77 Matching Annotations
  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Quiescent OXPHOS-High Triple-Negative Breast Cancer Cells That Persist After Chemotherapy Depend on BCL-XL for Survival
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    pmc.ncbi.nlm.nih.gov/articles/PMC12524137/
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cholesterol biosynthesis as a drug-induced vulnerability in diffuse large B cell lymphoma insensitive to EZH2 inhibition
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    pmc.ncbi.nlm.nih.gov/articles/PMC12596957/
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DeepTarget predicts anti-cancer mechanisms of action of small molecules by integrating drug and genetic screens
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    pmc.ncbi.nlm.nih.gov/articles/PMC12589559/
  5. Nov 2025
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Druggable genome CRISPR screening identifies the KEAP1/NRF2 axis as a mediator of PD-L1 expression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12630863/
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Systematic discovery of CRISPR-boosted CAR T cell immunotherapies
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    pmc.ncbi.nlm.nih.gov/articles/PMC12545207/
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Soluble MFGE8 mediates cell entry of Crimean-Congo hemorrhagic fever virus
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    pmc.ncbi.nlm.nih.gov/articles/PMC12505966/
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    UHRF1 restricts HCoV-229E infection through epigenetic silencing of the viral receptor APN
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    pmc.ncbi.nlm.nih.gov/articles/PMC12627610/
  10. www.nature.com www.nature.com
    KLF5 enables dichotomous lineage programs in pancreatic cancer via the AAA+ ATPase coactivators RUVBL1 and RUVBL2
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    nature.com/articles/s41467-025-66007-0
  11. Oct 2025
  12. www.nature.com www.nature.com
    Inducible CRISPR–Cas9 screening platform to interrogate non-proliferative cellular states
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    nature.com/articles/s41596-025-01251-8
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    Biphasic control of the B cell transcriptome by mTORC1 and GSK3
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    sciencedirect.com/science/article/pii/S2211124725011325
  14. Sep 2025
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Oxidative Phosphorylation is a Metabolic Vulnerability of Endocrine Therapy-Tolerant Persister Cells in ER+ Breast Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11908958/
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    d-cysteine impairs tumour growth by inhibiting cysteine desulfurase NFS1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12373508/
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Glycosylphosphatidylinositol biosynthesis functions as a conserved host defense pathway against coronaviruses via regulation of LY6E
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    pmc.ncbi.nlm.nih.gov/articles/PMC12407461/
  18. Aug 2025
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    mtKO: A dedicated guide RNA library for mitochondria research
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    pmc.ncbi.nlm.nih.gov/articles/PMC12304920/
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Virus-human chromatin interactions reorganise 3D genome and hijack KDM5B for promoting metastasis in nasopharyngeal carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12322282/
  21. Jul 2025
  22. www.sciencedirect.com www.sciencedirect.com
    HIF-independent oxygen sensing via KDM6A regulates ferroptosis
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    sciencedirect.com/science/article/pii/S1097276525005805
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    BLIMP1 negatively regulates IL-2 signaling in T cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12273773/
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    FAF2 is a bifunctional regulator of peroxisomal homeostasis and saturated lipid responses
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    pmc.ncbi.nlm.nih.gov/articles/PMC12219479/
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Opposing roles of pseudokinases NRBP1 and NRBP2 in regulating L1 retrotransposition
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    pmc.ncbi.nlm.nih.gov/articles/PMC12254500/
  26. Jun 2025
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Signal-induced NLRP3 phase separation initiates inflammasome activation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12134225/
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Resistance Signatures Manifested in Early Drug Response in Cancer and Across Species
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    pmc.ncbi.nlm.nih.gov/articles/PMC12132492/
  29. www.sciencedirect.com www.sciencedirect.com
    CRAMP1 drives linker histone expression to enable Polycomb repression
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    sciencedirect.com/science/article/pii/S1097276525004708
  30. 52.53.155.43 52.53.155.43
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  31. May 2025
  32. www.sciencedirect.com www.sciencedirect.com
    A specific form of cPRC1 containing CBX4 is co-opted to mediate oncogenic gene repression in diffuse midline glioma
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    sciencedirect.com/science/article/pii/S1097276525004058
  33. Apr 2025
  34. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/10.1111/febs.70099
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    m6A modification regulates cell proliferation via reprogramming the balance between glycolysis and pentose phosphate pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC11947274/
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-wide CRISPR screen identifies BUB1 kinase as a druggable vulnerability in malignant pleural mesothelioma
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    pmc.ncbi.nlm.nih.gov/articles/PMC11968822/
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-wide CRISPR/Cas9 screen reveals factors that influence the susceptibility of tumor cells to NK cell-mediated killing
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    pmc.ncbi.nlm.nih.gov/articles/PMC11962812/
  38. Feb 2025
  39. www.sciencedirect.com www.sciencedirect.com
    Potentiating anti-tumor immunity by re-engaging immune synapse molecules
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    sciencedirect.com/science/article/pii/S2666379125000485
  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CRISPR screen reveals modifiers of rAAV production including known rAAV infection genes playing an unexpected role in vector production
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    pmc.ncbi.nlm.nih.gov/articles/PMC11840188/
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The O-glycosyltransferase C1GALT1 promotes EWSR1::FLI1 expression and is a therapeutic target for Ewing sarcoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC11788431/
  42. Jan 2025
  43. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SLC35A2 gene product modulates paramyxovirus fusion events during infection
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    pmc.ncbi.nlm.nih.gov/articles/PMC11756793/
  44. www.sciencedirect.com www.sciencedirect.com
    1-s2.0-S2589004224027901-main-html.html
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  45. Nov 2024
  46. www.biorxiv.org www.biorxiv.org
    Endocrine persistence in ER+ breast cancer is accompanied by metabolic vulnerability in oxidative phosphorylation
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    biorxiv.org/content/10.1101/2024.09.26.615177v1
  47. Sep 2024
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide CRISPR screenings identified SMCHD1 as a host-restricting factor for AAV transduction
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    ncbi.nlm.nih.gov/pmc/articles/PMC11257396/
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TOPORS E3 ligase mediates resistance to hypomethylating agent cytotoxicity in acute myeloid leukemia cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11358519/
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Genome-Wide CRISPR Screen Identifies BRD4 as a Regulator of Cardiomyocyte Differentiation
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    ncbi.nlm.nih.gov/pmc/articles/PMC11361716/
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Gα13 restricts nutrient driven proliferation in mucosal germinal centers
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    ncbi.nlm.nih.gov/pmc/articles/PMC11362015/
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SLC35A2 modulates paramyxovirus fusion events during infection
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    ncbi.nlm.nih.gov/pmc/articles/PMC11382999/
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Decoding RNA Metabolism by RNA-linked CRISPR Screening in Human Cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11291135/
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Unbiased screening identifies regulators of cell-cell adhesion and treatment options in pemphigus
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    ncbi.nlm.nih.gov/pmc/articles/PMC11399147/
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    GeneRaMeN enables integration, comparison, and meta-analysis of multiple ranked gene lists to identify consensus, unique, and correlated genes
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    ncbi.nlm.nih.gov/pmc/articles/PMC11410378/
  56. Aug 2024
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide CRISPR/Cas9 screen identifies SLC39A9 and PIK3C3 as crucial entry factors for Ebola virus infection
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    ncbi.nlm.nih.gov/pmc/articles/PMC11341029/
  58. www.sciencedirect.com www.sciencedirect.com
    In vivo vulnerabilities to GPX4 and HDAC inhibitors in drug-persistent versus drug-resistant BRAFV600E lung adenocarcinoma
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    sciencedirect.com/science/article/pii/S266637912400377X
  59. Jul 2024
  60. www.sciencedirect.com www.sciencedirect.com
    IRF4 requires ARID1A to establish plasma cell identity in multiple myeloma
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    sciencedirect.com/science/article/pii/S1535610824002174
  61. www.sciencedirect.com www.sciencedirect.com
    Synthetic lethal CRISPR screen identifies a cancer cell-intrinsic role of PD-L1 in regulation of vulnerability to ferroptosis
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    sciencedirect.com/science/article/pii/S2211124724008064
  62. Jun 2024
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR/Cas9 screening reveals a distinct class of MHC-I binders with precise HLA-peptide recognition
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    ncbi.nlm.nih.gov/pmc/articles/PMC11209011/
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A genome-scale screen identifies sulfated glycosaminoglycans as pivotal in epithelial cell damage by Candida albicans
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    ncbi.nlm.nih.gov/pmc/articles/PMC11142209/
  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A synthetic lethal dependency on casein kinase 2 in response to replication-perturbing therapeutics in RB1-deficient cancer cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11114247/
  66. May 2024
  67. www.sciencedirect.com www.sciencedirect.com
    Molecular targets of glucocorticoids that elucidate their therapeutic efficacy in aggressive lymphomas
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    sciencedirect.com/science/article/pii/S1535610824001314
  68. Apr 2024
  69. www.sciencedirect.com www.sciencedirect.com
    GPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in hematologic malignancies
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    sciencedirect.com/science/article/pii/S1097276524002843
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Thymidine nucleotide metabolism controls human telomere length
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    ncbi.nlm.nih.gov/pmc/articles/PMC11000509/
  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functional CRISPR screens in T cells reveal new opportunities for cancer immunotherapies
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    ncbi.nlm.nih.gov/pmc/articles/PMC10996278/
  72. www.sciencedirect.com www.sciencedirect.com
    Targeting the GPI transamidase subunit GPAA1 abrogates the CD24 immune checkpoint in ovarian cancer
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    sciencedirect.com/science/article/pii/S2211124724003693
  73. Mar 2024
  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A whole-genome CRISPR screen identifies the spindle accessory checkpoint as a locus of nab-paclitaxel resistance in pancreatic cancer cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10896345/
  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PRMT5 is an actionable therapeutic target in CDK4/6 inhibitor-resistant ER+/RB-deficient breast cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10937713/
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Estrogen therapy induces receptor-dependent DNA damage enhanced by PARP inhibition in ER+ breast cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10528687/
  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting DHX9 Triggers Tumor-Intrinsic Interferon Response and Replication Stress in Small Cell Lung Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10905673/
  78. Feb 2024
  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sequential CRISPR screening reveals partial NatB inhibition as a strategy to mitigate alpha-synuclein levels in human neurons
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    ncbi.nlm.nih.gov/pmc/articles/PMC10857481/
  80. journals.plos.org journals.plos.org
    CRISPR screen for protein inclusion formation uncovers a role for SRRD in the regulation of intermediate filament dynamics and aggresome assembly
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    journals.plos.org/plosgenetics/article
  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting N-linked Glycosylation for the Therapy of Aggressive Lymphomas
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    ncbi.nlm.nih.gov/pmc/articles/PMC10524254/
  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mitochondrial-encoded complex I impairment induces a targetable dependency on aerobic fermentation in Hürthle cell carcinoma of the thyroid
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    ncbi.nlm.nih.gov/pmc/articles/PMC10524862/
  83. Dec 2023
  84. www.sciencedirect.com www.sciencedirect.com
    Single-cell functional genomics reveals determinants of sensitivity and resistance to natural killer cells in blood cancers
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    sciencedirect.com/science/article/pii/S1074761323004909
  85. Sep 2023
  86. www.nature.com www.nature.com
    Targeting cell cycle and apoptosis to overcome chemotherapy resistance in acute myeloid leukemia
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    nature.com/articles/s41375-022-01755-2
  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Comprehensive mapping of cell fates in microsatellite unstable cancer cells support dual targe6ng of WRN and ATR
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    ncbi.nlm.nih.gov/pmc/articles/PMC10473727/
  88. Jan 2023
  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A whole genome CRISPR screen identifies AHR loss as a mechanism of PARP7 inhibitor resistancePARP7 inhibitor CRISPR screen
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    ncbi.nlm.nih.gov/pmc/articles/PMC9769698/
  90. Nov 2022
  91. www.sciencedirect.com www.sciencedirect.com
    Dynamic quality control machinery that operates across compartmental borders mediates the degradation of mammalian nuclear membrane proteins
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    sciencedirect.com/science/article/pii/S2211124722015492
  92. Jun 2022
  93. 52.53.155.43 52.53.155.43
    mct-21-0841-html.html
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    52.53.155.43/75ea23e6e3f1fdb6f00b33953ca7605cb8248fa3/mct-21-0841 (2)-html.html
  94. Jul 2021
  95. www.embopress.org www.embopress.org
    A genome‐wide screen identifies IRF2 as a key regulator of caspase‐4 in human cells
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    embopress.org/doi/full/10.15252/embr.201948235
  96. May 2021
  97. www.sciencedirect.com www.sciencedirect.com
    Genome-wide Screens Identify Lineage- and Tumor-Specific Genes Modulating MHC-I- and MHC-II-Restricted Immunosurveillance of Human Lymphomas
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    sciencedirect.com/science/article/pii/S1074761320304672
  98. Apr 2021
  99. www.sciencedirect.com www.sciencedirect.com
    The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure
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    sciencedirect.com/science/article/pii/S1550413120306586
  100. www.sciencedirect.com www.sciencedirect.com
    Illuminating Host-Mycobacterial Interactions with Genome-wide CRISPR Knockout and CRISPRi Screens
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    sciencedirect.com/science/article/pii/S2405471220302945
  101. Feb 2021
  102. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A pooled genome-wide screening strategy to identify and rank influenza host restriction factors in cell-based vaccine production platforms
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    ncbi.nlm.nih.gov/pmc/articles/PMC7376217/
  103. Jan 2021
  104. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks
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    ncbi.nlm.nih.gov/pmc/articles/PMC7796900/
  105. www.sciencedirect.com www.sciencedirect.com
    USP15 Deubiquitinase Safeguards Hematopoiesis and Genome Integrity in Hematopoietic Stem Cells and Leukemia Cells
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    sciencedirect.com/science/article/pii/S2211124720315229