1,868 Matching Annotations
  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Glycolytic enolase 1-induced H4K12 lactylation activates quiescent breast cancer stem-like cells in triple-negative breast cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13493833/
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    Tumors exploit interclonal Hedgehog-Wnt crosstalk to drive tumor-promoting cell competition
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    sciencedirect.com/science/article/pii/S153458072600287X
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    Schisandrin A ameliorates obesity and MAFLD through bile acid context-dependent modulation of intestinal FXR signaling
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    sciencedirect.com/science/article/pii/S094471132600961X
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TRAF1 S146 is constitutively phosphorylated in OP9-cultured primary chronic lymphocytic leukemia cells by PKN1/2
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    pmc.ncbi.nlm.nih.gov/articles/PMC13480468/
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Caspase-5c amplifies Wnt via APC cleavage to promote intestinal homeostasis
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    pmc.ncbi.nlm.nih.gov/articles/PMC13476857/
  7. Aug 2026
  8. www.sciencedirect.com www.sciencedirect.com
    STING agonist profiling by nucleotide library defines structural determinants of cyclic dinucleotide recognition
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    sciencedirect.com/science/article/pii/S2589004226025575
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    3β-HSD1-mediated steroid back-conversion can maintain androgen signaling in prostate cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13458341/
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    AURORA A interacts with DICER and SETD2 to promote S-phase progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC13458143/
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    An ancient mitochondrial program tunes translation to haem availability
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    nature.com/articles/s41586-026-10885-x
  12. www.science.org www.science.org
    Lipidomic profiling reveals age-dependent changes in plasma membrane lipids that affect neural stem cell aging
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    science.org/doi/10.1126/sciadv.aeh9771
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    PKR engages viral RNA and intron-retained host transcripts during poxvirus infection
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    sciencedirect.com/science/article/pii/S2211124726009162
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    Integrative 3D genome and epigenomic analysis identifies TP53RK and SYBU as critical regulators of stemness and anti-tumor immunity in HCC
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    sciencedirect.com/science/article/pii/S2211124726008752
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A dual-pronged host-directed therapeutic targeting cyclophilin A and pathogenic interferon response abrogates virus-triggered pregnancy pathologies
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    pmc.ncbi.nlm.nih.gov/articles/PMC13392008/
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    An HDAC4-specific PROTAC degrader achieves radiation sensitization by enhancing ferroptosis in lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13389272/
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    African swine fever virus B66L drives extracellular mitochondrial release to promote systemic inflammation in mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC13388993/
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MTUS2-AS1 suppression promotes DDX5 protein degradation to enhance the sensitivity of PARP inhibitors in BRCA-wild triple negative breast cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13412408/
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Quartet of Native Orai Channel Isoforms Orchestrates Graded NFAT Activation and Transcription
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    pmc.ncbi.nlm.nih.gov/articles/PMC13404903/
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    PET117 Deficiency Confers Ferroptosis Resistance Through ACSF2 Downregulation in Cervical Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13405933/
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    Targeting MORC2 activates transposable element-mediated viral mimicry and potentiates immune checkpoint blockade in triple-negative breast cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13420440/
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    Targeting TOMM40 unleashes immunogenic mitophagy to facilitate antigen presentation and immunotherapy sensitization
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    pmc.ncbi.nlm.nih.gov/articles/PMC13409098/
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    Centriolar Protein POC5 Regulates Human Adipogenesis and Cellular Senescence: Insights From a Novel Metabolic Ciliopathy
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    pmc.ncbi.nlm.nih.gov/articles/PMC13404321/
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    Pyoderma gangrenosum caused by the molecular uncoupling of OTULIN catalytic activity and LUBAC binding
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    pmc.ncbi.nlm.nih.gov/articles/PMC13414579/
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SMARCA4 loss reprograms p300 chromatin occupancy to subvert p53-mediated transcriptional repression in ovarian small cell carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC13408698/
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A mitochondria-driven quality control mechanism for peroxisomal membrane proteins
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    pmc.ncbi.nlm.nih.gov/articles/PMC13402316/
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CD248 acts as a mechanosensory switch in fibroblast subsets to establish distinct pathological niches in renal fibrosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC13402351/
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ATL2 Recruits TRAK1 to Promote Mitochondrial Transport at ER–Mitochondria Contact Sites
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    pmc.ncbi.nlm.nih.gov/articles/PMC13423487/
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NNMT Loss Drives Cancer Progression by enhancing SAM availability for mTORC1 Signaling and Chromatin Methylation
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    pmc.ncbi.nlm.nih.gov/articles/PMC13430563/
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Integrative MeRIP-Seq and RNA-Seq Analyses Reveal Innate Immune and Infection-Related Transcriptomic Changes upon METTL3 Knockout
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    pmc.ncbi.nlm.nih.gov/articles/PMC13408962/
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Forebrain Lineage Factor DMRTA2 Is Not Required for Maintenance of H3G34‐Mutant Paediatric High‐Grade Gliomas
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    pmc.ncbi.nlm.nih.gov/articles/PMC13401718/
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Macrophage adenylyl cyclase 7 protects against myocardial ischemia/reperfusion injury in male mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC13408838/
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    LRP4 is an entry receptor for multiple encephalitic alphaviruses
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    pmc.ncbi.nlm.nih.gov/articles/PMC13402676/
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Loss of SETD2-mediated H3K36me3 Drives CD8+ T Cell Exhaustion in Lung Cancer through CXCL-dependent PMN-MDSC Recruitment and Arginine Deprivation
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    pmc.ncbi.nlm.nih.gov/articles/PMC13438026/
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SET1B Drives Sustained HIF Activity and Disease Progression in Clear-Cell Renal Cell Carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC13434302/
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    VPS33A and VPS18 orchestrate porcine epidemic diarrhea virus replication by modulating autophagic flux
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    pmc.ncbi.nlm.nih.gov/articles/PMC13432860/
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RPA-independent activation of the ATR/CHK1 pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC12890785/
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Golgi organization regulates stem cell function in the small intestine
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    pmc.ncbi.nlm.nih.gov/articles/PMC13424321/
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Intermediate accumulated upon interruption of fatty acid oxidation flux promotes tumoral ferroptosis and improves immunotherapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC13434651/
  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The second mitochondrial activator of caspases (SMAC) regulates growth, inflammation and mitochondrial integrity in cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC13434016/
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC13441298/
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PTPN13 Contributes to Ebola Virus-Induced Immune Dysregulation via Dephosphorylation of IRF3 and PI3K-p85
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    pmc.ncbi.nlm.nih.gov/articles/PMC13431591/
  43. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    HER2 heterogeneous breast cancer models reveal novel therapeutic targets and subclonal dynamics during evolution to resistance to HER2-targeted therapies
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    pmc.ncbi.nlm.nih.gov/articles/PMC13430225/
  44. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Unveiling a novel role for p19Arf (alternative reading frame) in mESC differentiation toward the pancreatic lineage
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    pmc.ncbi.nlm.nih.gov/articles/PMC13439060/
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DCLK1 regulates stemness and IL-6/STAT3–dependent metastatic niche formation in chemoresistant ovarian cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13404908/
  46. Jul 2026
  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Lipidomic profiling reveals age-dependent changes in plasma membrane lipids that affect neural stem cell aging
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    pmc.ncbi.nlm.nih.gov/articles/PMC13418745/
  48. www.sciencedirect.com www.sciencedirect.com
    Disruption of microhomology-mediated end joining in Ewing sarcoma
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    sciencedirect.com/science/article/pii/S109727652600451X
  49. www.science.org www.science.org
    Iron overload suppresses LKB1 and induces IL36G anti-tumor immunity in PDAC metastasis
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    science.org/doi/10.1126/sciadv.adz8681
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    Iron overload suppresses LKB1 and induces IL36G anti-tumor immunity in PDAC metastasis
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    pmc.ncbi.nlm.nih.gov/articles/PMC13378540/
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    A bivalent molecular glue linking lysine acetyltransferases to oncogene-induced cell death
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    sciencedirect.com/science/article/pii/S0092867426007579
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    Purine and pyrimidine-based bacterial cyclic dinucleotides egress the phagosome and activate the innate immune sensor STING
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    sciencedirect.com/science/article/pii/S1074761326002748
  53. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NGFR induces melanoma invasion and immunotherapy resistance through myosin light chain 2 modulation
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    pmc.ncbi.nlm.nih.gov/articles/PMC13373201/
  54. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    KLF4 Promotes a KRT13+ Hillock-Like State in Lung Squamous Cell Carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC13371669/
  55. www.biorxiv.org www.biorxiv.org
    Glandular architecture and malignant behaviour in colorectal cancer is regulated by the sialomucin Podocalyxin
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    biorxiv.org/content/10.64898/2026.07.10.737619v1
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    TMEM97 regulates cholesterol biosynthesis and mitochondrial metabolism in gastric carcinoma
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    sciencedirect.com/science/article/pii/S2589004226021516
  57. aacrjournals.org aacrjournals.org
    Targeting the Non-Homologous End-Joining Pathway Sensitizes MDM2-Amplified Liposarcoma to Doxorubicin by Enhancing p53-Mediated Senescence
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    aacrjournals.org/cancerres/article/86/11/2777/785299/Targeting-the-Non-Homologous-End-Joining-Pathway
  58. aacrjournals.org aacrjournals.org
    CLK2 Regulates the KEAP1/NRF2 and p53 Pathways to Suppress Ferroptosis in Colorectal Cancer
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    aacrjournals.org/cancerres/article/85/23/4734/767294/CLK2-Regulates-the-KEAP1-NRF2-and-p53-Pathways-to
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    A Peptide-Based PROTAC Degrader of BRCA2 Sensitizes Metastatic Castration-Resistant Prostate Cancer to PARP Inhibition
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    aacrjournals.org/cancerres/article/85/18/3490/764450/A-Peptide-Based-PROTAC-Degrader-of-BRCA2
  60. 54.241.53.176 54.241.53.176
    41419_2026_8660_MOESM1_ESM-html.html
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    The central precocious puberty-associated gene MKRN3 is a tumor suppressor regulating CSDE1 ubiquitination in ovarian cancer
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    Distinct metabolic dependency on BCAA defines cancer stemness and malignancy in human triple-negative breast cancer
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    sciencedirect.com/science/article/pii/S2211124726007084
  63. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PARG regulates the proteasomal degradation of TARG1
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    pmc.ncbi.nlm.nih.gov/articles/PMC13332792/
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    A viral ORFeome library for systems-level genetic dissection of host-pathogen interactions
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    Extracellular ATP-P2RY2 signaling drives intratumoral prostaglandin E2 accumulation and adaptive resistance to immunotherapy in solid tumors
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    sciencedirect.com/science/article/pii/S1074761326002578
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    Multiscale integration of tissue and chromatin context converts cell heterogeneity into stable intestinal patterning
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    sciencedirect.com/science/article/pii/S0092867426006963
  67. www.biorxiv.org www.biorxiv.org
    Vertical inhibition of the autophagy pathway impairs growth and enhances sensitivity to mTORC1 inhibition in pancreatic ductal adenocarcinoma
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    biorxiv.org/content/10.64898/2026.06.28.734981v1
  68. journals.plos.org journals.plos.org
    Dissecting the host determinants of orthoflavivirus infection using QIC-seq
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    journals.plos.org/plospathogens/article
  69. Jun 2026
  70. aacrjournals.org aacrjournals.org
    ZC3H13 Loss Drives Cancer Metastatic Progression by Disrupting m6A RNA Methylation
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    aacrjournals.org/cancerres/article/86/3/622/771927/ZC3H13-Loss-Drives-Cancer-Metastatic-Progression
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    Cuproptosis-immunity crosstalk informs strategy to overcome immunotherapy resistance
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    sciencedirect.com/science/article/pii/S0092867426006367
  72. www.biorxiv.org www.biorxiv.org
    Decoding the Mechanism of Action of a Parasite TGFβ antagonist Inspires the Creation of Cell-type-specific TGFβ Modulators
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    biorxiv.org/content/10.64898/2026.02.16.706112v1
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    Activation-induced SLC7A1 expression enhances T cell sensitivity to cGAMP-mediated STING signaling
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    sciencedirect.com/science/article/pii/S2211124726006583
  74. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    eIF4G2-Dependent Translation Restrains Pancreatic Cancer Progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC13276777/
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    LRRC58 defines an E3 ubiquitin ligase complex sensitive to cysteine abundance
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    sciencedirect.com/science/article/pii/S1097276526003850
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    VEGFR2 inhibition potentiates STING-mediated antitumor immunity
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    sciencedirect.com/science/article/pii/S2211124726006546
  77. www.biorxiv.org www.biorxiv.org
    Structural Mechanism and Cellular Restriction of Tau Seeding from Endolysosomes
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    biorxiv.org/content/10.64898/2026.06.08.731026v1
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    DPY30 is an epigenetic decoupler linking replication stress to immunoediting in pancreatic cancer
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    aacrjournals.org/cancerres/article/86/12/2837/785625/DPY30-Is-an-Epigenetic-Decoupler-Linking
  79. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DGAT1 Inhibition Induces Ferroptosis and Enhances Cancer Immunotherapy Efficacy
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    pmc.ncbi.nlm.nih.gov/articles/PMC13266341/
  80. www.sciencedirect.com www.sciencedirect.com
    ZNF512B safeguards genome integrity at regulatory regions to repress the SASP and inflammation
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    sciencedirect.com/science/article/pii/S1934590926002018
  81. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting DNA Polymerase Epsilon Induces Tumor Clearance and Activates an NF-κB-Mediated Inflammatory Response in Triple Negative Breast Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13154340/
  82. www.nature.com www.nature.com
    ULK1 knockout suppresses pancreatic cancer progression by inhibiting autophagy and enhancing antitumor immunity
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    nature.com/articles/s12276-025-01590-2
  83. www.biorxiv.org www.biorxiv.org
    Interferon-gamma induced RNF213 targets nascent double membrane vesicles to inhibit coronavirus primary translation
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    biorxiv.org/content/10.64898/2026.06.02.729663v1
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    Epigenetic control of microglial mitochondrial immunity by KAT7 drives Alzheimer’s disease pathogenesis
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    sciencedirect.com/science/article/pii/S0896627326003867
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    STING-OPTN signaling confers cytoprotection through TBK1-dependent mitophagy
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    sciencedirect.com/science/article/pii/S2211124726005930
  86. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Loss of ZNRF3/RNF43 unleashes EGFR in cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13068435/
  87. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SARS-CoV-2 N Protein Hijacks the m6A Reader YTHDF2 to Suppress Antiviral Gene Expression
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    pmc.ncbi.nlm.nih.gov/articles/PMC13211420/
  88. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Inactivation of PRMT5 by PARP Inhibitors Confers High Susceptibility in MTAP-Deficient Cancers
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  180. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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