68 Matching Annotations
  1. Sep 2026
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Multiplexed Simian Immunodeficiency Virus-Specific Paired RNA-Guided Cas9 Nickases Inactivate Proviral DNA
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC8577357/
  3. Aug 2026
  4. www.biorxiv.org www.biorxiv.org
    Mutagenic bypass of uracil-derived abasic sites underlies the SBS17 mutational signature
    1
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    biorxiv.org/content/10.64898/2026.08.21.746158v1
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Helicase-assisted continuous editing for programmable mutagenesis of endogenous genomes
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC13492663/
  6. Jun 2026
  7. karger.com karger.com
    Loss of DAXX/ATRX protein expression results in ischemia resistance and radiation sensitivity in pancreatic neuroendocrine tumor cells and is associated with improved response to trans-arterial radio-embolization
    2
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    karger.com/nen/article/115/9/730/930922/Loss-of-DAXX-ATRX-Protein-Expression-Results-in
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Neural cell state modulation by PARK2 and dopaminergic neuroprotection by small molecule Parkin agonism
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC13060259/
  9. Jan 2026
  10. www.sciencedirect.com www.sciencedirect.com
    CRISPR screens in the context of immune selection identify CHD1 and MAP3K7 as mediators of cancer immunotherapy resistance
    1
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    sciencedirect.com/science/article/pii/S266637912500638X
  11. Nov 2025
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    UGI relocation inside Cas9 reduces Cas9 dependent off target effects in cytosine base editors
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12514026/
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    An RGD motif on SARS-CoV-2 Spike induces TGF-β signaling and downregulates interferon
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12456147/
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Fine-tuning of gene expression through the Mettl3-Mettl14-Dnmt1 axis controls ESC differentiation
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12160003/
  15. Sep 2025
  16. journals.asm.org journals.asm.org
    An RGD motif on SARS-CoV-2 Spike induces TGF-β signaling and downregulates interferon
    1
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    journals.asm.org/doi/10.1128/jvi.00435-25
  17. Aug 2025
  18. isevjournals.onlinelibrary.wiley.com isevjournals.onlinelibrary.wiley.com
    Syntenin Controls Extracellular Vesicle-Induced Tumour Migration by Regulating the Expression of Adhesion Proteins on Small Extracellular Vesicles
    1
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    isevjournals.onlinelibrary.wiley.com/doi/10.1002/jev2.70133
  19. Jul 2025
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Repeat length as a key determinant for disease severity and antisense oligonucleotide activity in myotonic dystrophy type 1
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12221585/
  21. Jun 2025
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DNA nicks in both leading and lagging strand templates can trigger break-induced replication
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12095120/
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Construction of a proximity labeling vector to identify protein-protein interactions in human stem cells
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12124498/
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pathogenic variants in BORCS5 Cause a Spectrum of Neurodevelopmental and Neurodegenerative Disorders with Lysosomal Dysfunction
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12083638/
  25. link.springer.com link.springer.com
    Functional characterisation of rare variants in genes encoding the MAPK/ERK signalling pathway identified in long-lived Leiden Longevity Study participants
    1
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    link.springer.com/article/10.1007/s11357-025-01699-2
  26. Apr 2025
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DGCR8 haploinsufficiency leads to primate-specific RNA dysregulation and pluripotency defects
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11941479/
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Cap-proximal secondary structures of the 5′UTRs of parainfluenza virus 5 mRNAs specify differential sensitivity to type I interferon and IFIT1
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11950200/
  29. Mar 2025
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Generation of a Double Reporter mES Cell Line to Simultaneously Trace the Generation of Retinal Progenitors and Photoreceptors
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11854395/
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PBRM1 directs PBAF to pericentromeres and protects centromere integrity
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11865495/
  32. Feb 2025
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RIPK1 is required for ZBP1-driven necroptosis in human cells
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11844899/
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MDM2 functions as a timer reporting the length of mitosis
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11821534/
  35. Jan 2025
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pol II degradation activates cell death independently from the loss of transcription
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11661175/
  37. Sep 2024
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LOXHD1 is indispensable for maintaining TMC1 auditory mechanosensitive channels at the site of force transmission
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11387651/
  39. link.springer.com link.springer.com
    Vinculin-mediated axon growth requires interaction with actin but not talin in mouse neocortical neurons
    1
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    link.springer.com/article/10.1007/s00018-021-03879-7
  40. Aug 2024
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human pluripotent stem cell-derived kidney organoids reveal tubular epithelial pathobiology of heterozygous HNF1B-associated dysplastic kidney malformations
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11297557/
  42. Apr 2024
  43. www.embopress.org www.embopress.org
    The growth factor EPIREGULIN promotes basal progenitor cell proliferation in the developing neocortex
    2
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    embopress.org/doi/10.1038/s44318-024-00068-7
  44. www.embopress.org www.embopress.org
    The growth factor EPIREGULIN promotes basal progenitor cell proliferation in the developing neocortex
    1
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    embopress.org/doi/full/10.1038/s44318-024-00068-7
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PALB2-mutated human mammary cells display a broad spectrum of morphological and functional abnormalities induced by increased TGFβ signaling
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11006627/
  46. Mar 2024
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Primary cilia promote the differentiation of human neurons through the WNT signaling pathway
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10900739/
  48. Feb 2024
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LOXHD1 is indispensable for coupling auditory mechanosensitive channels to the site of force transmission
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10802736/
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The clarithromycin-binding proteins NIPSNAP1 and 2 regulate cytokine production through mitochondrial quality control
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10824736/
  51. Dec 2023
  52. dx.doi.org dx.doi.org
    DAXX promotes centromeric stability independently of ATRX by preventing the accumulation of R-loop-induced DNA double-stranded breaks
    1
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    dx.doi.org/10.1093/nar/gkad1141
  53. Sep 2023
  54. www.sciencedirect.com www.sciencedirect.com
    A NRF2 inhibitor selectively sensitizes KEAP1 mutant tumor cells to cisplatin and gefitinib by restoring NRF2-inhibitory function of KEAP1 mutants
    1
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    sciencedirect.com/science/article/pii/S2211124723011154
  55. Jul 2023
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Extracellular vesicle-associated tyrosine kinase-like orphan receptors ROR1 and ROR2 promote breast cancer progression
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10331971/
  57. Jun 2023
  58. www.biorxiv.org www.biorxiv.org
    Functional characterisation of rare variants in genes encoding the MAPK/ERK signalling pathway identified in long-lived Leiden Longevity Study participants
    1
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    biorxiv.org/content/10.1101/2023.06.01.541708v1
  59. Feb 2023
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Base editing screens map mutations affecting interferon-γ signaling in cancer
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC9942875/
  61. Jan 2023
  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Base editing screens map mutations affecting interferon-γ signaling in cancer
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC9942875/
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lymphatic PD-L1 Expression Restricts Tumor-Specific CD8+ T-cell Responses
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC9398148/
  64. Oct 2022
  65. aacrjournals.org aacrjournals.org
    Selenium modulates cancer cell response to pharmacologic ascorbate
    1
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    aacrjournals.org/cancerres/article/82/19/3486/709413/Selenium-Modulates-Cancer-Cell-Response-to
  66. elifesciences.org elifesciences.org
    A specific role for importin-5 and NASP in the import and nuclear hand-off of monomeric H3
    1
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    elifesciences.org/articles/81755
  67. Apr 2022
  68. www.jneurosci.org www.jneurosci.org
    S-Nitrosylation of p62 Inhibits Autophagic Flux to Promote α-Synuclein Secretion and Spread in Parkinson’s Disease and Lewy Body Dementia
    1
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    jneurosci.org/content/42/14/3011
  69. www.science.org www.science.org
    p53 directs leader cell behavior, migration, and clearance during epithelial repair
    1
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    science.org/doi/full/10.1126/science.abl8876
  70. Jan 2022
  71. www.nature.com www.nature.com
    Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants
    1
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    nature.com/articles/s41467-021-27601-0
  72. Sep 2021
  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cortical overgrowth in a preclinical forebrain organoid model of CNTNAP2-associated autism spectrum disorder
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC8410758/
  74. Aug 2021
  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting the Highly Expressed microRNA miR-146b with CRISPR/Cas9n Gene Editing System in Thyroid Cancer
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC8348963/
  76. www.sciencedirect.com www.sciencedirect.com
    The tumor suppressor Sef is a scaffold for the classical NF-κB/RELA:P50 signaling module
    1
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    sciencedirect.com/science/article/pii/S089865681930018X
  77. www.nature.com www.nature.com
    Expanding C–T base editing toolkit with diversified cytidine deaminases
    1
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    nature.com/articles/s41467-019-11562-6
  78. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    sciencedirect.com/science/article/pii/S1873506117301290
  79. Jul 2021
  80. www.mdpi.com www.mdpi.com
    Characterizing CDK8/19 Inhibitors through a NFκB-Dependent Cell-Based Assay
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    mdpi.com/2073-4409/8/10/1208/htm
  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SCAF4 and SCAF8, mRNA Anti-Terminator Proteins
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC6579486/
  82. May 2021
  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pannexin 1 mutation found in melanoma tumor reduces phosphorylation, glycosylation, and trafficking of the channel-forming protein
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC8098850/
  84. www.molbiolcell.org www.molbiolcell.org
    Pannexin 1 mutation found in melanoma tumour reduces phosphorylation, glycosylation, and trafficking of the channel-forming protein
    1
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    molbiolcell.org/doi/abs/10.1091/mbc.E19-10-0585
  85. Apr 2021
  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC7997658/
  87. Jan 2021
  88. www.sciencedirect.com www.sciencedirect.com
    Passenger Mutations Confound Phenotypes of SARM1-Deficient Mice
    1
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    sciencedirect.com/science/article/pii/S2211124720303879
  89. www.nature.com www.nature.com
    miR-379 deletion ameliorates features of diabetic kidney disease by enhancing adaptive mitophagy via FIS1
    1
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    nature.com/articles/s42003-020-01516-w
  90. Sep 2020
  91. www.sciencedirect.com www.sciencedirect.com
    Tandem Paired Nicking Promotes Precise Genome Editing with Scarce Interference by p53
    1
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    sciencedirect.com/science/article/pii/S2211124719317218
  92. www.sciencedirect.com www.sciencedirect.com
    The ZGRF1 Helicase Promotes Recombinational Repair of Replication-Blocking DNA Damage in Human Cells
    1
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    sciencedirect.com/science/article/pii/S2211124720308305
  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Metabolic alterations in Parkinson’s disease astrocytes
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC7468111/
  94. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Biallelic loss‐of‐function variants in TBC1D2B cause a neurodevelopmental disorder with seizures and gingival overgrowth
    1
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    onlinelibrary.wiley.com/doi/10.1002/humu.24071
  95. www.sciencedirect.com www.sciencedirect.com
    Unexpected Mutations by CRISPR/Cas9 CTG Repeat Excision in Myotonic Dystrophy and Use of CRISPR Interference as an Alternative Approach
    1
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    sciencedirect.com/science/article/pii/S232905012030111X
  96. www.sciencedirect.com www.sciencedirect.com
    Generation of OCT4-EGFP, NANOG-tdTomato dual reporter human induced pluripotent stem cell line, KKUi001-A, using the CRISPR/Cas9 system
    1
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    sciencedirect.com/science/article/pii/S1873506120302440
  97. Jan 2020
  98. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Transcriptional profiling of breast cancer‐associated lymphatic vessels reveals VCAM‐1 as regulator of lymphatic invasion and permeability
    1
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    onlinelibrary.wiley.com/doi/full/10.1002/ijc.32594
  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Species specific differences in use of ANP32 proteins by influenza A virus
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC6548507/
  100. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    sciencedirect.com/science/article/pii/S193459091830345X
  101. www.sciencedirect.com www.sciencedirect.com
    Dppa2/4 Facilitate Epigenetic Remodeling during Reprogramming to Pluripotency
    1
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    sciencedirect.com/science/article/pii/S1934590918303862