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Defining the functional role and potential as an immunotherapeutic target of ALCAM in neuroblastoma

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1. scibot 08 Apr 2026
  
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  RRID:Addgene_70183
  
  DOI: 10.1158/1535-7163.MCT-25-0136
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12729689/
Mar 2026
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Identifying targeted therapies for CBFA2T3::GLIS2 acute myeloid leukemia

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1. scibot 27 Mar 2026
  
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  DOI: 10.1038/s41375-025-02845-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12875880/
Feb 2026
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Identifying targeted therapies for CBFA2T3::GLIS2 acute myeloid leukemia

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1. scibot 10 Feb 2026
  
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  Addgene_70183
  
  DOI: 10.1038/s41375-025-02845-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12875880/
Nov 2025
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Phosphorylation of Plectin by Akt3 Promotes Triple-Negative Breast Cancer Cell Invasive Migration

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1. scibot 23 Nov 2025
  
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  70183
  
  DOI: 10.1016/j.isci.2025.113552
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12508894/
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Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia

2
1. scibot 22 Nov 2025
  
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  Addgene#70183
  
  DOI: 10.1016/j.cell.2025.10.028
  
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2. scibot 22 Nov 2025
  
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  plasmid_70183
  
  DOI: 10.1016/j.cell.2025.10.028
  
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sciencedirect.com/science/article/pii/S0092867425012334
Aug 2025
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A CDK11-dependent RNA polymerase II pause-checkpoint precedes CDK9-mediated transition to transcriptional elongation

1
1. scibot 26 Aug 2025
  
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  Addgene Cat#70183
  
  DOI: 10.1016/j.molcel.2025.08.001
  
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sciencedirect.com/science/article/pii/S1097276525006513
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Re-appraising assays on permeabilized blood cancer cells testing venetoclax or other BH3 mimetic agents selectively targeting pro-survival BCL2 proteins

1
1. scibot 10 Aug 2025
  
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  Addgene_70183
  
  DOI: 10.1038/s41418-025-01487-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12325916/
Mar 2025
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Both direct and indirect suppression of MCL1 synergizes with BCLXL inhibition in preclinical models of gastric cancer

1
1. scibot 23 Mar 2025
  
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  DOI: 10.1038/s41419-025-07481-8
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11904182/
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Differential regulation of BAX and BAK apoptotic activity revealed by small molecules

1
1. scibot 11 Mar 2025
  
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  70183
  
  DOI: 10.1126/sciadv.adr8146
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11881913/
Jan 2025
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UNC119 regulates T-cell receptor signalling in primary T cells and T acute lymphocytic leukaemia

1
1. scibot 27 Jan 2025
  
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  plasmid_70183
  
  DOI: 10.26508/lsa.202403066
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11735834/
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Super enhancer acquisition drives expression of oncogenic PPP1R15B that regulates protein homeostasis in multiple myeloma

1
1. scibot 22 Aug 2024
  
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  plasmid_70183
  
  DOI: 10.1038/s41467-024-50910-z
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11316114/
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Mutant p53 protects triple-negative breast adenocarcinomas from ferroptosis in vivo

1
1. scibot 02 Aug 2024
  
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  DOI: 10.1126/sciadv.adk1835
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10866549/
Jul 2024
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Mutational profiling of SARS-CoV-2 papain-like protease reveals requirements for function, structure, and drug escape

1
1. scibot 27 Jul 2024
  
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  plasmid_70183
  
  DOI: 10.1038/s41467-024-50566-9
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11266423/
Jun 2024
www.biorxiv.org www.biorxiv.org

Advancing the genetic engineering toolbox by combining AsCas12a knock-in mice with ultra-compact screening

1
1. scibot 07 Jun 2024
  
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  Addgene_70183
  
  DOI: 10.1101/2024.05.30.596755
  
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biorxiv.org/content/10.1101/2024.05.30.596755v1
May 2024
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Multiomics analysis identifies oxidative phosphorylation as a cancer vulnerability arising from myristoylation inhibition

1
1. scibot 12 May 2024
  
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  Addgene_70183
  
  DOI: 10.1186/s12967-024-05150-6
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11075276/
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TruD technology for the study of epi- and endothelial tubes in vitro

1
1. scibot 12 May 2024
  
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  Plasmid_70183
  
  DOI: 10.1371/journal.pone.0301099
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11086873/
Apr 2024
www.sciencedirect.com www.sciencedirect.com

Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers

3
1. scibot 26 Apr 2024
  
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  Addgene, Aubrey et al. 201564Cat #70183
  
  DOI: 10.1016/j.ccell.2024.04.004
  
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2. scibot 26 Apr 2024
  
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  Addgene Plasmid #70183
  
  DOI: 10.1016/j.ccell.2024.04.004
  
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  Curator: @abever99
  
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3. scibot 26 Apr 2024
  
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  Addgene Plasmid #70183
  
  DOI: 10.1016/j.ccell.2024.04.004
  
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sciencedirect.com/science/article/pii/S1535610824001284
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Recurrent mutations in tumor suppressor FBXW7 bypass Wnt/β-catenin addiction in cancer

1
1. scibot 14 Apr 2024
  
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  70183
  
  DOI: 10.1126/sciadv.adk1031
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10990278/
Mar 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The cholesterol biosynthesis enzyme FAXDC2 couples Wnt/β-catenin to RTK/MAPK signaling

1
1. scibot 17 Mar 2024
  
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  70183
  
  DOI: 10.1172/JCI171222
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10940096/
Feb 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Epigenomic analyses identify FOXM1 as a key regulator of anti-tumor immune response in esophageal adenocarcinoma

1
1. scibot 29 Feb 2024
  
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  70183
  
  DOI: 10.1038/s41419-024-06488-x
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10876663/
Jan 2024
www.sciencedirect.com www.sciencedirect.com

Pioneer and PRDM transcription factors coordinate bivalent epigenetic states to safeguard cell fate

1
1. scibot 11 Jan 2024
  
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  RRID:Addgene_70183
  
  DOI: 10.1016/j.molcel.2023.12.007
  
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sciencedirect.com/science/article/pii/S1097276523010262
Dec 2023
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ASCL1 characterizes adrenergic neuroblastoma via its pioneer function and cooperation with core regulatory circuit factors

1
1. scibot 20 Dec 2023
  
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  Addgene_70183
  
  DOI: 10.1016/j.celrep.2023.113541
  
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sciencedirect.com/science/article/pii/S221112472301553X
Nov 2023
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p120 RasGAP and ZO-2 are essential for Hippo signaling and tumor-suppressor function mediated by p190A RhoGAP

1
1. scibot 28 Nov 2023
  
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  Addgene_70183
  
  DOI: 10.1016/j.celrep.2023.113486
  
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sciencedirect.com/science/article/pii/S2211124723014985
Jul 2023
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Combining a Tetracycline (Tet)-inducible gRNA system and CRISPRa for titratable and timely controlled enhancement of endogenous SHISA3 activation in human induced pluripotent stem cells (hiPSC)

1
1. scibot 08 Jul 2023
  
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  RRID:Addgene_70183
  
  DOI: 10.1016/j.scr.2023.103163
  
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sciencedirect.com/science/article/pii/S1873506123001496
Apr 2023
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ITK degradation to block T cell receptor signaling and overcome therapeutic resistance in T cell lymphomas

1
1. scibot 06 Apr 2023
  
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  Addgene_70183
  
  DOI: 10.1016/j.chembiol.2023.03.007
  
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sciencedirect.com/science/article/pii/S2451945623000867
Feb 2023
www.sciencedirect.com www.sciencedirect.com

Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins

1
1. scibot 02 Feb 2023
  
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  Plasmid_70183
  
  DOI: 10.1016/j.celrep.2023.112065
  
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sciencedirect.com/science/article/pii/S2211124723000761
Oct 2022
rupress.org rupress.org

A specialized tyrosine-based endocytosis signal in MR1 controls antigen presentation to MAIT cells

1
1. scibot 25 Oct 2022
  
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  RRID:Addgene_70183
  
  DOI: 10.1083/jcb.202110125
  
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rupress.org/jcb/article/221/12/e202110125/213489/A-specialized-tyrosine-based-endocytosis-signal-in
Sep 2022
www.sciencedirect.com www.sciencedirect.com

The escape of Candida albicans from macrophages is enabled by the fungal toxin candidalysin and two host cell death pathways

1
1. scibot 21 Sep 2022
  
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  Plasmid_70183
  
  DOI: 10.1016/j.celrep.2022.111374
  
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sciencedirect.com/science/article/pii/S2211124722012062
academic.oup.com academic.oup.com

The high mobility group protein HMG20A cooperates with the histone reader PHF14 to modulate TGFβ and Hippo pathways

1
1. scibot 21 Sep 2022
  
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  RRID:Addgene_70183
  
  DOI: 10.1093/nar/gkac766
  
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academic.oup.com/nar/advance-article/doi/10.1093/nar/gkac766/6702467
Jul 2022
52.53.155.43 52.53.155.43

Loss of METTL3 Attenuates Blastic Plasmacytoid Dendritic Cell Neoplasm Response to PRMT5 Inhibition via IFN Signalling

1
1. scibot 01 Jul 2022
  
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  Addgene_70183
  
  DOI: 10.1182/bloodadvances.2021006306
  
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  Curator: @a5munoz
  
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52.53.155.43/677cda7f3a6b5fa0b89c505ec057146e920f9e90/bloodadvances.2021006306-html.html
Jun 2022
52.53.155.43 52.53.155.43

Loss of METTL3 Attenuates Blastic Plasmacytoid Dendritic Cell Neoplasm Response to PRMT5 Inhibition via IFN Signalling

1
1. scibot 25 Jun 2022
  
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  RRID: 90 Addgene_70183
  
  DOI: 10.1182/bloodadvances.2021006306
  
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52.53.155.43/677cda7f3a6b5fa0b89c505ec057146e920f9e90/bloodadvances.2021006306-html.html
May 2022
academic.oup.com academic.oup.com

Stromal cell senescence contributes to impaired endometrial decidualization and defective interaction with trophoblast cells

1
1. scibot 26 May 2022
  
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  Addgene_70183
  
  DOI: 10.1093/humrep/deac112
  
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academic.oup.com/humrep/advance-article/doi/10.1093/humrep/deac112/6590738
Mar 2022
www.nature.com www.nature.com

PLK1 inhibition selectively induces apoptosis in ARID1A deficient cells through uncoupling of oxygen consumption from ATP production

1
1. scibot 10 Mar 2022
  
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  RRID:Addgene_70183
  
  DOI: 10.1038/s41388-022-02219-8
  
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nature.com/articles/s41388-022-02219-8
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Selective modulation of a pan-essential protein as a therapeutic strategy in cancer

1
1. scibot 04 Mar 2022
  
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  RRID:Addgene_70183
  
  DOI: 10.1158/2159-8290.CD-20-1213
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8419012/
May 2021
www.sciencedirect.com www.sciencedirect.com

Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition

1
1. scibot 21 May 2021
  
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  Plasmid_70183
  
  DOI: 10.1016/j.molcel.2021.04.015
  
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scibot

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sciencedirect.com/science/article/pii/S1097276521003208
www.sciencedirect.com www.sciencedirect.com

The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer

1
1. scibot 18 May 2021
  
  in Public
  
  Addgene Cat#70183
  
  DOI: 10.1016/j.cell.2021.04.022
  
  Resource: RRID:Addgene_70183
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_70183
  
  What is this?
  
  RRIDCUR:Missing RRID:Addgene_70183
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RRID:Addgene_70183

RRIDCUR:Missing

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S009286742100502X
Apr 2021
www-sciencedirect-com.ezp.lib.cam.ac.uk www-sciencedirect-com.ezp.lib.cam.ac.uk

An Engineered CRISPR-Cas9 Mouse Line for Simultaneous Readout of Lineage Histories and Gene Expression Profiles in Single Cells

1
1. scibot 23 Apr 2021
  
  in Public
  
  RRID:Addgene_70183
  
  DOI: 10.1016/j.cell.2020.04.048
  
  Resource: RRID:Addgene_70183
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_70183
  
  What is this?
  
  RRID:Addgene_70183
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RRID:Addgene_70183

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scibot

URL

www-sciencedirect-com.ezp.lib.cam.ac.uk/science/article/pii/S0092867420305547
Sep 2020
www.sciencedirect.com www.sciencedirect.com

TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells

1
1. scibot 03 Sep 2020
  
  in Public
  
  Plasmid# 70183
  
  DOI: 10.1016/j.celrep.2020.03.056
  
  Resource: RRID:Addgene_70183
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:Addgene_70183
  
  What is this?
  
  RRID:Addgene_70183
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RRID:Addgene_70183

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scibot

URL

sciencedirect.com/science/article/pii/S2211124720303703
www.sciencedirect.com www.sciencedirect.com

Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection

1
1. scibot 03 Sep 2020
  
  in Public
  
  pFH1tUTG- H1-Tet-sgRNA plasmid
  
  DOI: 10.1016/j.immuni.2020.07.004
  
  Resource: RRID:Addgene_70183
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_70183
  
  Curator comments: FgH1tUTG
  
  What is this?
  
  RRID:Addgene_70183 RRIDCUR:Missing
Visit annotations in context

Tags

RRIDCUR:Missing

RRID:Addgene_70183

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S1074761320302843