132 Matching Annotations
  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Identification and inhibition of the Cyclin D Rb-docking interface that drives cell division
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    pmc.ncbi.nlm.nih.gov/articles/PMC12871278/
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dusp15 modulates mtHsp70 Thr116 phosphorylation state to preserve mito-UPR and attenuate cardiac dysfunction in diabetic cardiomyopathy
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    pmc.ncbi.nlm.nih.gov/articles/PMC13020309/
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dual recruitment of two CCM2 molecules to KRIT1 suppresses KLF4 expression
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    pmc.ncbi.nlm.nih.gov/articles/PMC13013565/
  5. Oct 2026
  6. www.sciencedirect.com www.sciencedirect.com
    A method for expressing two proteins at a tunable ratio allows for studying the kinetics of creatine transport by MCT12
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    sciencedirect.com/science/article/pii/S2589004226031007
  7. Sep 2026
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Laminin β4 is required for the development of human peripheral sensory neurons
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    pmc.ncbi.nlm.nih.gov/articles/PMC13615688/
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The anion channel GPR89 is a tumor-specific dependency in breast cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13598117/
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    A lysis-derived PMSF and orthovanadate oxidant defines a distinct cysteine-engagement profile
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    sciencedirect.com/science/article/pii/S2451945626002928
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CELF2 promotes 4R Tau splicing via nuclear clustering and drives cognitive dysfunction in tauopathy models
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    pmc.ncbi.nlm.nih.gov/articles/PMC13522573/
  12. Aug 2026
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Rosella-PLIN2 knock-in mouse reveals lipophagy and immunometabolic interplay in atherosclerosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC13502013/
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cyanine-modified ssODNs enhance CRISPR-Cas9 HDR in stem cell embryo models via chromatin and chemical modulation
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    pmc.ncbi.nlm.nih.gov/articles/PMC13392270/
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A cargo receptor entrapment complex is a therapeutic node for genetically and clinically distinct proteinopathies
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    pmc.ncbi.nlm.nih.gov/articles/PMC13404660/
  16. Jul 2026
  17. www.sciencedirect.com www.sciencedirect.com
    FGF21 synergizes with leptin to counteract obesity-related metabolic comorbidities by reversing hepatic leptin resistance
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    sciencedirect.com/science/article/pii/S1550413126002470
  18. www.science.org www.science.org
    Virome-wide ubiquitin ligase discovery reveals diverse mechanisms of immune evasion
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    science.org/doi/10.1126/science.aec6299
  19. Jun 2026
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Oxidative DNA lesions destabilize centromeres and drive chromosome instability
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    pmc.ncbi.nlm.nih.gov/articles/PMC13142297/
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-wide CRISPR screen identifies a cytokine-enhancer circuit driving HIF-2α activation in renal cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13178659/
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A viral APOBEC3 antagonist distinguishes HHV-6A from HHV-6B
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    pmc.ncbi.nlm.nih.gov/articles/PMC13134964/
  23. Apr 2026
  24. www.sciencedirect.com www.sciencedirect.com
    Unbiased niche labeling maps immune-excluded niche in bone metastasis
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    sciencedirect.com/science/article/pii/S0092867426003983
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RB loss modulates chromatin organization by regulating cohesin-dependent loops and enhancer-promoter interactions
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    pmc.ncbi.nlm.nih.gov/articles/PMC13103356/
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Inhibition of USP7 destabilizes the noncanonical PRC1.1 complex and induces neuroblastoma differentiation
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    pmc.ncbi.nlm.nih.gov/articles/PMC13082235/
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A CRISPR-Cas9 screen Reveals STEEP1 as a Key Host Dependency Factor for Epstein-Barr Virus Latent Membrane Protein 1 Trafficking and Signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC13015697/
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dissection of Gαs and Hedgehog Signaling Cross-talk Reveals Therapeutic Opportunities to Target Hedgehog-Dependent Tumors
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    pmc.ncbi.nlm.nih.gov/articles/PMC13055637/
  29. www.nature.com www.nature.com
    X-linked cancer-associated polypeptide (XCP) from lncRNA1456 modulates PHF8 histone demethylase activity to regulate the epigenome, gene expression, and cellular pathways in breast cancer
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    nature.com/articles/s41388-026-03740-w
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Reprogramming mRNA localization by targeted RNA-protein interference
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    pmc.ncbi.nlm.nih.gov/articles/PMC12991119/
  31. Mar 2026
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dominant-negative TP53 mutations potentiated by the HSF1-regulated proteostasis network
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    pmc.ncbi.nlm.nih.gov/articles/PMC12917913/
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CELF2 Promotes Tau Exon 10 Inclusion via Hinge Domain-Mediated Nuclear Condensation, Driving Cognitive Dysfunction in Tauopathy Models
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    pmc.ncbi.nlm.nih.gov/articles/PMC12869637/
  34. Feb 2026
  35. www.sciencedirect.com www.sciencedirect.com
    NAD+ sensing by PARP7 regulates the C/EBPβ-dependent transcription program during adipogenesis
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    sciencedirect.com/science/article/pii/S2211124726000070
  36. Jan 2026
  37. www.sciencedirect.com www.sciencedirect.com
    Dual targeting of SLC25A51 and succinate dehydrogenase selectively depletes mitochondrial NAD+ to eradicate KRAS-driven AML
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    sciencedirect.com/science/article/pii/S155041312600001X
  38. Dec 2025
  39. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    The TIM22 carrier translocase supports cell proliferation by facilitating mitochondrial iron uptake for Fe-S biogenesis
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    sciencedirect.com:5037/science/article/pii/S1097276525009396
  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting KRAS Inhibitor–Resistant Pancreatic Cancer with an MUC1-C Antibody–Drug Conjugate
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    pmc.ncbi.nlm.nih.gov/articles/PMC12703357/
  41. Nov 2025
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    APPswe mutation causes functional deficits in endothelial cells generated by transient ETV2 overexpression in human iPSCs
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    pmc.ncbi.nlm.nih.gov/articles/PMC12639930/
  43. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Conserved mode of nuclear lamina distortion by primate cytomegaloviruses: importance of the pSer22 motif, viral kinase and cis/trans isomerase Pin1 activity
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    pmc.ncbi.nlm.nih.gov/articles/PMC12578131/
  44. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A modular strategy for extracellular vesicle-mediated CRISPR-Cas9 delivery through aptamer-based loading and UV-activated cargo release
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    pmc.ncbi.nlm.nih.gov/articles/PMC12639036/
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Activation of a FOXO3-induced cell cycle arrest regulates ferroptosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12533257/
  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Lysosome-dependent nutrient scavenging underlies stress adaptation during epithelial-to-mesenchymal transition
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    pmc.ncbi.nlm.nih.gov/articles/PMC12485954/
  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Trastuzumab Deruxtecan (T-DXd) Resistance via Loss of HER2 Expression and Binding
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    pmc.ncbi.nlm.nih.gov/articles/PMC12631751/
  48. Sep 2025
  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CA-125 as a Biomarker in Renal Medullary Carcinoma: Integrated Molecular Profiling, Functional Characterization, and Prospective Clinical Validation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11913570/
  50. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Intron retention regulates STAT2 function and predicts immunotherapy response in lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12393442/
  51. Aug 2025
  52. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.70112
  53. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Drug tolerance and persistence to EGFR inhibitor treatment are mediated by an ILK-SFK-YAP signaling axis in lung adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12318776/
  54. Jun 2025
  55. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SWI/SNF ATPase silenced HLF potentiates lung metastasis in solid cancers
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    pmc.ncbi.nlm.nih.gov/articles/PMC12141477/
  56. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mutation of SMARCA4 Induces Cancer Cell–Intrinsic Defects in the Enhancer Landscape and Resistance to Immunotherapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12127800/
  57. May 2025
  58. dx.doi.org dx.doi.org
    RFX6 regulates human intestinal patterning and function upstream of PDX1
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    dx.doi.org/10.1242/dev.202529
  59. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Duplexed CeTEAM drug biosensors reveal determinants of PARP inhibitor selectivity in cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11986510/
  60. www.sciencedirect.com www.sciencedirect.com
    Sickle cell disease induces chromatin introversion and ferroptosis in CD8+ T cells to suppress anti-tumor immunity
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    sciencedirect.com/science/article/pii/S1074761325001839
  61. Apr 2025
  62. www.sciencedirect.com www.sciencedirect.com
    MLKL activity requires a splicing-regulated, druggable intramolecular interaction
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    sciencedirect.com/science/article/pii/S109727652500259X
  63. Mar 2025
  64. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Lethal co-expression intolerance underlies the mutually exclusive expression of ASCL1 and NEUROD1 in SCLC cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11906894/
  65. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dissection of Gαs and Hedgehog signaling crosstalk reveals therapeutic opportunities to target adenosine receptor 2b in Hedgehog-dependent tumors
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    pmc.ncbi.nlm.nih.gov/articles/PMC11888225/
  66. www.nature.com www.nature.com
    Converging mechanism of UM171 and KBTBD4 neomorphic cancer mutations
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    nature.com/articles/s41586-024-08533-3
  67. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    UM171 glues asymmetric CRL3–HDAC1/2 assembly to degrade CoREST corepressors
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    pmc.ncbi.nlm.nih.gov/articles/PMC11882444/
  68. Feb 2025
  69. dx.doi.org dx.doi.org
    Relaxin Modulates the Genomic Actions and Biological Effects of Estrogen in the Myometrium
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    dx.doi.org/10.1210/endocr/bqae123
  70. Jan 2025
  71. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Chromosome mis-segregation triggers cell cycle arrest through a mechanosensitive nuclear envelope checkpoint
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    pmc.ncbi.nlm.nih.gov/articles/PMC11735390/
  72. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RACK1 MARylation regulates translation and stress granules in ovarian cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11702359/
  73. Dec 2024
  74. www.jbc.org www.jbc.org
    Chikungunya virus nonstructural protein 1 is a versatile RNA capping and decapping enzyme
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    jbc.org/article/S0021-9258(23)02443-2/fulltext
  75. Sep 2024
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Frequent CHD1 deletions in prostate cancers of African American men is associated with rapid disease progression
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    ncbi.nlm.nih.gov/pmc/articles/PMC11411125/
  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mitotic gene regulation by the N-MYC-WDR5-PDPK1 nexus
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    ncbi.nlm.nih.gov/pmc/articles/PMC11007937/
  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RBN-2397, a PARP7 Inhibitor, Synergizes with Paclitaxel to Inhibit Proliferation and Migration of Ovarian Cancer Cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11370341/
  79. Aug 2024
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrative genomics identifies SHPRH as a tumor suppressor gene in lung adenocarcinoma that regulates DNA damage response
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    ncbi.nlm.nih.gov/pmc/articles/PMC11300780/
  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Oncogenic transcription factors instruct promoter-enhancer hubs in individual triple negative breast cancer cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11305386/
  82. Jul 2024
  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MUC1-C Dependence for the Progression of Pancreatic Neuroendocrine Tumors Identifies a Druggable Target for the Treatment of This Rare Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11274714/
  84. www.sciencedirect.com www.sciencedirect.com
    Proteomic analysis reveals a PLK1-dependent G2/M degradation program and a role for AKAP2 in coordinating the mitotic cytoskeleton
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    sciencedirect.com/science/article/pii/S2211124724008398
  85. Jun 2024
  86. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13672
  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pure estrogen receptor antagonists potentiate capecitabine activity in ESR1-mutant breast cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11162492/
  88. May 2024
  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    XIST and MUC1-C form an auto-regulatory pathway in driving cancer progression
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    ncbi.nlm.nih.gov/pmc/articles/PMC11091074/
  90. www.sciencedirect.com www.sciencedirect.com
    Metabolic regulator ERRγ governs gastric stem cell differentiation into acid-secreting parietal cells
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    sciencedirect.com/science/article/pii/S1934590924001437
  91. Apr 2024
  92. www.sciencedirect.com www.sciencedirect.com
    Unprocessed genomic uracil as a source of DNA replication stress in cancer cells
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    sciencedirect.com/science/article/pii/S109727652400282X
  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Increased frequency of CHD1 deletions in prostate cancers of African American men is associated with rapid disease progression without inducing homologous recombination deficiency
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    ncbi.nlm.nih.gov/pmc/articles/PMC11030533/
  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Nardilysin-regulated scission mechanism activates polo-like kinase 3 to suppress the development of pancreatic cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11009390/
  95. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Quaking isoforms cooperate to promote the mesenchymal phenotype
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    ncbi.nlm.nih.gov/pmc/articles/PMC10881146/
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The DNA Damage Response (DDR) landscape of endometrial cancer defines discrete disease subtypes and reveals therapeutic opportunities
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    ncbi.nlm.nih.gov/pmc/articles/PMC11000323/
  97. Mar 2024
  98. www.sciencedirect.com www.sciencedirect.com
    Transcription elongation defects link oncogenic SF3B1 mutations to targetable alterations in chromatin landscape
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    sciencedirect.com/science/article/pii/S1097276524001758
  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Passenger Gene Coamplifications Create Collateral Therapeutic Vulnerabilities in Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10911929/
  100. Feb 2024
  101. www.biorxiv.org www.biorxiv.org
    KDM6A Regulates Immune Response Genes in Multiple Myeloma
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    biorxiv.org/content/10.1101/2024.02.12.579179v1
  102. www.sciencedirect.com www.sciencedirect.com
    Specialized replication mechanisms maintain genome stability at human centromeres
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    sciencedirect.com/science/article/pii/S1097276524000546
  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Somatic estrogen receptor α mutations that induce dimerization promote receptor activity and breast cancer proliferation
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    ncbi.nlm.nih.gov/pmc/articles/PMC10760953/
  104. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MUC1-C is a target of salinomycin in inducing ferroptosis of cancer stem cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10770371/
  105. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dynamic proximity interaction profiling suggests that YPEL2 is involved in cellular stress surveillance
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    ncbi.nlm.nih.gov/pmc/articles/PMC10804680/
  106. Jan 2024
  107. www.sciencedirect.com www.sciencedirect.com
    BLM and BRCA1-BARD1 coordinate complementary mechanisms of joint DNA molecule resolution
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    sciencedirect.com/science/article/pii/S1097276523010869
  108. Dec 2023
  109. journals.plos.org journals.plos.org
    Functional regulation of the structure-specific endonuclease FEN1 by the human cytomegalovirus protein IE1 suggests a role for the re-initiation of stalled viral replication forks
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    journals.plos.org/plospathogens/article
  110. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ZNF524 directly interacts with telomeric DNA and supports telomere integrity
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    ncbi.nlm.nih.gov/pmc/articles/PMC10716145/
  111. Nov 2023
  112. www.sciencedirect.com www.sciencedirect.com
    Stabilizing vimentin phosphorylation inhibits stem-like cell properties and metastasis of hybrid epithelial/mesenchymal carcinomas
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    sciencedirect.com/science/article/pii/S2211124723014821
  113. www.sciencedirect.com www.sciencedirect.com
    Differences in syncytia formation by SARS-CoV-2 variants modify host chromatin accessibility and cellular senescence via TP53
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    sciencedirect.com/science/article/pii/S2211124723014900
  114. www.biorxiv.org www.biorxiv.org
    APC/C prevents non-canonical order of cyclin/CDK activity to maintain CDK4/6 inhibitor-induced arrest
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    biorxiv.org/content/10.1101/2023.11.09.566394v1
  115. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MUC1-C INTEGRATES AEROBIC GLYCOLYSIS WITH SUPPRESSION OF OXIDATIVE PHOSPHORYLATION IN TRIPLE-NEGATIVE BREAST CANCER STEM CELLS
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    ncbi.nlm.nih.gov/pmc/articles/PMC10616323/
  116. Oct 2023
  117. www.sciencedirect.com www.sciencedirect.com
    Lactate activates the mitochondrial electron transport chain independently of its metabolism
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  120. Sep 2023
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  122. Jun 2023
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  124. May 2023
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  126. Mar 2023
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  129. Feb 2023
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  132. Jan 2023
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  134. Nov 2022
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  136. Oct 2022
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  139. Aug 2022
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  142. Jun 2022
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  146. Mar 2022
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  148. Feb 2022
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  150. Dec 2021
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  152. Nov 2021
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  154. Oct 2021
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  156. Aug 2021
  157. journals.plos.org journals.plos.org
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  159. Jul 2021
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  163. Jun 2021
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  166. Apr 2021
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  169. Mar 2021
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  172. Feb 2021
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  174. Jan 2021
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  177. Dec 2020
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    Concurrent Mutations in STK11 and KEAP1 Promote Ferroptosis Protection and SCD1 Dependence in Lung Cancer
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  179. Sep 2020
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    Comprehensive Molecular Characterization Identifies Distinct Genomic and Immune Hallmarks of Renal Medullary Carcinoma
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  182. Jan 2020
  183. elifesciences.org elifesciences.org
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    Mechanical Stabilization of the Glandular Acinus by Linker of Nucleoskeleton and Cytoskeleton Complex
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