63 Matching Annotations
  1. Apr 2025
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Identification of a SNAI1 enhancer RNA that drives cancer cell plasticity
    1
    1. scibot 07 Apr 2025
      61425

      DOI: 10.1038/s41467-025-58032-w

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    pmc.ncbi.nlm.nih.gov/articles/PMC11937597/
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Modified screening of MYC promotor region elements using the CRISPR library in ovarian cancer
    1
    1. scibot 05 Apr 2025
      61,425

      DOI: 10.1186/s13048-025-01644-z

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    pmc.ncbi.nlm.nih.gov/articles/PMC11963443/
  4. Mar 2025
  5. www.sciencedirect.com www.sciencedirect.com
    Amplified dosage of the NKX2-1 lineage transcription factor controls its oncogenic role in lung adenocarcinoma
    1
    1. scibot 29 Mar 2025
      RRID:Addgene_61425

      DOI: 10.1016/j.molcel.2025.03.001

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    sciencedirect.com/science/article/pii/S1097276525001947
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Circulating tumor cell plasticity determines breast cancer therapy resistance via neuregulin 1–HER3 signaling
    1
    1. scibot 11 Mar 2025
      61425

      DOI: 10.1038/s43018-024-00882-2

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    pmc.ncbi.nlm.nih.gov/articles/PMC11779641/
  7. Feb 2025
  8. www.sciencedirect.com www.sciencedirect.com
    Development of cell lines with increased susceptibility to diverse adeno-associated viral vectors to enable in vitro potency assays
    1
    1. scibot 11 Feb 2025
      RRID:Addgene_61425

      DOI: 10.1016/j.omtm.2025.101416

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    sciencedirect.com/science/article/pii/S2329050125000117
  9. Dec 2024
  10. genomebiology.biomedcentral.com genomebiology.biomedcentral.com
    Functional screening reveals genetic dependencies and diverging cell cycle control in atypical teratoid rhabdoid tumors
    1
    1. scibot 05 Dec 2024
      Addgene #61425

      DOI: 10.1186/s13059-024-03438-w

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    genomebiology.biomedcentral.com/articles/10.1186/s13059-024-03438-w
  11. Sep 2024
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The proteogenomic landscape of multiple myeloma reveals insights into disease biology and therapeutic opportunities
    1
    1. scibot 29 Sep 2024
      61425

      DOI: 10.1038/s43018-024-00784-3

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    ncbi.nlm.nih.gov/pmc/articles/PMC11358022/
  13. www.biorxiv.org www.biorxiv.org
    Cytotoxicity of Activator Expression in CRISPR-based Transcriptional Activation Systems
    1
    1. scibot 27 Sep 2024
      RRID:Addgene_61425

      DOI: 10.1101/2024.09.23.614524

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    biorxiv.org/content/10.1101/2024.09.23.614524v1
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Evolved cytidine and adenine base editors with high precision and minimized off-target activity by a continuous directed evolution system in mammalian cells
    1
    1. scibot 25 Sep 2024
      61425

      DOI: 10.1038/s41467-024-52483-3

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    ncbi.nlm.nih.gov/pmc/articles/PMC11408606/
  15. Aug 2024
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lecithin-cholesterol acyltransferase is a potential tumor suppressor and predictive marker for hepatocellular carcinoma metastasis
    1
    1. scibot 26 Aug 2024
      61425

      DOI: 10.4251/wjgo.v16.i8.3651

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    ncbi.nlm.nih.gov/pmc/articles/PMC11334038/
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Crosstalk of MAP3K1 and EGFR signaling mediates gene-environment interactions that block developmental tissue closure
    1
    1. scibot 18 Aug 2024
      61425

      DOI: 10.1016/j.jbc.2024.107486

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    ncbi.nlm.nih.gov/pmc/articles/PMC11294703/
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Convergence of coronary artery disease genes onto endothelial cell programs
    1
    1. scibot 18 Aug 2024
      61425

      DOI: 10.1038/s41586-024-07022-x

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    ncbi.nlm.nih.gov/pmc/articles/PMC10921916/
  19. www.cell.com www.cell.com
    Epigenomic signatures of sarcomatoid differentiation to guide the treatment of renal cell carcinoma
    1
    1. scibot 13 Aug 2024
      Addgene: 61425

      DOI: 10.1016/j.celrep.2024.114350

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    cell.com/cell-reports/fulltext/S2211-1247(24)00678-8
  20. Jun 2024
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR/Cas9 screening reveals a distinct class of MHC-I binders with precise HLA-peptide recognition
    1
    1. scibot 30 Jun 2024
      Addgene_61425

      DOI: 10.1016/j.isci.2024.110120

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    ncbi.nlm.nih.gov/pmc/articles/PMC11209011/
  22. May 2024
  23. www.biorxiv.org www.biorxiv.org
    Conversion of natural cytokine receptors into orthogonal synthetic biosensors
    1
    1. scibot 25 May 2024
      plasmid_61425

      DOI: 10.1101/2024.03.23.586421

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    biorxiv.org/content/10.1101/2024.03.23.586421v1
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR-Cas13d screens identify KILR, a breast cancer risk-associated lncRNA that regulates DNA replication and repair
    1
    1. scibot 19 May 2024
      Addgene_61

      DOI: 10.1186/s12943-024-02021-y

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    ncbi.nlm.nih.gov/pmc/articles/PMC11094906/
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mapping of DDX11 genetic interactions defines sister chromatid cohesion as the major dependency
    1
    1. scibot 12 May 2024
      Addgene_61425

      DOI: 10.1093/g3journal/jkae052

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    ncbi.nlm.nih.gov/pmc/articles/PMC11075568/
  26. Apr 2024
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide CRISPR screens identify the YAP/TEAD axis as a driver of persister cells in EGFR mutant lung cancer
    1
    1. scibot 30 Apr 2024
      61425

      DOI: 10.1038/s42003-024-06190-w

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    ncbi.nlm.nih.gov/pmc/articles/PMC11043391/
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Loss of NEDD8 in cancer cells causes vulnerability to immune checkpoint blockade in triple-negative breast cancer
    1
    1. scibot 30 Apr 2024
      Addgene_61425

      DOI: 10.1038/s41467-024-47987-x

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    ncbi.nlm.nih.gov/pmc/articles/PMC11055868/
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Long noncoding RNA Malat1 protects against osteoporosis and bone metastasis
    1
    1. scibot 15 Apr 2024
      61425

      DOI: 10.1038/s41467-024-46602-3

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    ncbi.nlm.nih.gov/pmc/articles/PMC10944492/
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MAP3K1 regulates female reproductive tract development
    1
    1. scibot 14 Apr 2024
      #61425

      DOI: 10.1242/dmm.050669

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    ncbi.nlm.nih.gov/pmc/articles/PMC10985838/
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide CRISPR activation screen identifies JADE3 as an antiviral activator of NF-kB–dependent IFITM3 expression
    1
    1. scibot 13 Apr 2024
      Addgene_61425

      DOI: 10.1016/j.jbc.2024.107153

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    ncbi.nlm.nih.gov/pmc/articles/PMC11001640/
  32. www.sciencedirect.com www.sciencedirect.com
    Tumor cell-intrinsic epigenetic dysregulation shapes cancer-associated fibroblasts heterogeneity to metabolically support pancreatic cancer
    1
    1. scibot 05 Apr 2024
      RRID:Addgene_61425

      DOI: 10.1016/j.ccell.2024.03.005

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    sciencedirect.com/science/article/pii/S1535610824000904
  33. Mar 2024
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functionally-instructed modifiers of response to ATR inhibition in experimental glioma
    1
    1. scibot 15 Mar 2024
      RRID:Addgene_61425

      DOI: 10.1186/s13046-024-02995-z

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    ncbi.nlm.nih.gov/pmc/articles/PMC10935927/
  35. www.nature.com www.nature.com
    CDK9-55 guides the anaphase-promoting complex/cyclosome (APC/C) in choosing the DNA repair pathway choice
    1
    1. scibot 14 Mar 2024
      RRID:Addgene_61425

      DOI: 10.1038/s41388-024-02982-w

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    nature.com/articles/s41388-024-02982-w
  36. Feb 2024
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sequential CRISPR screening reveals partial NatB inhibition as a strategy to mitigate alpha-synuclein levels in human neurons
    1
    1. scibot 15 Feb 2024
      plasmid_61425

      DOI: 10.1126/sciadv.adj4767

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    ncbi.nlm.nih.gov/pmc/articles/PMC10857481/
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide quantification of copy-number aberration impact on gene expression in ovarian high-grade serous carcinoma
    1
    1. scibot 08 Feb 2024
      plasmid_61

      DOI: 10.1186/s12885-024-11895-6

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      RRID:Addgene_61425 RRIDCUR:Incorrect RRIDCUR:Unresolved
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    ncbi.nlm.nih.gov/pmc/articles/PMC10840274/
  39. Jan 2024
  40. www.nature.com www.nature.com
    Redox signalling regulates breast cancer metastasis via phenotypic and metabolic reprogramming due to p63 activation by HIF1α
    1
    1. scibot 23 Jan 2024
      plasmid_61425

      DOI: 10.1038/s41416-023-02522-5

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    nature.com/articles/s41416-023-02522-5
  41. Dec 2023
  42. www.sciencedirect.com www.sciencedirect.com
    The MHC-E peptide ligands for checkpoint CD94/NKG2A are governed by inflammatory signals, whereas LILRB1/2 receptors are peptide indifferent
    1
    1. scibot 20 Dec 2023
      Addgene Cat: 61425

      DOI: 10.1016/j.celrep.2023.113516

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    sciencedirect.com/science/article/pii/S2211124723015280
  43. www.sciencedirect.com www.sciencedirect.com
    Single-cell functional genomics reveals determinants of sensitivity and resistance to natural killer cells in blood cancers
    1
    1. scibot 17 Dec 2023
      RRID:Addgene_61425

      DOI: 10.1016/j.immuni.2023.11.008

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    sciencedirect.com/science/article/pii/S1074761323004909
  44. Nov 2023
  45. www.sciencedirect.com www.sciencedirect.com
    Differences in syncytia formation by SARS-CoV-2 variants modify host chromatin accessibility and cellular senescence via TP53
    1
    1. scibot 22 Nov 2023
      Addgene_61425

      DOI: 10.1016/j.celrep.2023.113478

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    sciencedirect.com/science/article/pii/S2211124723014900
  46. Oct 2023
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LINE-1 activation in the cerebellum drives ataxia
    2
    1. scibot 20 Oct 2023
      Addgene #61425

      DOI: 10.1016/j.neuron.2022.08.011

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    2. scibot 20 Oct 2023
      RRID:Addgene_61425

      DOI: 10.1016/j.neuron.2022.08.011

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    ncbi.nlm.nih.gov/pmc/articles/PMC9588660/
  48. Sep 2023
  49. www.biorxiv.org www.biorxiv.org
    Differential Modulation of Polycomb-Associated Histone Marks by cBAF, pBAF, and gBAF Complexes
    1
    1. scibot 30 Sep 2023
      RRID:Addgene_61425

      DOI: 10.1101/2023.09.23.557848

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    biorxiv.org/content/10.1101/2023.09.23.557848v2
  50. Jun 2023
  51. www.embopress.org www.embopress.org
    STAT1 is required to establish but not maintain interferon-γ-induced transcriptional memory
    1
    1. scibot 06 Jun 2023
      Addgene_61425

      DOI: 10.15252/embj.2022112259

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    embopress.org/doi/10.15252/embj.2022112259
  52. Jan 2023
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Single-cell profiling of lncRNAs in human germ cells and molecular analysis reveals transcriptional regulation of LNC1845 on LHX8
    1
    1. scibot 25 Jan 2023
      Addgene_61425

      DOI: 10.7554/eLife.78421

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    ncbi.nlm.nih.gov/pmc/articles/PMC9859043/
  54. Nov 2022
  55. www.sciencedirect.com www.sciencedirect.com
    Tumor-intrinsic SIRPA promotes sensitivity to checkpoint inhibition immunotherapy in melanoma
    1
    1. scibot 04 Nov 2022
      RRID:Addgene_61425

      DOI: 10.1016/j.ccell.2022.10.012

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    sciencedirect.com/science/article/pii/S1535610822005037
  56. www.sciencedirect.com www.sciencedirect.com
    Acute depletion of human core nucleoporin reveals direct roles in transcription control but dispensability for 3D genome organization
    1
    1. scibot 03 Nov 2022
      Addgene_61425

      DOI: 10.1016/j.celrep.2022.111576

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    sciencedirect.com/science/article/pii/S2211124722014371
  57. Oct 2022
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ZBTB7A promotes virus-host homeostasis during human coronavirus 229E infection
    1
    1. scibot 26 Oct 2022
      Addgene_61425

      DOI: 10.1016/j.celrep.2022.111540

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    ncbi.nlm.nih.gov/pmc/articles/PMC9533670/
  59. Aug 2022
  60. www.science.org www.science.org
    CRISPR interference interrogation of COPD GWAS genes reveals the functional significance of desmoplakin in iPSC-derived alveolar epithelial cells
    1
    1. scibot 11 Aug 2022
      RRID:Addgene_61425

      DOI: 10.1126/sciadv.abo6566

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    science.org/doi/10.1126/sciadv.abo6566
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR interference interrogation of COPD GWAS genes reveals the functional significance of desmoplakin in iPSC-derived alveolar epithelial cells
    1
    1. scibot 04 Aug 2022
      RRID:Addgene_61425

      DOI: 10.1126/sciadv.abo6566

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    ncbi.nlm.nih.gov/pmc/articles/PMC9278866/
  62. Apr 2022
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Reduced mitochondrial fusion and Huntingtin levels contribute to impaired dendritic maturation and behavioral deficits in Fmr1 mutant mice
    1
    1. scibot 13 Apr 2022
      Addgene_61425

      DOI: 10.1038/s41593-019-0338-y

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    ncbi.nlm.nih.gov/pmc/articles/PMC6556892/
  64. Feb 2022
  65. www.sciencedirect.com www.sciencedirect.com
    HiCAR is a robust and sensitive method to analyze open-chromatin-associated genome organization
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    1. scibot 23 Feb 2022
      RRID: Addgene_61425

      DOI: 10.1016/j.molcel.2022.01.023

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    sciencedirect.com/science/article/pii/S1097276522000983
  66. www.sciencedirect.com www.sciencedirect.com
    Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer
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    1. scibot 04 Feb 2022
      Plasmid_61425

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    sciencedirect.com/science/article/pii/S153561082200006X
  67. www.sciencedirect.com www.sciencedirect.com
    Upregulation of CD14 in mesenchymal stromal cells accelerates lipopolysaccharide-induced response and enhances antibacterial properties
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    1. scibot 02 Feb 2022
      RRID:Addgene_61425

      DOI: 10.1016/j.isci.2022.103759

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    sciencedirect.com/science/article/pii/S2589004222000293
  68. Oct 2021
  69. www.sciencedirect.com www.sciencedirect.com
    A bipartite element with allele-specific functions safeguards DNA methylation imprints at the Dlk1-Dio3 locus
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    1. scibot 28 Oct 2021
      Addgene_61425

      DOI: 10.1016/j.devcel.2021.10.004

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    sciencedirect.com/science/article/pii/S1534580721008054
  70. onlinelibrary.wiley.com onlinelibrary.wiley.com
    AT-rich interaction domain 5A regulates the transcription of interleukin-6 gene in prostate cancer cells
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    1. scibot 19 Oct 2021
      RRID:Addgene_61425

      DOI: 10.1002/pros.24251

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    onlinelibrary.wiley.com/doi/10.1002/pros.24251
  71. Aug 2021
  72. www.sciencedirect.com www.sciencedirect.com
    Enhancer RNA m6A methylation facilitates transcriptional condensate formation and gene activation
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    1. scibot 15 Aug 2021
      Addgene_61425

      DOI: 10.1016/j.molcel.2021.07.024

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    sciencedirect.com/science/article/pii/S1097276521005931
  73. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    1. scibot 13 Aug 2021
      RRID:Addgene_61425

      DOI: 10.1016/j.stem.2019.03.012

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    sciencedirect.com/science/article/pii/S1934590919301110
  74. Jul 2021
  75. www.sciencedirect.com www.sciencedirect.com
    Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis
    1
    1. scibot 27 Jul 2021
      RRID_Addgene_61425

      DOI: 10.1016/j.ccell.2019.12.007

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  76. elifesciences.org elifesciences.org
    BAP1/ASXL complex modulation regulates epithelial-mesenchymal transition during trophoblast differentiation and invasion
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    1. scibot 01 Jul 2021
      RRID:Addgene_61425

      DOI: 10.7554/eLife.63254

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  77. May 2021
  78. www.sciencedirect.com www.sciencedirect.com
    Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis
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    1. scibot 28 May 2021
      CAT#61425

      DOI: 10.1016/j.cell.2021.04.037

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    sciencedirect.com/science/article/pii/S0092867421005729
  79. Apr 2021
  80. www.sciencedirect.com www.sciencedirect.com
    Pooled CRISPR-activation screening coupled with single-cell RNA-seq in mouse embryonic stem cells
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    1. scibot 10 Apr 2021
      plasmid_61425

      DOI: 10.1016/j.xpro.2021.100426

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    sciencedirect.com/science/article/pii/S2666166721001337
  81. Feb 2021
  82. www.cell.com www.cell.com
    Hominoid-Specific Transposable Elements and KZFPs Facilitate Human Embryonic Genome Activation and Control Transcription in Naive Human ESCs
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    1. scibot 25 Feb 2021
      RRID:Addgene_61425

      DOI: 10.1016/j.stem.2019.03.012

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    cell.com/cell-stem-cell/abstract/S1934-5909(19)30111-0
  83. www.sciencedirect.com www.sciencedirect.com
    Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis
    1
    1. scibot 24 Feb 2021
      RRID:_Addgene_61425

      DOI: 10.1016/j.ccell.2019.12.007

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    sciencedirect.com/science/article/pii/S153561081930577X
  84. Jan 2021
  85. www.sciencedirect.com www.sciencedirect.com
    Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins
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    1. scibot 07 Jan 2021
      RRID:Addgene_61425

      DOI: 10.1016/j.celrep.2020.108532

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    sciencedirect.com/science/article/pii/S2211124720315217
  86. Sep 2020
  87. www.sciencedirect.com www.sciencedirect.com
    Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis
    1
    1. scibot 23 Sep 2020
      RRID:Addgene_61425

      DOI: 10.1016/j.ccell.2019.12.007

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    sciencedirect.com/science/article/pii/S153561081930577X
  88. www.sciencedirect.com www.sciencedirect.com
    DUX-miR-344-ZMYM2-Mediated Activation of MERVL LTRs Induces a Totipotent 2C-like State
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    1. scibot 15 Sep 2020
      RRID:Addgene_61425

      DOI: 10.1016/j.stem.2020.01.004

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    sciencedirect.com/science/article/pii/S1934590920300047
  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The COMET toolkit for composing customizable genetic programs in mammalian cells
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    1. scibot 13 Sep 2020
      plasmid_61425

      DOI: 10.1038/s41467-019-14147-5

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    ncbi.nlm.nih.gov/pmc/articles/PMC7005830/
  90. www.sciencedirect.com www.sciencedirect.com
    A Single-Cell Transcriptomics CRISPR-Activation Screen Identifies Epigenetic Regulators of the Zygotic Genome Activation Program
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    1. scibot 11 Sep 2020
      plasmid_61425

      DOI: 10.1016/j.cels.2020.06.004

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    sciencedirect.com/science/article/pii/S2405471220302015
  91. www.sciencedirect.com www.sciencedirect.com
    Super-Enhancer Redistribution as a Mechanism of Broad Gene Dysregulation in Repeatedly Drug-Treated Cancer Cells
    1
    1. scibot 09 Sep 2020
      RRID:Addgene_61425

      DOI: 10.1016/j.celrep.2020.107532

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    sciencedirect.com/science/article/pii/S2211124720304320
  92. Jan 2020
  93. www.sciencedirect.com www.sciencedirect.com
    Identification and Massively Parallel Characterization of Regulatory Elements Driving Neural Induction
    1
    1. scibot 13 Jan 2020
      RRID:Addgene_61425

      DOI: 10.1016/j.stem.2019.09.010

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    sciencedirect.com/science/article/pii/S1934590919304217
  94. www.nature.com www.nature.com
    Untitled document
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      Addgene_61425

      DOI: 10.1038/s41593-019-0338-y

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    nature.com/articles/s41593-019-0338-y