72 Matching Annotations
  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Screening strategy to identify Cas9 variants with higher HDR activity based on diphtheria toxin
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    pmc.ncbi.nlm.nih.gov/articles/PMC12673799/
  3. Nov 2025
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cytosine methylase and hydroxymethylase activity in mammalian mitochondria
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    pmc.ncbi.nlm.nih.gov/articles/PMC12568578/
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CRISPR/Cas9 generated DSB clusters mimic complex lesions induced by high-LET radiation and shift repair from c-NHEJ to mutagenic repair pathways
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    pmc.ncbi.nlm.nih.gov/articles/PMC12537819/
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Development of programmable RNA imaging with RNA-guided GFP via click chemistry
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    pmc.ncbi.nlm.nih.gov/articles/PMC12597101/
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Loop engineering of AtCas9 for effective and broad genome editing
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    pmc.ncbi.nlm.nih.gov/articles/PMC12634846/
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Identification of Potential Therapeutic Agents for Type I Interferonopathy Using iPSC-Based Disease Modeling
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    pmc.ncbi.nlm.nih.gov/articles/PMC12484275/
  9. Aug 2025
  10. www.sciencedirect.com www.sciencedirect.com
    MYC deregulation sensitizes cancer cells to N-myristoyltransferase inhibition
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    sciencedirect.com/science/article/pii/S2211124725009519
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Conserved and unique features of terminal telomeric sequences in ALT-positive cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12316455/
  12. Jul 2025
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeted in vivo gene integration of a secretion-enabled GLP-1 receptor agonist reverses diet-induced non-genetic obesity and pre-diabetes
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    pmc.ncbi.nlm.nih.gov/articles/PMC12241343/
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Transcription Factor-Wide Association Studies to Identify Functional SNPs in Alzheimer's Disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC11714347/
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Repeat length as a key determinant for disease severity and antisense oligonucleotide activity in myotonic dystrophy type 1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12221585/
  16. Jun 2025
  17. www.cell.com www.cell.com
    Phase separation of TTBK2 and CEP164 is necessary for ciliogenesis
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    cell.com/cell-reports/fulltext/S2211-1247(25)00581-9
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Beyond Trypanosoma cruzi: LINE-1 Activation as a Driver of Chronic Inflammation in Chagas Disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC12111687/
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Identification of maternal allele sequences of IG-DMR that are essential for neonatal viability
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    pmc.ncbi.nlm.nih.gov/articles/PMC12097578/
  20. Apr 2025
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Light-induced expression of gRNA allows for optogenetic gene editing of T lymphocytes in vivo
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    pmc.ncbi.nlm.nih.gov/articles/PMC11925727/
  22. Mar 2025
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    KNTC1 introduces segmental heterogeneity to mitochondria
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    pmc.ncbi.nlm.nih.gov/articles/PMC11911638/
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dual-directional epi-genotoxicity assay for assessing chemically induced epigenetic effects utilizing the housekeeping TK gene
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    pmc.ncbi.nlm.nih.gov/articles/PMC11882845/
  25. Jan 2025
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    GATA4 binding to the Sox9 enhancer mXYSRa/Enh13 is critical for testis differentiation in mouse
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    pmc.ncbi.nlm.nih.gov/articles/PMC11743149/
  27. 52.53.155.43 52.53.155.43
    jkaf012-html.html
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    52.53.155.43/ad66d1769782719c2c3cb2ffd8f6b0a226401c33/jkaf012-html.html
  28. Dec 2024
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Lipid Nanoparticles Enable Efficient In Vivo DNA Knock-In via HITI-Mediated Genome Editing
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    pmc.ncbi.nlm.nih.gov/articles/PMC11673532/
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The cells are all-right: Regulation of the Lefty genes by separate enhancers in mouse embryonic stem cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11676945/
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Perinuclear assembly of vimentin intermediate filaments induces cancer cell nuclear dysmorphia
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    pmc.ncbi.nlm.nih.gov/articles/PMC11647624/
  32. Sep 2024
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Generation and analysis of mouse embryonic stem cells with knockout of the Mcph1 (microcephalin) gene
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    ncbi.nlm.nih.gov/pmc/articles/PMC11393655/
  34. www.sciencedirect.com www.sciencedirect.com
    Generation of a fluorescent mNeonGreen insulin reporter line in the H1 (WA01) hESC background
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    sciencedirect.com/science/article/pii/S1873506124002575
  35. Aug 2024
  36. www.sciencedirect.com www.sciencedirect.com
    Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication
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    sciencedirect.com/science/article/pii/S1097276521000046
  37. pubs.acs.org pubs.acs.org
    Mammalian Genomic Manipulation with Orthogonal Bxb1 DNA Recombinase Sites for the Functional Characterization of Protein Variants
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    pubs.acs.org/doi/full/10.1021/acssynbio.3c00355
  38. Jul 2024
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine
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    pmc.ncbi.nlm.nih.gov/articles/PMC11442470/
  40. May 2024
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ERLIN1/2 scaffolds bridge TMUB1 and RNF170 and restrict cholesterol esterification to regulate the secretory pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC11116810/
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Assessing cell lines with inducible depletion of cohesin and condensins components through analysis of metaphase chromosome morphology
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    ncbi.nlm.nih.gov/pmc/articles/PMC11057366/
  43. www.biorxiv.org www.biorxiv.org
    ERLIN1/2 scaffolds bridge TMUB1 and RNF170 and restrict cholesterol esterification to regulate the secretory pathway
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    biorxiv.org/content/10.1101/2024.01.17.576039v1
  44. www.cell.com www.cell.com
    Variant-to-function analysis of the childhood obesity chr12q13 locus implicates rs7132908 as a causal variant within the 3′ UTR of FAIM2
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    cell.com/cell-genomics/fulltext/S2666-979X(24)00122-8
  45. Apr 2024
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The pRb/RBL2-E2F1/4-GCN5 axis regulates cancer stem cell formation and G0 phase entry/exit by paracrine mechanisms
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    ncbi.nlm.nih.gov/pmc/articles/PMC11055877/
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transduction and Genome Editing of the Heart with Adeno-Associated Viral Vectors Loaded onto Electrospun Polydioxanone Nonwoven Fabrics
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    ncbi.nlm.nih.gov/pmc/articles/PMC11047894/
  48. www.sciencedirect.com www.sciencedirect.com
    Progesterone-mediated remodeling of the maternal-fetal interface by a PGRMC1-dependent mechanism
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    sciencedirect.com/science/article/pii/S0165037824000536
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Evolution of a novel regulatory mechanism of hypoxia inducible factor in hypoxia-tolerant electric fishes
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    ncbi.nlm.nih.gov/pmc/articles/PMC10958119/
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Promoting the production of challenging proteins via induced expression in CHO cells and modified cell-free lysates harboring T7 RNA polymerase and mutant eIF2α
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    ncbi.nlm.nih.gov/pmc/articles/PMC11004649/
  51. 52.53.155.43 52.53.155.43
    Perturbation of the insomnia WDR90 GWAS locus pinpoints rs3752495 as a causal variant influencing distal expression of neighboring gene, PIG-Q
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    52.53.155.43/03aa9aacb5042e3b32574d0ae05db80d0356b971/zsae085-html.html
  52. Feb 2024
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SpCas9-HF1 enhances accuracy of cell cycle-dependent genome editing by increasing HDR efficiency, and by reducing off-target effects and indel rates
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    ncbi.nlm.nih.gov/pmc/articles/PMC10848011/
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tumor Pigmentation Does Not Affect Light-Activated Belzupacap Sarotalocan Treatment but Influences Macrophage Polarization in a Murine Melanoma Model
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    ncbi.nlm.nih.gov/pmc/articles/PMC10829805/
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Fluorogenic CRISPR for genomic DNA imaging
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    ncbi.nlm.nih.gov/pmc/articles/PMC10831063/
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Absence of the RING domain in MID1 results in patterning defects in the developing human brain
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    ncbi.nlm.nih.gov/pmc/articles/PMC10796562/
  57. Dec 2023
  58. pubs.acs.org pubs.acs.org
    Mammalian Genomic Manipulation with Orthogonal Bxb1 DNA Recombinase Sites for the Functional Characterization of Protein Variants
    1
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    pubs.acs.org/doi/full/10.1021/acssynbio.3c00355
  59. Nov 2023
  60. www.biorxiv.org www.biorxiv.org
    A Proximal Sox2 Enhancer Cluster is Required for the Anterior Regional Identity of Neural Progenitors
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    biorxiv.org/content/10.1101/2023.11.09.566464v1
  61. Oct 2023
  62. 52.53.155.43 52.53.155.43
    BRD9-SMAD2/3 orchestrates stemness and tumorigenesis in pancreatic ductal adenocarcinoma
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    52.53.155.43/7e131b55ec1d758dbf0613142d9050421d02fd72/1-s2.0-S0016508523050126-main-html.html
  63. Sep 2023
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Unrepaired base excision repair intermediates in template DNA strands trigger replication fork collapse and PARP inhibitor sensitivity
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    ncbi.nlm.nih.gov/pmc/articles/PMC10505916/
  65. Aug 2023
  66. www.biorxiv.org www.biorxiv.org
    Perturbation of the insomnia WDR90 GWAS locus pinpoints rs3752495 as a causal variant influencing distal expression of neighboring gene, PIG-Q
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    biorxiv.org/content/10.1101/2023.08.17.553739v1
  67. www.sciencedirect.com www.sciencedirect.com
    Generation of CHOPe003-A ESC line to study an ACTG2 variant affecting smooth muscle development and function
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    sciencedirect.com/science/article/pii/S1873506123001721
  68. www.biorxiv.org www.biorxiv.org
    Variant-to-function analysis of the childhood obesity chr12q13 locus implicates rs7132908 as a causal variant within the 3’ UTR of FAIM2
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    biorxiv.org/content/10.1101/2023.08.21.553157v1
  69. Jun 2023
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In vivo18F-DOPA PET imaging identifies a dopaminergic deficit in a rat model with a G51D α-synuclein mutation
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    ncbi.nlm.nih.gov/pmc/articles/PMC10244711/
  71. Jan 2023
  72. www.nature.com www.nature.com
    Epigenetic and transcriptional regulations prime cell fate before division during human pluripotent stem cell differentiation
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    nature.com/articles/s41467-023-36116-9
  73. May 2022
  74. www.sciencedirect.com www.sciencedirect.com
    XIST loss impairs mammary stem cell differentiation and increases tumorigenicity through Mediator hyperactivation
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    sciencedirect.com/science/article/pii/S0092867422005323
  75. Mar 2022
  76. www.nature.com www.nature.com
    PLK1 inhibition selectively induces apoptosis in ARID1A deficient cells through uncoupling of oxygen consumption from ATP production
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    nature.com/articles/s41388-022-02219-8
  77. Dec 2021
  78. www.mdpi.com www.mdpi.com
    Antagonistic Roles of the Tumor Suppressor miR-210-3p and Oncomucin MUC4 Forming a Negative Feedback Loop in Pancreatic Adenocarcinoma
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    mdpi.com/2072-6694/13/24/6197
  79. Nov 2021
  80. www.sciencedirect.com www.sciencedirect.com
    An expansion of the non-coding genome and its regulatory potential underlies vertebrate neuronal diversity
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    sciencedirect.com/science/article/pii/S0896627321007820
  81. Oct 2021
  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Analysis of CRISPR/Cas9 Guide RNA Efficiency and Specificity Against Genetically Diverse HIV-1 Isolates
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    ncbi.nlm.nih.gov/pmc/articles/PMC7549012/
  83. Aug 2021
  84. www.sciencedirect.com www.sciencedirect.com
    Human-Specific Adaptations in Vpu Conferring Anti-tetherin Activity Are Critical for Efficient Early HIV-1 Replication In Vivo
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    sciencedirect.com/science/article/pii/S1931312817305450
  85. Jul 2021
  86. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    sciencedirect.com/science/article/pii/S1934590918305927
  87. www.sciencedirect.com www.sciencedirect.com
    Esrrb Unlocks Silenced Enhancers for Reprogramming to Naive Pluripotency
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    sciencedirect.com/science/article/pii/S1934590918302388
  88. www.nature.com www.nature.com
    Precise in vivo genome editing via single homology arm donor mediated intron-targeting gene integration for genetic disease correction
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    nature.com/articles/s41422-019-0213-0
  89. www.sciencedirect.com www.sciencedirect.com
    The BTB-domain transcription factor ZBTB2 recruits chromatin remodelers and a histone chaperone during the exit from pluripotency
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    sciencedirect.com/science/article/pii/S002192582100747X
  90. May 2021
  91. www.sciencedirect.com www.sciencedirect.com
    A Non-Coding Disease Modifier of Pancreatic Agenesis Identified by Genetic Correction in a Patient-Derived iPSC Line
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    sciencedirect.com/science/article/pii/S1934590920301995
  92. Apr 2021
  93. www.sciencedirect.com www.sciencedirect.com
    Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells
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    sciencedirect.com/science/article/pii/S1934590921001119
  94. Mar 2021
  95. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Study of the effect of the introduction of mitochondrial import determinants into the gRNA structure on the activity of the gRNA/SpCas9 complex in vitro
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    ncbi.nlm.nih.gov/pmc/articles/PMC7716540/
  96. Feb 2021
  97. www.embopress.org www.embopress.org
    Transcriptionally active enhancers in human cancer cells
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    embopress.org/doi/abs/10.15252/msb.20209873
  98. Nov 2020
  99. www.sciencedirect.com www.sciencedirect.com
    Generation of PAX7 Reporter Cells to Investigate Skeletal Myogenesis from Human Pluripotent Stem Cells
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    sciencedirect.com/science/article/pii/S2666166720301453
  100. Sep 2020
  101. www.mdpi.com www.mdpi.com
    Tumor Cell Associated Hyaluronan-CD44 Signaling Promotes Pro-Tumor Inflammation in Breast Cancer
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    mdpi.com/2072-6694/12/5/1325
  102. www.sciencedirect.com www.sciencedirect.com
    A Human Skeletal Muscle Atlas Identifies the Trajectories of Stem and Progenitor Cells across Development and from Human Pluripotent Stem Cells
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    sciencedirect.com/science/article/pii/S1934590920301569
  103. Jan 2020
  104. www.sciencedirect.com www.sciencedirect.com
    HSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for Mouse Spermatogenesis
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    sciencedirect.com/science/article/pii/S2211124719307351
  105. onlinelibrary.wiley.com onlinelibrary.wiley.com
    SNAIL1 employs β‐Catenin‐LEF1 complexes to control colorectal cancer cell invasion and proliferation
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    onlinelibrary.wiley.com/doi/10.1002/ijc.32644
  106. www.sciencedirect.com www.sciencedirect.com
    Esrrb Unlocks Silenced Enhancers for Reprogramming to Naive Pluripotency
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    sciencedirect.com/science/article/pii/S1934590918302388
  107. www.sciencedirect.com www.sciencedirect.com
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    sciencedirect.com/science/article/pii/S1934590918305927