94 Matching Annotations
  1. Last 7 days
  2. www.nature.com www.nature.com
    Genome-wide CRISPR screens identify an RXR–MYLIP–LDLR axis regulating BH3 mimetic sensitivity in peripheral T-cell lymphomas
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    nature.com/articles/s41388-026-03970-y
  3. Aug 2026
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Disease Gene THAP12 is a Transcriptional Regulator of Mitochondrial ETC Complex I
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    pmc.ncbi.nlm.nih.gov/articles/PMC13404843/
  5. Jun 2026
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-wide CRISPR screen identifies a cytokine-enhancer circuit driving HIF-2α activation in renal cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13178659/
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Cyclin C-CDK8/19 Mediator kinase module controls PRCC-TFE3 driven senescence in renal epithelium and tumorigenesis in TFE3-RCC
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    pmc.ncbi.nlm.nih.gov/articles/PMC13069303/
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Endogenous protein tagging coupled with a CRISPR screening approach identifies UBE3C as a potential MYC oncogene regulator
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    pmc.ncbi.nlm.nih.gov/articles/PMC13076874/
  9. Apr 2026
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Prion propagation is controlled by a hierarchical network involving the nuclear Tfap2c and hnRNP K factors and the cytosolic mTORC1 complex
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    pmc.ncbi.nlm.nih.gov/articles/PMC13108870/
  11. www.sciencedirect.com www.sciencedirect.com
    Systematic discovery of pro- and anti-HIV host factors in primary human CD4+ T cells
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    sciencedirect.com/science/article/pii/S009286742600382X
  12. www.biorxiv.org www.biorxiv.org
    Marker-based CRISPR screens identify POU2F1 as a regulator of DLL3 and neuroendocrine identity in small cell lung cancer
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    biorxiv.org/content/10.64898/2026.04.08.717069v1
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Protocol to identify SINE-VNTR-Alu regulators using genome-wide screening in human K562 cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC13058971/
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Fidelity-Ensuring Consistency of Mitosis is Safeguarded by the 53BP1-USP28-p53 Pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC13015497/
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The aryl hydrocarbon receptor (AHR) drives human leukocyte antigen (HLA)-II expression in human melanoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC13032475/
  16. Mar 2026
  17. www.biorxiv.org www.biorxiv.org
    SMAD4 loss drives chromosomal instability during tumourigenesis via translational reprogramming
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    biorxiv.org/content/10.64898/2026.03.23.712291v1
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-wide CRISPR screen identifies neddylation as a regulator of neuronal aging and AD neurodegeneration
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    pmc.ncbi.nlm.nih.gov/articles/PMC12973372/
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pharmacological Inhibition of SLC33A1 Promotes Endoplasmic Reticulum Hyperoxidation and Induces Adaptive IRE1/XBP1s Signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC12934820/
  20. Feb 2026
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    BRRIAR lncRNA alters breast cancer risk by modulating interferon signaling in cis and in trans
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    pmc.ncbi.nlm.nih.gov/articles/PMC12777463/
  22. Jan 2026
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Target Discovery in Head-and-Neck Squamous Cell Carcinoma: Genome-Wide CRISPR Screens Illuminate Therapeutic Resistance and Actionable Dependencies
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    pmc.ncbi.nlm.nih.gov/articles/PMC12730985/
  24. Dec 2025
  25. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    Cell-surface RNA forms ternary complex with RNA-binding proteins and heparan sulfate to recruit immune receptors
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    sciencedirect.com:5037/science/article/pii/S1097276525009372
  26. Nov 2025
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Quiescent OXPHOS-High Triple-Negative Breast Cancer Cells That Persist After Chemotherapy Depend on BCL-XL for Survival
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    pmc.ncbi.nlm.nih.gov/articles/PMC12524137/
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cholesterol biosynthesis as a drug-induced vulnerability in diffuse large B cell lymphoma insensitive to EZH2 inhibition
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    pmc.ncbi.nlm.nih.gov/articles/PMC12596957/
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DeepTarget predicts anti-cancer mechanisms of action of small molecules by integrating drug and genetic screens
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    pmc.ncbi.nlm.nih.gov/articles/PMC12589559/
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Druggable genome CRISPR screening identifies the KEAP1/NRF2 axis as a mediator of PD-L1 expression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12630863/
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Systematic discovery of CRISPR-boosted CAR T cell immunotherapies
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    pmc.ncbi.nlm.nih.gov/articles/PMC12545207/
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Soluble MFGE8 mediates cell entry of Crimean-Congo hemorrhagic fever virus
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    pmc.ncbi.nlm.nih.gov/articles/PMC12505966/
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    UHRF1 restricts HCoV-229E infection through epigenetic silencing of the viral receptor APN
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    pmc.ncbi.nlm.nih.gov/articles/PMC12627610/
  34. www.nature.com www.nature.com
    KLF5 enables dichotomous lineage programs in pancreatic cancer via the AAA+ ATPase coactivators RUVBL1 and RUVBL2
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    nature.com/articles/s41467-025-66007-0
  35. Oct 2025
  36. www.nature.com www.nature.com
    Inducible CRISPR–Cas9 screening platform to interrogate non-proliferative cellular states
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    nature.com/articles/s41596-025-01251-8
  37. www.sciencedirect.com www.sciencedirect.com
    Biphasic control of the B cell transcriptome by mTORC1 and GSK3
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    sciencedirect.com/science/article/pii/S2211124725011325
  38. Sep 2025
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Oxidative Phosphorylation is a Metabolic Vulnerability of Endocrine Therapy-Tolerant Persister Cells in ER+ Breast Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11908958/
  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    d-cysteine impairs tumour growth by inhibiting cysteine desulfurase NFS1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12373508/
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Glycosylphosphatidylinositol biosynthesis functions as a conserved host defense pathway against coronaviruses via regulation of LY6E
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    pmc.ncbi.nlm.nih.gov/articles/PMC12407461/
  42. Aug 2025
  43. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    mtKO: A dedicated guide RNA library for mitochondria research
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    pmc.ncbi.nlm.nih.gov/articles/PMC12304920/
  44. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Virus-human chromatin interactions reorganise 3D genome and hijack KDM5B for promoting metastasis in nasopharyngeal carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12322282/
  45. Jul 2025
  46. www.sciencedirect.com www.sciencedirect.com
    HIF-independent oxygen sensing via KDM6A regulates ferroptosis
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    sciencedirect.com/science/article/pii/S1097276525005805
  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    BLIMP1 negatively regulates IL-2 signaling in T cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12273773/
  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    FAF2 is a bifunctional regulator of peroxisomal homeostasis and saturated lipid responses
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    pmc.ncbi.nlm.nih.gov/articles/PMC12219479/
  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Opposing roles of pseudokinases NRBP1 and NRBP2 in regulating L1 retrotransposition
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    pmc.ncbi.nlm.nih.gov/articles/PMC12254500/
  50. Jun 2025
  51. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Signal-induced NLRP3 phase separation initiates inflammasome activation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12134225/
  52. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Resistance Signatures Manifested in Early Drug Response in Cancer and Across Species
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    pmc.ncbi.nlm.nih.gov/articles/PMC12132492/
  53. www.sciencedirect.com www.sciencedirect.com
    CRAMP1 drives linker histone expression to enable Polycomb repression
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    sciencedirect.com/science/article/pii/S1097276525004708
  54. 52.53.155.43 52.53.155.43
    PDF-html.html
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    52.53.155.43/6d05284590fa38103d7fbc1633c815ab1c347fcd/PDF-html.html
  55. May 2025
  56. www.sciencedirect.com www.sciencedirect.com
    A specific form of cPRC1 containing CBX4 is co-opted to mediate oncogenic gene repression in diffuse midline glioma
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    sciencedirect.com/science/article/pii/S1097276525004058
  57. Apr 2025
  58. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/10.1111/febs.70099
  59. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    m6A modification regulates cell proliferation via reprogramming the balance between glycolysis and pentose phosphate pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC11947274/
  60. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-wide CRISPR screen identifies BUB1 kinase as a druggable vulnerability in malignant pleural mesothelioma
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    pmc.ncbi.nlm.nih.gov/articles/PMC11968822/
  61. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-wide CRISPR/Cas9 screen reveals factors that influence the susceptibility of tumor cells to NK cell-mediated killing
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    pmc.ncbi.nlm.nih.gov/articles/PMC11962812/
  62. Feb 2025
  63. www.sciencedirect.com www.sciencedirect.com
    Potentiating anti-tumor immunity by re-engaging immune synapse molecules
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    sciencedirect.com/science/article/pii/S2666379125000485
  64. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CRISPR screen reveals modifiers of rAAV production including known rAAV infection genes playing an unexpected role in vector production
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    pmc.ncbi.nlm.nih.gov/articles/PMC11840188/
  65. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The O-glycosyltransferase C1GALT1 promotes EWSR1::FLI1 expression and is a therapeutic target for Ewing sarcoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC11788431/
  66. Jan 2025
  67. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SLC35A2 gene product modulates paramyxovirus fusion events during infection
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    pmc.ncbi.nlm.nih.gov/articles/PMC11756793/
  68. www.sciencedirect.com www.sciencedirect.com
    1-s2.0-S2589004224027901-main-html.html
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    sciencedirect.com/science/article/pii/S2589004224027901
  69. Nov 2024
  70. www.biorxiv.org www.biorxiv.org
    Endocrine persistence in ER+ breast cancer is accompanied by metabolic vulnerability in oxidative phosphorylation
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    biorxiv.org/content/10.1101/2024.09.26.615177v1
  71. Sep 2024
  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide CRISPR screenings identified SMCHD1 as a host-restricting factor for AAV transduction
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    ncbi.nlm.nih.gov/pmc/articles/PMC11257396/
  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TOPORS E3 ligase mediates resistance to hypomethylating agent cytotoxicity in acute myeloid leukemia cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11358519/
  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Genome-Wide CRISPR Screen Identifies BRD4 as a Regulator of Cardiomyocyte Differentiation
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    ncbi.nlm.nih.gov/pmc/articles/PMC11361716/
  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Gα13 restricts nutrient driven proliferation in mucosal germinal centers
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    ncbi.nlm.nih.gov/pmc/articles/PMC11362015/
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SLC35A2 modulates paramyxovirus fusion events during infection
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    ncbi.nlm.nih.gov/pmc/articles/PMC11382999/
  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Decoding RNA Metabolism by RNA-linked CRISPR Screening in Human Cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11291135/
  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Unbiased screening identifies regulators of cell-cell adhesion and treatment options in pemphigus
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    ncbi.nlm.nih.gov/pmc/articles/PMC11399147/
  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    GeneRaMeN enables integration, comparison, and meta-analysis of multiple ranked gene lists to identify consensus, unique, and correlated genes
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    ncbi.nlm.nih.gov/pmc/articles/PMC11410378/
  80. Aug 2024
  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide CRISPR/Cas9 screen identifies SLC39A9 and PIK3C3 as crucial entry factors for Ebola virus infection
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    ncbi.nlm.nih.gov/pmc/articles/PMC11341029/
  82. www.sciencedirect.com www.sciencedirect.com
    In vivo vulnerabilities to GPX4 and HDAC inhibitors in drug-persistent versus drug-resistant BRAFV600E lung adenocarcinoma
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    sciencedirect.com/science/article/pii/S266637912400377X
  83. Jul 2024
  84. www.sciencedirect.com www.sciencedirect.com
    IRF4 requires ARID1A to establish plasma cell identity in multiple myeloma
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    sciencedirect.com/science/article/pii/S1535610824002174
  85. www.sciencedirect.com www.sciencedirect.com
    Synthetic lethal CRISPR screen identifies a cancer cell-intrinsic role of PD-L1 in regulation of vulnerability to ferroptosis
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    sciencedirect.com/science/article/pii/S2211124724008064
  86. Jun 2024
  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR/Cas9 screening reveals a distinct class of MHC-I binders with precise HLA-peptide recognition
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    ncbi.nlm.nih.gov/pmc/articles/PMC11209011/
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A genome-scale screen identifies sulfated glycosaminoglycans as pivotal in epithelial cell damage by Candida albicans
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    ncbi.nlm.nih.gov/pmc/articles/PMC11142209/
  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A synthetic lethal dependency on casein kinase 2 in response to replication-perturbing therapeutics in RB1-deficient cancer cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11114247/
  90. May 2024
  91. www.sciencedirect.com www.sciencedirect.com
    Molecular targets of glucocorticoids that elucidate their therapeutic efficacy in aggressive lymphomas
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    sciencedirect.com/science/article/pii/S1535610824001314
  92. Apr 2024
  93. www.sciencedirect.com www.sciencedirect.com
    GPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in hematologic malignancies
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    sciencedirect.com/science/article/pii/S1097276524002843
  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Thymidine nucleotide metabolism controls human telomere length
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    ncbi.nlm.nih.gov/pmc/articles/PMC11000509/
  95. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functional CRISPR screens in T cells reveal new opportunities for cancer immunotherapies
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    ncbi.nlm.nih.gov/pmc/articles/PMC10996278/
  96. www.sciencedirect.com www.sciencedirect.com
    Targeting the GPI transamidase subunit GPAA1 abrogates the CD24 immune checkpoint in ovarian cancer
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    sciencedirect.com/science/article/pii/S2211124724003693
  97. Mar 2024
  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A whole-genome CRISPR screen identifies the spindle accessory checkpoint as a locus of nab-paclitaxel resistance in pancreatic cancer cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10896345/
  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PRMT5 is an actionable therapeutic target in CDK4/6 inhibitor-resistant ER+/RB-deficient breast cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10937713/
  100. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Estrogen therapy induces receptor-dependent DNA damage enhanced by PARP inhibition in ER+ breast cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10528687/
  101. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting DHX9 Triggers Tumor-Intrinsic Interferon Response and Replication Stress in Small Cell Lung Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10905673/
  102. Feb 2024
  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sequential CRISPR screening reveals partial NatB inhibition as a strategy to mitigate alpha-synuclein levels in human neurons
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    ncbi.nlm.nih.gov/pmc/articles/PMC10857481/
  104. journals.plos.org journals.plos.org
    CRISPR screen for protein inclusion formation uncovers a role for SRRD in the regulation of intermediate filament dynamics and aggresome assembly
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    journals.plos.org/plosgenetics/article
  105. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting N-linked Glycosylation for the Therapy of Aggressive Lymphomas
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    ncbi.nlm.nih.gov/pmc/articles/PMC10524254/
  106. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mitochondrial-encoded complex I impairment induces a targetable dependency on aerobic fermentation in Hürthle cell carcinoma of the thyroid
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    ncbi.nlm.nih.gov/pmc/articles/PMC10524862/
  107. Dec 2023
  108. www.sciencedirect.com www.sciencedirect.com
    Single-cell functional genomics reveals determinants of sensitivity and resistance to natural killer cells in blood cancers
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    sciencedirect.com/science/article/pii/S1074761323004909
  109. Sep 2023
  110. www.nature.com www.nature.com
    Targeting cell cycle and apoptosis to overcome chemotherapy resistance in acute myeloid leukemia
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    nature.com/articles/s41375-022-01755-2
  111. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Comprehensive mapping of cell fates in microsatellite unstable cancer cells support dual targe6ng of WRN and ATR
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    ncbi.nlm.nih.gov/pmc/articles/PMC10473727/
  112. Jan 2023
  113. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A whole genome CRISPR screen identifies AHR loss as a mechanism of PARP7 inhibitor resistancePARP7 inhibitor CRISPR screen
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    ncbi.nlm.nih.gov/pmc/articles/PMC9769698/
  114. Nov 2022
  115. www.sciencedirect.com www.sciencedirect.com
    Dynamic quality control machinery that operates across compartmental borders mediates the degradation of mammalian nuclear membrane proteins
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    sciencedirect.com/science/article/pii/S2211124722015492
  116. Jun 2022
  117. 52.53.155.43 52.53.155.43
    mct-21-0841-html.html
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    52.53.155.43/75ea23e6e3f1fdb6f00b33953ca7605cb8248fa3/mct-21-0841 (2)-html.html
  118. Jul 2021
  119. www.embopress.org www.embopress.org
    A genome‐wide screen identifies IRF2 as a key regulator of caspase‐4 in human cells
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    embopress.org/doi/full/10.15252/embr.201948235
  120. May 2021
  121. www.sciencedirect.com www.sciencedirect.com
    Genome-wide Screens Identify Lineage- and Tumor-Specific Genes Modulating MHC-I- and MHC-II-Restricted Immunosurveillance of Human Lymphomas
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    sciencedirect.com/science/article/pii/S1074761320304672
  122. Apr 2021
  123. www.sciencedirect.com www.sciencedirect.com
    The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure
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    sciencedirect.com/science/article/pii/S1550413120306586
  124. www.sciencedirect.com www.sciencedirect.com
    Illuminating Host-Mycobacterial Interactions with Genome-wide CRISPR Knockout and CRISPRi Screens
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    sciencedirect.com/science/article/pii/S2405471220302945
  125. Feb 2021
  126. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A pooled genome-wide screening strategy to identify and rank influenza host restriction factors in cell-based vaccine production platforms
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    ncbi.nlm.nih.gov/pmc/articles/PMC7376217/
  127. Jan 2021
  128. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks
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    ncbi.nlm.nih.gov/pmc/articles/PMC7796900/
  129. www.sciencedirect.com www.sciencedirect.com
    USP15 Deubiquitinase Safeguards Hematopoiesis and Genome Integrity in Hematopoietic Stem Cells and Leukemia Cells
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    sciencedirect.com/science/article/pii/S2211124720315229