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A smart gene circuit for precise regulation of tumor cell behavior

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1. scibot 23 Sep 2025
  
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  plasmid_61422
  
  DOI: 10.1016/j.synbio.2025.09.016
  
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sciencedirect.com/science/article/pii/S2405805X25001577
Jul 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

CDK2 inhibition sensitizes anthracycline-induced immunogenic cell death and enhances the efficacy of anti-PD-1 therapy

1
1. scibot 20 Jul 2025
  
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  61422
  
  DOI: 10.3389/fimmu.2025.1570040
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12185487/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

A long noncoding RNA with enhancer-like function in pig zygotic genome activation

1
1. scibot 20 Jul 2025
  
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  61422
  
  DOI: 10.1093/jmcb/mjae061
  
  Resource: RRID:Addgene_61422
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12210014/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Novel drug-inducible CRISPRa/i systems for rapid and reversible manipulation of gene transcription

1
1. scibot 20 Jul 2025
  
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  plasmid_61422
  
  DOI: 10.1007/s00018-025-05786-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12185803/
Jun 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Inhibition of tumor-intrinsic NAT10 enhances antitumor immunity by triggering type I interferon response via MYC/CDK2/DNMT1 pathway

1
1. scibot 15 Jun 2025
  
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  61422
  
  DOI: 10.1038/s41467-025-60293-4
  
  Resource: RRID:Addgene_61422
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12134272/
Apr 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Human Satellite 3 DNA encodes megabase-scale transcription factor binding platforms

1
1. scibot 18 Apr 2025
  
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  plasmid_61422
  
  DOI: 10.1101/2024.10.22.616524
  
  Resource: RRID:Addgene_61422
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11526998/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Genetic analysis of cis-enhancers associated with bone mineral density and periodontitis in the gene SOST

1
1. scibot 07 Apr 2025
  
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  plasmid_61422
  
  DOI: 10.1371/journal.pone.0319259
  
  Resource: RRID:Addgene_61422
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11932464/
Feb 2025
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Identification of molecular determinants of gene-specific bursting patterns by high-throughput imaging screens

1
1. scibot 20 Feb 2025
  
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  Addgene61422
  
  DOI: 10.1016/j.molcel.2025.01.022
  
  Resource: RRID:Addgene_61422
  
  Curator: @areedewitt04
  
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sciencedirect.com/science/article/pii/S1097276525000565
Jan 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Optimizing approaches for targeted integration of transgenic cassettes by integrase-mediated cassette exchange in mouse and human stem cells

1
1. scibot 23 Jan 2025
  
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  Addgene_61422
  
  DOI: 10.1093/stmcls/sxae092
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11740728/
Dec 2024
elifesciences.org elifesciences.org

Telomere length sensitive regulation of interleukin receptor 1 type 1 (IL1R1) by the shelterin protein TRF2 modulates immune signalling in the tumour microenvironment

1
1. scibot 29 Dec 2024
  
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  61422
  
  DOI: 10.7554/eLife.95106
  
  Resource: RRID:Addgene_61422
  
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elifesciences.org/articles/95106
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

LINC01270 Regulates the NF-κB-Mediated Pro-Inflammatory Response via the miR-326/LDOC1 Axis in THP-1 Cells

1
1. scibot 28 Dec 2024
  
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  dCas9-VPR64
  
  DOI: 10.3390/cells13232027
  
  Resource: RRID:Addgene_61422
  
  Curator: @olekpark
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11640305/
Sep 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

BOD1L mediates chromatin binding and non-canonical function of H3K4 methyltransferase SETD1A

2
1. scibot 28 Sep 2024
  
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  61422
  
  DOI: 10.1093/nar/gkae605
  
  Resource: RRID:Addgene_61422
  
  Curator: @olekpark
  
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2. scibot 28 Sep 2024
  
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  Addgene_61422
  
  DOI: 10.1093/nar/gkae605
  
  Resource: RRID:Addgene_61422
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11381347/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A Ctnnb1 enhancer transcriptionally regulates Wnt signaling dosage to balance homeostasis and tumorigenesis of intestinal epithelia

1
1. scibot 27 Sep 2024
  
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  Addgene_61422
  
  DOI: 10.7554/eLife.98238
  
  Resource: RRID:Addgene_61422
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11424096/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Alternative splicing of CARM1 regulated by LincGET-guided paraspeckles biases the first cell fate in mammalian early embryos

1
1. scibot 25 Sep 2024
  
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  61422
  
  DOI: 10.1038/s41594-024-01292-9
  
  Resource: RRID:Addgene_61422
  
  Curator: @olekpark
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11402786/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Multiplex, single-cell CRISPRa screening for cell type specific regulatory elements

1
1. scibot 25 Sep 2024
  
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  Plasmid_61422
  
  DOI: 10.1038/s41467-024-52490-4
  
  Resource: RRID:Addgene_61422
  
  Curator: @scibot
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11411074/
Jun 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Identification of molecular determinants of gene-specific bursting patterns by high-throughput imaging screens

1
1. scibot 30 Jun 2024
  
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  61422
  
  DOI: 10.1101/2024.06.08.597999
  
  Resource: RRID:Addgene_61422
  
  Curator: @olekpark
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11188098/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

An Integrative Transcriptome Subtraction Strategy to Identify Human lncRNAs That Specifically Play a Role in Activation of Human Hepatic Stellate Cells

1
1. scibot 30 Jun 2024
  
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  61422
  
  DOI: 10.3390/ncrna10030034
  
  Resource: RRID:Addgene_61422
  
  Curator: @olekpark
  
  SciCrunch record: RRID:Addgene_61422
  
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  RRID:Addgene_61422
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ncbi.nlm.nih.gov/pmc/articles/PMC11206700/
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A novel lentiviral vector-based approach to generate chimeric antigen receptor T cells targeting Aspergillus fumigatus

1
1. scibot 13 Apr 2024
  
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  dCAS9-VP64-GFP
  
  DOI: 10.1128/mbio.03413-23
  
  Resource: RRID:Addgene_61422
  
  Curator: @olekpark
  
  SciCrunch record: RRID:Addgene_61422
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11005356/
Mar 2024
www.sciencedirect.com www.sciencedirect.com

The sirtuin-associated human senescence program converges on the activation of placenta-specific gene PAPPA

2
1. scibot 14 Mar 2024
  
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  plasmid_61422
  
  DOI: 10.1016/j.devcel.2024.02.008
  
  Resource: RRID:Addgene_61422
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_61422
  
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  RRID:Addgene_61422
2. scibot 14 Mar 2024
  
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  plasmid_61422
  
  DOI: 10.1016/j.devcel.2024.02.008
  
  Resource: RRID:Addgene_61422
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S1534580724001072
Oct 2023
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Three-dimensional genome architecture coordinates key regulators of lineage specification in mammary epithelial cells

1
1. scibot 27 Oct 2023
  
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  RRID:Addgene_61422
  
  DOI: 10.1016/j.xgen.2023.100424
  
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sciencedirect.com/science/article/pii/S2666979X23002501
Jun 2023
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SINE RNA of the imprinted miRNA clusters mediates constitutive type III interferon expression and antiviral protection in hemochorial placentas

1
1. scibot 23 Jun 2023
  
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  RRID:Addgene_61422
  
  DOI: 10.1016/j.chom.2023.05.018
  
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sciencedirect.com/science/article/pii/S1931312823002111
Apr 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A lncRNA identifies Irf8 enhancer element in negative feedback control of dendritic cell differentiation

1
1. scibot 04 Apr 2023
  
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  Addgene_61422
  
  DOI: 10.7554/eLife.83342
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10042546/
May 2022
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XIST loss impairs mammary stem cell differentiation and increases tumorigenicity through Mediator hyperactivation

1
1. scibot 25 May 2022
  
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  Plasmid_61422
  
  DOI: 10.1016/j.cell.2022.04.034
  
  Resource: RRID:Addgene_61422
  
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sciencedirect.com/science/article/pii/S0092867422005323
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Gene body methylation of the lymphocyte-specific gene CARD11 results in its overexpression and regulates cancer mTOR signaling

1
1. scibot 05 May 2022
  
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  RRID:Addgene_61422
  
  DOI: 10.1158/1541-7786.MCR-20-0753
  
  Resource: RRID:Addgene_61422
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8568653/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Selective requirement of MYB for oncogenic hyperactivation of a translocated enhancer in leukemia

1
1. scibot 03 May 2022
  
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  RRID:Addgene_61422
  
  DOI: 10.1158/2159-8290.CD-20-1793
  
  Resource: RRID:Addgene_61422
  
  Curator: @scibot
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8563373/
Apr 2022
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The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes

1
1. scibot 22 Apr 2022
  
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  Addgene61422
  
  DOI: 10.1016/j.stem.2022.03.015
  
  Resource: RRID:Addgene_61422
  
  Curator: @sophiastull
  
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sciencedirect.com/science/article/pii/S1934590922001503
Feb 2022
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Histone marks regulate the epithelial-to-mesenchymal transition via alternative splicing

1
1. scibot 16 Feb 2022
  
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  Addgene61422
  
  DOI: 10.1016/j.celrep.2022.110357
  
  Resource: RRID:Addgene_61422
  
  Curator: @sophiastull
  
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sciencedirect.com/science/article/pii/S2211124722000766
Oct 2021
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Generation and validation of CRISPR-engineered human natural killer cell lines for research and therapeutic applications

1
1. scibot 22 Oct 2021
  
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  RRID:Addgene_61422
  
  DOI: 10.1016/j.xpro.2021.100874
  
  Resource: RRID:Addgene_61422
  
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sciencedirect.com/science/article/pii/S2666166721005803
Sep 2020
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

Enhancer RNAs predict enhancer–gene regulatory links and are critical for enhancer function in neuronal systems

1
1. scibot 26 Sep 2020
  
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  plasmid_61422
  
  DOI: 10.1093/nar/gkaa671
  
  Resource: Addgene_61422
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_61422
  
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  RRIDCUR:Validated RRID:Addgene_61422
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pubmed.ncbi.nlm.nih.gov/32810208/