40 Matching Annotations
  1. Last 7 days
  2. www.nature.com www.nature.com
    A streamlined base editor engineering strategy to reduce bystander editing
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    nature.com/articles/s41467-025-63609-6
  3. Jul 2025
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Epigenetic editing and epi-drugs: a combination strategy to simultaneously target KDM4 as a novel anticancer approach
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    pmc.ncbi.nlm.nih.gov/articles/PMC12177974/
  5. Jun 2025
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The ubiquitin ligase HUWE1 enhances WNT signaling by antagonizing destruction complex-mediated β-catenin degradation and through a mechanism independent of changes in β-catenin abundance
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    pmc.ncbi.nlm.nih.gov/articles/PMC12148233/
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The antibacterial factor APOL3 couples lysosomal damage to mitochondrial DNA efflux and type I IFN induction
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    pmc.ncbi.nlm.nih.gov/articles/PMC12139963/
  8. May 2025
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MSH2 is not required for either maintenance of DNA methylation or repeat contraction at the FMR1 locus in fragile X syndrome or the FXN locus in Friedreich’s ataxia
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    pmc.ncbi.nlm.nih.gov/articles/PMC12036138/
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Utility of the Base Editing System for Introducing Drug-Resistant Gene Mutations Into Human Leukemia Cellular Models
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    pmc.ncbi.nlm.nih.gov/articles/PMC12060998/
  11. Mar 2025
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SOX9 haploinsufficiency reveals SOX9-Noggin interaction in BMP-SMAD signaling pathway in chondrogenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11872873/
  13. Aug 2024
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    β-catenin mediates endodermal commitment of human ES cells via distinct transactivation functions
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    ncbi.nlm.nih.gov/pmc/articles/PMC11267888/
  15. Jul 2024
  16. www.biorxiv.org www.biorxiv.org
    Reduced SH3RF3 may protect against Alzheimer’s disease by lowering microglial pro-inflammatory responses via modulation of JNK and NFkB signaling
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    biorxiv.org/content/10.1101/2024.06.23.600281v1
  17. Jun 2024
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Multimodal HLA-I genotype regulation by human cytomegalovirus US10 and resulting surface patterning
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    ncbi.nlm.nih.gov/pmc/articles/PMC11189632/
  19. May 2024
  20. www.sciencedirect.com www.sciencedirect.com
    Cox7a1 controls skeletal muscle physiology and heart regeneration through complex IV dimerization
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    sciencedirect.com/science/article/pii/S1534580724002375
  21. Apr 2024
  22. www.sciencedirect.com www.sciencedirect.com
    Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons
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    sciencedirect.com/science/article/pii/S1934590924000948
  23. Mar 2024
  24. www.sciencedirect.com www.sciencedirect.com
    The Y49H cytochrome c variant enhances megakaryocytic maturation of K-562 cells
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    sciencedirect.com/science/article/pii/S0925443924001236
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The ubiquitin ligase HUWE1 enhances WNT signaling by antagonizing destruction complex-mediated β-catenin degradation and through a mechanism independent of β-catenin stability
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10896346/
  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RTF2 controls replication repriming and ribonucleotide excision at the replisome
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    ncbi.nlm.nih.gov/pmc/articles/PMC10908796/
  27. Feb 2024
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cellular Targets and Lysine Selectivity of the HERC5 ISG15 Ligase
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    ncbi.nlm.nih.gov/pmc/articles/PMC10831901/
  29. May 2023
  30. www.biorxiv.org www.biorxiv.org
    Identification of B56alpha, B56gamma; and BAP1 as PRR14L binding partners
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    biorxiv.org/content/10.1101/2023.04.29.538809v1
  31. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    A LGR5 reporter pig model closely resembles human intestine for improved study of stem cells in disease
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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202300223R
  32. Apr 2023
  33. www.sciencedirect.com www.sciencedirect.com
    Generation of two induced pluripotent stem cell lines with heterozygous and homozygous amyotrophic lateral sclerosis-causing mutation P525L (c.1574 C>T) in FUS gene
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    sciencedirect.com/science/article/pii/S1873506123000892
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RTF2 controls replication repriming and ribonucleotide excision at the replisome
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    ncbi.nlm.nih.gov/pmc/articles/PMC10054921/
  35. Mar 2023
  36. www.sciencedirect.com www.sciencedirect.com
    Generation of two induced pluripotent stem cell lines with heterozygous and homozygous amyotrophic lateral sclerosis-causing mutation R521G (c.1561C > G) in FUS gene
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    sciencedirect.com/science/article/pii/S1873506123000648
  37. Feb 2023
  38. www.sciencedirect.com www.sciencedirect.com
    The mechanosensitive ion channel Piezo1 modulates the migration and immune response of microglia
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    sciencedirect.com/science/article/pii/S2589004223000706
  39. Oct 2022
  40. www.sciencedirect.com www.sciencedirect.com
    Mechanisms and significance of tissue-specific MICU regulation of the mitochondrial calcium uniporter complex
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    sciencedirect.com/science/article/pii/S1097276522008954
  41. Aug 2022
  42. www.sciencedirect.com www.sciencedirect.com
    Glycosphingolipids are mediators of cancer plasticity through independent signaling pathways
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    sciencedirect.com/science/article/pii/S2211124722009949
  43. Jan 2022
  44. www.embopress.org www.embopress.org
    Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency
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    embopress.org/doi/abs/10.15252/embj.2021109108
  45. Nov 2021
  46. mct.aacrjournals.org mct.aacrjournals.org
    SLFN11 is Widely Expressed in Pediatric Sarcoma and Induces Variable Sensitization to Replicative Stress Caused By DNA-Damaging Agents
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    mct.aacrjournals.org/content/20/11/2151
  47. Sep 2021
  48. www.sciencedirect.com www.sciencedirect.com
    Generation of two induced pluripotent stem cell lines with heterozygous and homozygous GAG deletion in TOR1A gene from a healthy hiPSC line
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    sciencedirect.com/science/article/pii/S1873506121003834
  49. Aug 2021
  50. www.sciencedirect.com www.sciencedirect.com
    CRISPR-Mediated Base Editing Enables Efficient Disruption of Eukaryotic Genes through Induction of STOP Codons
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    sciencedirect.com/science/article/pii/S1097276517306056
  51. Jun 2021
  52. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Folate receptor α increases chemotherapy resistance through stabilizing MDM2 in cooperation with PHB2 that is overcome by MORAb-202 in gastric cancer
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    onlinelibrary.wiley.com/doi/10.1002/ctm2.454
  53. May 2021
  54. www.sciencedirect.com www.sciencedirect.com
    Plasticity of distal nephron epithelia from human kidney organoids enables the induction of ureteric tip and stalk
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    sciencedirect.com/science/article/pii/S1934590920305853
  55. www.sciencedirect.com www.sciencedirect.com
    Translational Repression of G3BP in Cancer and Germ Cells Suppresses Stress Granules and Enhances Stress Tolerance
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    sciencedirect.com/science/article/pii/S1097276520304664
  56. Apr 2021
  57. www.sciencedirect.com www.sciencedirect.com
    STAG2 mutations alter CTCF-anchored loop extrusion, reduce cis-regulatory interactions and EWSR1-FLI1 activity in Ewing sarcoma
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    sciencedirect.com/science/article/pii/S1535610821002087
  58. Mar 2021
  59. www.sciencedirect.com www.sciencedirect.com
    SARM1 is required in human derived sensory neurons for injury-induced and neurotoxic axon degeneration
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    sciencedirect.com/science/article/pii/S0014488621000418
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Scaf1 promotes respiratory supercomplexes and metabolic efficiency in zebrafish
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    ncbi.nlm.nih.gov/pmc/articles/PMC7332985/
  61. Sep 2020
  62. www.sciencedirect.com www.sciencedirect.com
    Heat Shock Factor 2 Protects against Proteotoxicity by Maintaining Cell-Cell Adhesion
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    sciencedirect.com/science/article/pii/S2211124719316948
  63. academic.oup.com academic.oup.com
    A point mutation in the nuclease domain of MLH3 eliminates repeat expansions in a mouse stem cell model of the Fragile X-related disorders
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    academic.oup.com/nar/article/doi/10.1093/nar/gkaa573/5867105
  64. www.sciencedirect.com www.sciencedirect.com
    Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase
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    sciencedirect.com/science/article/pii/S2211124720309037
  65. Jan 2020
  66. www.sciencedirect.com www.sciencedirect.com
    A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP β-CTFs, Not Aβ
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    sciencedirect.com/science/article/pii/S0896627319306361
  67. www.nature.com www.nature.com
    Tau interactome analyses in CRISPR-Cas9 engineered neuronal cells reveal ATPase-dependent binding of wild-type but not P301L Tau to non-muscle myosins
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    nature.com/articles/s41598-019-52543-5