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54.241.53.176 54.241.53.176

2025.12.02.691925.full-html.html

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1. scibot 16 Dec 2025
  
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  DOI: 10.64898/2025.12.02.691925
  
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54.241.53.176/cd1b7ae1b6e0f6a28fee1f41b647536d452cfc4e/2025.12.02.691925.full-html.html
Nov 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Enhancer activation from transposable elements in extrachromosomal DNA

1
1. scibot 24 Nov 2025
  
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  DOI: 10.1038/s41556-025-01788-6
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12611757/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Modulating the PPARγ pathway upregulates NECTIN4 and enhances chimeric antigen receptor (CAR) T cell therapy in bladder cancer

1
1. scibot 23 Nov 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12423289/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Protocol for simplified parallel perturbations using an abridged long non-coding RNA CRISPR library

1
1. scibot 10 Nov 2025
  
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  Plasmid_46911
  
  DOI: 10.1016/j.xpro.2025.104110
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12509891/
Aug 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

HBV Remodels PP2A Complexes to Rewire Kinase Signaling in Hepatocellular Carcinoma

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1. scibot 19 Aug 2025
  
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  DOI: 10.1158/0008-5472.CAN-24-0456
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11949624/
Jul 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Plagl1 and Lrrc58 control mammalian body size by triggering target-directed microRNA degradation of miR-322 and miR-503

1
1. scibot 20 Jul 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12236722/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

PADI4-mediated citrullination of histone H3 stimulates HIV-1 transcription

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1. scibot 20 Jul 2025
  
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  plasmid_46911
  
  DOI: 10.1038/s41467-025-61029-0
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12198384/
May 2025
www.sciencedirect.com www.sciencedirect.com

Two waves of adipogenesis in developing avian skin and dermal plasticity

1
1. scibot 29 May 2025
  
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  DOI: 10.1016/j.ydbio.2025.05.019
  
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sciencedirect.com/science/article/pii/S0012160625001423
Apr 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Identification of a SNAI1 enhancer RNA that drives cancer cell plasticity

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1. scibot 07 Apr 2025
  
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  DOI: 10.1038/s41467-025-58032-w
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11937597/
Mar 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Two unrelated distal genes activated by a shared enhancer benefit from localizing inside the same small topological domain

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1. scibot 11 Mar 2025
  
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  DOI: 10.1101/gad.352235.124
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11874980/
Feb 2025
www.sciencedirect.com www.sciencedirect.com

Long-range enhancer-controlled genes are hypersensitive to regulatory factor perturbations

1
1. scibot 27 Feb 2025
  
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  DOI: 10.1016/j.xgen.2025.100778
  
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sciencedirect.com/science/article/pii/S2666979X25000345
link.springer.com link.springer.com

Single-cell multiomics reveals a gene regulatory circuit driving leukemia cell differentiation

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1. scibot 25 Feb 2025
  
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  DOI: 10.1038/s41388-025-03309-z
  
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link.springer.com/article/10.1038/s41388-025-03309-z
Dec 2024
52.53.155.43 52.53.155.43

PDF-html.html

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1. scibot 28 Dec 2024
  
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  DOI: 10.1111/j.1469-7580.2009.01173.x
  
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52.53.155.43/e965e8c267bcac477ace8b0fa7455c4f20806539/PDF-html.html
52.53.155.43 52.53.155.43

can-24-0456-html.html

1
1. scibot 13 Dec 2024
  
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  DOI: 10.1158/0008-5472.can-24-0456
  
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52.53.155.43/e3985cf6f143830bda4dc2c0ff3a15e131833b3e/can-24-0456-html.html
www.sciencedirect.com www.sciencedirect.com

A commonly inherited human PCSK9 germline variant drives breast cancer metastasis via LRP1 receptor

1
1. scibot 10 Dec 2024
  
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  RRID:Addgene_46911
  
  DOI: 10.1016/j.cell.2024.11.009
  
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sciencedirect.com/science/article/pii/S0092867424013266
www.science.org www.science.org

Coordination between the eIF2 kinase GCN2 and p53 signaling supports purine metabolism and the progression of prostate cancer

1
1. scibot 03 Dec 2024
  
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  RRID:Addgene_46911
  
  DOI: 10.1126/scisignal.adp1375
  
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science.org/doi/10.1126/scisignal.adp1375
Sep 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A Ctnnb1 enhancer transcriptionally regulates Wnt signaling dosage to balance homeostasis and tumorigenesis of intestinal epithelia

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1. scibot 27 Sep 2024
  
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  DOI: 10.7554/eLife.98238
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11424096/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Enhancer activation from transposable elements in extrachromosomal DNA

1
1. scibot 25 Sep 2024
  
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  DOI: 10.1101/2024.09.04.611262
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11398463/
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A novel reporter for helicase activity in translation uncovers DDX3X interactions

1
1. scibot 13 Aug 2024
  
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  DOI: 10.1261/rna.079837.123
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11251518/
Jun 2024
journals.plos.org journals.plos.org

CRISPRi screen of long non-coding RNAs identifies LINC03045 regulating glioblastoma invasion

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1. scibot 22 Jun 2024
  
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  DOI: 10.1371/journal.pgen.1011314
  
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journals.plos.org/plosgenetics/article
May 2024
www.biorxiv.org www.biorxiv.org

Single-cell multiomics reveals a gene regulatory circuit promoting leukemia cell differentiation

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1. scibot 16 May 2024
  
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  RRID:Addgene_46911
  
  DOI: 10.1101/2024.02.29.582681
  
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biorxiv.org/content/10.1101/2024.02.29.582681v1
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Improving prime editing with an endogenous small RNA-binding protein

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1. scibot 23 Apr 2024
  
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  DOI: 10.1038/s41586-024-07259-6
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11023932/
www.sciencedirect.com www.sciencedirect.com

DDX21 mediates co-transcriptional RNA m6A modification to promote transcription termination and genome stability

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1. scibot 04 Apr 2024
  
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  DOI: 10.1016/j.molcel.2024.03.006
  
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  DOI: 10.1016/j.molcel.2024.03.006
  
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sciencedirect.com/science/article/pii/S1097276524001886
Mar 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Integration of transcription regulation and functional genomic data reveals lncRNA SNHG6’s role in hematopoietic differentiation and leukemia

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1. scibot 01 Mar 2024
  
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  plasmid_46911
  
  DOI: 10.1186/s12929-024-01015-8
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10900714/
Feb 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Multiplex single-cell chemical genomics reveals the kinase dependence of the response to targeted therapy

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1. scibot 29 Feb 2024
  
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  DOI: 10.1016/j.xgen.2023.100487
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10879025/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Aneuploid embryonic stem cells drive teratoma metastasis

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1. scibot 13 Feb 2024
  
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  DOI: 10.1038/s41467-024-45265-4
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10844504/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Mechanosensitive super-enhancers regulate genes linked to atherosclerosis in endothelial cells

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1. scibot 01 Feb 2024
  
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  DOI: 10.1083/jcb.202211125
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10794123/
Jan 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Large tandem duplications in cancer result from transcription and DNA replication collisions

1
1. scibot 30 Jan 2024
  
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  plasmid_46911
  
  DOI: 10.1101/2023.05.17.23290140
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10802642/
Oct 2023
www.sciencedirect.com www.sciencedirect.com

Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation

1
1. scibot 28 Oct 2023
  
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  DOI: 10.1016/j.stem.2023.09.007
  
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sciencedirect.com/science/article/pii/S1934590923003284
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Determinants of DDX3X sensitivity uncovered using a helicase activity in translation reporter

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1. scibot 06 Oct 2023
  
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  DOI: 10.1101/2023.09.14.557805
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10515938/
Mar 2023
www.sciencedirect.com www.sciencedirect.com

Lipid peroxidation increases membrane tension, Piezo1 gating, and cation permeability to execute ferroptosis

1
1. scibot 10 Mar 2023
  
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  DOI: 10.1016/j.cub.2023.02.060
  
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sciencedirect.com/science/article/pii/S0960982223002002
Jan 2023
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

Maximizing CRISPRi efficacy and accessibility with dual-sgRNA libraries and optimal effectors

1
1. scibot 11 Jan 2023
  
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  DOI: 10.7554/eLife.81856
  
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pubmed.ncbi.nlm.nih.gov/36576240/
Nov 2022
aacrjournals.org aacrjournals.org

Resistance to ATR Inhibitors Is Mediated by Loss of the Nonsense-Mediated Decay Factor UPF2

1
1. scibot 18 Nov 2022
  
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  DOI: 10.1158/0008-5472.CAN-21-4335
  
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aacrjournals.org/cancerres/article/82/21/3950/709947/Resistance-to-ATR-Inhibitors-Is-Mediated-by-Loss
Feb 2022
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HOTTIP-dependent R-loop formation regulates CTCF boundary activity and TAD integrity in leukemia

1
1. scibot 18 Feb 2022
  
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  RRID:Addgene_46911
  
  DOI: 10.1016/j.molcel.2022.01.014
  
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sciencedirect.com/science/article/pii/S1097276522000570
Oct 2021
www.sciencedirect.com www.sciencedirect.com

A bipartite element with allele-specific functions safeguards DNA methylation imprints at the Dlk1-Dio3 locus

1
1. scibot 28 Oct 2021
  
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  Plasmid_46911
  
  DOI: 10.1016/j.devcel.2021.10.004
  
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sciencedirect.com/science/article/pii/S1534580721008054
May 2021
www.embopress.org www.embopress.org

A stress-induced tyrosine-tRNA depletion response mediates codon-based translational repression and growth suppression

1
1. scibot 20 May 2021
  
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  DOI: 10.15252/embj.2020106696
  
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embopress.org/doi/abs/10.15252/embj.2020106696
onlinelibrary.wiley.com onlinelibrary.wiley.com

In vivo CRISPR screening for novel noncoding RNA functional targets in glioblastoma models

1
1. scibot 18 May 2021
  
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  RRID:Addgene_46911
  
  DOI: 10.1002/jnr.24850
  
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  RRID:Addgene_46911
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scibot

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onlinelibrary.wiley.com/doi/10.1002/jnr.24850
www.sciencedirect.com www.sciencedirect.com

Histone methyltransferase activity programs nuclear peripheral genome positioning

1
1. scibot 09 May 2021
  
  in Public
  
  RRID:Addgene_46911
  
  DOI: 10.1016/j.ydbio.2020.07.010
  
  Resource: RRID:Addgene_46911
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_46911
  
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  RRID:Addgene_46911
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sciencedirect.com/science/article/pii/S0012160620302062
www.sciencedirect.com www.sciencedirect.com

Conserved Functions of Ether Lipids and Sphingolipids in the Early Secretory Pathway

1
1. scibot 04 May 2021
  
  in Public
  
  plasmid_46911
  
  DOI: 10.1016/j.cub.2020.07.059
  
  Resource: RRID:Addgene_46911
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_46911
  
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  RRID:Addgene_46911
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sciencedirect.com/science/article/pii/S0960982220310848
Apr 2021
www.sciencedirect.com www.sciencedirect.com

Illuminating Host-Mycobacterial Interactions with Genome-wide CRISPR Knockout and CRISPRi Screens

1
1. scibot 27 Apr 2021
  
  in Public
  
  Addgene_46911
  
  DOI: 10.1016/j.cels.2020.08.010
  
  Resource: RRID:Addgene_46911
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_46911
  
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  RRID:Addgene_46911
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sciencedirect.com/science/article/pii/S2405471220302945
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B cell-specific XIST complex enforces X-inactivation and restrains atypical B cells

1
1. scibot 27 Apr 2021
  
  in Public
  
  Addgene_46911
  
  DOI: 10.1016/j.cell.2021.02.015
  
  Resource: RRID:Addgene_46911
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_46911
  
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sciencedirect.com/science/article/pii/S0092867421001653
Dec 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

TGFβ promotes widespread enhancer chromatin opening and operates on genomic regulatory domains

1
1. scibot 09 Dec 2020
  
  in Public
  
  RRID:Addgene_46911
  
  DOI: 10.1038/s41467-020-19877-5
  
  Resource: RRID:Addgene_46911
  
  Curator: @evieth
  
  SciCrunch record: RRID:Addgene_46911
  
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  RRID:Addgene_46911 RRIDCUR:Validated
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RRID:Addgene_46911

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scibot

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ncbi.nlm.nih.gov/pmc/articles/PMC7713251/
Jan 2020
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CRISPR Interference-Based Platform for Multimodal Genetic Screens in Human iPSC-Derived Neurons

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:Addgene_46911
  
  DOI: 10.1016/j.neuron.2019.07.014
  
  Resource: RRID:Addgene_46911
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:Addgene_46911
  
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  RRID:Addgene_46911 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S0896627319306403
elifesciences.org elifesciences.org

PUMILIO, but not RBMX, binding is required for regulation of genomic stability by noncoding RNA NORAD

1
1. scibot 13 Jan 2020
  
  in Public
  
  plasmid_46911
  
  DOI: 10.7554/eLife.48625
  
  Resource: RRID:Addgene_46911
  
  Curator: @Naa003
  
  SciCrunch record: plasmid_46911
  
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  RRID:Addgene_46911 RRIDCUR:Validated
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elifesciences.org/articles/48625
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HOTTIP lncRNA Promotes Hematopoietic Stem Cell Self-Renewal Leading to AML-like Disease in Mice

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:Addgene_46911
  
  DOI: 10.1016/j.ccell.2019.10.011
  
  Resource: RRID:Addgene_46911
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:Addgene_46911
  
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  RRID:Addgene_46911 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:Addgene_46911

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scibot

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sciencedirect.com/science/article/pii/S1535610819304854