76 Matching Annotations
  1. Jul 2026
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    KLF4 Promotes a KRT13+ Hillock-Like State in Lung Squamous Cell Carcinoma
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC13371669/
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Segmentally Duplicated Regulatory Elements Undergo Human-Specific Rewiring
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC13333887/
  4. Jun 2026
  5. ashpublications.org ashpublications.org
    Optimized CRISPR-Cas12a genome-wide screen reveals PTPA phosphatase pathway in fetal hemoglobin silencing
    1
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    ashpublications.org/blood/article/147/17/1999/565976/An-optimized-CRISPR-Cas12a-genome-wide-screen
  6. www.mdpi.com www.mdpi.com
    Long Non-Coding RNA DUXAP10 Promotes Tumorigenesis and Metastasis in Anaplastic Thyroid Cancer
    1
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    mdpi.com/2072-6694/17/23/3852
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The exonic SNP rs11676272-C risk allele mediates diet-induced obesity and reduces enhancer activation
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC13172560/
  8. May 2026
  9. www.sciencedirect.com www.sciencedirect.com
    The circadian gene Dec2 promotes pancreatic cancer progression and dormancy through immune evasion
    1
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    sciencedirect.com/science/article/pii/S1534580726001243
  10. Apr 2026
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    LINE-1 Locus Transcription Nucleates Oncogenic Chromatin Architecture
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC13040219/
  12. www.nature.com www.nature.com
    Catabolism of extracellular glutathione supplies cysteine to support tumours
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    nature.com/articles/s41586-026-10268-2
  13. Mar 2026
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Integrating traditional omics and AI-driven approaches for discovery and validation of novel MicroRNA biomarkers and therapeutic targets in thyroid cancer
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12891075/
  15. www.sciencedirect.com www.sciencedirect.com
    Targeting the ferritinophagy-lysosome axis as a therapeutic vulnerability in gastroenteropancreatic neuroendocrine tumors
    1
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    sciencedirect.com/science/article/pii/S2666379126001126
  16. www.biorxiv.org www.biorxiv.org
    Promoter mutagenesis and a massively parallel reporter screen of the MAPT locus identifies cis-regulatory elements and genetic variation effects
    1
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    biorxiv.org/content/10.64898/2026.03.06.710116v1
  17. Feb 2026
  18. www.sciencedirect.com www.sciencedirect.com
    BRD4-mediated ER membrane contact creates functionally distinct mitochondrial subtypes
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    sciencedirect.com/science/article/pii/S1097276526000328
  19. Jan 2026
  20. www.sciencedirect.com www.sciencedirect.com
    Tissue-specific restriction of transposon-derived regulatory elements safeguards cell-type identity
    2
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    sciencedirect.com/science/article/pii/S221112472501589X
  21. Dec 2025
  22. 54.241.53.176 54.241.53.176
    2025.12.03.692127.full-html.html
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    54.241.53.176/176fcd66c5f9708731e5db404d18c8bd3c524e14/2025.12.03.692127.full-html.html
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Bipolar and schizophrenia risk gene AKAP11 encodes an autophagy receptor coupling the regulation of PKA kinase network homeostasis to synaptic transmission
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12663438/
  24. Nov 2025
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RUNX2 cooperates with SREBP1 to rewire cancer metabolism and promote aggressiveness
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12577400/
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A gene regulatory element modulates myosin expression and controls cardiomyocyte response to stress
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12581865/
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Interrogating subclonal heterogeneity of liver cancer with single-cell multi-omics analysis
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12594797/
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Modification of adipose mass by targeting distal enhancers of Ptrf
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12482881/
  29. 54.241.53.176 54.241.53.176
    1-s2.0-S2589004225023016-main-html.html
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    54.241.53.176/2dc2795dad89007f55257c4b18d6264229fd76eb/1-s2.0-S2589004225023016-main-html.html
  30. Sep 2025
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    hnRNPL–CstF64 complex: coordinating CSR and LSR in IgH locus recombination dynamics through eRNA and NHEJ regulation
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12407099/
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    AAV-dCas9 vector unsilences paternal Ube3a in neurons by impeding Ube3a-ATS transcription
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12405439/
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Stage-specific requirement for METTL3-dependent m6A epitranscriptomic regulation during myogenesis
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12398539/
  34. Jul 2025
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    p62 mRNA suppresses NLRP1 expression in cutaneous SCC cells through miR-34a-5p
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12218052/
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Prion-induced ferroptosis is facilitated by RAC3
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12198409/
  37. Jun 2025
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genetically encoded fluorescent reporter for polyamines
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12117157/
  39. May 2025
  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Reshaping the chromatin landscape in HUVECs from small-for-gestational-age newborns
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    pmc.ncbi.nlm.nih.gov/articles/PMC12038915/
  41. Apr 2025
  42. www.nature.com www.nature.com
    Targeting PIKfyve-driven lipid metabolism in pancreatic cancer
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    nature.com/articles/s41586-025-08917-z
  43. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Involvement of lncRNA MIR205HG in idiopathic pulmonary fibrosis and IL-33 regulation via Alu elements
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11949018/
  44. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    KLF4 promotes a KRT13+ hillock-like state in squamous lung cancer
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11952405/
  45. Mar 2025
  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Tumour-wide RNA splicing aberrations generate actionable public neoantigens
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    pmc.ncbi.nlm.nih.gov/articles/PMC11903331/
  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Inhibition of triglyceride metabolism‐associated enhancers alters lipid deposition during adipocyte differentiation
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11774232/
  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The lncRNA DUBR is regulated by CTCF and coordinates chromatin landscape and gene expression in hematopoietic cells
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11850227/
  49. Dec 2024
  50. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DNA Methylation in the CYP3A Distal Regulatory Region (DRR) Is Associated with the Expression of CYP3A5 and CYP3A7 in Human Liver Samples
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    pmc.ncbi.nlm.nih.gov/articles/PMC11596782/
  51. Nov 2024
  52. www.sciencedirect.com www.sciencedirect.com
    Human genetics identify convergent signals in mitochondrial LACTB-mediated lipid metabolism in cardiovascular-kidney-metabolic syndrome
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    sciencedirect.com/science/article/pii/S1550413124004030
  53. Sep 2024
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A genetically encoded fluorescent reporter for polyamines
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11383275/
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Exploring the transcriptional cooperation between RUNX2 and its associated elncRNA RAIN
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    ncbi.nlm.nih.gov/pmc/articles/PMC11399121/
  56. Aug 2024
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neuronal MAPT expression is mediated by long-range interactions with cis-regulatory elements
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    ncbi.nlm.nih.gov/pmc/articles/PMC10870142/
  58. Jun 2024
  59. www.sciencedirect.com www.sciencedirect.com
    Cancer-specific epigenome identifies oncogenic hijacking by nuclear factor I family proteins for medulloblastoma progression
    2
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    sciencedirect.com/science/article/pii/S1534580724003307
  60. May 2024
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A CRISPRi/a screening platform to study cellular nutrient transport in diverse microenvironments
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11098743/
  62. Apr 2024
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lineage specific transcription factor waves reprogram neuroblastoma from self-renewal to differentiation
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11039666/
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Fatty acid-binding protein 5 is a functional biomarker and indicator of ferroptosis in cerebral hypoxia
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11039673/
  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrated proteomics reveals autophagy landscape and an autophagy receptor controlling PKA-RI complex homeostasis in neurons
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11006854/
  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting PIKfyve-driven lipid homeostasis as a metabolic vulnerability in pancreatic cancer
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10983929/
  67. Mar 2024
  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Novel meriolin derivatives activate the mitochondrial apoptosis pathway in the presence of antiapoptotic Bcl-2
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10924942/
  69. Feb 2024
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    KDM3B inhibitors disrupt the oncogenic activity of PAX3-FOXO1 in fusion-positive rhabdomyosarcoma
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10894237/
  71. www.biorxiv.org www.biorxiv.org
    BRD4-mediated epigenetic regulation of endoplasmic reticulum-mitochondria contact sites is governed by the mitochondrial complex III
    1
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    biorxiv.org/content/10.1101/2024.02.02.578646v1
  72. journals.plos.org journals.plos.org
    CRISPR screen for protein inclusion formation uncovers a role for SRRD in the regulation of intermediate filament dynamics and aggresome assembly
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    journals.plos.org/plosgenetics/article
  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mechanosensitive genomic enhancers potentiate the cellular response to matrix stiffness
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    ncbi.nlm.nih.gov/pmc/articles/PMC10802421/
  74. Sep 2023
  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lorazepam Stimulates IL6 Production and Is Associated with Poor Survival Outcomes in Pancreatic Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10502465/
  76. dx.doi.org dx.doi.org
    FOXA2 Cooperates with Mutant KRAS to Drive Invasive Mucinous Adenocarcinoma of the Lung
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    dx.doi.org/10.1158/0008-5472.CAN-22-2805
  77. www.nature.com www.nature.com
    Netrin-1 blockade inhibits tumor associated Myeloid-derived suppressor cells, cancer stemness and alleviates resistance to chemotherapy and immune checkpoint inhibitor
    1
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    nature.com/articles/s41418-023-01209-x
  78. May 2023
  79. www.embopress.org www.embopress.org
    Presynaptic targeting of botulinum neurotoxin type A requires a tripartite PSG-Syt1-SV2 plasma membrane nanocluster for synaptic vesicle entry
    1
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    embopress.org/doi/10.15252/embj.2022112095
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    UBE2C promotes leptomeningeal dissemination and is a therapeutic target in brain metastatic disease
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10195208/
  81. Apr 2023
  82. www.nature.com www.nature.com
    Optimization of Cas9 activity through the addition of cytosine extensions to single-guide RNAs
    1
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    nature.com/articles/s41551-023-01011-7
  83. Mar 2023
  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of karyopherin β1-mediated nuclear import disrupts oncogenic lineage- defining transcription factor activity in small cell lung cancer
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC9444950/
  85. Dec 2022
  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A novel intergenic enhancer that regulates Bdnf expression in developing cortical neurons
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC9792897/
  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systematic discovery and functional dissection of enhancers needed for cancer cell fitness and proliferation
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    ncbi.nlm.nih.gov/pmc/articles/PMC9687083/
  88. Aug 2022
  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPRi-mediated knock-down of PRDM1/BLIMP1 programs central memory differentiation in ex vivo-expanded human T cells
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC9376159/
  90. Jul 2022
  91. 52.53.155.43 52.53.155.43
    can-21-3713-html.html
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    52.53.155.43/10b1307b786c1d01a6cf28f8a0210c58728fe8fb/can-21-3713-html.html
  92. Jun 2022
  93. link.springer.com link.springer.com
    Repression of HIV-1 reactivation mediated by CRISPR/dCas9-KRAB in lymphoid and myeloid cell models
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    link.springer.com/article/10.1186/s12977-022-00600-9
  94. www.sciencedirect.com www.sciencedirect.com
    Oncofusion-driven de novo enhancer assembly promotes malignancy in Ewing sarcoma via aberrant expression of the stereociliary protein LOXHD1
    1
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    sciencedirect.com/science/article/pii/S2211124722007574
  95. Apr 2022
  96. www.sciencedirect.com www.sciencedirect.com
    CRISPRi-mediated transcriptional silencing in iPSCs for the study of human brain development
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    sciencedirect.com/science/article/pii/S2666166722001654
  97. Mar 2022
  98. link.springer.com link.springer.com
    OVOL2 impairs RHO GTPase signaling to restrain mitosis and aggressiveness of Anaplastic Thyroid Cancer
    1
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    link.springer.com/article/10.1186/s13046-022-02316-2
  99. Dec 2021
  100. link.springer.com link.springer.com
    Loss of hexokinase 1 sensitizes ovarian cancer to high-dose metformin
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    link.springer.com/article/10.1186/s40170-021-00277-2
  101. Aug 2021
  102. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Netrin G1 promotes pancreatic tumorigenesis through cancer associated fibroblast driven nutritional support and immunosuppression
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    ncbi.nlm.nih.gov/pmc/articles/PMC7858242/
  103. May 2021
  104. www.sciencedirect.com www.sciencedirect.com
    Mutations in Spliceosomal Genes PPIL1 and PRP17 Cause Neurodegenerative Pontocerebellar Hypoplasia with Microcephaly
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    sciencedirect.com/science/article/pii/S089662732030859X
  105. Apr 2021
  106. www.sciencedirect.com www.sciencedirect.com
    Cholesterol Pathway Inhibition Induces TGF-β Signaling to Promote Basal Differentiation in Pancreatic Cancer
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    sciencedirect.com/science/article/pii/S1535610820304268
  107. Mar 2021
  108. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of a long non-coding RNA regulator of liver carcinoma cell survival
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    ncbi.nlm.nih.gov/pmc/articles/PMC7884843/
  109. Feb 2021
  110. www.sciencedirect.com www.sciencedirect.com
    The corepressors GPS2 and SMRT control enhancer and silencer remodeling via eRNA transcription during inflammatory activation of macrophages
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    sciencedirect.com/science/article/pii/S1097276520309618
  111. Jan 2021
  112. www.sciencedirect.com www.sciencedirect.com
    Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity
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    sciencedirect.com/science/article/pii/S2666379120302433
  113. Sep 2020
  114. www.cell.com www.cell.com
    Hominoid-Specific Transposable Elements and KZFPs Facilitate Human Embryonic Genome Activation and Control Transcription in Naive Human ESCs
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    cell.com/cell-stem-cell/abstract/S1934-5909(19)30111-0
  115. www.sciencedirect.com www.sciencedirect.com
    Cell Type-Specific Intralocus Interactions Reveal Oligodendrocyte Mechanisms in MS
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    sciencedirect.com/science/article/pii/S0092867420302646