106 Matching Annotations
  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genetic landscape and functional exploration of kidney cancer predisposition in cross-ancestral populations
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    pmc.ncbi.nlm.nih.gov/articles/PMC13275800/
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    High-resolution promoter interaction analysis implicates genes involved in the activation of Type 3 Innate Lymphoid Cells in autoimmune disease risk
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    pmc.ncbi.nlm.nih.gov/articles/PMC12821085/
  4. Sep 2026
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PRMT5‐Dependent Stabilization of VPS34 Orchestrates Copper Trafficking to Shield Cancer Cells from Cuproptosis and Radiotherapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC13345692/
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Promoter-proximal CTCF-binding promotes long-range-enhancer dependent gene activation
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    pmc.ncbi.nlm.nih.gov/articles/PMC7913465/
  7. Aug 2026
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Restoring the Balance: CRISPRa-Driven β-Tubulin Compensation as a Strategy for Tubulinopathy Treatment
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    pmc.ncbi.nlm.nih.gov/articles/PMC13466901/
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    LRP4 is an entry receptor for multiple encephalitic alphaviruses
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    pmc.ncbi.nlm.nih.gov/articles/PMC13402676/
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Molecular modulators of cyclin-dependent kinase 4/6 inhibitor response in experimental glioma identified through genome-wide CRISPR-Cas9 screening
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    pmc.ncbi.nlm.nih.gov/articles/PMC13437906/
  11. Jul 2026
  12. aacrjournals.org aacrjournals.org
    ZNF296 Drives Immune Evasion in Epithelial Cancers by Repressing Immune Stimulatory Genes
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    aacrjournals.org/cancerres/article/86/1/116/771155/ZNF296-Drives-Immune-Evasion-in-Epithelial-Cancers
  13. 54.241.53.176 54.241.53.176
    Functional impact of genetic background on variable expressivity in neurodevelopmental disorders
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    54.241.53.176/2868cce4ce48d1d5a131d67e5ff5a9d8c6cf1519/s41467-026-72598-z_reference-html.html
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A whole genomic CRISPR-Cas9 screen identifies the amino acid transporter SLC43A1 (LAT3) as a major determinant of oxaliplatin sensitivity in colorectal cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC13317012/
  15. Jun 2026
  16. aacrjournals.org aacrjournals.org
    ZC3H13 Loss Drives Cancer Metastatic Progression by Disrupting m6A RNA Methylation
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    aacrjournals.org/cancerres/article/86/3/622/771927/ZC3H13-Loss-Drives-Cancer-Metastatic-Progression
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    Genome instability triggers intercellular DNA transfer between human cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC13193222/
  18. May 2026
  19. www.sciencedirect.com www.sciencedirect.com
    Human pancreatic progenitor organoids define genetic and epigenetic barriers to early PDAC transformation
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    sciencedirect.com/science/article/pii/S1534580726001590
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    A CRISPR activation screen identifies SPART as a pan-orthoflavivirus restriction factor
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    sciencedirect.com/science/article/pii/S1931312826001745
  21. www.sciencedirect.com www.sciencedirect.com
    Transcription and cohesin direct domain boundary spatial positioning and are linked to Friedreich’s ataxia
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    sciencedirect.com/science/article/pii/S109727652600273X
  22. Mar 2026
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ROME, an Ancient Gene with a Novel Function in Vertebrates, Is a Key Modulator of Embryonal Development and Cancer Metastasis
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    pmc.ncbi.nlm.nih.gov/articles/PMC13012068/
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    Functional chromatin signatures premark future lineage-specific enhancers
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    sciencedirect.com/science/article/pii/S2666979X26000510
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Enhancing gene therapy vectors manufacturing: CEBPA as a master regulator of rAAV biogenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12866504/
  26. Feb 2026
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Multidimensional mapping of stimulation-responsive regulatory elements and candidate causal variants in T cell activation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12757029/
  28. Dec 2025
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    LncRNA NONHSAT248596.1 Promotes Osteoarthritis via miR-146a-5p/CXCR4 Axis by Inducing Chondrocyte Apoptosis and Extracellular Matrix Degradation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12703374/
  30. www.tandfonline.com www.tandfonline.com
    LncRNA NONHSAT248596.1 Promotes Osteoarthritis via miR-146a-5p/CXCR4 Axis by Inducing Chondrocyte Apoptosis and Extracellular Matrix Degradation
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    tandfonline.com/doi/abs/10.2147/JIR.S558704
  31. Nov 2025
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Conformation of HLA-E/peptide complex guides interaction with two novel HLA-E receptors: Stabilin 1 and 2
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    pmc.ncbi.nlm.nih.gov/articles/PMC12517498/
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The key role of acss1 in mammary gland development and lactation: a study based on gene co-expression network analysis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12523080/
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Soluble MFGE8 mediates cell entry of Crimean-Congo hemorrhagic fever virus
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    pmc.ncbi.nlm.nih.gov/articles/PMC12505966/
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    Single-cell activation screen identifies hepatic maturation regulators with zonal resolution
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    sciencedirect.com/science/article/pii/S1534580725006653
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    UHRF1 restricts HCoV-229E infection through epigenetic silencing of the viral receptor APN
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    pmc.ncbi.nlm.nih.gov/articles/PMC12627610/
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Family with sequence similarity 114 member A1 orchestrates immune evasion in triple-negative breast cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12624017/
  38. Oct 2025
  39. www.biorxiv.org www.biorxiv.org
    Parkinson’s disease LRRK2 mutations dysregulate iron homeostasis and promote oxidative stress and ferroptosis in human neurons and astrocytes
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    biorxiv.org/content/10.1101/2025.09.26.678370v1
  40. Sep 2025
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    An isoform-specific RUNX1C–BTG2 axis governs AML quiescence and chemoresistance.
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    pmc.ncbi.nlm.nih.gov/articles/PMC12405853/
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Prolonging lung cancer response to EGFR inhibition by targeting the selective advantage of resistant cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12373916/
  43. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Conversion of natural cytokine receptors into orthogonal synthetic biosensors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12380174/
  44. www.nature.com www.nature.com
    Cytotoxicity of activator expression in CRISPR-based transcriptional activation systems
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    nature.com/articles/s41467-025-63570-4
  45. www.cell.com www.cell.com
    Endogenous fine-mapping and prioritization of functional regulatory elements in complex genetic loci
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    cell.com/cell-genomics/abstract/S2666-979X(25)00238-1
  46. Aug 2025
  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Membrane-wide screening identifies potential tissue-specific determinants of SARS-CoV-2 tropism
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    pmc.ncbi.nlm.nih.gov/articles/PMC12286382/
  48. Jul 2025
  49. www.medrxiv.org www.medrxiv.org
    An integrated framework for functional dissection of variable expressivity in genetic disorders
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    medrxiv.org/content/10.1101/2025.07.22.25331885v2
  50. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Prion-induced ferroptosis is facilitated by RAC3
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    pmc.ncbi.nlm.nih.gov/articles/PMC12198409/
  51. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Near-infrared light activatable chemically induced CRISPR system
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    pmc.ncbi.nlm.nih.gov/articles/PMC12214668/
  52. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Leveraging CRISPR activation for rapid assessment of gene editing products in human pluripotent stem cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12181958/
  53. www.sciencedirect.com www.sciencedirect.com
    An alternate receptor for adeno-associated viruses
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    sciencedirect.com/science/article/pii/S0092867425006920
  54. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Requirement for Cyclin D1 Underlies Cell-Autonomous HIF2 Dependence in Kidney Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12223508/
  55. Jun 2025
  56. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Systemic genome-epigenome analysis captures a lineage-specific super-enhancer for MYB in gastrointestinal adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12130324/
  57. May 2025
  58. www.sciencedirect.com www.sciencedirect.com
    Integrative characterization of MYC RNA-binding function
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    sciencedirect.com/science/article/pii/S2666979X2500134X
  59. Apr 2025
  60. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Identification of a SNAI1 enhancer RNA that drives cancer cell plasticity
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    pmc.ncbi.nlm.nih.gov/articles/PMC11937597/
  61. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Modified screening of MYC promotor region elements using the CRISPR library in ovarian cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11963443/
  62. Mar 2025
  63. www.sciencedirect.com www.sciencedirect.com
    Amplified dosage of the NKX2-1 lineage transcription factor controls its oncogenic role in lung adenocarcinoma
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    sciencedirect.com/science/article/pii/S1097276525001947
  64. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Circulating tumor cell plasticity determines breast cancer therapy resistance via neuregulin 1–HER3 signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC11779641/
  65. Feb 2025
  66. www.sciencedirect.com www.sciencedirect.com
    Development of cell lines with increased susceptibility to diverse adeno-associated viral vectors to enable in vitro potency assays
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    sciencedirect.com/science/article/pii/S2329050125000117
  67. Dec 2024
  68. genomebiology.biomedcentral.com genomebiology.biomedcentral.com
    Functional screening reveals genetic dependencies and diverging cell cycle control in atypical teratoid rhabdoid tumors
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    genomebiology.biomedcentral.com/articles/10.1186/s13059-024-03438-w
  69. Sep 2024
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The proteogenomic landscape of multiple myeloma reveals insights into disease biology and therapeutic opportunities
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    ncbi.nlm.nih.gov/pmc/articles/PMC11358022/
  71. www.biorxiv.org www.biorxiv.org
    Cytotoxicity of Activator Expression in CRISPR-based Transcriptional Activation Systems
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    biorxiv.org/content/10.1101/2024.09.23.614524v1
  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Evolved cytidine and adenine base editors with high precision and minimized off-target activity by a continuous directed evolution system in mammalian cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11408606/
  73. Aug 2024
  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lecithin-cholesterol acyltransferase is a potential tumor suppressor and predictive marker for hepatocellular carcinoma metastasis
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    ncbi.nlm.nih.gov/pmc/articles/PMC11334038/
  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Crosstalk of MAP3K1 and EGFR signaling mediates gene-environment interactions that block developmental tissue closure
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    ncbi.nlm.nih.gov/pmc/articles/PMC11294703/
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Convergence of coronary artery disease genes onto endothelial cell programs
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    ncbi.nlm.nih.gov/pmc/articles/PMC10921916/
  77. www.cell.com www.cell.com
    Epigenomic signatures of sarcomatoid differentiation to guide the treatment of renal cell carcinoma
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    cell.com/cell-reports/fulltext/S2211-1247(24)00678-8
  78. Jun 2024
  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR/Cas9 screening reveals a distinct class of MHC-I binders with precise HLA-peptide recognition
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    ncbi.nlm.nih.gov/pmc/articles/PMC11209011/
  80. May 2024
  81. www.biorxiv.org www.biorxiv.org
    Conversion of natural cytokine receptors into orthogonal synthetic biosensors
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    biorxiv.org/content/10.1101/2024.03.23.586421v1
  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR-Cas13d screens identify KILR, a breast cancer risk-associated lncRNA that regulates DNA replication and repair
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    ncbi.nlm.nih.gov/pmc/articles/PMC11094906/
  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mapping of DDX11 genetic interactions defines sister chromatid cohesion as the major dependency
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    ncbi.nlm.nih.gov/pmc/articles/PMC11075568/
  84. Apr 2024
  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide CRISPR screens identify the YAP/TEAD axis as a driver of persister cells in EGFR mutant lung cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11043391/
  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Loss of NEDD8 in cancer cells causes vulnerability to immune checkpoint blockade in triple-negative breast cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11055868/
  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Long noncoding RNA Malat1 protects against osteoporosis and bone metastasis
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    ncbi.nlm.nih.gov/pmc/articles/PMC10944492/
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MAP3K1 regulates female reproductive tract development
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    ncbi.nlm.nih.gov/pmc/articles/PMC10985838/
  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide CRISPR activation screen identifies JADE3 as an antiviral activator of NF-kB–dependent IFITM3 expression
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    ncbi.nlm.nih.gov/pmc/articles/PMC11001640/
  90. www.sciencedirect.com www.sciencedirect.com
    Tumor cell-intrinsic epigenetic dysregulation shapes cancer-associated fibroblasts heterogeneity to metabolically support pancreatic cancer
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    sciencedirect.com/science/article/pii/S1535610824000904
  91. Mar 2024
  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functionally-instructed modifiers of response to ATR inhibition in experimental glioma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10935927/
  93. www.nature.com www.nature.com
    CDK9-55 guides the anaphase-promoting complex/cyclosome (APC/C) in choosing the DNA repair pathway choice
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    nature.com/articles/s41388-024-02982-w
  94. Feb 2024
  95. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sequential CRISPR screening reveals partial NatB inhibition as a strategy to mitigate alpha-synuclein levels in human neurons
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    ncbi.nlm.nih.gov/pmc/articles/PMC10857481/
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide quantification of copy-number aberration impact on gene expression in ovarian high-grade serous carcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10840274/
  97. Jan 2024
  98. www.nature.com www.nature.com
    Redox signalling regulates breast cancer metastasis via phenotypic and metabolic reprogramming due to p63 activation by HIF1α
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    nature.com/articles/s41416-023-02522-5
  99. Dec 2023
  100. www.sciencedirect.com www.sciencedirect.com
    The MHC-E peptide ligands for checkpoint CD94/NKG2A are governed by inflammatory signals, whereas LILRB1/2 receptors are peptide indifferent
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    sciencedirect.com/science/article/pii/S2211124723015280
  101. www.sciencedirect.com www.sciencedirect.com
    Single-cell functional genomics reveals determinants of sensitivity and resistance to natural killer cells in blood cancers
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    sciencedirect.com/science/article/pii/S1074761323004909
  102. Nov 2023
  103. www.sciencedirect.com www.sciencedirect.com
    Differences in syncytia formation by SARS-CoV-2 variants modify host chromatin accessibility and cellular senescence via TP53
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    sciencedirect.com/science/article/pii/S2211124723014900
  104. Oct 2023
  105. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LINE-1 activation in the cerebellum drives ataxia
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    ncbi.nlm.nih.gov/pmc/articles/PMC9588660/
  106. Sep 2023
  107. www.biorxiv.org www.biorxiv.org
    Differential Modulation of Polycomb-Associated Histone Marks by cBAF, pBAF, and gBAF Complexes
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    biorxiv.org/content/10.1101/2023.09.23.557848v2
  108. Jun 2023
  109. www.embopress.org www.embopress.org
    STAT1 is required to establish but not maintain interferon-γ-induced transcriptional memory
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    embopress.org/doi/10.15252/embj.2022112259
  110. Jan 2023
  111. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Single-cell profiling of lncRNAs in human germ cells and molecular analysis reveals transcriptional regulation of LNC1845 on LHX8
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    ncbi.nlm.nih.gov/pmc/articles/PMC9859043/
  112. Nov 2022
  113. www.sciencedirect.com www.sciencedirect.com
    Tumor-intrinsic SIRPA promotes sensitivity to checkpoint inhibition immunotherapy in melanoma
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    sciencedirect.com/science/article/pii/S1535610822005037
  114. www.sciencedirect.com www.sciencedirect.com
    Acute depletion of human core nucleoporin reveals direct roles in transcription control but dispensability for 3D genome organization
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    sciencedirect.com/science/article/pii/S2211124722014371
  115. Oct 2022
  116. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ZBTB7A promotes virus-host homeostasis during human coronavirus 229E infection
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    ncbi.nlm.nih.gov/pmc/articles/PMC9533670/
  117. Aug 2022
  118. www.science.org www.science.org
    CRISPR interference interrogation of COPD GWAS genes reveals the functional significance of desmoplakin in iPSC-derived alveolar epithelial cells
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    science.org/doi/10.1126/sciadv.abo6566
  119. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR interference interrogation of COPD GWAS genes reveals the functional significance of desmoplakin in iPSC-derived alveolar epithelial cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC9278866/
  120. Apr 2022
  121. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Reduced mitochondrial fusion and Huntingtin levels contribute to impaired dendritic maturation and behavioral deficits in Fmr1 mutant mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC6556892/
  122. Feb 2022
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    HiCAR is a robust and sensitive method to analyze open-chromatin-associated genome organization
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