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Nov 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

CRISPR/Cas9 generated DSB clusters mimic complex lesions induced by high-LET radiation and shift repair from c-NHEJ to mutagenic repair pathways

1
1. scibot 24 Nov 2025
  
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  Addgene_44719
  
  DOI: 10.1038/s41598-025-22945-9
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12537819/
Oct 2025
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3D-generation of high-purity midbrain dopaminergic progenitors and lineage-guided refinement of grafts supports Parkinson’s disease cell therapy

1
1. scibot 28 Oct 2025
  
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  RRID:Addgene_44719
  
  DOI: 10.1016/j.stem.2025.10.001
  
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sciencedirect.com/science/article/pii/S1934590925003698
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Tissue microenvironment dictates the state of human iPSC-derived endothelial cells of distinct developmental origin in 3D cardiac microtissues

1
1. scibot 09 Oct 2025
  
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  plasmid_44719
  
  DOI: 10.1016/j.isci.2025.113611
  
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sciencedirect.com/science/article/pii/S2589004225018723
Sep 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Neolactotetraosylceramide enables urinary detection of bladder cancer

1
1. scibot 16 Sep 2025
  
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  RRID:Addgene_44719
  
  DOI: 10.1016/j.xcrm.2025.102246
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12432384/
Aug 2025
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MYC deregulation sensitizes cancer cells to N-myristoyltransferase inhibition

1
1. scibot 26 Aug 2025
  
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  Addgene plasmid 44719
  
  DOI: 10.1016/j.celrep.2025.116180
  
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sciencedirect.com/science/article/pii/S2211124725009519
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Human stem cell-derived A10 dopaminergic neurons specifically integrate into mouse circuits and improve depression-like behaviors

1
1. scibot 12 Aug 2025
  
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  RRID:Addgene_44719
  
  DOI: 10.1016/j.stem.2025.07.007
  
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sciencedirect.com/science/article/pii/S1934590925002644
Jul 2025
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Macropinocytosis maintains CAF subtype identity under metabolic stress in pancreatic cancer

1
1. scibot 25 Jul 2025
  
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  AddgeneCat# 44719
  
  DOI: 10.1016/j.ccell.2025.06.021
  
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sciencedirect.com/science/article/pii/S1535610825002715
Jun 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Loss of Ubiquitin-Specific Protease 11 Mitigates Pulmonary Fibrosis in Human Pluripotent Stem Cell-Derived Alveolar Organoids

1
1. scibot 15 Jun 2025
  
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  44719
  
  DOI: 10.15283/ijsc25011
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12122244/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Stepwise strategy for generating human trophoblast stem-like cells from embryonic stem cells reveals specific role of TFAP2C in acquiring self-renewability

1
1. scibot 15 Jun 2025
  
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  44719
  
  DOI: 10.1038/s41598-025-03830-x
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12125314/
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Targeting USP11 counteracts SFTPCI73T-associated interstitial lung disease in hiPSCs-derived alveolar organoids and in vivo models

1
1. scibot 21 May 2025
  
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  Addgene_44719
  
  DOI: 10.7150/thno.105994
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11984411/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The kinase domain of TRPM7 interacts with PAK1 and regulates pancreatic cancer cell epithelial-to-mesenchymal transition

1
1. scibot 19 May 2025
  
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  plasmid_44719
  
  DOI: 10.1038/s41419-025-07665-2
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12022261/
Feb 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

MTCH2 controls energy demand and expenditure to fuel anabolism during adipogenesis

1
1. scibot 20 Feb 2025
  
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  Plasmid_44719
  
  DOI: 10.1038/s44318-024-00335-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11832942/
Jan 2025
52.53.155.43 52.53.155.43

jkaf012-html.html

1
1. scibot 25 Jan 2025
  
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  plasmid_44719
  
  DOI: 10.1093/g3journal/jkaf012
  
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52.53.155.43/ad66d1769782719c2c3cb2ffd8f6b0a226401c33/jkaf012-html.html
www.embopress.org www.embopress.org

MTCH2 controls energy demand and expenditure to fuel anabolism during adipogenesis

1
1. scibot 08 Jan 2025
  
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  Plasmid_44719
  
  DOI: 10.1038/s44318-024-00335-7
  
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embopress.org/doi/10.1038/s44318-024-00335-7
Dec 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The cells are all-right: Regulation of the Lefty genes by separate enhancers in mouse embryonic stem cells

1
1. scibot 29 Dec 2024
  
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  44719
  
  DOI: 10.1371/journal.pgen.1011513
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11676945/
Sep 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Regulation of the cell surface expression of classical and non-classical MHC proteins by the human cytomegalovirus UL40 and rhesus cytomegalovirus Rh67 proteins

1
1. scibot 25 Sep 2024
  
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  plasmid_44719
  
  DOI: 10.1128/jvi.01206-24
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11406984/
www.sciencedirect.com www.sciencedirect.com

Generation of a fluorescent mNeonGreen insulin reporter line in the H1 (WA01) hESC background

2
1. scibot 15 Sep 2024
  
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  RRID:Addgene_44719
  
  DOI: 10.1016/j.scr.2024.103559
  
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  Curator: @mzhang007
  
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  RRID:Addgene_44719
2. scibot 15 Sep 2024
  
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  RRID:Addgene_44719
  
  DOI: 10.1016/j.scr.2024.103559
  
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sciencedirect.com/science/article/pii/S1873506124002575
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Using CRISPR-Cas9 to Generate Gene-Corrected Autologous iPSCs for the Treatment of Inherited Retinal Degeneration

1
1. scibot 21 Aug 2024
  
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  Addgene_44719
  
  DOI: 10.1016/j.ymthe.2017.05.015
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5589061/
Jul 2024
www.nature.com www.nature.com

ASS1 metabolically contributes to the nuclear and cytosolic p53-mediated DNA damage response

1
1. scibot 18 Jul 2024
  
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  Addgene, 44719
  
  DOI: 10.1038/s42255-024-01060-5
  
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  RRID:Addgene_44719 DOI:10.1038/s42255-024-01060-5
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DOI:10.1038/s42255-024-01060-5

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nature.com/articles/s42255-024-01060-5
Jun 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

m5C methylated lncRncr3–MeCP2 interaction restricts miR124a-initiated neurogenesis

1
1. scibot 20 Jun 2024
  
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  RRID:Addgene_44719
  
  DOI: 10.1038/s41467-024-49368-w
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11180186/
www.sciencedirect.com www.sciencedirect.com

Interferon-γ induces combined pyroptotic angiopathy and APOL1 expression in human kidney disease

1
1. scibot 07 Jun 2024
  
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  Addgene44719
  
  DOI: 10.1016/j.celrep.2024.114310
  
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  DOI:10.1016/j.celrep.2024.114310 RRID:Addgene_44719
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DOI:10.1016/j.celrep.2024.114310

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sciencedirect.com/science/article/pii/S2211124724006387
May 2024
www.cell.com www.cell.com

Variant-to-function analysis of the childhood obesity chr12q13 locus implicates rs7132908 as a causal variant within the 3′ UTR of FAIM2

1
1. scibot 02 May 2024
  
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  RRID:Addgene_44719
  
  DOI: 10.1016/j.xgen.2024.100556
  
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cell.com/cell-genomics/fulltext/S2666-979X(24)00122-8
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Long-term expandable mouse and human-induced nephron progenitor cells enable kidney organoid maturation and modeling of plasticity and disease

2
1. scibot 01 May 2024
  
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  RRID:Addgene_44719
  
  DOI: 10.1016/j.stem.2024.04.002
  
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  RRID:Addgene_44719
2. scibot 01 May 2024
  
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  RRID:Addgene_44719
  
  DOI: 10.1016/j.stem.2024.04.002
  
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sciencedirect.com/science/article/pii/S1934590924001292
Apr 2024
www.sciencedirect.com www.sciencedirect.com

Progesterone-mediated remodeling of the maternal-fetal interface by a PGRMC1-dependent mechanism

1
1. scibot 20 Apr 2024
  
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  Addgene_44719
  
  DOI: 10.1016/j.jri.2024.104244
  
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sciencedirect.com/science/article/pii/S0165037824000536
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The antibodies 3D12 and 4D12 recognise distinct epitopes and conformations of HLA-E

1
1. scibot 11 Apr 2024
  
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  RRID:Addgene_44719
  
  DOI: 10.3389/fimmu.2024.1329032
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10987726/
52.53.155.43 52.53.155.43

Perturbation of the insomnia WDR90 GWAS locus pinpoints rs3752495 as a causal variant influencing distal expression of neighboring gene, PIG-Q

1
1. scibot 10 Apr 2024
  
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  RRID:Addgene_44719
  
  DOI: 10.1093/sleep/zsae085
  
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52.53.155.43/03aa9aacb5042e3b32574d0ae05db80d0356b971/zsae085-html.html
Nov 2023
www.biorxiv.org www.biorxiv.org

A Proximal Sox2 Enhancer Cluster is Required for the Anterior Regional Identity of Neural Progenitors

1
1. scibot 17 Nov 2023
  
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  plasmid_44719
  
  DOI: 10.1101/2023.11.09.566464
  
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biorxiv.org/content/10.1101/2023.11.09.566464v1
Aug 2023
www.biorxiv.org www.biorxiv.org

Perturbation of the insomnia WDR90 GWAS locus pinpoints rs3752495 as a causal variant influencing distal expression of neighboring gene, PIG-Q

1
1. scibot 29 Aug 2023
  
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  RRID:Addgene_44719
  
  DOI: 10.1101/2023.08.17.553739
  
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biorxiv.org/content/10.1101/2023.08.17.553739v1
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Generation of CHOPe003-A ESC line to study an ACTG2 variant affecting smooth muscle development and function

1
1. scibot 27 Aug 2023
  
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  RRID:Addgene_44719
  
  DOI: 10.1016/j.scr.2023.103186
  
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sciencedirect.com/science/article/pii/S1873506123001721
www.biorxiv.org www.biorxiv.org

Variant-to-function analysis of the childhood obesity chr12q13 locus implicates rs7132908 as a causal variant within the 3’ UTR of FAIM2

1
1. scibot 27 Aug 2023
  
  in Public
  
  RRID:Addgene_44719
  
  DOI: 10.1101/2023.08.21.553157
  
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biorxiv.org/content/10.1101/2023.08.21.553157v1
Jun 2023
www.sciencedirect.com www.sciencedirect.com

Complex regulation of Eomes levels mediated through distinct functional features of the Meteor long non-coding RNA locus

1
1. scibot 02 Jun 2023
  
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  plasmid_44719
  
  DOI: 10.1016/j.celrep.2023.112569
  
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sciencedirect.com/science/article/pii/S2211124723005806
Mar 2023
www.sciencedirect.com www.sciencedirect.com

Mapping of clonal lineages across developmental stages in human neural differentiation

1
1. scibot 18 Mar 2023
  
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  RRID:Addgene_44719
  
  DOI: 10.1016/j.stem.2023.02.007
  
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sciencedirect.com/science/article/pii/S1934590923000449
Feb 2023
www.sciencedirect.com www.sciencedirect.com

Transgenerational inheritance of acquired epigenetic signatures at CpG islands in mice

1
1. scibot 09 Feb 2023
  
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  Addgene_44719
  
  DOI: 10.1016/j.cell.2022.12.047
  
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sciencedirect.com/science/article/pii/S0092867422016300
Jan 2023
www.sciencedirect.com www.sciencedirect.com

Introduction of a Geminin mScarlet reporter into H2B-mTurq2 hiPSCs for Live-cell imaging of proliferation and cell cycling

1
1. scibot 24 Jan 2023
  
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  Addgene_44719
  
  DOI: 10.1016/j.scr.2023.103031
  
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sciencedirect.com/science/article/pii/S187350612300017X
Dec 2022
www.sciencedirect.com www.sciencedirect.com

Generation of a CRISPR/Cas9-corrected-hiPSC line (DDLABi001-A) from Fabry disease (FD)-derived iPSCs having α-galactosidase (GLA) gene mutation (c.803_806del)

1
1. scibot 11 Dec 2022
  
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  RRID:Addgene_44719
  
  DOI: 10.1016/j.scr.2022.103001
  
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sciencedirect.com/science/article/pii/S1873506122003506
Mar 2022
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PLK1 inhibition selectively induces apoptosis in ARID1A deficient cells through uncoupling of oxygen consumption from ATP production

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1. scibot 10 Mar 2022
  
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  RRID:Addgene_44719
  
  DOI: 10.1038/s41388-022-02219-8
  
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nature.com/articles/s41388-022-02219-8
Dec 2021
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Antagonistic Roles of the Tumor Suppressor miR-210-3p and Oncomucin MUC4 Forming a Negative Feedback Loop in Pancreatic Adenocarcinoma

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1. scibot 29 Dec 2021
  
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  RRID:Addgene_44719
  
  DOI: 10.3390/cancers13246197
  
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mdpi.com/2072-6694/13/24/6197
Nov 2021
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Generation of LUMCi041-A-2: equipping a PAX3 reporter iPSC line with doxycycline inducible H2B-mTurquoise2 for live cell imaging

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1. scibot 04 Nov 2021
  
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  Addgene_44719
  
  DOI: 10.1016/j.scr.2021.102592
  
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sciencedirect.com/science/article/pii/S1873506121004396
Aug 2021
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Human sensorimotor organoids derived from healthy and amyotrophic lateral sclerosis stem cells form neuromuscular junctions

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1. scibot 16 Aug 2021
  
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  RRID:Addgene_44719
  
  DOI: 10.1038/s41467-021-24776-4
  
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nature.com/articles/s41467-021-24776-4
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Actinin BioID reveals sarcomere crosstalk with oxidative metabolism through interactions with IGF2BP2

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1. scibot 11 Aug 2021
  
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  Addgene Cat. #44719
  
  DOI: 10.1016/j.celrep.2021.109512
  
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sciencedirect.com/science/article/pii/S2211124721009426
Jul 2021
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Modelling human hepato-biliary-pancreatic organogenesis from the foregut–midgut boundary

1
1. scibot 30 Jul 2021
  
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  Cas9–2A–GFP
  
  DOI: 10.1038/s41586-019-1598-0
  
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nature.com/articles/s41586-019-1598-0
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A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP β-CTFs, Not Aβ

1
1. scibot 29 Jul 2021
  
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  RRID:Addgene 44719
  
  DOI: 10.1016/j.neuron.2019.07.010
  
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sciencedirect.com/science/article/pii/S0896627319306361
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Untitled document

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1. scibot 27 Jul 2021
  
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  plasmid_44719
  
  DOI: 10.1016/j.stem.2018.11.018
  
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sciencedirect.com/science/article/pii/S193459091830554X
academic.oup.com academic.oup.com

Untitled document

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1. scibot 27 Jul 2021
  
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  plasmid_44719
  
  DOI: 10.1210/en.2017-00478
  
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academic.oup.com/endo/article/158/10/3696/3977957
May 2021
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Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes

1
1. scibot 09 May 2021
  
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  RRID:Addgene_44719
  
  DOI: 10.1016/j.stem.2020.12.016
  
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sciencedirect.com/science/article/pii/S1934590920306007
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Human Stem Cell-Derived Neurons Repair Circuits and Restore Neural Function

1
1. scibot 09 May 2021
  
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  RRID:Addgene_44719
  
  DOI: 10.1016/j.stem.2020.08.014
  
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sciencedirect.com/science/article/pii/S1934590920304100
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A Non-Coding Disease Modifier of Pancreatic Agenesis Identified by Genetic Correction in a Patient-Derived iPSC Line

1
1. scibot 08 May 2021
  
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  RRID:Addgene_44719
  
  DOI: 10.1016/j.stem.2020.05.001
  
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sciencedirect.com/science/article/pii/S1934590920301995
Apr 2021
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STAG2 mutations alter CTCF-anchored loop extrusion, reduce cis-regulatory interactions and EWSR1-FLI1 activity in Ewing sarcoma

1
1. scibot 30 Apr 2021
  
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  RRID:Addgene_44719
  
  DOI: 10.1016/j.ccell.2021.04.001
  
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sciencedirect.com/science/article/pii/S1535610821002087
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Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells

1
1. scibot 29 Apr 2021
  
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  plasmid_44719
  
  DOI: 10.1016/j.stem.2021.03.005
  
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sciencedirect.com/science/article/pii/S1934590921001119
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Allele-Specific Chromosome Removal after Cas9 Cleavage in Human Embryos

1
1. scibot 24 Apr 2021
  
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  RRID:Addgene_44719
  
  DOI: 10.1016/j.cell.2020.10.025
  
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sciencedirect.com/science/article/pii/S0092867420313891
Sep 2020
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In Vivo Chimeric Alzheimer’s Disease Modeling of Apolipoprotein E4 Toxicity in Human Neurons

1
1. scibot 09 Sep 2020
  
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  RRID:Addgene_44719
  
  DOI: 10.1016/j.celrep.2020.107962
  
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  RRIDCUR:Validated RRID:Addgene_44719
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sciencedirect.com/science/article/pii/S2211124720309438
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Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase

1
1. scibot 06 Sep 2020
  
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  Addgene_44719
  
  DOI: 10.1016/j.celrep.2020.107922
  
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  RRIDCUR:Validated RRID:Addgene_44719
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sciencedirect.com/science/article/pii/S2211124720309037
Jan 2020
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Generation of Human PSC-Derived Kidney Organoids with Patterned Nephron Segments and a De Novo Vascular Network

1
1. scibot 13 Jan 2020
  
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  RRID:Addgene_44719
  
  DOI: 10.1016/j.stem.2019.06.009
  
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  RRID:Addgene_44719 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1934590919302735
onlinelibrary.wiley.com onlinelibrary.wiley.com

SNAIL1 employs β‐Catenin‐LEF1 complexes to control colorectal cancer cell invasion and proliferation

1
1. scibot 13 Jan 2020
  
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  plasmid_44719
  
  DOI: 10.1002/ijc.32644
  
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  RRID:Addgene_44719 RRIDCUR:Validated
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onlinelibrary.wiley.com/doi/10.1002/ijc.32644
www.nature.com www.nature.com

Variation in zygotic CRISPR/Cas9 gene editing outcomes generates novel reporter and deletion alleles at the Gdf11 locus

1
1. scibot 13 Jan 2020
  
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  RRID:Addgene_44719
  
  DOI: 10.1038/s41598-019-54766-y
  
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  RRID:Addgene_44719 RRIDCUR:Validated
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nature.com/articles/s41598-019-54766-y
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Modeling Steatohepatitis in Humans with Pluripotent Stem Cell-Derived Organoids

1
1. scibot 13 Jan 2020
  
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  RRID:Addgene_44719
  
  DOI: 10.1016/j.cmet.2019.05.007
  
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  RRID:Addgene_44719 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1550413119302475
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Metabolic and Organelle Morphology Defects in Mice and Human Patients Define Spinocerebellar Ataxia Type 7 as a Mitochondrial Disease

1
1. scibot 12 Jan 2020
  
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  RRID:Addgene_44719
  
  DOI: 10.1016/j.celrep.2019.01.028
  
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  RRID:Addgene_44719 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2211124719300373