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pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Functional editing of the OTC locus by targeted integration with phenotype correction and restoration of endogenous expression patterns

1
1. scibot 30 Sep 2026
  
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  plasmid_61593
  
  DOI: 10.1016/j.ymthe.2026.06.044
  
  Resource: RRID:Addgene_61593
  
  Curator: @scibot
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13555538/
Mar 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Descending locus coeruleus noradrenergic signaling to spinal astrocyte subset is required for stress-induced mechanical pain hypersensitivity

1
1. scibot 27 Mar 2026
  
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  61593
  
  DOI: 10.7554/eLife.104453
  
  Resource: RRID:Addgene_61593
  
  Curator: @olekpark
  
  SciCrunch record: RRID:Addgene_61593
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12971058/
Apr 2025
www.biorxiv.org www.biorxiv.org

Activated Interferon Signaling Suppresses Age-Dependent Liver Cancer

1
1. scibot 10 Apr 2025
  
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  plasmid_61593
  
  DOI: 10.1101/2024.07.31.606057
  
  Resource: RRID:Addgene_61593
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_61593
  
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biorxiv.org/content/10.1101/2024.07.31.606057v1
Mar 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

SLC13A2 promotes hepatocyte metabolic remodeling and liver regeneration by enhancing de novo cholesterol biosynthesis

1
1. scibot 11 Mar 2025
  
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  61593
  
  DOI: 10.1038/s44318-025-00362-y
  
  Resource: RRID:Addgene_61593
  
  Curator: @olekpark
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11876347/
Aug 2024
www.sciencedirect.com www.sciencedirect.com

Therapeutic siRNA targeting PLIN2 ameliorates steatosis, inflammation, and fibrosis in steatotic liver disease models

1
1. scibot 27 Aug 2024
  
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  Addgene; Cat# 61593
  
  DOI: 10.1016/j.jlr.2024.100635
  
  Resource: RRID:Addgene_61593
  
  Curator: @vtello
  
  SciCrunch record: RRID:Addgene_61593
  
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sciencedirect.com/science/article/pii/S0022227524001408
Jun 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Protective role of RIPK1 scaffolding against HDV-induced hepatocyte cell death and the significance of cytokines in mice

1
1. scibot 07 Jun 2024
  
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  plasmid_61593
  
  DOI: 10.1371/journal.ppat.1011749
  
  Resource: RRID:Addgene_61593
  
  Curator: @scibot
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11115361/
Mar 2024
52.53.155.43 52.53.155.43

Efficient and safe therapeutic use of paired Cas9-nickases for primary hyperoxaluria type 1

2
1. scibot 21 Mar 2024
  
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  RRID:Addgene_61593
  
  DOI: 10.1038/s44321-023-00008-8
  
  Resource: RRID:Addgene_61593
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_61593
  
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  RRID:Addgene_61593
2. scibot 02 Mar 2024
  
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  RRID:Addgene_61593
  
  DOI: 10.1038/s44321-023-00008-8
  
  Resource: RRID:Addgene_61593
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_61593
  
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52.53.155.43/b4a5d5f166b97df7aae394dba3752d5bbdf7ed06/torella-et-al-2024-efficient-and-safe-therapeutic-use-of-paired-cas9-nickases-for-primary-hyperoxaluria-type-1-html.html
Jan 2024
www.sciencedirect.com www.sciencedirect.com

AAV-based gene editing of type 1 collagen mutation to treat osteogenesis imperfecta

1
1. scibot 07 Jan 2024
  
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  RRID:Addgene_61593
  
  DOI: 10.1016/j.omtn.2023.102111
  
  Resource: RRID:Addgene_61593
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S2162253123003293
Nov 2021
www.sciencedirect.com www.sciencedirect.com

Impaired glucocorticoid receptor expression in liver disrupts feeding-induced gene expression, glucose uptake, and glycogen storage

1
1. scibot 03 Nov 2021
  
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  RRID:Addgene_61593
  
  DOI: 10.1016/j.celrep.2021.109938
  
  Resource: RRID:Addgene_61593
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_61593
  
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sciencedirect.com/science/article/pii/S221112472101411X
Jul 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

m6A Regulates Liver Metabolic Disorders and Hepatogenous Diabetes

1
1. scibot 08 Jul 2021
  
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  RRID:Addgene_61593
  
  DOI: 10.1016/j.gpb.2020.06.003
  
  Resource: RRID:Addgene_61593
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_61593
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8242261/
May 2021
www.cell.com www.cell.com

TMEM41B acts as an ER scramblase required for lipoprotein biogenesis and lipid homeostasis

1
1. scibot 20 May 2021
  
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  Cat# 61593
  
  DOI: 10.1016/j.cmet.2021.05.006
  
  Resource: RRID:Addgene_61593
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_61593
  
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  RRID:Addgene_61593 RRIDCUR:Missing
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cell.com/cell-metabolism/fulltext/S1550-4131(21)00223-0
www.sciencedirect.com www.sciencedirect.com

Induction of core symptoms of autism spectrum disorders by in vivo CRISPR/Cas9-based gene editing in the brain of adolescent rhesus monkeys

1
1. scibot 08 May 2021
  
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  RRID:Addgene_61593
  
  DOI: 10.1016/j.scib.2020.12.017
  
  Resource: RRID:Addgene_61593
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_61593
  
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sciencedirect.com/science/article/pii/S2095927320307623
www.sciencedirect.com www.sciencedirect.com

Programmable Extracellular Vesicles for Macromolecule Delivery and Genome Modifications

1
1. scibot 05 May 2021
  
  in Public
  
  plasmid_61593
  
  DOI: 10.1016/j.devcel.2020.11.007
  
  Resource: RRID:Addgene_61593
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_61593
  
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sciencedirect.com/science/article/pii/S1534580720308832
Apr 2021
www.sciencedirect.com www.sciencedirect.com

Receptor-Mediated ER Export of Lipoproteins Controls Lipid Homeostasis in Mice and Humans

1
1. scibot 30 Apr 2021
  
  in Public
  
  Addgene_61593
  
  DOI: 10.1016/j.cmet.2020.10.020
  
  Resource: RRID:Addgene_61593
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_61593
  
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  RRID:Addgene_61593
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sciencedirect.com/science/article/pii/S1550413120305532