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pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Epigenetic editing of marine medaka (Oryzias melastigma) fgf2 using CRISPR/dCas9-Tet1CD

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1. scibot 08 Oct 2026
  
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  Addgene_51133
  
  DOI: 10.24272/j.issn.2095-8137.2025.089
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13276642/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Generation of a PKP2 heterozygous knockout pig model of arrhythmogenic cardiomyopathy

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1. scibot 08 Oct 2026
  
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  plasmid_51133
  
  DOI: 10.24272/j.issn.2095-8137.2025.044
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13276653/
Aug 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Genetic screening identifies WNT5A/RYK as a determinant of extracellular vesicle fate

1
1. scibot 07 Aug 2026
  
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  pGL3-U6-sgRNA-PGK-puromycin
  
  DOI: 10.1126/sciadv.aeb2877
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13426412/
Jul 2026
www.sciencedirect.com www.sciencedirect.com

PUMILIO proteins maintain lineage balance via post-transcriptional repression of germline fate and promotion of somatic differentiation

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1. scibot 11 Jul 2026
  
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  RRID:Addgene_51133
  
  DOI: 10.1016/j.celrep.2026.117682
  
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sciencedirect.com/science/article/pii/S2211124726007606
Jun 2026
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Poising and connectivity of emergent human developmental enhancers in the transition from naive to primed pluripotency

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1. scibot 07 Jun 2026
  
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  RRID:Addgene_51133
  
  DOI: 10.1016/j.celrep.2026.117402
  
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sciencedirect.com/science/article/pii/S2211124726004808
May 2026
www.nature.com www.nature.com

PIWIL1 activates the R2TP-TELO2-mTORC1 axis independently of piRNA to promote TOP mRNA translation in gastric cancer

1
1. scibot 01 May 2026
  
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  RRID:Addgene_51133
  
  DOI: 10.1038/s41388-026-03791-z
  
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nature.com/articles/s41388-026-03791-z
Dec 2025
advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com

Effectiveness of Multivitamins vs Folic Acid on Prevention of Neural Tube Defects in Mouse Genetic Models and Human Organoids

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1. scibot 13 Dec 2025
  
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  RRID:Addgene_51133
  
  DOI: 10.1002/advs.202513609
  
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advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202513609
Nov 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Adenine base editing rescues disrupted BCKDH function and reduces BCAAs toxic accumulation in maple syrup urine disease patient iPSC-hepatic organoids

1
1. scibot 23 Nov 2025
  
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  51133
  
  DOI: 10.1186/s13287-025-04630-w
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12465149/
Sep 2025
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A rare genetic variant confers resistance to neurodegeneration across multiple neurological disorders by augmenting selective autophagy

1
1. scibot 13 Sep 2025
  
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  plasmid_51133
  
  DOI: 10.1016/j.neuron.2025.08.018
  
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sciencedirect.com/science/article/pii/S0896627325006245
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Estrogen-induced chromatin looping changes identify a subset of functional regulatory elements

1
1. scibot 06 Sep 2025
  
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  51133
  
  DOI: 10.1101/gr.279699.124
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11960465/
Aug 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The RNA-binding protein RRP1 brakes macrophage one-carbon metabolism to suppress autoinflammation

1
1. scibot 11 Aug 2025
  
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  51133
  
  DOI: 10.1038/s41467-025-62173-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12297237/
Jul 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Y12C mutation disrupts IMPDH cytoophidia and alters cancer metabolism

1
1. scibot 20 Jul 2025
  
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  51133
  
  DOI: 10.1111/febs.70086
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12265856/
Jan 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Identification of a distal enhancer of Ucp1 essential for thermogenesis and mitochondrial function in brown fat

1
1. scibot 27 Jan 2025
  
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  Addgene_51133
  
  DOI: 10.1038/s42003-025-07468-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11718246/
Dec 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

dCas9-HDAC8-EGFP fusion enables epigenetic editing of breast cancer cells by H3K9 deacetylation

1
1. scibot 29 Dec 2024
  
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  plasmid_51133
  
  DOI: 10.1016/j.ejcb.2024.151463
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11677611/
Sep 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The RhoB p.S73F mutation leads to cerebral palsy through dysregulation of lipid homeostasis

1
1. scibot 26 Sep 2024
  
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  Addgene_51133
  
  DOI: 10.1038/s44321-024-00113-2
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11393352/
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

USP20 deubiquitinates and stabilizes the reticulophagy receptor RETREG1/FAM134B to drive reticulophagy

1
1. scibot 26 Aug 2024
  
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  51,133
  
  DOI: 10.1080/15548627.2024.2347103
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11262213/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

CRISPR/dCas9-Mediated DNA Methylation Editing on emx2 in Chinese Tongue Sole (Cynoglossus semilaevis) Testis Cells

1
1. scibot 18 Aug 2024
  
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  plasmid_51133
  
  DOI: 10.3390/ijms25147637
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11277268/
Jul 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Estrogen-induced chromatin looping changes identify a subset of functional regulatory elements

1
1. scibot 01 Jul 2024
  
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  51133
  
  DOI: 10.1101/2024.06.12.598690
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11195280/
Jun 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

m5C methylated lncRncr3–MeCP2 interaction restricts miR124a-initiated neurogenesis

1
1. scibot 20 Jun 2024
  
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  RRID:Addgene_51133
  
  DOI: 10.1038/s41467-024-49368-w
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11180186/
May 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The IMPDH cytoophidium couples metabolism and fetal development in mice

1
1. scibot 12 May 2024
  
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  51,133
  
  DOI: 10.1007/s00018-024-05233-z
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11078715/
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Co-delivery of Cas9 mRNA and guide RNAs for editing of LGMN gene represses breast cancer cell metastasis

1
1. scibot 13 Apr 2024
  
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  Addgene_51133
  
  DOI: 10.1038/s41598-024-58765-6
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10998893/
Mar 2024
www.nature.com www.nature.com

CDK9-55 guides the anaphase-promoting complex/cyclosome (APC/C) in choosing the DNA repair pathway choice

1
1. scibot 14 Mar 2024
  
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  RRID:Addgene_51133
  
  DOI: 10.1038/s41388-024-02982-w
  
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nature.com/articles/s41388-024-02982-w
Feb 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A synthetic agent ameliorates polycystic kidney disease by promoting apoptosis of cystic cells through increased oxidative stress

1
1. scibot 01 Feb 2024
  
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  Plasmid_51133
  
  DOI: 10.1073/pnas.2317344121
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10823221/
Jan 2024
www.sciencedirect.com www.sciencedirect.com

Kidney organoid models reveal cilium-autophagy metabolic axis as a therapeutic target for PKD both in vitro and in vivo

1
1. scibot 11 Jan 2024
  
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  DOI: 10.1016/j.stem.2023.12.003
  
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sciencedirect.com/science/article/pii/S1934590923004332
Jun 2022
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A TET1-PSPC1-Neat1 molecular axis modulates PRC2 functions in controlling stem cell bivalency

1
1. scibot 09 Jun 2022
  
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  Addgene_51133
  
  DOI: 10.1016/j.celrep.2022.110928
  
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sciencedirect.com/science/article/pii/S2211124722007100
Feb 2022
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Aberrant cyclin C nuclear release induces mitochondrial fragmentation and dysfunction in MED13L syndrome fibroblasts

2
1. scibot 11 Feb 2022
  
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  Addgene51133
  
  DOI: 10.1016/j.isci.2022.103823
  
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2. scibot 11 Feb 2022
  
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  Addgene51133
  
  DOI: 10.1016/j.isci.2022.103823
  
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sciencedirect.com/science/article/pii/S2589004222000931
Dec 2021
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TM6SF2/PNPLA3/MBOAT7 Loss-of-Function Genetic Variants Impact on NAFLD Development and Progression Both in Patients and in In Vitro Models

1
1. scibot 11 Dec 2021
  
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  RRID:Addgene_51133
  
  DOI: 10.1016/j.jcmgh.2021.11.007
  
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sciencedirect.com/science/article/pii/S2352345X21002411
Jul 2021
www.nature.com www.nature.com

Modelling human hepato-biliary-pancreatic organogenesis from the foregut–midgut boundary

1
1. scibot 30 Jul 2021
  
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  pGL3-U6-sgRNA-PGK-puromycin
  
  DOI: 10.1038/s41586-019-1598-0
  
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nature.com/articles/s41586-019-1598-0
Jan 2020
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Modeling Steatohepatitis in Humans with Pluripotent Stem Cell-Derived Organoids

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1. scibot 13 Jan 2020
  
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  RRID:Addgene_51133
  
  DOI: 10.1016/j.cmet.2019.05.007
  
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  Curator: @ethanbadger
  
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sciencedirect.com/science/article/pii/S1550413119302475