1,809 Matching Annotations
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  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PARG regulates the proteasomal degradation of TARG1
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    pmc.ncbi.nlm.nih.gov/articles/PMC13332792/
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    A viral ORFeome library for systems-level genetic dissection of host-pathogen interactions
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    sciencedirect.com/science/article/pii/S0092867426005830
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    Extracellular ATP-P2RY2 signaling drives intratumoral prostaglandin E2 accumulation and adaptive resistance to immunotherapy in solid tumors
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    sciencedirect.com/science/article/pii/S1074761326002578
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    Multiscale integration of tissue and chromatin context converts cell heterogeneity into stable intestinal patterning
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    sciencedirect.com/science/article/pii/S0092867426006963
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    Vertical inhibition of the autophagy pathway impairs growth and enhances sensitivity to mTORC1 inhibition in pancreatic ductal adenocarcinoma
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    biorxiv.org/content/10.64898/2026.06.28.734981v1
  7. Jul 2026
  8. journals.plos.org journals.plos.org
    Dissecting the host determinants of orthoflavivirus infection using QIC-seq
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    journals.plos.org/plospathogens/article
  9. Jun 2026
  10. aacrjournals.org aacrjournals.org
    ZC3H13 Loss Drives Cancer Metastatic Progression by Disrupting m6A RNA Methylation
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    aacrjournals.org/cancerres/article/86/3/622/771927/ZC3H13-Loss-Drives-Cancer-Metastatic-Progression
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    Cuproptosis-immunity crosstalk informs strategy to overcome immunotherapy resistance
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    sciencedirect.com/science/article/pii/S0092867426006367
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    Decoding the Mechanism of Action of a Parasite TGFβ antagonist Inspires the Creation of Cell-type-specific TGFβ Modulators
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    biorxiv.org/content/10.64898/2026.02.16.706112v1
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    Activation-induced SLC7A1 expression enhances T cell sensitivity to cGAMP-mediated STING signaling
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    sciencedirect.com/science/article/pii/S2211124726006583
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    eIF4G2-Dependent Translation Restrains Pancreatic Cancer Progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC13276777/
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    LRRC58 defines an E3 ubiquitin ligase complex sensitive to cysteine abundance
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    sciencedirect.com/science/article/pii/S1097276526003850
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    VEGFR2 inhibition potentiates STING-mediated antitumor immunity
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    sciencedirect.com/science/article/pii/S2211124726006546
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    Structural Mechanism and Cellular Restriction of Tau Seeding from Endolysosomes
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    biorxiv.org/content/10.64898/2026.06.08.731026v1
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DPY30 is an epigenetic decoupler linking replication stress to immunoediting in pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13266346/
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DGAT1 Inhibition Induces Ferroptosis and Enhances Cancer Immunotherapy Efficacy
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    pmc.ncbi.nlm.nih.gov/articles/PMC13266341/
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    ZNF512B safeguards genome integrity at regulatory regions to repress the SASP and inflammation
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    sciencedirect.com/science/article/pii/S1934590926002018
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting DNA Polymerase Epsilon Induces Tumor Clearance and Activates an NF-κB-Mediated Inflammatory Response in Triple Negative Breast Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13154340/
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    ULK1 knockout suppresses pancreatic cancer progression by inhibiting autophagy and enhancing antitumor immunity
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    nature.com/articles/s12276-025-01590-2
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    Interferon-gamma induced RNF213 targets nascent double membrane vesicles to inhibit coronavirus primary translation
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    biorxiv.org/content/10.64898/2026.06.02.729663v1
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    Epigenetic control of microglial mitochondrial immunity by KAT7 drives Alzheimer’s disease pathogenesis
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    sciencedirect.com/science/article/pii/S0896627326003867
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    STING-OPTN signaling confers cytoprotection through TBK1-dependent mitophagy
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    sciencedirect.com/science/article/pii/S2211124726005930
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    Loss of ZNRF3/RNF43 unleashes EGFR in cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13068435/
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SARS-CoV-2 N Protein Hijacks the m6A Reader YTHDF2 to Suppress Antiviral Gene Expression
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    pmc.ncbi.nlm.nih.gov/articles/PMC13211420/
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    Inactivation of PRMT5 by PARP Inhibitors Confers High Susceptibility in MTAP-Deficient Cancers
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    pmc.ncbi.nlm.nih.gov/articles/PMC13163060/
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    Cell‐cycle regulation of sarcomere integrity—Role for Actn2 phosphorylation
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    pmc.ncbi.nlm.nih.gov/articles/PMC13062941/
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    Glucose restriction reprograms lipid metabolism and enhances immunotherapy through ZNRF3-Wnt-SCD signaling axis
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    pmc.ncbi.nlm.nih.gov/articles/PMC13239590/
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Integrated in vitro and multi-cohort cross-omics analysis of HTLV-1-associated lung pathology reveals a RelA-dependent mechanism for monocyte recruitment and differentiation
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    pmc.ncbi.nlm.nih.gov/articles/PMC13237950/
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Differential DNA damage response to WRN inhibition identifies a targetable vulnerability in ARID1A-mutated cancers
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    pmc.ncbi.nlm.nih.gov/articles/PMC13240190/
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    IRS4 is a PI3K-activating cancer dependency up-regulated through DNA rearrangements or epigenetic mechanisms in multiple solid tumors
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    Uncovering functional variants using a high-efficiency PE3-based screening platform
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    pmc.ncbi.nlm.nih.gov/articles/PMC13240188/
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    GLUT1-mediated glucose flux constrains autoreactive but not foreign antigen-specific B-cell responses
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    pmc.ncbi.nlm.nih.gov/articles/PMC13213815/
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mitochondria limit coenzyme Q export under cholesterol biosynthetic stress
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  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The atypical E3 ligase HOIL-1 safeguards the ribosome during cellular stress
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    pmc.ncbi.nlm.nih.gov/articles/PMC13179138/
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    Inhibition of circulating glycocholic acid-regulated signaling potentiates immune checkpoint therapy in colorectal cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13230736/
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    Nicotinamide N-methyltransferase as a therapeutic target in taxane-resistant castration-resistant prostate cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13216299/
  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SMARCA4 activation engages FOSL1 to drive enhancer reprogramming and tumorigenic phenotypes in SMARCA4-deficient LUAD cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC13223256/
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    Fibulin-4 expressed in metastatic breast cancer is a target of peptide-based imaging probes and experimental therapeutics
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    pmc.ncbi.nlm.nih.gov/articles/PMC13158586/
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Beyond Free Virions: Interconnected Secretory Pathways and Reticulon 3 (RTN3) Coordinate Extracellular Vesicle Diversity for Infectious Exosome Generation
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    pmc.ncbi.nlm.nih.gov/articles/PMC13162583/
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    Single-cell landscape of melanoma reveals ETV5-driven C3 ID4+ tumor subpopulation with extracellular vesicle-associated immunosuppressive and pro-metastatic potential
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    pmc.ncbi.nlm.nih.gov/articles/PMC13128620/
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    Single‐Cell Analysis Identifies LYPD6B as a Tumor‐Intrinsic Candidate Associated With Immunotherapy Nonresponse in Breast Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13240201/
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sulconazole Suppresses Colorectal Cancer Immune Evasion by Inhibiting Glycolysis to Upregulate OVOL2 PARylation and Induce PANoptosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC13244120/
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    The role of ATP synthase subunit e (ATP5I) in mediating the metabolic and antiproliferative effects of metformin in cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC13179060/
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    Therapeutic pressure drives the evolution of a protective ecotype characterized by AR-loss-induced senescence in prostate cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13232435/
  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Localized heme sensing through a ternary molecular glue
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    pmc.ncbi.nlm.nih.gov/articles/PMC13174492/
  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Adapting Upright Light Sheet Fluorescence Microscopy for Imaging at Air-Liquid Interface
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    pmc.ncbi.nlm.nih.gov/articles/PMC13082110/
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    Coronavirus M protein disperses the trans-Golgi network and inhibits anterograde protein trafficking in the secretory pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC13167032/
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    Sequencing complete plasmids on Oxford Nanopore Technologies sequencers using R2C2 and Chopper
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    pmc.ncbi.nlm.nih.gov/articles/PMC13068223/
  52. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ADNP missense variant p.C687R disrupts chromatin regulation and GABAergic differentiation in Helsmoortel–Van der Aa syndrome
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    pmc.ncbi.nlm.nih.gov/articles/PMC13078061/
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    Stress adaptation pathways and HA–CD44 signaling maintain the survival of pancreatic cancer cells with centrosome amplification
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    pmc.ncbi.nlm.nih.gov/articles/PMC13217673/
  54. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-wide CRISPR screen identifies a cytokine-enhancer circuit driving HIF-2α activation in renal cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13178659/
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    Optimized optogenetic anti-CRISPR for endogenous gene regulation in Drosophila
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  56. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A copper uptake ABC transport system is essential for Mycobacterium tuberculosis virulence
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  57. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    GTPase Rab11b and effector Rab11-FIP2 promote NLRP3 stability during inflammasome priming
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    Tissue-selective COPII modulator SEC16B aggravates cardiovascular disease by promoting lipid export
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    pmc.ncbi.nlm.nih.gov/articles/PMC13226660/
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    ELF3 drives glioblastoma multiforme progression through the regulation of MXRA8 expression
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    pmc.ncbi.nlm.nih.gov/articles/PMC13183993/
  60. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CRISPR tiling deletion screens reveal functional enhancers and allelic compensation effects (ACE) on SIN3A transcription
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    pmc.ncbi.nlm.nih.gov/articles/PMC13181091/
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    Mitochondrial AK3 inhibits nuclear β-catenin localization and its activation through enhancing mitochondrial activity
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    pmc.ncbi.nlm.nih.gov/articles/PMC13234369/
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    Characterization and therapeutic suppression of KEAP1-NRF2-driven resistance to KRAS inhibitors in pancreatic and lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13131474/
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    HIV and Cocaine exposure promote Tau phosphorylation through RSK-1 in a GSK3β-independent manner
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    pmc.ncbi.nlm.nih.gov/articles/PMC13104828/
  64. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CHARIOT-AAV: Conjugation of diverse vectors to adeno-associated viruses for delivery of large genes
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    Proteomic Screening Identifies HNRNPA2B1 as an Epigenetic Repressor of Epstein-Barr Virus Reactivation
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    pmc.ncbi.nlm.nih.gov/articles/PMC13160016/
  66. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    mSWI/SNF complex inhibition sensitizes KRAS-mutant lung cancers to targeted therapies via epithelial-mesenchymal subversion
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    pmc.ncbi.nlm.nih.gov/articles/PMC13160128/
  67. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CRISPR/Cas9-Mediated Knockout of CGNL1 Confers Resistance to Aflatoxin B1 in Porcine Intestinal Epithelial Cells via Suppressing ROS Generation
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    pmc.ncbi.nlm.nih.gov/articles/PMC13163822/
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    Interaction of NDRG1 and MRE11 Modulates DNA Replication and Repair
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    pmc.ncbi.nlm.nih.gov/articles/PMC13115477/
  69. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dispensable players: N-WASP and WASP are not crucial for homology-directed DNA repair
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    pmc.ncbi.nlm.nih.gov/articles/PMC13219447/
  70. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ZAP targets aberrant mRNA transcripts encoding proteins with defective signal peptides for degradation
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    pmc.ncbi.nlm.nih.gov/articles/PMC13084044/
  71. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Endogenous protein tagging coupled with a CRISPR screening approach identifies UBE3C as a potential MYC oncogene regulator
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  72. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The ISG Atlas: a loss-of-function analysis characterizes antiviral properties of interferon stimulated genes
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    pmc.ncbi.nlm.nih.gov/articles/PMC13156316/
  73. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A viral APOBEC3 antagonist distinguishes HHV-6A from HHV-6B
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    pmc.ncbi.nlm.nih.gov/articles/PMC13134964/
  74. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Cyclin C-CDK8/19 Mediator kinase module controls PRCC-TFE3 driven senescence in renal epithelium and tumorigenesis in TFE3-RCC
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    pmc.ncbi.nlm.nih.gov/articles/PMC13069303/
  75. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Inhibition of N‐Terminal Acetyltransferase C Mitigates Endoplasmic Reticulum Stress–Mediated Muscle Atrophy in Cancer Cachexia
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    pmc.ncbi.nlm.nih.gov/articles/PMC13140329/
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    CD20 tails interact with the 14-3-3/GEF-H1 complex and microtubule network upon PKCδ phosphorylation
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    pmc.ncbi.nlm.nih.gov/articles/PMC13226681/
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    PCBP1 orchestrates amino acid metabolism burst during the naïve-to-primed pluripotency transition
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    sciencedirect.com/science/article/pii/S221367112600161X
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    nsP3-FXR co-condensation enables alphavirus replication and reveals a targetable alphavirus vulnerability
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    sciencedirect.com/science/article/pii/S2211124726005735
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    FGF21 suppresses hepatocellular carcinoma by driving competitive cell-cell interactions
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    sciencedirect.com/science/article/pii/S2211124726004882
  80. May 2026
  81. www.biorxiv.org www.biorxiv.org
    Dissecting the host determinants of flavivirus infection using QIC-seq
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    biorxiv.org/content/10.1101/2025.07.15.664960v1
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    Uncovering spatially resolved functional genomics with CRISPR screen sequencing
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    sciencedirect.com/science/article/pii/S0092867426005167
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    Ganaxolone, an approved therapy for CDKL5-Deficiency Disorder, is an inhibitor of PTP1B
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    sciencedirect.com/science/article/pii/S0021925826020508
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    Intrinsic bias of the genetic code shapes the folding and stability landscapes of microproteins
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    sciencedirect.com/science/article/pii/S1097276526002753
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    A CRISPR activation screen identifies SPART as a pan-orthoflavivirus restriction factor
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    sciencedirect.com/science/article/pii/S1931312826001745
  86. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DHODH-Mediated Suppression of Ferroptosis Supports Radioresistance and Represents a Therapeutic Vulnerability in Lung Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13179828/
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    Cooperative response loops enhanced by histamine signaling during tumor-neutrophil crosstalk in pleural mesothelioma
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    sciencedirect.com/science/article/pii/S2211124726004390
  88. www.science.org www.science.org
    IRS4 is a PI3K-activating cancer dependency up-regulated through DNA rearrangements or epigenetic mechanisms in multiple solid tumors
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    science.org/doi/10.1126/sciadv.aeb3503
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    Dendritic cell redundancy enables priming of anti-tumor CD4+ T cells in pancreatic cancer
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