44 Matching Annotations
  1. Aug 2026
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    KRASG12V/A146T mutations are associated with nCRT resistance via enhanced DNA double-strand break repair and support a deep learning prediction framework in LARC
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    pmc.ncbi.nlm.nih.gov/articles/PMC13397665/
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PHF20 stabilizes the GAS7-F-actin axis to drive DNA damage repair and chemoresistance in cutaneous squamous cell carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC13424561/
  4. Jun 2026
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dysfunctional DNA Mismatch Repair Drives the Evolution of Gene Amplification in MTX-Resistant Human Colorectal Cancer Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC13163856/
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    FASN Inhibition Enhances the Efficacy of Chemotherapy in Colorectal Cancer by Inhibiting the DNA Damage Response
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    pmc.ncbi.nlm.nih.gov/articles/PMC13007557/
  7. May 2026
  8. www.sciencedirect.com www.sciencedirect.com
    Reciprocal compensation of caspase-2 and p53 regulates the DNA damage response in HCT116 colon cancer cells
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    sciencedirect.com/science/article/pii/S0021925826020715
  9. Nov 2025
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cisplatin-mediated activation of NF-κB promotes lung cancer stem cell formation via DNA repair pathways
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    pmc.ncbi.nlm.nih.gov/articles/PMC12639660/
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    GX15-070 enhances niraparib efficacy in ovarian cancer by promoting a shift in Mcl1-mediated DNA repair pathway from HR to NHEJ
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    pmc.ncbi.nlm.nih.gov/articles/PMC12607189/
  12. Oct 2025
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CRISPR Screen Identifies HDAC3 as a Novel Radiosensitizing Target in Small Cell Lung Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12493205/
  14. Aug 2025
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Tumor-derived CD84 promotes growth of acute myeloid leukemia cells via regulating nonhomologous DNA end-joining pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC12309267/
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Ivabradine induces RAD51 degradation, potentiating PARP inhibitor efficacy in non-germline BRCA pathogenic variant triple-negative breast cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12323259/
  17. Jul 2025
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PALB2 deficiency may sensitize H3K27M-mutant pediatric HGG cells to BMN673/talazoparib
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    pmc.ncbi.nlm.nih.gov/articles/PMC12256224/
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell
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    pmc.ncbi.nlm.nih.gov/articles/PMC12241572/
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Steroid‐Modulated Transcription Synergistically Forms DNA Double‐Strand Breaks With Topoisomerase II Inhibitor
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    pmc.ncbi.nlm.nih.gov/articles/PMC12210024/
  21. Jun 2025
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Nuclear VPS35 attenuates NHEJ repair by sequestering Ku protein
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    pmc.ncbi.nlm.nih.gov/articles/PMC12147292/
  23. May 2025
  24. 52.53.155.43 52.53.155.43
    PDF-html.html
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    52.53.155.43/934070a9a2d77450bd4205d4f9ad5da4d7cdf39e/PDF-html.html
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A first-in-class inhibitor of homologous recombination DNA repair counteracts tumour growth, metastasis and therapeutic resistance in pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12020112/
  26. Apr 2025
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Interleukin-33 (IL-33) promotes DNA damage-resistance in lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11992107/
  28. Mar 2025
  29. academic.oup.com academic.oup.com
    Homeodomain protein PRRX1 anchors the Ku heterodimers at DNA double-strand breaks to promote nonhomologous end-joining
    1
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    academic.oup.com/nar/article/53/6/gkaf200/8089753
  30. Dec 2024
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    BCAT1 Associates with DNA Repair Proteins KU70 and KU80 and Contributes to Regulate DNA Repair in T-Cell Acute Lymphoblastic Leukemia (T-ALL)
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11676169/
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Oleanolic Acid Modulates DNA Damage Response to Camptothecin Increasing Cancer Cell Death
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    pmc.ncbi.nlm.nih.gov/articles/PMC11676975/
  33. Sep 2024
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance
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    ncbi.nlm.nih.gov/pmc/articles/PMC11254748/
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    L3MBTL1, a polycomb protein, promotes Osimertinib acquired resistance through epigenetic regulation of DNA damage response in lung adenocarcinoma
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11374981/
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Synergistic Effect of Ubiquitin-Specific Protease 14 and Poly(ADP-Ribose) Glycohydrolase Co-Inhibition in BRCA1-Mutant, Poly(ADP-Ribose) Polymerase Inhibitor-Resistant Triple-Negative Breast Cancer Cells
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11385694/
  37. www.sciencedirect.com www.sciencedirect.com
    Characterization of DNA damage repair pathway utilization in high-grade serous ovarian cancers yields rational therapeutic approaches
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    sciencedirect.com/science/article/pii/S1936523324002468
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of Aberrantly Overexpressed Polo-like Kinase 4 Is a Potential Effective Treatment for DNA Damage Repair–Deficient Uterine Leiomyosarcoma
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11369621/
  39. Aug 2024
  40. molecular-cancer.biomedcentral.com molecular-cancer.biomedcentral.com
    BTApep-TAT peptide inhibits ADP-ribosylation of BORIS to induce DNA damage in cancer
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    molecular-cancer.biomedcentral.com/articles/10.1186/s12943-022-01621-w
  41. Jun 2024
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HELLS regulates transcription in T-cell lymphomas by reducing unscheduled R-loops and by facilitating RNAPII progression
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11194065/
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SNM1A is crucial for efficient repair of complex DNA breaks in human cells
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11199599/
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    UCHL3 induces radiation resistance and acquisition of mesenchymal phenotypes by deubiquitinating POLD4 in glioma stem cells
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11149539/
  45. Mar 2024
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Repression of the SUMO-conjugating enzyme UBC9 is associated with lowered double minutes and reduced tumor progression
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10936631/
  47. www.nature.com www.nature.com
    CDK9-55 guides the anaphase-promoting complex/cyclosome (APC/C) in choosing the DNA repair pathway choice
    1
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    nature.com/articles/s41388-024-02982-w
  48. Jan 2024
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FAK Drives Resistance to Therapy in HPV-Negative Head and Neck Cancer in a p53-Dependent Manner
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10767302/
  50. Nov 2023
  51. www.nature.com www.nature.com
    Repression of LSD1 potentiates homologous recombination-proficient ovarian cancer to PARP inhibitors through down-regulation of BRCA1/2 and RAD51
    2
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    nature.com/articles/s41467-023-42850-x
  52. Jul 2023
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The hydrophilic extract from a new tomato genotype (named DHO) kills cancer cell lines through the modulation of the DNA damage response induced by Campthotecin treatment
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10318356/
  54. Dec 2022
  55. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    APOBEC3G protects the genome of human cultured cells and mice from radiation-induced damage
    1
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    febs.onlinelibrary.wiley.com/doi/10.1111/febs.16673
  56. Sep 2022
  57. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    CANCER-ASSOCIATED SF3B1 MUTATIONS CONFER A BRCA-LIKE CELLULAR PHENOTYPE AND SYNTHETIC LETHALITY TO PARP INHIBITORS
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    pubmed.ncbi.nlm.nih.gov/35027467/
  58. Apr 2022
  59. aacrjournals.org aacrjournals.org
    Loss of Claudin-4 Reduces DNA Damage Repair and Increases Sensitivity to PARP Inhibitors
    1
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    aacrjournals.org/mct/article/21/4/647/689566/Loss-of-Claudin-4-Reduces-DNA-Damage-Repair-and
  60. Oct 2021
  61. www.sciencedirect.com www.sciencedirect.com
    Shift in MSL1 alternative polyadenylation in response to DNA damage protects cancer cells from chemotherapeutic agent-induced apoptosis
    1
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    sciencedirect.com/science/article/pii/S2211124721012791
  62. Aug 2021
  63. cancerres.aacrjournals.org cancerres.aacrjournals.org
    SHP2-Mediated Inhibition of DNA Repair Contributes to cGAS–STING Activation and Chemotherapeutic Sensitivity in Colon Cancer
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    cancerres.aacrjournals.org/content/81/12/3215
  64. www.embopress.org www.embopress.org
    Homologous recombination is reduced in female embryonic stem cells by two active X chromosomes
    1
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    embopress.org/doi/full/10.15252/embr.202052190
  65. Jul 2021
  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PINK1/Parkin Influences Cell Cycle by Sequestering TBK1 at Damaged Mitochondria, Inhibiting Mitosis
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC6880866/
  67. Feb 2021
  68. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RB1 Deletion in Retinoblastoma Protein Pathway-Disrupted Cells Results in DNA Damage and Cancer Progression
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC6664603/
  69. Oct 2020
  70. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    TGFβR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment
    1
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    pubmed.ncbi.nlm.nih.gov/33027668/