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Mbd4 and MutSα protect cells from spontaneous deamination of 5-methylcytosine

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1. scibot 08 Oct 2026
  
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  Addgene_50946
  
  DOI: 10.1093/nar/gkaf1493
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12817082/
Sep 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

DOT1L provides transcriptional memory through PRC1.1 antagonism

2
1. scibot 19 Sep 2026
  
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  50946
  
  DOI: 10.1038/s41556-025-01859-8
  
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2. scibot 19 Sep 2026
  
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  50946
  
  DOI: 10.1038/s41556-025-01859-8
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12904788/
Aug 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Chromatin condensates tune nuclear mechanosensing and preserve nuclear integrity to prevent cGAS activation

1
1. scibot 20 Aug 2026
  
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  Addgene_50946
  
  DOI: 10.1038/s44318-026-00884-z
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13584762/
Jun 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Transposable elements shape stemness in normal and leukemic hematopoiesis

1
1. scibot 06 Jun 2026
  
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  50946
  
  DOI: 10.1038/s41588-026-02585-z
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13175892/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Architecture of clathrin-independent AP3:ARF1-coated carriers

1
1. scibot 06 Jun 2026
  
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  plasmid_50946
  
  DOI: 10.1126/sciadv.aed1529
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13178560/
Apr 2026
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Targeting the novel immune checkpoint KLRG1 is markedly therapeutic against cancer through multiple lymphocyte subsets

1
1. scibot 18 Apr 2026
  
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  RRID:Addgene_50946
  
  DOI: 10.1136/jitc-2025-013869
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13084953/
Sep 2025
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Mapping the genetic landscape of iron metabolism uncovers the SETD2 methyltransferase as a modulator of iron flux

1
1. scibot 22 Sep 2025
  
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  50946
  
  DOI: 10.1126/sciadv.adw9095
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12442849/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Aging-associated DNA methylation of LEF1 modulates inflammation and neurodegenerative pathways

1
1. scibot 06 Sep 2025
  
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  50946
  
  DOI: 10.3389/fimmu.2025.1656442
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12408614/
Aug 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Tumor cell-intrinsic Decr2 regulates ferroptosis and immunotherapy efficacy

1
1. scibot 05 Aug 2025
  
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  RRID:Addgene_50946
  
  DOI: 10.1158/2326-6066.CIR-24-0519
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12314507/
Jun 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Evaluating the feasibility of gene replacement strategies to treat MTRFR deficiency

1
1. scibot 18 Jun 2025
  
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  RRID:Addgene_50946
  
  DOI: 10.1242/dmm.052120
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12171093/
52.53.155.43 52.53.155.43

PDF-html.html

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1. scibot 17 Jun 2025
  
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  RRID:Addgene_50946
  
  DOI: 10.1158/2326-6066.cir-24-0519
  
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52.53.155.43/b476b28c82bb83bd9fe4ec113cb042cd5e05e58b/PDF-html.html
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Fibroblast hierarchy dynamics during mammary gland morphogenesis and tumorigenesis

1
1. scibot 15 Jun 2025
  
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  50946
  
  DOI: 10.1038/s44318-025-00422-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12130467/
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The interplay between FOXO3 and FOXM1 influences sensitivity to AKT inhibition in PIK3CA and PIK3CA/PTEN altered estrogen receptor positive breast cancer

1
1. scibot 19 May 2025
  
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  Addgene_50946
  
  DOI: 10.1038/s41523-025-00752-9
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12015352/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Syndecans and glycosaminoglycans influence B-cell development and activation

1
1. scibot 17 May 2025
  
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  pKLV-U6gRNA(BbsI)-PGKpuro2ABFP
  
  DOI: 10.1038/s44319-025-00432-6
  
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  Curator: @olekpark
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12069707/
Mar 2025
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Both direct and indirect suppression of MCL1 synergizes with BCLXL inhibition in preclinical models of gastric cancer

1
1. scibot 23 Mar 2025
  
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  50946
  
  DOI: 10.1038/s41419-025-07481-8
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11904182/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Tuning the tropism and infectivity of SARS-CoV-2 virus-like particles for mRNA delivery

1
1. scibot 06 Mar 2025
  
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  RRID:Addgene_50946
  
  DOI: 10.1093/nar/gkaf133
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11879429/
Feb 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

MTCH2 controls energy demand and expenditure to fuel anabolism during adipogenesis

1
1. scibot 20 Feb 2025
  
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  Plasmid_50946
  
  DOI: 10.1038/s44318-024-00335-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11832942/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung disease

1
1. scibot 18 Feb 2025
  
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  50946
  
  DOI: 10.1038/s44318-024-00328-6
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11790967/
Jan 2025
www.sciencedirect.com www.sciencedirect.com

1-s2.0-S2589004224027901-main-html.html

1
1. scibot 09 Jan 2025
  
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  AddgeneCat#50946
  
  DOI: 10.1016/j.isci.2024.111563
  
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  Curator: @areedewitt04
  
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sciencedirect.com/science/article/pii/S2589004224027901
www.embopress.org www.embopress.org

MTCH2 controls energy demand and expenditure to fuel anabolism during adipogenesis

1
1. scibot 08 Jan 2025
  
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  Plasmid_50946
  
  DOI: 10.1038/s44318-024-00335-7
  
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embopress.org/doi/10.1038/s44318-024-00335-7
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The interferon γ pathway enhances pluripotency and X-chromosome reactivation in iPSC reprogramming

1
1. scibot 21 Aug 2024
  
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  RRID:Addgene_50946
  
  DOI: 10.1126/sciadv.adj8862
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11305397/
Jul 2024
www.nature.com www.nature.com

ASS1 metabolically contributes to the nuclear and cytosolic p53-mediated DNA damage response

1
1. scibot 18 Jul 2024
  
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  Addgene, 50946
  
  DOI: 10.1038/s42255-024-01060-5
  
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nature.com/articles/s42255-024-01060-5
Jun 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Atlastin-1 regulates endosomal tubulation and lysosomal proteolysis in human cortical neurons

2
1. scibot 21 Jun 2024
  
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  plasmid_50946
  
  DOI: 10.1016/j.nbd.2024.106556
  
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2. scibot 21 Jun 2024
  
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  RRID:Addgene_50
  
  DOI: 10.1016/j.nbd.2024.106556
  
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  Curator: @abever99
  
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  RRID:Addgene_50946 RRIDCUR:Unresolved
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ncbi.nlm.nih.gov/pmc/articles/PMC11300884/
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Genome-wide CRISPR screens identify the YAP/TEAD axis as a driver of persister cells in EGFR mutant lung cancer

1
1. scibot 30 Apr 2024
  
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  50946
  
  DOI: 10.1038/s42003-024-06190-w
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11043391/
www.sciencedirect.com www.sciencedirect.com

Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers

1
1. scibot 26 Apr 2024
  
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  Addgene, Koike-Yusa et al. 201460Cat #50946
  
  DOI: 10.1016/j.ccell.2024.04.004
  
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sciencedirect.com/science/article/pii/S1535610824001284
Mar 2024
www.biorxiv.org www.biorxiv.org

Atlastin-1 regulates endosomal tubulation and lysosomal proteolysis in human cortical neurons

1
1. scibot 09 Mar 2024
  
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  RRID:Addgene_50946
  
  DOI: 10.1101/2024.02.29.582512
  
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biorxiv.org/content/10.1101/2024.02.29.582512v1
Oct 2023
www.biorxiv.org www.biorxiv.org

Genome-wide CRISPR/Cas9 screen identifies MAT2A as a critical host factor for BK Polyomavirus

1
1. scibot 27 Oct 2023
  
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  RRID:Addgene_50946
  
  DOI: 10.1101/2023.10.20.563362
  
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biorxiv.org/content/10.1101/2023.10.20.563362v1
Aug 2023
www.sciencedirect.com www.sciencedirect.com

The SMC5/6 complex compacts and silences unintegrated HIV-1 DNA and is antagonized by Vpr

1
1. scibot 19 Aug 2023
  
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  Addgene_50946
  
  DOI: 10.1016/j.chom.2021.03.001
  
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  RRIDCUR:Validated RRID:Addgene_50946
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sciencedirect.com/science/article/pii/S1931312821001013
Jun 2023
www.sciencedirect.com www.sciencedirect.com

Complex regulation of Eomes levels mediated through distinct functional features of the Meteor long non-coding RNA locus

1
1. scibot 02 Jun 2023
  
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  plasmid_50946
  
  DOI: 10.1016/j.celrep.2023.112569
  
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sciencedirect.com/science/article/pii/S2211124723005806
May 2023
www.sciencedirect.com www.sciencedirect.com

Proteomics of immune cells from liver tumors reveals immunotherapy targets

1
1. scibot 31 May 2023
  
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  RRID:Addgene_50946
  
  DOI: 10.1016/j.xgen.2023.100331
  
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sciencedirect.com/science/article/pii/S2666979X2300099X
www.sciencedirect.com www.sciencedirect.com

MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells

1
1. scibot 10 May 2023
  
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  RRID:Addgene_50946
  
  DOI: 10.1016/j.celrep.2023.112484
  
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sciencedirect.com/science/article/pii/S2211124723004953
Mar 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Drug–gene Interaction Screens Coupled to Tumor Data Analyses Identify the Most Clinically Relevant Cancer Vulnerabilities Driving Sensitivity to PARP Inhibition

1
1. scibot 29 Mar 2023
  
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  RRID:Addgene_50946
  
  DOI: 10.1158/2767-9764.CRC-22-0119
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10035383/
Jan 2023
www.sciencedirect.com www.sciencedirect.com

The loss of epithelial Smad4 drives immune evasion via CXCL1 while displaying vulnerability to combinatorial immunotherapy in gastric cancer

1
1. scibot 28 Jan 2023
  
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  RRID:Addgene_50946
  
  DOI: 10.1016/j.celrep.2022.111878
  
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sciencedirect.com/science/article/pii/S2211124722017740
Dec 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

AP-4 regulates neuronal lysosome composition, function, and transport via regulating export of critical lysosome receptor proteins at the trans-Golgi network

1
1. scibot 09 Dec 2022
  
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  RRID:Addgene_50946
  
  DOI: 10.1091/mbc.E21-09-0473
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9635302/
Sep 2022
www.sciencedirect.com www.sciencedirect.com

Inhibition of the CtBP complex and FBXO11 enhances MHC class II expression and anti-cancer immune responses

1
1. scibot 30 Sep 2022
  
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  Addgene_50946
  
  DOI: 10.1016/j.ccell.2022.09.007
  
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sciencedirect.com/science/article/pii/S1535610822004366
May 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

DNA-PK promotes DNA end resection at DNA double strand breaks in G0 cells

1
1. scibot 24 May 2022
  
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  RRID:Addgene_50946
  
  DOI: 10.7554/eLife.74700
  
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  SciCrunch record: RRID:Addgene_50946
  
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  RRID:Addgene_50946
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scibot

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ncbi.nlm.nih.gov/pmc/articles/PMC9122494/
Dec 2021
www.sciencedirect.com www.sciencedirect.com

TRACE generates fluorescent human reporter cell lines to characterize epigenetic pathways

1
1. scibot 28 Dec 2021
  
  in Public
  
  Addgene_50946
  
  DOI: 10.1016/j.molcel.2021.11.035
  
  Resource: RRID:Addgene_50946
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_50946
  
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  RRID:Addgene_50946
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sciencedirect.com/science/article/pii/S1097276521010376
Sep 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

LIN37-DREAM prevents DNA end resection and homologous recombination at DNA double-strand breaks in quiescent cells

2
1. scibot 11 Sep 2021
  
  in Public
  
  Addgene50946
  
  DOI: 10.7554/eLife.68466
  
  Resource: RRID:Addgene_50946
  
  Curator: @evieth
  
  SciCrunch record: RRID:Addgene_50946
  
  What is this?
  
  RRID:Addgene_50946
2. scibot 11 Sep 2021
  
  in Public
  
  plasmid_50946
  
  DOI: 10.7554/eLife.68466
  
  Resource: RRID:Addgene_50946
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_50946
  
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  RRID:Addgene_50946
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ncbi.nlm.nih.gov/pmc/articles/PMC8416021/
Aug 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

NF1 regulates mesenchymal glioblastoma plasticity and aggressiveness through the AP-1 transcription factor FOSL1

1
1. scibot 21 Aug 2021
  
  in Public
  
  plasmid_50946
  
  DOI: 10.7554/eLife.64846
  
  Resource: RRID:Addgene_50946
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_50946
  
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  RRID:Addgene_50946
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ncbi.nlm.nih.gov/pmc/articles/PMC8370767/
Jul 2021
www.sciencedirect.com www.sciencedirect.com

An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer

1
1. scibot 29 Jul 2021
  
  in Public
  
  Addgene: 50946
  
  DOI: 10.1016/j.ccell.2019.08.008
  
  Resource: RRID:Addgene_50946
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:Addgene_50946
  
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  RRID:Addgene_50946 RRIDCUR:Unrecognized
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sciencedirect.com/science/article/pii/S1535610819303769
www.embopress.org www.embopress.org

A genome‐wide screen identifies IRF2 as a key regulator of caspase‐4 in human cells

1
1. scibot 27 Jul 2021
  
  in Public
  
  plasmid_50946
  
  DOI: 10.15252/embr.201948235
  
  Resource: RRID:Addgene_50946
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_50946
  
  Curator comments: pKLV-U6gRNA(BbsI)-PGKpuro2ABFP https://www.addgene.org/50946/
  
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  RRID:Addgene_50946 RRIDCUR:Unresolved RRIDCUR:SyntaxError
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RRIDCUR:SyntaxError

RRIDCUR:Unresolved

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URL

embopress.org/doi/full/10.15252/embr.201948235
May 2021
www.sciencedirect.com www.sciencedirect.com

Cargo receptor-assisted endoplasmic reticulum export of pathogenic α1-antitrypsin polymers

1
1. scibot 19 May 2021
  
  in Public
  
  RRID:Addgene_50946
  
  DOI: 10.1016/j.celrep.2021.109144
  
  Resource: RRID:Addgene_50946
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_50946
  
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  RRID:Addgene_50946
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sciencedirect.com/science/article/pii/S2211124721004836
www.sciencedirect.com www.sciencedirect.com

Histone methyltransferase activity programs nuclear peripheral genome positioning

1
1. scibot 09 May 2021
  
  in Public
  
  RRID:Addgene_50946
  
  DOI: 10.1016/j.ydbio.2020.07.010
  
  Resource: RRID:Addgene_50946
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_50946
  
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  RRID:Addgene_50946
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sciencedirect.com/science/article/pii/S0012160620302062
Apr 2021
www.sciencedirect.com www.sciencedirect.com

The SMC5/6 complex compacts and silences unintegrated HIV-1 DNA and is antagonized by Vpr

1
1. scibot 03 Apr 2021
  
  in Public
  
  Addgene_50946
  
  DOI: 10.1016/j.chom.2021.03.001
  
  Resource: RRID:Addgene_50946
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_50946
  
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  RRID:Addgene_50946
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sciencedirect.com/science/article/pii/S1931312821001013
Nov 2020
www.sciencedirect.com www.sciencedirect.com

De Novo VPS4A Mutations Cause Multisystem Disease with Abnormal Neurodevelopment

1
1. scibot 20 Nov 2020
  
  in Public
  
  RRID:Addgene_50946
  
  DOI: 10.1016/j.ajhg.2020.10.012
  
  Resource: RRID:Addgene_50946
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_50946
  
  What is this?
  
  RRID:Addgene_50946 RRIDCUR:Validated
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RRIDCUR:Validated

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sciencedirect.com/science/article/pii/S0002929720303700
febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com

FEBS Press

1
1. scibot 10 Nov 2020
  
  in Public
  
  RRID:Addgene_50946
  
  DOI: 10.1002/1878-0261.12835
  
  Resource: RRID:Addgene_50946
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_50946
  
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  RRID:Addgene_50946 RRIDCUR:Validated
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RRIDCUR:Validated

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febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.12835
Oct 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Quantitative Proteomics Analysis of Lytic KSHV Infection in Human Endothelial Cells Reveals Targets of Viral Immune Modulation

1
1. scibot 24 Oct 2020
  
  in Public
  
  Addgene_50946
  
  DOI: 10.1016/j.celrep.2020.108249
  
  Resource: RRID:Addgene_50946
  
  Curator: @evieth
  
  SciCrunch record: RRID:Addgene_50946
  
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  RRIDCUR:Validated RRID:Addgene_50946
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RRID:Addgene_50946

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scibot

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ncbi.nlm.nih.gov/pmc/articles/PMC7567700/
Sep 2020
elifesciences.org elifesciences.org

The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1

1
1. scibot 26 Sep 2020
  
  in Public
  
  Addgene_50946
  
  DOI: 10.7554/eLife.40009
  
  Resource: RRID:Addgene_50946
  
  Curator: @evieth
  
  SciCrunch record: RRID:Addgene_50946
  
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  RRIDCUR:Validated RRID:Addgene_50946
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scibot

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elifesciences.org/articles/40009