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    Unraveling ETC complex I function in ferroptosis reveals a potential ferroptosis-inducing therapeutic strategy for LKB1-deficient cancers
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    sciencedirect.com/science/article/pii/S1097276524003241
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    Non-canonical substrate recognition by the human WDR26-CTLH E3 ligase regulates prodrug metabolism
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    Osr2 functions as a biomechanical checkpoint to aggravate CD8+ T cell exhaustion in tumor
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    PRRSV degrades MDA5 via dual autophagy receptors P62 and CCT2 to evade antiviral innate immunity
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    ncbi.nlm.nih.gov/pmc/articles/PMC11074645/
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    Genomic context– and H2AK119 ubiquitination–dependent inheritance of human Polycomb silencing
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    Identifying human pre-mRNA cleavage and polyadenylation factors by genome-wide CRISPR screens using a dual fluorescence readthrough reporter
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    Prolonged depletion of profilin 1 or F-actin causes an adaptive response in microtubules
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    p53 modulates kinase inhibitor resistance and lineage plasticity in NF1-related MPNSTs
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    DNA-PK controls Apollo’s access to leading-end telomeres
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      plasmid_52961

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  11. May 2024
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    Cysteine Rich Intestinal Protein 2 is a copper-responsive regulator of skeletal muscle differentiation
    1
    1. scibot 09 May 2024
      plasmid_52961

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    biorxiv.org/content/10.1101/2024.05.03.592485v1
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    De novo generation of multi-target compounds using deep generative chemistry
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    Differential histone acetylation and super-enhancer regulation underlie melanoma cell dedifferentiation
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    Selective CDK7 inhibition suppresses cell cycle progression and MYC signaling while enhancing apoptosis in therapy-resistant estrogen receptor positive breast cancer
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    The epigenetic regulators EP300/CREBBP represent promising therapeutic targets in MLL-rearranged acute myeloid leukemia
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    NFATC2IP is a mediator of SUMO-dependent genome integrity
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    De Novo Purine Metabolism is a Metabolic Vulnerability of Cancers with Low p16 Expression
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      Addgene_52961

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    RNA expression of 6 genes from metastatic mucosal gastric cancer serves as the global prognostic marker for gastric cancer with functional validation
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      Addgene_52961

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    Spindle assembly checkpoint-dependent mitotic delay is required for cell division in absence of centrosomes
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      DOI: 10.7554/eLife.84875.2

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    Clinical Correlates of Venetoclax-Based Combination Sensitivities to Augment Acute Myeloid Leukemia Therapy
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    Prime editing functionally corrects cystic fibrosis-causing CFTR mutations in human organoids and airway epithelial cells
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    sciencedirect.com/science/article/pii/S2666379124002349
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    CBF-beta mitigates PI3K-alpha-specific inhibitor killing through PIM1 in PIK3CA mutant gastric cancer
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      RRID:Addgene_52961

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    Influenza Virus Reduces Ubiquitin E3 Ligase MARCH10 Expression to Decrease Ciliary Beat Frequency
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    1. scibot 02 May 2024
      RRID:Addgene_52961

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    The role of Piezo1 mechanotransduction in high-grade serous ovarian cancer: Insights from an in vitro model of collective detachment
    1
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    PRMT1 promotes epigenetic reprogramming associated with acquired chemoresistance in pancreatic cancer
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    Long-term expandable mouse and human-induced nephron progenitor cells enable kidney organoid maturation and modeling of plasticity and disease
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  28. Apr 2024
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    Proximity proteomics reveals UCH-L1 as an essential regulator of NLRP3-mediated IL-1β production in human macrophages and microglia
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  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Combined SNPs sequencing and allele specific proteomics capture reveal functional causality underpinning the 2p25 prostate cancer susceptibility locus
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    N4BP1 functions as a dimerization-dependent linear ubiquitin reader which regulates TNF signalling
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    Expansion of human centromeric arrays in cells undergoing break-induced replication
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    CK2α-mediated phosphorylation of GRP94 facilitates the metastatic cascade in triple-negative breast cancer
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      LentiCRISPRv2

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    AMD1 promotes breast cancer aggressiveness via a spermidine-eIF5A hypusination-TCF4 axis
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      lentiCRISPR v2

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    MYADM binds human parechovirus 1 and is essential for viral entry
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  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    High throughput functional profiling of genes at intraocular pressure loci reveals distinct networks for glaucoma
    1
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      plasmid_52961

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  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Fatty acid-binding protein 5 is a functional biomarker and indicator of ferroptosis in cerebral hypoxia
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  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The role of Piezo1 mechanotransduction in high-grade serous ovarian cancer: Insights from an in vitro model of collective detachment
    1
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  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Prevention of age-related truncation of γ-glutamylcysteine ligase catalytic subunit (GCLC) delays cataract formation
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  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A MTA2-SATB2 chromatin complex restrains colonic plasticity toward small intestine by retaining HNF4A at colonic chromatin
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  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The E3 Ubiquitin Protein Ligase LINCR Amplifies the TLR-Mediated Signals through Direct Degradation of MKP1
    1
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      lentiCRISPRv2

      DOI: 10.3390/cells13080687

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    ncbi.nlm.nih.gov/pmc/articles/PMC11048823/
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SCFFBXW11 Complex Targets Interleukin-17 Receptor A for Ubiquitin–Proteasome-Mediated Degradation
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    ncbi.nlm.nih.gov/pmc/articles/PMC11047997/
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PMF-seq: a highly scalable screening strategy for linking genetics to mitochondrial bioenergetics
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    ncbi.nlm.nih.gov/pmc/articles/PMC11052718/
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MHC class I-dressing is mediated via phosphatidylserine recognition and is enhanced by polyI:C
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    ncbi.nlm.nih.gov/pmc/articles/PMC11046299/
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mechanism of Ψ-Pro/C-degron recognition by the CRL2FEM1B ubiquitin ligase
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  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Residue K28 of Zika Virus NS5 Protein Is Implicated in Virus Replication and Antagonism of STAT2
    1
    1. scibot 29 Apr 2024
      Addgene_52961

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  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sprouty1 is a broad mediator of cellular senescence
    1
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      RRID:Addgene_52961

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  48. www.sciencedirect.com www.sciencedirect.com
    Positive selection CRISPR screens reveal a druggable pocket in an oligosaccharyltransferase required for inflammatory signaling to NF-κB
    1
    1. scibot 26 Apr 2024
      plasmid_52961

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    sciencedirect.com/science/article/pii/S0092867424003131
  49. www.sciencedirect.com www.sciencedirect.com
    Integrated drug profiling and CRISPR screening identify BCR::ABL1-independent vulnerabilities in chronic myeloid leukemia
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    sciencedirect.com/science/article/pii/S2666379124001903
  50. www.sciencedirect.com www.sciencedirect.com
    Collagen IV assembly is influenced by fluid flow in kidney cell-derived matrices
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  51. www.sciencedirect.com www.sciencedirect.com
    IGSF8 is an innate immune checkpoint and cancer immunotherapy target
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      AddgeneCat# 52961

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  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HDAC10 inhibition represses melanoma cell growth and BRAF inhibitor resistance via upregulating SPARC expression
    1
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  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Porcine reproductive and respiratory syndrome virus 2 hijacks CMA-mediated lipolysis through upregulation of small GTPase RAB18
    1
    1. scibot 23 Apr 2024
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  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Nardilysin-regulated scission mechanism activates polo-like kinase 3 to suppress the development of pancreatic cancer
    1
    1. scibot 23 Apr 2024
      lentiCRISPR v2

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  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Influence of RNA circularity on Target RNA-Directed MicroRNA Degradation
    1
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      52961

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  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systematic investigation of chemo-immunotherapy synergism to shift anti-PD-1 resistance in cancer
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    1. scibot 23 Apr 2024
      52961

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    ncbi.nlm.nih.gov/pmc/articles/PMC11015024/
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Augmented ERO1α upon mTORC1 activation induces ferroptosis resistance and tumor progression via upregulation of SLC7A11
    1
    1. scibot 23 Apr 2024
      Lenti-CRISPRv2

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    ncbi.nlm.nih.gov/pmc/articles/PMC11015652/
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Unveiling IL6R and MYC as Targeting Biomarkers in Imatinib-Resistant Chronic Myeloid Leukemia through Advanced Non-Invasive Apoptosis Detection Sensor Version 2 Detection
    1
    1. scibot 23 Apr 2024
      52961

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  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HOIL1 mediates MDA5 activation through ubiquitination of LGP2
    2
    1. scibot 23 Apr 2024
      52961

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    ncbi.nlm.nih.gov/pmc/articles/PMC11014604/
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HOIL-1L deficiency induces cell cycle alteration which causes immaturity of skeletal muscle and cardiomyocytes
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      52961

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    ncbi.nlm.nih.gov/pmc/articles/PMC11024103/
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Development of an orally bioavailable mSWI/SNF ATPase degrader and acquired mechanisms of resistance in prostate cancer
    1
    1. scibot 23 Apr 2024
      Addgene_52961

      DOI: 10.1073/pnas.2322563121

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  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Nerve growth factor receptor limits inflammation to promote remodeling and repair of osteoarthritic joints
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    1. scibot 23 Apr 2024
      plasmid_52961

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    ncbi.nlm.nih.gov/pmc/articles/PMC11018862/
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Efficient deletion of microRNAs using CRISPR/Cas9 with dual guide RNAs
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    1. scibot 23 Apr 2024
      plasmid_52961

      DOI: 10.3389/fmolb.2023.1295507

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  64. www.sciencedirect.com www.sciencedirect.com
    Sustained ERK signaling promotes G2 cell cycle exit and primes cells for whole-genome duplication
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    1. scibot 20 Apr 2024
      Addgene_52961

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    sciencedirect.com/science/article/pii/S1534580724002004
  65. aacrjournals.org aacrjournals.org
    Adipose triglyceride lipase is a therapeutic target in advanced prostate cancer that promotes metabolic plasticity
    2
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      RRID:Addgene_52961

      DOI: 10.1158/0008-5472.CAN-23-0555

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    aacrjournals.org/cancerres/article/84/5/703/734936/Adipose-Triglyceride-Lipase-Is-a-Therapeutic
  66. www.biorxiv.org www.biorxiv.org
    Pharmacogenomic discovery of genetically targeted cancer therapies optimized against clinical outcomes
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      DOI: 10.1101/2024.01.05.574245

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    biorxiv.org/content/10.1101/2024.01.05.574245v1
  67. aacrjournals.org aacrjournals.org
    Oncogenic KRAS drives lipo-fibrogenesis to promote angiogenesis and colon cancer progression
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    1. scibot 19 Apr 2024
      RRID:Addgene_52961

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    aacrjournals.org/cancerdiscovery/article/13/12/2652/731609/Oncogenic-KRAS-Drives-Lipofibrogenesis-to-Promote
  68. aacrjournals.org aacrjournals.org
    PRMT1 inhibition activates the interferon pathway to potentiate antitumor immunity and enhance checkpoint blockade efficacy in melanoma
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      RRID:Addgene_52961

      DOI: 10.1158/0008-5472.CAN-23-1082

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  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FL118 Is a Potent Therapeutic Agent against Chronic Myeloid Leukemia Resistant to BCR-ABL Inhibitors through Targeting RNA Helicase DDX5
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    1. scibot 18 Apr 2024
      RRID:Addgene_52961

      DOI: 10.3390/ijms25073693

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  70. www.sciencedirect.com www.sciencedirect.com
    Targeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti-tumor secretome
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      RRID:Addgene_52961

      DOI: 10.1016/j.celrep.2024.114111

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  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Nek2A prevents centrosome clustering and induces cell death in cancer cells via KIF2C interaction
    1
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  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Calcium transients trigger switch-like discharge of prostaglandin E2 in an extracellular signal-regulated kinase-dependent manner
    1
    1. scibot 15 Apr 2024
      52961

      DOI: 10.7554/eLife.86727

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  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Exploiting spatiotemporal regulation of FZD5 during neural patterning for efficient ventral midbrain specification
    1
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      52961

      DOI: 10.1242/dev.202545

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  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Centriole structural integrity defects are a crucial feature of Hydrolethalus Syndrome
    1
    1. scibot 15 Apr 2024
      plasmid_52961

      DOI: 10.1101/2024.03.06.583733

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  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mitochondrial outer membrane integrity regulates a ubiquitin-dependent and NF-κB-mediated inflammatory response
    1
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      Addgene_52961

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  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Aberrant non-canonical NF-κB signalling reprograms the epigenome landscape to drive oncogenic transcriptomes in multiple myeloma
    1
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      plasmid_52961

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  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    AURKA emerges as a vulnerable target for KEAP1-deficient non-small cell lung cancer by activation of asparagine synthesis
    1
    1. scibot 15 Apr 2024
      Addgene_52961

      DOI: 10.1038/s41419-024-06577-x

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  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Synergistic toxicity with copper contributes to NAT2-associated isoniazid toxicity
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      Addgene_52961

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  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Induction of Viral Mimicry Upon Loss of DHX9 and ADAR1 in Breast Cancer Cells
    1
    1. scibot 13 Apr 2024
      52961

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  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DePARylation is critical for S phase progression and cell survival
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      52961

      DOI: 10.7554/eLife.89303

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  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    iRhom2 regulates ectodomain shedding and surface expression of the major histocompatibility complex (MHC) class I
    1
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      52961

      DOI: 10.1007/s00018-024-05201-7

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  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cooperative interaction of interferon regulatory factor -1 and bromodomain—containing protein 4 on RNA polymerase activation for intrinsic innate immunity
    1
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      52961

      DOI: 10.3389/fimmu.2024.1366235

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  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Interferon lambda restricts herpes simplex virus skin disease by suppressing neutrophil-mediated pathology
    1
    1. scibot 13 Apr 2024
      lentiCRISPRv2

      DOI: 10.1128/mbio.02623-23

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  84. www.sciencedirect.com www.sciencedirect.com
    EPB41L5 controls podocyte extracellular matrix assembly by adhesome-dependent force transmission
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    1. scibot 10 Apr 2024
      RRID:Addgene_52961

      DOI: 10.1016/j.celrep.2021.108883

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  85. www.sciencedirect.com www.sciencedirect.com
    Genetic interactions reveal distinct biological and therapeutic implications in breast cancer
    1
    1. scibot 09 Apr 2024
      AddgeneCat# 52961

      DOI: 10.1016/j.ccell.2024.03.006

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  86. www.sciencedirect.com www.sciencedirect.com
    Pharmacological induction of chromatin remodeling drives chemosensitization in triple-negative breast cancer
    1
    1. scibot 09 Apr 2024
      RRID:Addgene_52961

      DOI: 10.1016/j.xcrm.2024.101504

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    sciencedirect.com/science/article/pii/S2666379124001733
  87. www.nature.com www.nature.com
    Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy
    1
    1. scibot 05 Apr 2024
      RRID:Addgene_52961

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  88. www.sciencedirect.com www.sciencedirect.com
    Tumor cell-intrinsic epigenetic dysregulation shapes cancer-associated fibroblasts heterogeneity to metabolically support pancreatic cancer
    1
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      RRID:Addgene_52961

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    sciencedirect.com/science/article/pii/S1535610824000904
  89. www.sciencedirect.com www.sciencedirect.com
    Targeting the GPI transamidase subunit GPAA1 abrogates the CD24 immune checkpoint in ovarian cancer
    1
    1. scibot 04 Apr 2024
      RRID:Addgene_52961

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    sciencedirect.com/science/article/pii/S2211124724003693
  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2
    1
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      52961

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    ncbi.nlm.nih.gov/pmc/articles/PMC10965441/
  91. Mar 2024
  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BMP‐ACVR1 Axis is Critical for Efficacy of PRC2 Inhibitors in B‐Cell Lymphoma
    1
    1. scibot 31 Mar 2024
      Addgene_52961

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  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting the receptor tyrosine kinase MerTK shows therapeutic value in gastric adenocarcinoma
    1
    1. scibot 31 Mar 2024
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  94. www.sciencedirect.com www.sciencedirect.com
    Initiation of a ZAKα-dependent ribotoxic stress response by the innate immunity endoribonuclease RNase L
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    1. scibot 29 Mar 2024
      RRID:Addgene_52961

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  95. www.nature.com www.nature.com
    RBBP6 maintains glioblastoma stem cells through CPSF3-dependent alternative polyadenylation
    2
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      RRID:Addgene_52961

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  96. www.sciencedirect.com www.sciencedirect.com
    DISRUPTION OF POLYUNSATURATED FATTY ACID BIOSYNTHESIS DRIVES STING-DEPENDENT ACUTE MYELOID LEUKEMIA CELL MATURATION AND DEATH
    1
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      plasmid_52961

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  97. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting DNA methylation and B7-H3 in RB1-deficient and neuroendocrine prostate cancer
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    1. scibot 23 Mar 2024
      plasmid_52961

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  98. www.sciencedirect.com www.sciencedirect.com
    Clinical drug screening reveals clofazimine potentiates the efficacy while reducing the toxicity of anti-PD-1 and CTLA-4 immunotherapy
    1
    1. scibot 22 Mar 2024
      AddgeneCat#52961

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  99. www.sciencedirect.com www.sciencedirect.com
    FAM86A methylation of eEF2 links mRNA translation elongation to tumorigenesis
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    1. scibot 22 Mar 2024
      Addgene_52961

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  100. www.sciencedirect.com www.sciencedirect.com
    De novo steroidogenesis in tumor cells drives bone metastasis and osteoclastogenesis
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    1. scibot 19 Mar 2024
      Addgene, Cat# 52961

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  101. www.sciencedirect.com www.sciencedirect.com
    A kinetic dichotomy between mitochondrial and nuclear gene expression processes
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    1. scibot 19 Mar 2024
      Addgene_52961

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  102. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ubiquitin ligase subunit FBXO9 inhibits V-ATPase assembly and impedes lung cancer metastasis
    1
    1. scibot 17 Mar 2024
      LentiCRISPR v2

      DOI: 10.1186/s40164-024-00497-4

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    ncbi.nlm.nih.gov/pmc/articles/PMC10938814/
  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Blocking TGF-β- and Epithelial-to-Mesenchymal Transition (EMT)-mediated activation of vessel-associated mural cells in glioblastoma impacts tumor angiogenesis
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    1. scibot 17 Mar 2024
      52961

      DOI: 10.17879/freeneuropathology-2024-5188

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    ncbi.nlm.nih.gov/pmc/articles/PMC10919159/
  104. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Microtubule disruption synergizes with STING signaling to show potent and broad-spectrum antiviral activity
    1
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      plentiCRISPR v2

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    ncbi.nlm.nih.gov/pmc/articles/PMC10919859/
  105. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Organelle resolved proteomics uncovers PLA2R1 as a novel cell surface marker required for chordoma growth
    1
    1. scibot 17 Mar 2024
      lentiCRISPRv2

      DOI: 10.1186/s40478-024-01751-w

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    ncbi.nlm.nih.gov/pmc/articles/PMC10921702/
  106. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A SWI/SNF-dependent transcriptional regulation mediated by POU2AF2/C11orf53 at enhancer
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      52961

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    ncbi.nlm.nih.gov/pmc/articles/PMC10920751/
  107. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PRMT5 is an actionable therapeutic target in CDK4/6 inhibitor-resistant ER+/RB-deficient breast cancer
    1
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      52961

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    ncbi.nlm.nih.gov/pmc/articles/PMC10937713/
  108. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An efficient and cost-effective method for disrupting genes in RAW264.7 macrophages using CRISPR-Cas9
    1
    1. scibot 17 Mar 2024
      plasmid_52961

      DOI: 10.1371/journal.pone.0299513

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    ncbi.nlm.nih.gov/pmc/articles/PMC10939251/
  109. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR/Cas9 model of prostate cancer identifies Kmt2c deficiency as a metastatic driver by Odam/Cabs1 gene cluster expression
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    1. scibot 17 Mar 2024
      plasmid_52961

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    ncbi.nlm.nih.gov/pmc/articles/PMC10920892/
  110. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of BRD4 Attenuates ER Stress-induced Renal Ischemic-Reperfusion Injury
    1
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      52961

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    ncbi.nlm.nih.gov/pmc/articles/PMC10929187/
  111. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Induction of Multiple Alternative Mitogenic Signaling Pathways Accompanies the Emergence of Drug-Tolerant Cancer Cells
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      52961

      DOI: 10.3390/cancers16051001

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    ncbi.nlm.nih.gov/pmc/articles/PMC10930612/
  112. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    USP22 regulates APL differentiation via PML-RARα stabilization and IFN repression
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      plasmid_52961

      DOI: 10.1038/s41420-024-01894-8

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    ncbi.nlm.nih.gov/pmc/articles/PMC10928094/
  113. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sirt6 ablation in the liver causes fatty liver that increases cancer risky by upregulating Serpina12
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      lentiCRISPR v2

      DOI: 10.1038/s44319-024-00071-3

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    ncbi.nlm.nih.gov/pmc/articles/PMC10933290/
  114. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NSP6 inhibits the production of ACE2-containing exosomes to promote SARS-CoV-2 infectivity
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      plasmid_52961

      DOI: 10.1128/mbio.03358-23

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    ncbi.nlm.nih.gov/pmc/articles/PMC10936183/
  115. www.sciencedirect.com www.sciencedirect.com
    Housekeeping U1 snRNA facilitates antiviral innate immunity by promoting TRIM25-mediated RIG-I activation
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      Addgene_52961

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    sciencedirect.com/science/article/pii/S2211124724002730
  116. www.sciencedirect.com www.sciencedirect.com
    Multimodal stimulation screens reveal unique and shared genes limiting T cell fitness
    3
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      RRID:Addgene_52961

      DOI: 10.1016/j.ccell.2024.02.016

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      RRID:Addgene_52961

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    sciencedirect.com/science/article/pii/S1535610824000606
  117. www.nature.com www.nature.com
    Inhibition of 7-dehydrocholesterol reductase prevents hepatic ferroptosis under an active state of sterol synthesis
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    1. scibot 14 Mar 2024
      RRID:Addgene_52961

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    nature.com/articles/s41467-024-46386-6
  118. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IFI35 limits antitumor immunity in triple-negative breast cancer via CCL2 secretion
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      52961

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    ncbi.nlm.nih.gov/pmc/articles/PMC10907302/
  119. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology
    1
    1. scibot 08 Mar 2024
      lentiCRISPRv2

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    ncbi.nlm.nih.gov/pmc/articles/PMC10907300/
  120. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of mitochondrial folate metabolism drives differentiation through mTORC1 mediated purine sensing
    1
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      52961

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    ncbi.nlm.nih.gov/pmc/articles/PMC10908830/
  121. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Weakened APC/C activity at mitotic exit drives cancer vulnerability to KIF18A inhibition
    1
    1. scibot 08 Mar 2024
      52961

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  122. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Variant to gene mapping for carpal tunnel syndrome risk loci implicates skeletal muscle regulatory elements
    1
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      52961

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    ncbi.nlm.nih.gov/pmc/articles/PMC10909706/
  123. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Porcine circovirus type 2 infection promotes the SUMOylation of nucleophosmin-1 to facilitate the viral circular single-stranded DNA replication
    1
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      Addgene_52961

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    ncbi.nlm.nih.gov/pmc/articles/PMC10917307/
  124. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Trans-lesion synthesis and mismatch repair pathway crosstalk defines chemoresistance and hypermutation mechanisms in glioblastoma
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      plasmid_52961

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  125. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Apurinic/apyrimidinic endodeoxyribonuclease 1 (APE1) promotes stress granule formation via YBX1 phosphorylation in ovarian cancer
    1
    1. scibot 07 Mar 2024
      lentiCRISPR v2

      DOI: 10.1007/s00018-023-05086-y

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  126. www.sciencedirect.com www.sciencedirect.com
    Generation and characterization of three CRISPR/Cas9 edited RB1 null hiPSC lines for retinoblastoma disease modelling
    1
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      Plasmid_52961

      DOI: 10.1016/j.scr.2024.103373

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  127. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Translational response to mitochondrial stresses is orchestrated by tRNA modifications
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      52961

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  128. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A conserved ion channel function of STING mediates noncanonical autophagy and cell death
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  129. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A methylation-phosphorylation switch controls EZH2 stability and hematopoiesis
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  130. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An immunosuppressive vascular niche drives macrophage polarization and immunotherapy resistance in glioblastoma
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  131. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    N-MYC regulates cell survival via eIF4G1 in inv(16) acute myeloid leukemia
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  132. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integration of transcription regulation and functional genomic data reveals lncRNA SNHG6’s role in hematopoietic differentiation and leukemia
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      plasmid_52961

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  133. www.sciencedirect.com www.sciencedirect.com
    PEDV nucleocapsid antagonizes Zinc-finger Antiviral Protein by disrupting the interaction with its obligate co-factor, TRIM25.
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  134. Feb 2024
  135. www.sciencedirect.com www.sciencedirect.com
    DUB3 is a MAGEA3 deubiquitinase and a potential therapeutic target in hepatocellular carcinoma
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      AddgeneCat#52961

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  136. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    αKG-mediated carnitine synthesis promotes homologous recombination via histone acetylation
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  137. www.sciencedirect.com www.sciencedirect.com
    CRISPR editing to mimic porphyria combined with light: a new preclinical approach for prostate cancer
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      RRID:Addgene_52961

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  138. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Plasticity-induced repression of Irf6 underlies acquired resistance to cancer immunotherapy in pancreatic ductal adenocarcinoma
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      plasmid_52961

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  139. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Intracellular trafficking of HIV-1 Gag via Syntaxin 6-positive compartments/vesicles: Involvement in tumor necrosis factor secretion
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      Lenti-CRISPRv2

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  140. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human Betacoronavirus OC43 Interferes with the Integrated Stress Response Pathway in Infected Cells
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      plasmid_52961

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  141. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    KDM3B inhibitors disrupt the oncogenic activity of PAX3-FOXO1 in fusion-positive rhabdomyosarcoma
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  142. 52.53.155.43 52.53.155.43
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  143. 52.53.155.43 52.53.155.43
    419-html.html
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  144. www.sciencedirect.com www.sciencedirect.com
    In vivo CRISPR knockout screen identifies p47 as a suppressor of HER2+ breast cancer metastasis by regulating NEMO trafficking and autophagy flux
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      Addgene Cat # 52961

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  145. www.biorxiv.org www.biorxiv.org
    New submission 27/09/2023, 09:17:54
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  146. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Personalized allele-specific CRISPR-Cas9 strategies for myofibrillar myopathy 6
    1
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      52961

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  147. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Asialoglycoprotein receptor 1 promotes SARS-CoV-2 infection of human normal hepatocytes
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      52961

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  148. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hexokinase 1 and 2 mediates glucose utilization to regulate the synthesis of kappa casein via ribosome protein subunit 6 kinase 1 in bovine mammary epithelial cells
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      52961

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  149. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hijacking of nucleotide biosynthesis and deamidation-mediated glycolysis by an oncogenic herpesvirus
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    1. scibot 21 Feb 2024
      pLentiCRISPR v2

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  150. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SEL1L-HRD1 interaction is required to form a functional HRD1 ERAD complex
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  151. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HuR promotes castration-resistant prostate cancer progression by altering ERK5 activation via posttranscriptional regulation of BCAT1
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      lentiCRISPRV2

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  152. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A landscape of gene expression regulation for synovium in arthritis
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      Addgene_52961

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  153. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Landscape of prostate-specific membrane antigen heterogeneity and regulation in AR-positive and AR-negative metastatic prostate cancer
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      RRID:Addgene_52961

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  154. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tumor-derived Small Extracellular Vesicles Inhibit the Efficacy of CAR T Cells against Solid Tumors
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      RRID:Addgene_52961

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  155. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Aggregability of the SQSTM1/p62-based aggresome-like induced structures determines the sensitivity to parthanatos
    1
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      lenti-CRISPRv2

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  156. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hyaluronic acid turnover controls the severity of cerebral cavernous malformations in bioengineered human micro-vessels
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  157. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SOX2 Expression Does Not Guarantee Cancer Stem Cell-like Characteristics in Lung Adenocarcinoma
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      plasmid_52961

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  158. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genomic and epigenomic basis of breast invasive lobular carcinomas lacking CDH1 genetic alterations
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      Addgene_52961

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  159. www.biorxiv.org www.biorxiv.org
    DOT1L stimulates MYC/Mondo transcription factor activity by promoting its degradation cycle on chromatin
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      Addgene_52961

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    biorxiv.org/content/10.1101/2024.02.06.579191v1
  160. www.biorxiv.org www.biorxiv.org
    Circadian period is compensated for repressor protein turnover rates in single cells
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  161. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Exploiting epigenetic targets to overcome taxane resistance in prostate cancer
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  162. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tubeimosides are pan-coronavirus and filovirus inhibitors that can block their fusion protein binding to Niemann-Pick C1
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  163. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cell cycle arrest induces lipid droplet formation and confers ferroptosis resistance
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      lentiCRISPR v2

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  164. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pharmaceutical targeting of OTUB2 sensitizes tumors to cytotoxic T cells via degradation of PD-L1
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      lentiCRISPR v2

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  165. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Constitutive Plasma Membrane Turnover in T-REx293 cells via Ordered Membrane Domain Endocytosis under Mitochondrial Control
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  166. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    EBV abortive lytic cycle promotes nasopharyngeal carcinoma progression through recruiting monocytes and regulating their directed differentiation
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  167. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A small-molecule degrader selectively inhibits the growth of ALK-rearranged lung cancer with ceritinib resistance
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    1. scibot 10 Feb 2024
      Addgene_52961

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  168. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Host ZCCHC3 blocks HIV-1 infection and production through a dual mechanism
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    1. scibot 09 Feb 2024
      plasmid_52961

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  169. www.biorxiv.org www.biorxiv.org
    RPL22 is a tumor suppressor in MSI-high cancers and a key splicing regulator of MDM4
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      RRID:Addgene_52961

      DOI: 10.1101/2023.12.10.570873

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    2. scibot 09 Feb 2024
      RRID:Addgene_52961

      DOI: 10.1101/2023.12.10.570873

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    biorxiv.org/content/10.1101/2023.12.10.570873v1
  170. www.biorxiv.org www.biorxiv.org
    HDAC10 blockade upregulates SPARC expression thereby repressing melanoma cell growth and BRAF inhibitor resistance
    3
    1. scibot 09 Feb 2024
      RRID:Addgene_52961

      DOI: 10.1101/2023.12.05.570182

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    2. scibot 09 Feb 2024
      RRID:Addgene_52961

      DOI: 10.1101/2023.12.05.570182

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    3. scibot 09 Feb 2024
      RRID:Addgene_52961

      DOI: 10.1101/2023.12.05.570182

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    biorxiv.org/content/10.1101/2023.12.05.570182v1
  171. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cyclical palmitoylation regulates TLR9 signalling and systemic autoimmunity in mice
    1
    1. scibot 08 Feb 2024
      52961

      DOI: 10.1038/s41467-023-43650-z

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    ncbi.nlm.nih.gov/pmc/articles/PMC10762000/
  172. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The low-density lipoprotein receptor promotes infection of multiple encephalitic alphaviruses
    1
    1. scibot 08 Feb 2024
      52961

      DOI: 10.1038/s41467-023-44624-x

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    ncbi.nlm.nih.gov/pmc/articles/PMC10764363/
  173. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence
    1
    1. scibot 08 Feb 2024
      52961

      DOI: 10.1038/s41467-023-44502-6

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    ncbi.nlm.nih.gov/pmc/articles/PMC10764958/
  174. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Nuclear membrane protein SUN2 promotes replication of flaviviruses through modulating cytoskeleton reorganization mediated by NS1
    1
    1. scibot 08 Feb 2024
      52961

      DOI: 10.1038/s41467-023-44580-6

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    ncbi.nlm.nih.gov/pmc/articles/PMC10766649/
  175. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of iRhom1 by CD44-targeting nanocarrier for improved cancer immunochemotherapy
    1
    1. scibot 08 Feb 2024
      52961

      DOI: 10.1038/s41467-023-44572-6

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    ncbi.nlm.nih.gov/pmc/articles/PMC10766965/
  176. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    R-spondin-1 induces Axin degradation via the LRP6-CK1ε axis
    1
    1. scibot 08 Feb 2024
      LentiCRISPRv2

      DOI: 10.1186/s12964-023-01456-y

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    ncbi.nlm.nih.gov/pmc/articles/PMC10768284/
  177. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transforming Growth Factor-β/Smad Signaling Inhibits Melanoma Cancer Stem Cell Self-Renewal, Tumor Formation and Metastasis
    1
    1. scibot 08 Feb 2024
      52961

      DOI: 10.3390/cancers16010224

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    ncbi.nlm.nih.gov/pmc/articles/PMC10778361/
  178. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Screens in aging-relevant human ALS-motor neurons identify MAP4Ks as therapeutic targets for the disease
    1
    1. scibot 08 Feb 2024
      Addgene_52961

      DOI: 10.1038/s41419-023-06395-7

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    ncbi.nlm.nih.gov/pmc/articles/PMC10766628/
  179. www.sciencedirect.com www.sciencedirect.com
    p53 promotes antiviral innate immunity by driving hexosamine metabolism
    1
    1. scibot 07 Feb 2024
      Addgene_52961

      DOI: 10.1016/j.celrep.2024.113724

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    sciencedirect.com/science/article/pii/S2211124724000524
  180. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The heterogeneity of signaling pathways and drug responses in intrahepatic cholangiocarcinoma with distinct genetic mutations
    1
    1. scibot 06 Feb 2024
      52961

      DOI: 10.1038/s41419-023-06406-7

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    ncbi.nlm.nih.gov/pmc/articles/PMC10784283/
  181. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hypomorphic variants of SEL1L-HRD1 ER-associated degradation are associated with neurodevelopmental disorders
    1
    1. scibot 05 Feb 2024
      52961

      DOI: 10.1172/JCI170054

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    ncbi.nlm.nih.gov/pmc/articles/PMC10786691/
  182. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Biallelic Cys141Tyr variant of SEL1L is associated with neurodevelopmental disorders, agammaglobulinemia, and premature death
    1
    1. scibot 05 Feb 2024
      52961

      DOI: 10.1172/JCI170882

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    ncbi.nlm.nih.gov/pmc/articles/PMC10786703/
  183. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mitochondrial stress activates YAP/TAZ through RhoA oxidation to promote liver injury
    1
    1. scibot 05 Feb 2024
      52961

      DOI: 10.1038/s41419-024-06448-5

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    ncbi.nlm.nih.gov/pmc/articles/PMC10789791/
  184. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SEL1L-HRD1 ER-associated degradation regulates leptin receptor maturation and signaling in POMC neurons in diet-induced obesity
    1
    1. scibot 05 Feb 2024
      52961

      DOI: 10.21203/rs.3.rs-3768472/v1

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    ncbi.nlm.nih.gov/pmc/articles/PMC10802724/
  185. www.biorxiv.org www.biorxiv.org
    Loss of ZNRF3/RNF43 Unleashes EGFR in Cancer
    1
    1. scibot 05 Feb 2024
      52961

      DOI: 10.1101/2024.01.10.574969

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    biorxiv.org/content/10.1101/2024.01.10.574969v1
  186. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NatD epigenetically activates FOXA2 expression to promote breast cancer progression by facilitating MMP14 expression
    1
    1. scibot 05 Feb 2024
      52961

      DOI: 10.1016/j.isci.2024.108840

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    ncbi.nlm.nih.gov/pmc/articles/PMC10830889/
  187. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Micronucleus is not a potent inducer of the cGAS/STING pathway
    1
    1. scibot 05 Feb 2024
      52961

      DOI: 10.26508/lsa.202302424

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    ncbi.nlm.nih.gov/pmc/articles/PMC10837050/
  188. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Alternative splicing of latrophilin-3 controls synapse formation
    1
    1. scibot 04 Feb 2024
      52961

      DOI: 10.1038/s41586-023-06913-9

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    ncbi.nlm.nih.gov/pmc/articles/PMC10830413/
  189. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Bone resorption by osteoclasts involves fine tuning of RHOA activity by its microtubule-associated exchange factor GEF-H1
    1
    1. scibot 04 Feb 2024
      RRID:Addgene_52961

      DOI: 10.3389/fphys.2024.1342024

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    ncbi.nlm.nih.gov/pmc/articles/PMC10834693/
  190. www.nature.com www.nature.com
    Activation of recombinases at specific DNA loci by zinc-finger domain insertions
    1
    1. scibot 02 Feb 2024
      RRID:Addgene_52961

      DOI: 10.1038/s41587-023-02121-y

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    nature.com/articles/s41587-023-02121-y