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Genome-wide CRISPR screening identifies cellular factors controlling nonviral genome editing efficiency

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1. scibot 27 Aug 2026
  
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  Addgene_73179
  
  DOI: 10.1038/s41467-026-76350-5
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13473100/
Aug 2026
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Orthogonal CRISPR screens and human liver chimeric mice identify hepatitis B virus host factors

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1. scibot 08 Aug 2026
  
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  RRID:Addgene_73179
  
  DOI: 10.64898/2026.07.23.740386
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13420443/
Jul 2026
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FATP2-mediated lipid metabolism enhances chimeric antigen receptor T-cell therapy resistance in B-cell acute lymphoblastic leukemia

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1. scibot 03 Jul 2026
  
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  Addgene_73179
  
  DOI: 10.1038/s41375-026-03030-0
  
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nature.com/articles/s41375-026-03030-0
Jun 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Genome-wide CRISPR screens identify DNA repair and R-loop suppression as regulators of the cellular sensitivity to environmentally relevant Bisphenol A exposure

1
1. scibot 10 Jun 2026
  
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  73179
  
  DOI: 10.64898/2026.04.13.718249
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13105094/
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Glucose restriction reprograms lipid metabolism and enhances immunotherapy through ZNRF3-Wnt-SCD signaling axis

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1. scibot 10 Jun 2026
  
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  Addgene_73179
  
  DOI: 10.1136/jitc-2026-014927
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13239590/
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ZAP targets aberrant mRNA transcripts encoding proteins with defective signal peptides for degradation

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1. scibot 06 Jun 2026
  
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  73179
  
  DOI: 10.1038/s44318-026-00720-4
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13084044/
May 2026
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Intrinsic bias of the genetic code shapes the folding and stability landscapes of microproteins

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1. scibot 20 May 2026
  
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  Addgene_73179
  
  DOI: 10.1016/j.molcel.2026.04.021
  
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sciencedirect.com/science/article/pii/S1097276526002753
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Vitamin B2 and B3 nutrigenomics reveals a therapy for NAXD disease

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1. scibot 01 May 2026
  
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  RRID:Addgene_73179-LV
  
  DOI: 10.1016/j.cell.2026.01.022
  
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sciencedirect.com/science/article/pii/S0092867426001091
Apr 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Genome-wide CRISPR screens identify DNA repair and R-loop suppression as regulators of the cellular sensitivity to environmentally relevant Bisphenol A exposure

1
1. scibot 21 Apr 2026
  
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  Addgene 73179
  
  DOI: 10.64898/2026.04.13.718249
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13105094/
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LENG8 mediates RNA nuclear retention and degradation in eukaryotes

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1. scibot 08 Apr 2026
  
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  73179
  
  DOI: 10.1016/j.molcel.2026.02.023
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13005043/
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ULK1 drives NDP52-mediated selective autophagic degradation of MHC-I to promote immune evasion in HPV-positive head and neck cancer

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1. scibot 08 Apr 2026
  
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  Addgene_73179
  
  DOI: 10.64898/2026.03.14.711071
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13015544/
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ADA2-deficient cells exhibit increased levels of cell death and metabolic disturbances

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1. scibot 02 Apr 2026
  
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  73179
  
  DOI: 10.1038/s41420-026-03027-9
  
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nature.com/articles/s41420-026-03027-9
Mar 2026
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RNF25 confers mRNA damage tolerance by curbing activation of the integrated stress response

1
1. scibot 24 Mar 2026
  
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  Addgene pooled library #73179
  
  DOI: 10.1016/j.molcel.2026.02.024
  
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sciencedirect.com/science/article/pii/S1097276526001383
Feb 2026
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Functional nutrient-genetic profiling reveals biotin and FBXW7 are essential to bypass glutamine addiction

1
1. scibot 26 Feb 2026
  
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  RRID:Addgene_73179
  
  DOI: 10.1016/j.molcel.2026.02.002
  
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sciencedirect.com/science/article/pii/S1097276526000973
Jan 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Genome-wide CRISPR screening reveals a PKA-driven resistance mechanism to metformin for oral cancer prevention that can be exploited by combination with NSAIDs

1
1. scibot 28 Jan 2026
  
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  RRID:Addgene_73179
  
  DOI: 10.1158/1940-6207.CAPR-25-0264
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12826122/
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A shear stress-responsive pathway in monocytes drives cardiopulmonary bypass-induced inflammation via spectrin/RAF1/store-operated calcium entry

1
1. scibot 27 Jan 2026
  
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  Addgene_73179
  
  DOI: 10.1016/j.celrep.2025.116903
  
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sciencedirect.com/science/article/pii/S2211124725016754
Oct 2025
www.nature.com www.nature.com

Inducible CRISPR–Cas9 screening platform to interrogate non-proliferative cellular states

1
1. scibot 23 Oct 2025
  
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  Addgene, cat. no. 73179
  
  DOI: 10.1038/s41596-025-01251-8
  
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nature.com/articles/s41596-025-01251-8
Aug 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

De novo pyrimidine biosynthesis inhibition synergizes with BCL-XL targeting in pancreatic cancer

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1. scibot 05 Aug 2025
  
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  Addgene_73179
  
  DOI: 10.1038/s41467-025-61242-x
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12311037/
Jul 2025
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An updated inventory of genes essential for oxidative phosphorylation identifies a mitochondrial origin in familial Ménière’s disease

1
1. scibot 29 Jul 2025
  
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  RRID:Addgene_73179
  
  DOI: 10.1016/j.celrep.2025.116069
  
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sciencedirect.com/science/article/pii/S221112472500840X
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HIF-independent oxygen sensing via KDM6A regulates ferroptosis

1
1. scibot 25 Jul 2025
  
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  Addgene_73179
  
  DOI: 10.1016/j.molcel.2025.07.001
  
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sciencedirect.com/science/article/pii/S1097276525005805
May 2025
febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com

E3 ubiquitin ligase RMND5A maintains the self-renewal state of human neural stem/precursor cells by regulating Wnt and mTOR signaling pathways

1
1. scibot 29 May 2025
  
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  Addgene_73179
  
  DOI: 10.1002/1873-3468.70067
  
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febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.70067
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

SFSWAP is a negative regulator of OGT intron detention and global pre-mRNA splicing

1
1. scibot 22 May 2025
  
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  Addgene_73179
  
  DOI: 10.7554/eLife.104439
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12017769/
Apr 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Cooperative role of PACT and ADAR1 in preventing aberrant PKR activation by self-derived double-stranded RNA

1
1. scibot 07 Apr 2025
  
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  Addgene_73179
  
  DOI: 10.1038/s41467-025-58412-2
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11971382/
Mar 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

A genome-wide atlas of human cell morphology

1
1. scibot 23 Mar 2025
  
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  73179
  
  DOI: 10.1038/s41592-024-02537-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11903339/
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Spatial control of m6A deposition on enhancer and promoter RNAs through co-acetylation of METTL3 and H3K27 on chromatin

1
1. scibot 20 Mar 2025
  
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  Addgene_73179
  
  DOI: 10.1016/j.molcel.2025.02.016
  
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sciencedirect.com/science/article/pii/S1097276525001479
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Bone morphogenetic protein (BMP) signaling determines neuroblastoma cell fate and sensitivity to retinoic acid

1
1. scibot 11 Mar 2025
  
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  Addgene_73179
  
  DOI: 10.1038/s41467-025-57185-y
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11871043/
Feb 2025
www.sciencedirect.com www.sciencedirect.com

NSD2 drives t(4;14) myeloma cell dependence on adenylate kinase 2 by diverting one-carbon metabolism to the epigenome

1
1. scibot 20 Feb 2025
  
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  RRID:Addgene_73179
  
  DOI: 10.1182/blood.2023022859
  
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sciencedirect.com/science/article/pii/S0006497124009662
Dec 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

CRISPR knockout genome-wide screens identify the HELQ-RAD52 axis in regulating the repair of cisplatin-induced single-stranded DNA gaps

1
1. scibot 24 Dec 2024
  
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  73179
  
  DOI: 10.1093/nar/gkae998
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11662931/
academic.oup.com academic.oup.com

CAF-1 promotes efficient PrimPol recruitment to nascent DNA for single-stranded DNA gap formation

1
1. scibot 13 Dec 2024
  
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  Addgene 73 179
  
  DOI: 10.1093/nar/gkae1068
  
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academic.oup.com/nar/advance-article/doi/10.1093/nar/gkae1068/7903364
Sep 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Genome Engineering of Primary and Pluripotent Stem Cell-Derived Hepatocytes for Modeling Liver Tumor Formation

1
1. scibot 29 Sep 2024
  
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  73179
  
  DOI: 10.3390/biology13090684
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11428634/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Unbiased screening identifies regulators of cell-cell adhesion and treatment options in pemphigus

1
1. scibot 25 Sep 2024
  
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  73179
  
  DOI: 10.1038/s41467-024-51747-2
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11399147/
aacrjournals.org aacrjournals.org

Chromatin Rewiring by Mismatch Repair Protein MSH2 Alters Cell Adhesion Pathways and Sensitivity to BET Inhibition in Gastric Cancer

1
1. scibot 12 Sep 2024
  
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  RRID:Addgene_73179
  
  DOI: 10.1158/0008-5472.CAN-21-2072
  
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aacrjournals.org/cancerres/article/82/14/2538/706949/Chromatin-Rewiring-by-Mismatch-Repair-Protein-MSH2
Jun 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

SMAD4 depletion contributes to endocrine resistance by integrating ER and ERBB signaling in HR + HER2− breast cancer

1
1. scibot 30 Jun 2024
  
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  73179
  
  DOI: 10.1038/s41419-024-06838-9
  
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  Curator: @olekpark
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11196642/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Evolution of STAT2 resistance to flavivirus NS5 occurred multiple times despite genetic constraints

1
1. scibot 30 Jun 2024
  
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  Addgene_73179
  
  DOI: 10.1038/s41467-024-49758-0
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11208600/
May 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

CRISPR knockout genome-wide screens identify the HELQ-RAD52 axis in regulating the repair of cisplatin-induced single stranded DNA gaps

1
1. scibot 05 May 2024
  
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  73179
  
  DOI: 10.1101/2024.04.17.589988
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11042333/
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

An in vitro CRISPR screen of cell-free DNA identifies apoptosis as the primary mediator of cell-free DNA release

1
1. scibot 13 Apr 2024
  
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  73179
  
  DOI: 10.1038/s42003-024-06129-1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11006667/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Functional CRISPR screens in T cells reveal new opportunities for cancer immunotherapies

1
1. scibot 13 Apr 2024
  
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  Addgene_73179
  
  DOI: 10.1186/s12943-024-01987-z
  
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scibot

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ncbi.nlm.nih.gov/pmc/articles/PMC10996278/
Jun 2023
aacrjournals.org aacrjournals.org

(R)-2-hydroxyglutarate inhibits KDM5 histone lysine demethylases to drive transformation in IDH-mutant cancers

1
1. scibot 10 Jun 2023
  
  in Public
  
  RRID:Addgene_73179
  
  DOI: 10.1158/2159-8290.CD-22-0825
  
  Resource: RRID:Addgene_73179
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_73179
  
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  RRID:Addgene_73179
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aacrjournals.org/cancerdiscovery/article/13/6/1478/726967/R-2-Hydroxyglutarate-Inhibits-KDM5-Histone-Lysine
May 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The genomic landscape of sensitivity to arsenic trioxide uncovered by genome-wide CRISPR-Cas9 screening

1
1. scibot 31 May 2023
  
  in Public
  
  RRID:Addgene_73179
  
  DOI: 10.3389/fonc.2023.1178686
  
  Resource: RRID:Addgene_73179
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_73179
  
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  RRID:Addgene_73179
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ncbi.nlm.nih.gov/pmc/articles/PMC10214836/
Feb 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

CRISPR screening reveals a dependency on ribosome recycling for efficient SARS-CoV-2 programmed ribosomal frameshifting and viral replication

1
1. scibot 08 Feb 2023
  
  in Public
  
  RRID:Addgene_73179
  
  DOI: 10.1016/j.celrep.2023.112076
  
  Resource: RRID:Addgene_73179
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_73179
  
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  RRID:Addgene_73179
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ncbi.nlm.nih.gov/pmc/articles/PMC9884621/
Jun 2022
52.53.155.43 52.53.155.43

can-21-2072-html.html

1
1. scibot 30 Jun 2022
  
  in Public
  
  RRID:Addgene_73179
  
  DOI: 10.1158/0008-5472.can-21-2072
  
  Resource: RRID:Addgene_73179
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_73179
  
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  RRID:Addgene_73179
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52.53.155.43/170847d59a031feb550122423bcef303df6c67ab/can-21-2072-html.html
Apr 2022
www.nature.com www.nature.com

CHMP2A regulates tumor sensitivity to natural killer cell-mediated cytotoxicity

1
1. scibot 12 Apr 2022
  
  in Public
  
  Addgene_73179
  
  DOI: 10.1038/s41467-022-29469-0
  
  Resource: RRID:Addgene_73179
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_73179
  
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  RRID:Addgene_73179
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nature.com/articles/s41467-022-29469-0
May 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

SAM homeostasis is regulated by CFIm-mediated splicing of MAT2A

1
1. scibot 27 May 2021
  
  in Public
  
  Addgene_73179
  
  DOI: 10.7554/eLife.64930
  
  Resource: RRID:Addgene_73179
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_73179
  
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  RRID:Addgene_73179
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ncbi.nlm.nih.gov/pmc/articles/PMC8139829/
www.sciencedirect.com www.sciencedirect.com

The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer

1
1. scibot 18 May 2021
  
  in Public
  
  Addgene Cat#73179
  
  DOI: 10.1016/j.cell.2021.04.022
  
  Resource: RRID:Addgene_73179
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_73179
  
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  RRIDCUR:Missing RRID:Addgene_73179
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RRID:Addgene_73179

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sciencedirect.com/science/article/pii/S009286742100502X
Jan 2021
www.sciencedirect.com www.sciencedirect.com

Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins

1
1. scibot 07 Jan 2021
  
  in Public
  
  RRID:Addgene_73179
  
  DOI: 10.1016/j.celrep.2020.108532
  
  Resource: RRID:Addgene_73179
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_73179
  
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  RRIDCUR:Validated RRID:Addgene_73179
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RRIDCUR:Validated

RRID:Addgene_73179

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scibot

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sciencedirect.com/science/article/pii/S2211124720315217
Dec 2020
www.sciencedirect.com www.sciencedirect.com

Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q

1
1. scibot 17 Dec 2020
  
  in Public
  
  Brunello CRISPR-SpCas9 sgRNA library
  
  DOI: 10.1016/j.celrep.2020.108493
  
  Resource: RRID:Addgene_73179
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_73179
  
  Curator comments: Human sgRNA library Brunello in lentiCRISPRv2
  
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  RRID:Addgene_73179 RRIDCUR:Missing
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RRID:Addgene_73179

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scibot

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sciencedirect.com/science/article/pii/S2211124720314820
www.sciencedirect.com www.sciencedirect.com

Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD

1
1. scibot 17 Dec 2020
  
  in Public
  
  Addgene_73179
  
  DOI: 10.1016/j.molcel.2020.12.006
  
  Resource: RRID:Addgene_73179
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_73179
  
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  RRIDCUR:Validated RRID:Addgene_73179
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RRIDCUR:Validated

RRID:Addgene_73179

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sciencedirect.com/science/article/pii/S1097276520308984
Sep 2020
www.sciencedirect.com www.sciencedirect.com

Genome-Scale CRISPR Screening in Human Intestinal Organoids Identifies Drivers of TGF-β Resistance

1
1. scibot 16 Sep 2020
  
  in Public
  
  RRID:Addgene_73179
  
  DOI: 10.1016/j.stem.2020.02.007
  
  Resource: RRID:Addgene_73179
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:Addgene_73179
  
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  RRIDCUR:Validated RRID:Addgene_73179
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RRIDCUR:Validated

RRID:Addgene_73179

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scibot

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sciencedirect.com/science/article/pii/S1934590920300606
www.sciencedirect.com www.sciencedirect.com

Ribosome Recycling by ABCE1 Links Lysosomal Function and Iron Homeostasis to 3ʹ UTR-Directed Regulation and Nonsense-Mediated Decay

1
1. scibot 12 Sep 2020
  
  in Public
  
  Addgene_73179
  
  DOI: 10.1016/j.celrep.2020.107895
  
  Resource: RRID:Addgene_73179
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_73179
  
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  RRID:Addgene_73179 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:Addgene_73179

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scibot

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sciencedirect.com/science/article/pii/S2211124720308767
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A CRISPR knockout negative screen reveals synergy between CDKs inhibitor and metformin in the treatment of human cancer in vitro and in vivo

1
1. scibot 09 Sep 2020
  
  in Public
  
  RRID:Addgene_73179
  
  DOI: 10.1038/s41392-020-0203-1
  
  Resource: RRID:Addgene_73179
  
  Curator: @evieth
  
  SciCrunch record: RRID:Addgene_73179
  
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  RRID:Addgene_73179 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:Addgene_73179

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC7434905/