40 Matching Annotations
  1. Jul 2026
  2. www.biorxiv.org www.biorxiv.org
    Mapping Functional Tumor Suppressor Networks in Esophageal Adenocarcinoma Using In Vivo CRISPR Screening and Perturb-sequencing
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    biorxiv.org/content/10.64898/2026.07.19.739473v1
  3. Jun 2026
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cas9-expressing HC-04 hepatocytes facilitate CRISPR-based analysis of Plasmodium falciparum sporozoite-host interactions
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    pmc.ncbi.nlm.nih.gov/articles/PMC13215610/
  5. Mar 2026
  6. www.biorxiv.org www.biorxiv.org
    SMAD4 loss drives chromosomal instability during tumourigenesis via translational reprogramming
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    biorxiv.org/content/10.64898/2026.03.23.712291v1
  7. Feb 2026
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Identifying targeted therapies for CBFA2T3::GLIS2 acute myeloid leukemia
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    pmc.ncbi.nlm.nih.gov/articles/PMC12875880/
  9. Aug 2025
  10. www.sciencedirect.com www.sciencedirect.com
    A CDK11-dependent RNA polymerase II pause-checkpoint precedes CDK9-mediated transition to transcriptional elongation
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    sciencedirect.com/science/article/pii/S1097276525006513
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Re-appraising assays on permeabilized blood cancer cells testing venetoclax or other BH3 mimetic agents selectively targeting pro-survival BCL2 proteins
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    pmc.ncbi.nlm.nih.gov/articles/PMC12325916/
  12. Jul 2025
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Prospective Isolation According to Melanin Pigment Content of Melanoma Cells With Heterogeneous Potentials for Disease Propagation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12209049/
  14. Mar 2025
  15. www.sciencedirect.com www.sciencedirect.com
    Lipid-metabolism-focused CRISPR screens identify enzymes of the mevalonate pathway as essential for prostate cancer growth
    1
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    sciencedirect.com/science/article/pii/S2211124725002414
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Both direct and indirect suppression of MCL1 synergizes with BCLXL inhibition in preclinical models of gastric cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11904182/
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Differential regulation of BAX and BAK apoptotic activity revealed by small molecules
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    pmc.ncbi.nlm.nih.gov/articles/PMC11881913/
  18. Jan 2025
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    UNC119 regulates T-cell receptor signalling in primary T cells and T acute lymphocytic leukaemia
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    pmc.ncbi.nlm.nih.gov/articles/PMC11735834/
  20. Sep 2024
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IKKɛ induces STING non-IFN immune responses via a mechanism analogous to TBK1
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11387596/
  22. Aug 2024
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Super enhancer acquisition drives expression of oncogenic PPP1R15B that regulates protein homeostasis in multiple myeloma
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11316114/
  24. www.cell.com www.cell.com
    SETDB1 suppresses NK cell-mediated immunosurveillance in acute myeloid leukemia with granulo-monocytic differentiation
    1
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    cell.com/cell-reports/fulltext/S2211-1247(24)00865-9
  25. May 2024
  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Multiomics analysis identifies oxidative phosphorylation as a cancer vulnerability arising from myristoylation inhibition
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11075276/
  27. Apr 2024
  28. www.sciencedirect.com www.sciencedirect.com
    Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers
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    sciencedirect.com/science/article/pii/S1535610824001284
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Recurrent mutations in tumor suppressor FBXW7 bypass Wnt/β-catenin addiction in cancer
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10990278/
  30. Mar 2024
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The cholesterol biosynthesis enzyme FAXDC2 couples Wnt/β-catenin to RTK/MAPK signaling
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10940096/
  32. Feb 2024
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Epigenomic analyses identify FOXM1 as a key regulator of anti-tumor immune response in esophageal adenocarcinoma
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10876663/
  34. Sep 2023
  35. www.sciencedirect.com www.sciencedirect.com
    Mitotic perturbation is a key mechanism of action of decitabine in myeloid tumor treatment
    1
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    sciencedirect.com/science/article/pii/S2211124723011099
  36. May 2023
  37. www.biorxiv.org www.biorxiv.org
    Group comparison based on genetic information reveals lineage-specific therapeutic vulnerabilities in acute myeloid leukemia
    1
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    biorxiv.org/content/10.1101/2023.05.18.541265v1
  38. Apr 2023
  39. www.sciencedirect.com www.sciencedirect.com
    Generation and multi-dimensional profiling of a childhood cancer cell line atlas defines new therapeutic opportunities
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    sciencedirect.com/science/article/pii/S1535610823000806
  40. Feb 2023
  41. www.sciencedirect.com www.sciencedirect.com
    Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins
    1
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    sciencedirect.com/science/article/pii/S2211124723000761
  42. Nov 2022
  43. www.nature.com www.nature.com
    Sensory nerves enhance triple-negative breast cancer invasion and metastasis via the axon guidance molecule PlexinB3
    2
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    nature.com/articles/s41523-022-00485-z
  44. Oct 2022
  45. rupress.org rupress.org
    A specialized tyrosine-based endocytosis signal in MR1 controls antigen presentation to MAIT cells
    1
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    rupress.org/jcb/article/221/12/e202110125/213489/A-specialized-tyrosine-based-endocytosis-signal-in
  46. Sep 2022
  47. www.sciencedirect.com www.sciencedirect.com
    Inhibition of the CtBP complex and FBXO11 enhances MHC class II expression and anti-cancer immune responses
    1
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    sciencedirect.com/science/article/pii/S1535610822004366
  48. academic.oup.com academic.oup.com
    The high mobility group protein HMG20A cooperates with the histone reader PHF14 to modulate TGFβ and Hippo pathways
    1
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    academic.oup.com/nar/advance-article/doi/10.1093/nar/gkac766/6702467
  49. Jul 2022
  50. 52.53.155.43 52.53.155.43
    Loss of METTL3 Attenuates Blastic Plasmacytoid Dendritic Cell Neoplasm Response to PRMT5 Inhibition via IFN Signalling
    1
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    52.53.155.43/677cda7f3a6b5fa0b89c505ec057146e920f9e90/bloodadvances.2021006306-html.html
  51. Jun 2022
  52. 52.53.155.43 52.53.155.43
    Loss of METTL3 Attenuates Blastic Plasmacytoid Dendritic Cell Neoplasm Response to PRMT5 Inhibition via IFN Signalling
    1
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    52.53.155.43/677cda7f3a6b5fa0b89c505ec057146e920f9e90/bloodadvances.2021006306-html.html
  53. Mar 2022
  54. www.nature.com www.nature.com
    PLK1 inhibition selectively induces apoptosis in ARID1A deficient cells through uncoupling of oxygen consumption from ATP production
    1
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    nature.com/articles/s41388-022-02219-8
  55. Feb 2022
  56. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway
    2
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    pubmed.ncbi.nlm.nih.gov/35139355/
  57. Sep 2021
  58. www.embopress.org www.embopress.org
    HOIP limits anti-tumor immunity by protecting against combined TNF and IFN-gamma-induced apoptosis
    1
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    embopress.org/doi/full/10.15252/embr.202153391
  59. Jul 2021
  60. www.sciencedirect.com www.sciencedirect.com
    An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer
    1
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    sciencedirect.com/science/article/pii/S1535610819303769
  61. www.sciencedirect.com www.sciencedirect.com
    Natural Killer Cells Suppress T Cell-Associated Tumor Immune Evasion
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    sciencedirect.com/science/article/pii/S2211124719310502
  62. May 2021
  63. www.sciencedirect.com www.sciencedirect.com
    The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer
    1
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    sciencedirect.com/science/article/pii/S009286742100502X
  64. Jan 2021
  65. www.sciencedirect.com www.sciencedirect.com
    TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells
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    sciencedirect.com/science/article/pii/S2211124720303703
  66. Sep 2020
  67. www.sciencedirect.com www.sciencedirect.com
    Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection
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    sciencedirect.com/science/article/pii/S1074761320302843