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53 Matching Annotations

Jan 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Treatment of Huntington’s disease with a pan-HTT-targeting CRISPR nuclease

1
1. scibot 26 Jan 2026
  
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  Addgene_71814
  
  DOI: 10.64898/2025.12.20.695720
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12776121/
Nov 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Cdh2, a downstream target of Hes7, regulates somitogenesis by supporting FGF signalling

1
1. scibot 23 Nov 2025
  
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  plasmid_71814
  
  DOI: 10.1242/dev.204743
  
  Resource: RRID:Addgene_71814
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12516320/
Sep 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

CALR Type 1‐Like Mutations Increase Endoplasmic Reticulum Free Ca2+ and Induce ERK1/2 Activation Independent of Thrombopoietin Receptor Activation

1
1. scibot 22 Sep 2025
  
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  RRID:Addgene_71814
  
  DOI: 10.1002/cbin.70053
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12445808/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Deciphering the role of the lncRNA TRIBAL in hepatocyte models

1
1. scibot 07 Sep 2025
  
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  plasmid_71814
  
  DOI: 10.1371/journal.pone.0322975
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12404505/
Aug 2025
www.biorxiv.org www.biorxiv.org

DFFB suppresses interferon to enable cancer persister cell regrowth

1
1. scibot 27 Aug 2025
  
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  RRID:Addgene_71814
  
  DOI: 10.1101/2025.08.15.670603
  
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biorxiv.org/content/10.1101/2025.08.15.670603v1
Jul 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Modeling the t(2;5) Translocation of Anaplastic Large Cell Lymphoma Using CRISPR-Mediated Chromosomal Engineering

1
1. scibot 13 Jul 2025
  
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  plasmid_71
  
  DOI: 10.3390/cancers17132226
  
  Resource: None
  
  Curator: @olekpark
  
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  RRIDCUR:Unresolved RRIDCUR:Incorrect RRID:Addgene_71814
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pmc.ncbi.nlm.nih.gov/articles/PMC12249153/
Jun 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Mitochondrial calcium signaling regulates branched-chain amino acid catabolism in fibrolamellar carcinoma

1
1. scibot 15 Jun 2025
  
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  71814
  
  DOI: 10.1126/sciadv.adu9512
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12118637/
Feb 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Trisomic rescue via allele-specific multiple chromosome cleavage using CRISPR-Cas9 in trisomy 21 cells

1
1. scibot 24 Feb 2025
  
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  plasmid_71814
  
  DOI: 10.1093/pnasnexus/pgaf022
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11832276/
Nov 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Genome-wide mapping of native co-localized G4s and R-loops in living cells

1
1. scibot 08 Nov 2024
  
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  Addgene_71814
  
  DOI: 10.7554/eLife.99026
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11469684/
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Mutant huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure

1
1. scibot 26 Aug 2024
  
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  71814
  
  DOI: 10.1038/s41467-024-51216-w
  
  Resource: RRID:Addgene_71814
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11341898/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The kinesin-3 KIF1C undergoes liquid-liquid phase separation for accumulation of specific transcripts at the cell periphery

1
1. scibot 13 Aug 2024
  
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  71814
  
  DOI: 10.1038/s44318-024-00147-9
  
  Resource: RRID:Addgene_71814
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11294625/
www.researchsquare.com www.researchsquare.com

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1
1. scibot 02 Aug 2024
  
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  RRID :Addgene_71814
  
  DOI: 10.21203/rs.3.rs-1515167/v1
  
  Resource: RRID:Addgene_71814
  
  Curator: @sophiastull
  
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researchsquare.com/article/rs-7216019/'https://www.researchsquare.com/article/rs-7216019/v1
Jul 2024
www.sciencedirect.com www.sciencedirect.com

Systematic dissection of sequence features affecting binding specificity of a pioneer factor reveals binding synergy between FOXA1 and AP-1

1
1. scibot 17 Jul 2024
  
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  RRID:Addgene_71814
  
  DOI: 10.1016/j.molcel.2024.06.022
  
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sciencedirect.com/science/article/pii/S109727652400529X
www.biorxiv.org www.biorxiv.org

Reduced SH3RF3 may protect against Alzheimer’s disease by lowering microglial pro-inflammatory responses via modulation of JNK and NFkB signaling

1
1. scibot 03 Jul 2024
  
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  RRID:Addgene_71814
  
  DOI: 10.1101/2024.06.23.600281
  
  Resource: RRID:Addgene_71814
  
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biorxiv.org/content/10.1101/2024.06.23.600281v1
www.nature.com www.nature.com

PAM-flexible Engineered FnCas9 variants for robust and ultra-precise genome editing and diagnostics

1
1. scibot 01 Jul 2024
  
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  71814
  
  DOI: 10.1038/s41467-024-49233-w
  
  Resource: RRID:Addgene_71814
  
  Curator: @olekpark
  
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nature.com/articles/s41467-024-49233-w
Jun 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Mitochondrial Calcium Signaling Regulates Branched-Chain Amino Acid Catabolism in Fibrolamellar Carcinoma

1
1. scibot 15 Jun 2024
  
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  71814
  
  DOI: 10.1101/2024.05.27.596106
  
  Resource: RRID:Addgene_71814
  
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  RRID:Addgene_71814
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ncbi.nlm.nih.gov/pmc/articles/PMC11160645/
May 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

CD32 captures committed haemogenic endothelial cells during human embryonic development

2
1. scibot 19 May 2024
  
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  Addgene_71814
  
  DOI: 10.1038/s41556-024-01403-0
  
  Resource: RRID:Addgene_71814
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_71814
  
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  RRID:Addgene_71814
2. scibot 19 May 2024
  
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  Addgene_71814
  
  DOI: 10.1038/s41556-024-01403-0
  
  Resource: RRID:Addgene_71814
  
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  RRID:Addgene_71814
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ncbi.nlm.nih.gov/pmc/articles/PMC11098737/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

KCTD Proteins Have Redundant Functions in Controlling Cellular Growth

1
1. scibot 12 May 2024
  
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  Addgene_71814
  
  DOI: 10.3390/ijms25094993
  
  Resource: RRID:Addgene_71814
  
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  RRID:Addgene_71814
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ncbi.nlm.nih.gov/pmc/articles/PMC11084553/
Apr 2024
www.sciencedirect.com www.sciencedirect.com

Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons

1
1. scibot 16 Apr 2024
  
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  AddgeneCat#71814; http://n2t.net/addgene:71814; RRID:Addgene_71814
  
  DOI: 10.1016/j.stem.2024.03.013
  
  Resource: RRID:Addgene_71814
  
  Curator: @abever99
  
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  RRID:Addgene_71814
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sciencedirect.com/science/article/pii/S1934590924000948
Feb 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

SpCas9-HF1 enhances accuracy of cell cycle-dependent genome editing by increasing HDR efficiency, and by reducing off-target effects and indel rates

1
1. scibot 13 Feb 2024
  
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  plasmid_71814
  
  DOI: 10.1016/j.omtn.2024.102124
  
  Resource: RRID:Addgene_71814
  
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  RRID:Addgene_71814
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ncbi.nlm.nih.gov/pmc/articles/PMC10848011/
www.nature.com www.nature.com

CRISPR/Cas9-mediated deletion of a GA-repeat in human GPM6B leads to disruption of neural cell differentiation from NT2 cells

1
1. scibot 01 Feb 2024
  
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  RRID:Addgene_71814
  
  DOI: 10.1038/s41598-024-52675-3
  
  Resource: RRID:Addgene_71814
  
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  RRID:Addgene_71814
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nature.com/articles/s41598-024-52675-3
Jan 2024
www.nature.com www.nature.com

CRISPR/Cas9-mediated deletion of a GA-repeat in human GPM6B leads to disruption of neural cell differentiation from NT2 cells

1
1. scibot 30 Jan 2024
  
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  RRID:Addgene_71814
  
  DOI: 10.1038/s41598-024-52675-3
  
  Resource: RRID:Addgene_71814
  
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nature.com/articles/s41598-024-52675-3
Nov 2023
link.springer.com link.springer.com

The Development of SpCas9 Variants with High Specificity and Efficiency Based on the HH Theory

1
1. scibot 25 Nov 2023
  
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  RRID:Addgene_71814
  
  DOI: 10.1134/S0026893324010187
  
  Resource: RRID:Addgene_71814
  
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link.springer.com/article/10.1134/S0026893324010187
www.sciencedirect.com www.sciencedirect.com

Unexpected extra exon skipping in the DYSF gene during restoring the reading frame by CRISPR/Cas9

1
1. scibot 17 Nov 2023
  
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  RRID:Addgene_71814
  
  DOI: 10.1016/j.biosystems.2023.105072
  
  Resource: RRID:Addgene_71814
  
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sciencedirect.com/science/article/pii/S0303264723002472
www.biorxiv.org www.biorxiv.org

Systematic Dissection of Sequence Features Affecting the Binding Specificity of a Pioneer Factor Reveals Binding Synergy Between FOXA1 and AP-1

1
1. scibot 17 Nov 2023
  
  in Public
  
  RRID:Addgene_71814
  
  DOI: 10.1101/2023.11.08.566246
  
  Resource: RRID:Addgene_71814
  
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biorxiv.org/content/10.1101/2023.11.08.566246v1
Oct 2023
www.sciencedirect.com www.sciencedirect.com

Repurposing of glycine transport inhibitors for the treatment of erythropoietic protoporphyria

1
1. scibot 23 Oct 2023
  
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  RRID:Addgene_71814
  
  DOI: 10.1016/j.chembiol.2021.02.021
  
  Resource: RRID:Addgene_71814
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_71814
  
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  RRIDCUR:Validated RRID:Addgene_71814
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sciencedirect.com/science/article/pii/S2451945621001069
Sep 2023
www.sciencedirect.com www.sciencedirect.com

Generating high-fidelity cochlear organoids from human pluripotent stem cells

1
1. scibot 29 Sep 2023
  
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  Addgene_71814
  
  DOI: 10.1016/j.stem.2023.06.006
  
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sciencedirect.com/science/article/pii/S1934590923002175
May 2023
www.sciencedirect.com www.sciencedirect.com

Differential cell-cycle control by oscillatory versus sustained Hes1 expression via p21

1
1. scibot 18 May 2023
  
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  RRID:Addgene_71814
  
  DOI: 10.1016/j.celrep.2023.112520
  
  Resource: RRID:Addgene_71814
  
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sciencedirect.com/science/article/pii/S2211124723005314
Apr 2023
www.sciencedirect.com www.sciencedirect.com

Deleting specific residues from the HNH linkers creates a CRISPR-SpCas9 variant with high fidelity and efficiency

1
1. scibot 29 Apr 2023
  
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  RRID:Addgene_71814
  
  DOI: 10.1016/j.jbiotec.2023.04.008
  
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sciencedirect.com/science/article/pii/S0168165623000809
www.mdpi.com www.mdpi.com

Bridging Gaps in HDR Improvement: The Role of MAD2L2, SCAI, and SCR7

1
1. scibot 08 Apr 2023
  
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  RRID:Addgene_71814
  
  DOI: 10.3390/ijms24076704
  
  Resource: RRID:Addgene_71814
  
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mdpi.com/1422-0067/24/7/6704
Jan 2023
www.sciencedirect.com www.sciencedirect.com

T cell-derived interleukin-22 drives the expression of CD155 by cancer cells to suppress NK cell function and promote metastasis

1
1. scibot 12 Jan 2023
  
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  RRID:Addgene_71814
  
  DOI: 10.1016/j.immuni.2022.12.010
  
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sciencedirect.com/science/article/pii/S107476132200646X
currentprotocols.onlinelibrary.wiley.com currentprotocols.onlinelibrary.wiley.com

Determining On-Target, Off-Target, and Copy Number Status of Transgenic Events After CRISPR/Cas9 Targeted AAVS1 Safe-Harbor Modification of iPSCs Using Double-Control Quantitative Copy Number PCR

1
1. scibot 12 Jan 2023
  
  in Public
  
  RRID:Addgene_71814
  
  DOI: 10.1002/cpz1.635
  
  Resource: RRID:Addgene_71814
  
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currentprotocols.onlinelibrary.wiley.com/doi/10.1002/cpz1.635
bmccancer.biomedcentral.com bmccancer.biomedcentral.com

The anti-estrogen receptor drug, tamoxifen, is selectively Lethal to P-glycoprotein-expressing Multidrug resistant tumor cells

1
1. scibot 07 Jan 2023
  
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  RRID:Addgene_71814
  
  DOI: 10.1186/s12885-022-10474-x
  
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bmccancer.biomedcentral.com/articles/10.1186/s12885-022-10474-x
Aug 2022
www.sciencedirect.com www.sciencedirect.com

Temporal control of PDGFRα regulates the fibroblast-to-myofibroblast transition in wound healing

1
1. scibot 17 Aug 2022
  
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  Addgene_71814
  
  DOI: 10.1016/j.celrep.2022.111192
  
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sciencedirect.com/science/article/pii/S2211124722010099
Jun 2022
www.researchsquare.com www.researchsquare.com

Home

1
1. scibot 23 Jun 2022
  
  in Public
  
  plasmid_71814
  
  DOI: 10.21203/rs.3.rs-658360/v1
  
  Resource: RRID:Addgene_71814
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_71814
  
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researchsquare.com/article/rs-7216019/'https://www.researchsquare.com/article/rs-7216019/v1
journals.plos.org journals.plos.org

Investigating CRISPR/Cas9 gene drive for production of disease-preventing prion gene alleles

1
1. scibot 09 Jun 2022
  
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  RRID:Addgene_71814
  
  DOI: 10.1371/journal.pone.0269342
  
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journals.plos.org/plosone/article
May 2022
link.springer.com link.springer.com

Rational Design of ssODN to Correct Mutations by Gene Editing

1
1. scibot 17 May 2022
  
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  RRID:Addgene_71814
  
  DOI: 10.1134/S0006297922050078
  
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link.springer.com/article/10.1134/S0006297922050078
Apr 2022
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Knockout of P-glycoprotein abolish the collateral sensitivity of CHORC5 multidrug resistant cells

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1. scibot 07 Apr 2022
  
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  RRID:Addgene_71814
  
  DOI: 10.1016/j.bbrc.2022.03.148
  
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sciencedirect.com/science/article/pii/S0006291X22004934
Nov 2021
elifesciences.org elifesciences.org

A functional genetic toolbox for human tissue-derived organoids

1
1. scibot 05 Nov 2021
  
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  plasmid_71814
  
  DOI: 10.7554/eLife.67886
  
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elifesciences.org/articles/67886
Oct 2021
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Tracing the emergence of primordial germ cells from bilaminar disc rabbit embryos and pluripotent stem cells

1
1. scibot 13 Oct 2021
  
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  Plasmid_71814
  
  DOI: 10.1016/j.celrep.2021.109812
  
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sciencedirect.com/science/article/pii/S2211124721012766
Aug 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Untitled document

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1. scibot 13 Aug 2021
  
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  plasmid_71814
  
  DOI: 10.1016/j.molcel.2019.01.027
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6458999/
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CRISPR-Mediated Base Editing Enables Efficient Disruption of Eukaryotic Genes through Induction of STOP Codons

1
1. scibot 04 Aug 2021
  
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  Plasmid_71814
  
  DOI: 10.1016/j.molcel.2017.08.008
  
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sciencedirect.com/science/article/pii/S1097276517306056
Jul 2021
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The E3 Ubiquitin Ligase Mind Bomb 1 Controls Adenovirus Genome Release at the Nuclear Pore Complex

1
1. scibot 31 Jul 2021
  
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  Addgene #71814
  
  DOI: 10.1016/j.celrep.2019.11.064
  
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sciencedirect.com/science/article/pii/S2211124719315554
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Untitled document

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1. scibot 28 Jul 2021
  
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  plasmid_71814
  
  DOI: 10.1016/j.neuron.2017.10.008
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5851281/
Jun 2021
elifesciences.org elifesciences.org

PHAROH lncRNA regulates Myc translation in hepatocellular carcinoma via sequestering TIAR

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1. scibot 05 Jun 2021
  
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  RRID:Addgene_71814
  
  DOI: 10.7554/eLife.68263
  
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elifesciences.org/articles/68263
Apr 2021
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FANCM regulates repair pathway choice at stalled replication forks

1
1. scibot 23 Apr 2021
  
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  Addgene_71814
  
  DOI: 10.1016/j.molcel.2021.03.044
  
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sciencedirect.com/science/article/pii/S1097276521002653
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Repurposing of glycine transport inhibitors for the treatment of erythropoietic protoporphyria

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1. scibot 02 Apr 2021
  
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  RRID:Addgene_71814
  
  DOI: 10.1016/j.chembiol.2021.02.021
  
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sciencedirect.com/science/article/pii/S2451945621001069
Jan 2021
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Critical Roles of Translation Initiation and RNA Uridylation in Endogenous Retroviral Expression and Neural Differentiation in Pluripotent Stem Cells

1
1. scibot 15 Jan 2021
  
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  Addgene_71814
  
  DOI: 10.1016/j.celrep.2020.107715
  
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  RRIDCUR:Validated RRID:Addgene_71814
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sciencedirect.com/science/article/pii/S2211124720306926
Dec 2020
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

MAGE-A3 is a prognostic biomarker for poor clinical outcome in cutaneous squamous cell carcinoma with perineural invasion via modulation of cell proliferation

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1. scibot 07 Dec 2020
  
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  Addgene_71814
  
  DOI: 10.1371/journal.pone.0241551
  
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pubmed.ncbi.nlm.nih.gov/33227008/
Jan 2020
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Trans-Synaptic Signaling through the Glutamate Receptor Delta-1 Mediates Inhibitory Synapse Formation in Cortical Pyramidal Neurons

1
1. scibot 13 Jan 2020
  
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  RRID:Addgene_71814
  
  DOI: 10.1016/j.neuron.2019.09.027
  
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sciencedirect.com/science/article/pii/S0896627319308013
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CD146 Regulates Growth Factor-Induced mTORC2 Activity Independent of the PI3K and mTORC1 Pathways

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1. scibot 13 Jan 2020
  
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  RRID:Addgene_71814
  
  DOI: 10.1016/j.celrep.2019.09.047
  
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sciencedirect.com/science/article/pii/S2211124719312355
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Esrrb Unlocks Silenced Enhancers for Reprogramming to Naive Pluripotency

1
1. scibot 13 Jan 2020
  
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  Plasmid_71814
  
  DOI: 10.1016/j.stem.2018.05.020
  
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  Curator: @Jmenke
  
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  RRID:Addgene_71814 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1934590918302388