Hypothesis

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Nov 2025
54.241.53.176 54.241.53.176

1-s2.0-S2589004225024058-main-html.html

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1. scibot 22 Nov 2025
  
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  Addgene 46757
  
  DOI: 10.1016/j.isci.2025.114144
  
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54.241.53.176/363ac440fe4fd09e6c215b8cac88403cba003940/1-s2.0-S2589004225024058-main-html.html
Sep 2025
anatomypubs.onlinelibrary.wiley.com anatomypubs.onlinelibrary.wiley.com

Lineage labeling with zebrafish hand2 Cre and CreERT2 recombinase CRISPR knock-ins

1
1. scibot 24 Sep 2025
  
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  Addgene_46757
  
  DOI: 10.1002/dvdy.70022
  
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anatomypubs.onlinelibrary.wiley.com/doi/full/10.1002/dvdy.70022
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Pth4 neurons define a novel hypothalamic circuit that promotes sleep via brainstem monoaminergic neurons

1
1. scibot 22 Sep 2025
  
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  pT3TS-nCas9n
  
  DOI: 10.1101/2025.09.09.675233
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12439947/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Identifying in vivo genetic dependencies of melanocyte and melanoma development

1
1. scibot 07 Sep 2025
  
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  Addgene_46757
  
  DOI: 10.7554/eLife.100257
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12396812/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

A quadratic paradigm describes the relationship between phenotype severity and variation

1
1. scibot 06 Sep 2025
  
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  plasmid_46757
  
  DOI: 10.1038/s41467-025-63316-2
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12402270/
Jul 2025
52.53.155.43 52.53.155.43

ssrn-5353044-html.html

1
1. scibot 25 Jul 2025
  
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  RRID:Addgene_46757
  
  DOI: 10.2139/ssrn.5353044
  
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52.53.155.43/6f055e2327548a4d44d1455e8cde232efc1eedcd/ssrn-5353044-html.html
Jun 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

p21, ccng1, foxo3b, and fbxw7 contribute to p53-dependent cell cycle arrest

1
1. scibot 14 Jun 2025
  
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  46757
  
  DOI: 10.1016/j.isci.2025.112558
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12145846/
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The Gq/11 family of Gα subunits is necessary and sufficient for lower jaw development

1
1. scibot 21 May 2025
  
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  plasmid_46757
  
  DOI: 10.1242/dev.204396
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12045641/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Endogenous acrolein accumulation in akr7a3 mutants causes microvascular dysfunction due to increased arachidonic acid metabolism

1
1. scibot 17 May 2025
  
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  pT3TS-nCas9n
  
  DOI: 10.1016/j.redox.2025.103639
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12051060/
Apr 2025
www.medrxiv.org www.medrxiv.org

Autophagy regulator ATG7 links energy metabolism to tubular cell fate specialization and kidney disease

1
1. scibot 02 Apr 2025
  
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  46757
  
  DOI: 10.1101/2025.03.26.25324675
  
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medrxiv.org/content/10.1101/2025.03.26.25324675v1
Mar 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The Dissemination of Rift Valley Fever Virus to the Eye and Sensory Neurons of Zebrafish Larvae Is Stat1-Dependent

1
1. scibot 11 Mar 2025
  
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  46757
  
  DOI: 10.3390/v17010087
  
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  RRID:Addgene_46757 DOI:10.3390/v17010087
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pmc.ncbi.nlm.nih.gov/articles/PMC11768566/
Jan 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The master male sex determinant Gdf6Y of the turquoise killifish arose through allelic neofunctionalization

1
1. scibot 27 Jan 2025
  
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  plasmid_46757
  
  DOI: 10.1038/s41467-025-55899-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11718055/
Dec 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Lineage labeling with zebrafish hand2 Cre and CreERT2 recombinase CRISPR knock-ins

1
1. scibot 28 Dec 2024
  
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  Addgene_46757
  
  DOI: 10.1101/2024.12.04.626907
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11643050/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Novel Transgenic Zebrafish Lines to Study the CHRNA3‐B4‐A5 Gene Cluster

1
1. scibot 28 Dec 2024
  
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  Addgene_46757
  
  DOI: 10.1002/dneu.22956
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11650009/
www.sciencedirect.com www.sciencedirect.com

tp53 R217H and R242H mutant zebrafish exhibit dysfunctional p53 hallmarks and recapitulate Li-Fraumeni syndrome phenotypes

1
1. scibot 05 Dec 2024
  
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  plasmid_46757
  
  DOI: 10.1016/j.bbadis.2024.167612
  
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sciencedirect.com/science/article/pii/S0925443924006069
Sep 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Variants in ZFX are associated with an X-linked neurodevelopmental disorder with recurrent facial gestalt

1
1. scibot 28 Sep 2024
  
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  Addgene_46757
  
  DOI: 10.1016/j.ajhg.2024.01.007
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10940019/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

p65 signaling dynamics drive the developmental progression of hematopoietic stem and progenitor cells through cell cycle regulation

1
1. scibot 12 Sep 2024
  
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  Addgene_46757
  
  DOI: 10.1038/s41467-024-51922-5
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11379711/
www.sciencedirect.com www.sciencedirect.com

ABCA7-dependent induction of neuropeptide Y is required for synaptic resilience in Alzheimer’s disease through BDNF/NGFR signaling

1
1. scibot 04 Sep 2024
  
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  Plasmid_46757
  
  DOI: 10.1016/j.xgen.2024.100642
  
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sciencedirect.com/science/article/pii/S2666979X24002465
Aug 2024
www.biorxiv.org www.biorxiv.org

tp53 R217H and R242H Mutant Zebrafish Exhibit Dysfunctional p53 Hallmarks and Recapitulate Li-Fraumeni Syndrome Phenotypes

1
1. scibot 20 Aug 2024
  
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  RRID:Addgene_46757
  
  DOI: 10.1101/2024.07.31.605368
  
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biorxiv.org/content/10.1101/2024.07.31.605368v1
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Complimentary vertebrate Wac models exhibit phenotypes relevant to DeSanto-Shinawi Syndrome

1
1. scibot 13 Aug 2024
  
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  pT3TS-nCas9n
  
  DOI: 10.1101/2024.05.26.595966
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11142245/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

miR-34a is a tumor suppressor in zebrafish and its expression levels impact metabolism, hematopoiesis and DNA damage

1
1. scibot 13 Aug 2024
  
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  46757
  
  DOI: 10.1371/journal.pgen.1011290
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11166285/
Jul 2024
www.cell.com www.cell.com

The evolutionarily conserved choroid plexus contributes to the homeostasis of brain ventricles in zebrafish

2
1. scibot 19 Jul 2024
  
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  RRID:Addgene_46757
  
  DOI: 10.1016/j.celrep.2024.114331
  
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  RRID:Addgene_46757
2. scibot 18 Jul 2024
  
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  RRID:Addgene_46757
  
  DOI: 10.1016/j.celrep.2024.114331
  
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cell.com/cell-reports/abstract/S2211-1247(24)00659-4
Jun 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Genetically defined nucleus incertus neurons differ in connectivity and function

1
1. scibot 03 Jun 2024
  
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  plasmid_46757
  
  DOI: 10.7554/eLife.89516
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11142643/
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A brain-specific angiogenic mechanism enabled by tip cell specialization

1
1. scibot 30 Apr 2024
  
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  46757
  
  DOI: 10.1038/s41586-024-07283-6
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11041701/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Gag proteins encoded by endogenous retroviruses are required for zebrafish development

1
1. scibot 13 Apr 2024
  
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  addgene_46757
  
  DOI: 10.1101/2024.03.25.586437
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10996621/
Mar 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The transcription factor ChREBP Orchestrates liver carcinogenesis by coordinating the PI3K/AKT signaling and cancer metabolism

1
1. scibot 08 Mar 2024
  
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  plasmid_46757
  
  DOI: 10.1038/s41467-024-45548-w
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10904844/
Feb 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Genetic and chemical disruption of amyloid precursor protein processing impairs zebrafish sleep maintenance

1
1. scibot 08 Feb 2024
  
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  RRID:Addgene_46757
  
  DOI: 10.1016/j.isci.2024.108870
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10839650/
Jan 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The forkhead transcription factor Foxj1 controls vertebrate olfactory cilia biogenesis and sensory neuron differentiation

1
1. scibot 28 Jan 2024
  
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  plasmid_46757
  
  DOI: 10.1371/journal.pbio.3002468
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10810531/
May 2023
www.biorxiv.org www.biorxiv.org

Foxj1 controls olfactory ciliogenesis and differentiation program of the olfactory sensory neurons

1
1. scibot 18 May 2023
  
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  plasmid_46757
  
  DOI: 10.1101/2023.05.10.540158
  
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biorxiv.org/content/10.1101/2023.05.10.540158v1
Feb 2023
www.biorxiv.org www.biorxiv.org

Zebrafish Cre/lox regulated UFlip alleles generated by CRISPR/Cas targeted integration provide cell-type specific conditional gene inactivation

1
1. scibot 28 Feb 2023
  
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  Addgene_46757
  
  DOI: 10.1101/2021.06.18.448732
  
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biorxiv.org/content/10.1101/2021.06.18.448732v1
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Cre/lox regulated conditional rescue and inactivation with zebrafish UFlip alleles generated by CRISPR-Cas9 targeted integration

1
1. scibot 28 Feb 2023
  
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  Addgene_46757
  
  DOI: 10.7554/eLife.71478
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9270027/
Jun 2022
www.sciencedirect.com www.sciencedirect.com

An integrated model for Gpr124 function in Wnt7a/b signaling among vertebrates

1
1. scibot 03 Jun 2022
  
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  Addgene_46757
  
  DOI: 10.1016/j.celrep.2022.110902
  
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sciencedirect.com/science/article/pii/S2211124722006775
May 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Correction: The recycling endosome protein Rab25 coordinates collective cell movements in the zebrafish surface epithelium

1
1. scibot 21 May 2022
  
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  RRID:Addgene_46757
  
  DOI: 10.7554/eLife.79841
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9119674/
www.sciencedirect.com www.sciencedirect.com

Zn-regulated GTPase metalloprotein activator 1 modulates vertebrate zinc homeostasis

1
1. scibot 18 May 2022
  
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  AddgeneCAT#46757
  
  DOI: 10.1016/j.cell.2022.04.011
  
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  Curator: @sophiastull
  
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sciencedirect.com/science/article/pii/S0092867422004585
Mar 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Butterfly eyespots evolved via cooption of an ancestral gene-regulatory network that also patterns antennae, legs, and wings

1
1. scibot 04 Mar 2022
  
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  plasmid_46757
  
  DOI: 10.1073/pnas.2108661119
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8872758/
Dec 2021
elifesciences.org elifesciences.org

Specialized neurons in the right habenula mediate response to aversive olfactory cues

1
1. scibot 29 Dec 2021
  
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  plasmid_46757
  
  DOI: 10.7554/eLife.72345
  
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elifesciences.org/articles/72345
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Usher syndrome Type 1-associated gene, pcdh15b, is required for photoreceptor structural integrity in zebrafish

1
1. scibot 17 Dec 2021
  
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  RRID:Addgene_46757
  
  DOI: 10.1242/dmm.048965
  
  Resource: RRID:Addgene_46757
  
  Curator: @scibot
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8669488/
May 2021
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CRISPR-Cas13d Induces Efficient mRNA Knockdown in Animal Embryos

1
1. scibot 05 May 2021
  
  in Public
  
  plasmid_46757
  
  DOI: 10.1016/j.devcel.2020.07.013
  
  Resource: RRID:Addgene_46757
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S1534580720305876
Apr 2021
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A non-canonical type 2 immune response coordinates tuberculous granuloma formation and epithelialization

1
1. scibot 27 Apr 2021
  
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  RRID:Addgene_46757
  
  DOI: 10.1016/j.cell.2021.02.046
  
  Resource: RRID:Addgene_46757
  
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sciencedirect.com/science/article/pii/S009286742100235X
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The recycling endosome protein Rab25 coordinates collective cell movements in the zebrafish surface epithelium

1
1. scibot 14 Apr 2021
  
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  RRID:Addgene_46757
  
  DOI: 10.7554/eLife.66060
  
  Resource: RRID:Addgene_46757
  
  Curator: @evieth
  
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  RRIDCUR:Validated RRID:Addgene_46757
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ncbi.nlm.nih.gov/pmc/articles/PMC8034978/
Mar 2021
elifesciences.org elifesciences.org

Efficient targeted integration directed by short homology in zebrafish and mammalian cells

1
1. scibot 09 Mar 2021
  
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  plasmid_46757
  
  DOI: 10.7554/eLife.53968
  
  Resource: RRID:Addgene_46757
  
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elifesciences.org/articles/53968
Feb 2021
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A switch in pdgfrb+ cell-derived ECM composition prevents inhibitory scarring and promotes axon regeneration in the zebrafish spinal cord

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1. scibot 25 Feb 2021
  
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  Plasmid_46757
  
  DOI: 10.1016/j.devcel.2020.12.009
  
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  RRIDCUR:Validated RRID:Addgene_46757
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cell.com/developmental-cell/abstract/S1534-5807(20)30984-9
Jan 2021
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Ythdf m6A Readers Function Redundantly during Zebrafish Development

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1. scibot 05 Jan 2021
  
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  Addgene_46757
  
  DOI: 10.1016/j.celrep.2020.108598
  
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  RRIDCUR:Validated RRID:Addgene_46757
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sciencedirect.com/science/article/pii/S2211124720315874
Jan 2020
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Brd4 and P300 Confer Transcriptional Competency during Zygotic Genome Activation

1
1. scibot 13 Jan 2020
  
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  Addgene_46757
  
  DOI: 10.1016/j.devcel.2019.05.037
  
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sciencedirect.com/science/article/pii/S1534580719304502