translation by a Viral Ubiquitin Deconjugase
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    52.53.155.43/56dd9657520d89efd227b99f30a1871711d5fdb7/2023.01.31.526464v1.full-html.html
  103. www.biorxiv.org www.biorxiv.org
    The Dietary Supplement Taurine Suppresses Ovarian Cancer Growth
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    biorxiv.org/content/10.1101/2023.02.24.529893v1
  104. Feb 2023
  105. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Stress Granules determine the Development of Obesity-associated Pancreatic Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC9357213/
  106. Sep 2022
  107. www.sciencedirect.com www.sciencedirect.com
    A nuclear cAMP microdomain suppresses tumor growth by Hippo pathway inactivation
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    sciencedirect.com/science/article/pii/S2211124722012530
  108. Aug 2022
  109. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    AR-V7 exhibits non-canonical mechanisms of nuclear import and chromatin engagement in castrate-resistant prostate cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC9398446/
  110. Jul 2022
  111. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Quantitative Assay for Ca2+ Uptake through Normal and Pathological Hemichannels
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    ncbi.nlm.nih.gov/pmc/articles/PMC9266989/
  112. Apr 2022
  113. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Data-driven learning how oncogenic gene expression locally alters heterocellular networks
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  115. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation
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    Developmental maturation of the hematopoietic system controlled by a Lin28b-let-7-Cbx2 axis
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  118. Mar 2022
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  120. Feb 2022
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  122. Oct 2021
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    Exocyst complex mediates recycling of internal cilia
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    CLIP-170S is a microtubule +TIP variant that confers resistance to taxanes by impairing drug-target engagement
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  125. Sep 2021
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    Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps
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  127. Aug 2021
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  129. Jul 2021
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    Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization
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    BHLHE40 Regulates IL-10 and IFN-γ Production in T Cells but Does Not Interfere With Human Type 1 Regulatory T Cell Differentiation
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  132. May 2021
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    RANK links senescence to stemness in the mammary epithelia, delaying tumor onset but increasing tumor aggressiveness
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    HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple Mechanisms of Unrestrained DNA Synthesis
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  135. Apr 2021
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    The white matter is a pro-differentiative niche for glioblastoma
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  138. Jan 2021
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    Post-transcriptional Gene Regulation by MicroRNA-194 Promotes Neuroendocrine Transdifferentiation in Prostate Cancer
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  140. Sep 2020
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    Identification of ALPPL2 as a Naive Pluripotent State-Specific Surface Protein Essential for Human Naive Pluripotency Regulation
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    Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense
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    Codon optimization is an essential parameter for the efficient allotopic expression of mtDNA genes
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    KRAB-zinc finger protein gene expansion in response to active retrotransposons in the murine lineage
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