55 Matching Annotations
  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Ceritinib overcomes proteasome inhibitor resistance in multiple myeloma by suppressing the protein folding response
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    pmc.ncbi.nlm.nih.gov/articles/PMC13628017/
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    SPARCS enables scalable recovery of complex image-based phenotypes for genetic screening
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    sciencedirect.com/science/article/pii/S0092867426011232
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-wide CRISPR screens identify the EXO1-CAF-1 pathway suppressing R-loop-associated DNA damage
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    pmc.ncbi.nlm.nih.gov/articles/PMC12993451/
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SPEN inactivation drives resistance to androgen receptor pathway inhibitors in metastatic prostate cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13563593/
  6. Oct 2026
  7. www.sciencedirect.com www.sciencedirect.com
    Dual roles of host N-glycosylation in enteropathogenic Escherichia coli infection
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    sciencedirect.com/science/article/pii/S2211124726011216
  8. Aug 2026
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-wide CRISPR screening identifies cellular factors controlling nonviral genome editing efficiency
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    pmc.ncbi.nlm.nih.gov/articles/PMC13473100/
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Orthogonal CRISPR screens and human liver chimeric mice identify hepatitis B virus host factors
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    pmc.ncbi.nlm.nih.gov/articles/PMC13420443/
  11. Jul 2026
  12. www.nature.com www.nature.com
    FATP2-mediated lipid metabolism enhances chimeric antigen receptor T-cell therapy resistance in B-cell acute lymphoblastic leukemia
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    nature.com/articles/s41375-026-03030-0
  13. Jun 2026
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-wide CRISPR screens identify DNA repair and R-loop suppression as regulators of the cellular sensitivity to environmentally relevant Bisphenol A exposure
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    pmc.ncbi.nlm.nih.gov/articles/PMC13105094/
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Glucose restriction reprograms lipid metabolism and enhances immunotherapy through ZNRF3-Wnt-SCD signaling axis
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    pmc.ncbi.nlm.nih.gov/articles/PMC13239590/
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ZAP targets aberrant mRNA transcripts encoding proteins with defective signal peptides for degradation
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    pmc.ncbi.nlm.nih.gov/articles/PMC13084044/
  17. May 2026
  18. www.sciencedirect.com www.sciencedirect.com
    Intrinsic bias of the genetic code shapes the folding and stability landscapes of microproteins
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    sciencedirect.com/science/article/pii/S1097276526002753
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    Vitamin B2 and B3 nutrigenomics reveals a therapy for NAXD disease
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    sciencedirect.com/science/article/pii/S0092867426001091
  20. Apr 2026
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-wide CRISPR screens identify DNA repair and R-loop suppression as regulators of the cellular sensitivity to environmentally relevant Bisphenol A exposure
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    pmc.ncbi.nlm.nih.gov/articles/PMC13105094/
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    LENG8 mediates RNA nuclear retention and degradation in eukaryotes
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    pmc.ncbi.nlm.nih.gov/articles/PMC13005043/
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ULK1 drives NDP52-mediated selective autophagic degradation of MHC-I to promote immune evasion in HPV-positive head and neck cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13015544/
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    ADA2-deficient cells exhibit increased levels of cell death and metabolic disturbances
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    nature.com/articles/s41420-026-03027-9
  25. Mar 2026
  26. www.sciencedirect.com www.sciencedirect.com
    RNF25 confers mRNA damage tolerance by curbing activation of the integrated stress response
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    sciencedirect.com/science/article/pii/S1097276526001383
  27. Feb 2026
  28. www.sciencedirect.com www.sciencedirect.com
    Functional nutrient-genetic profiling reveals biotin and FBXW7 are essential to bypass glutamine addiction
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    sciencedirect.com/science/article/pii/S1097276526000973
  29. Jan 2026
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-wide CRISPR screening reveals a PKA-driven resistance mechanism to metformin for oral cancer prevention that can be exploited by combination with NSAIDs
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    pmc.ncbi.nlm.nih.gov/articles/PMC12826122/
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    A shear stress-responsive pathway in monocytes drives cardiopulmonary bypass-induced inflammation via spectrin/RAF1/store-operated calcium entry
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    sciencedirect.com/science/article/pii/S2211124725016754
  32. Oct 2025
  33. www.nature.com www.nature.com
    Inducible CRISPR–Cas9 screening platform to interrogate non-proliferative cellular states
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    nature.com/articles/s41596-025-01251-8
  34. Aug 2025
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    De novo pyrimidine biosynthesis inhibition synergizes with BCL-XL targeting in pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12311037/
  36. Jul 2025
  37. www.sciencedirect.com www.sciencedirect.com
    An updated inventory of genes essential for oxidative phosphorylation identifies a mitochondrial origin in familial Ménière’s disease
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    sciencedirect.com/science/article/pii/S221112472500840X
  38. www.sciencedirect.com www.sciencedirect.com
    HIF-independent oxygen sensing via KDM6A regulates ferroptosis
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    sciencedirect.com/science/article/pii/S1097276525005805
  39. May 2025
  40. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    E3 ubiquitin ligase RMND5A maintains the self-renewal state of human neural stem/precursor cells by regulating Wnt and mTOR signaling pathways
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    febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.70067
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SFSWAP is a negative regulator of OGT intron detention and global pre-mRNA splicing
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    pmc.ncbi.nlm.nih.gov/articles/PMC12017769/
  42. Apr 2025
  43. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cooperative role of PACT and ADAR1 in preventing aberrant PKR activation by self-derived double-stranded RNA
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    pmc.ncbi.nlm.nih.gov/articles/PMC11971382/
  44. Mar 2025
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A genome-wide atlas of human cell morphology
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    pmc.ncbi.nlm.nih.gov/articles/PMC11903339/
  46. www.sciencedirect.com www.sciencedirect.com
    Spatial control of m6A deposition on enhancer and promoter RNAs through co-acetylation of METTL3 and H3K27 on chromatin
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    sciencedirect.com/science/article/pii/S1097276525001479
  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Bone morphogenetic protein (BMP) signaling determines neuroblastoma cell fate and sensitivity to retinoic acid
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    pmc.ncbi.nlm.nih.gov/articles/PMC11871043/
  48. Feb 2025
  49. www.sciencedirect.com www.sciencedirect.com
    NSD2 drives t(4;14) myeloma cell dependence on adenylate kinase 2 by diverting one-carbon metabolism to the epigenome
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    sciencedirect.com/science/article/pii/S0006497124009662
  50. Dec 2024
  51. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CRISPR knockout genome-wide screens identify the HELQ-RAD52 axis in regulating the repair of cisplatin-induced single-stranded DNA gaps
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    pmc.ncbi.nlm.nih.gov/articles/PMC11662931/
  52. academic.oup.com academic.oup.com
    CAF-1 promotes efficient PrimPol recruitment to nascent DNA for single-stranded DNA gap formation
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    academic.oup.com/nar/advance-article/doi/10.1093/nar/gkae1068/7903364
  53. Sep 2024
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome Engineering of Primary and Pluripotent Stem Cell-Derived Hepatocytes for Modeling Liver Tumor Formation
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    ncbi.nlm.nih.gov/pmc/articles/PMC11428634/
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Unbiased screening identifies regulators of cell-cell adhesion and treatment options in pemphigus
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    ncbi.nlm.nih.gov/pmc/articles/PMC11399147/
  56. aacrjournals.org aacrjournals.org
    Chromatin Rewiring by Mismatch Repair Protein MSH2 Alters Cell Adhesion Pathways and Sensitivity to BET Inhibition in Gastric Cancer
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    aacrjournals.org/cancerres/article/82/14/2538/706949/Chromatin-Rewiring-by-Mismatch-Repair-Protein-MSH2
  57. Jun 2024
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SMAD4 depletion contributes to endocrine resistance by integrating ER and ERBB signaling in HR + HER2− breast cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11196642/
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Evolution of STAT2 resistance to flavivirus NS5 occurred multiple times despite genetic constraints
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    ncbi.nlm.nih.gov/pmc/articles/PMC11208600/
  60. May 2024
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR knockout genome-wide screens identify the HELQ-RAD52 axis in regulating the repair of cisplatin-induced single stranded DNA gaps
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    ncbi.nlm.nih.gov/pmc/articles/PMC11042333/
  62. Apr 2024
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An in vitro CRISPR screen of cell-free DNA identifies apoptosis as the primary mediator of cell-free DNA release
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    ncbi.nlm.nih.gov/pmc/articles/PMC11006667/
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functional CRISPR screens in T cells reveal new opportunities for cancer immunotherapies
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    ncbi.nlm.nih.gov/pmc/articles/PMC10996278/
  65. Jun 2023
  66. aacrjournals.org aacrjournals.org
    (R)-2-hydroxyglutarate inhibits KDM5 histone lysine demethylases to drive transformation in IDH-mutant cancers
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    aacrjournals.org/cancerdiscovery/article/13/6/1478/726967/R-2-Hydroxyglutarate-Inhibits-KDM5-Histone-Lysine
  67. May 2023
  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The genomic landscape of sensitivity to arsenic trioxide uncovered by genome-wide CRISPR-Cas9 screening
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    ncbi.nlm.nih.gov/pmc/articles/PMC10214836/
  69. Feb 2023
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR screening reveals a dependency on ribosome recycling for efficient SARS-CoV-2 programmed ribosomal frameshifting and viral replication
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    ncbi.nlm.nih.gov/pmc/articles/PMC9884621/
  71. Jun 2022
  72. 52.53.155.43 52.53.155.43
    can-21-2072-html.html
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  73. Apr 2022
  74. www.nature.com www.nature.com
    CHMP2A regulates tumor sensitivity to natural killer cell-mediated cytotoxicity
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    nature.com/articles/s41467-022-29469-0
  75. May 2021
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SAM homeostasis is regulated by CFIm-mediated splicing of MAT2A
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    ncbi.nlm.nih.gov/pmc/articles/PMC8139829/
  77. www.sciencedirect.com www.sciencedirect.com
    The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer
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    sciencedirect.com/science/article/pii/S009286742100502X
  78. Jan 2021
  79. www.sciencedirect.com www.sciencedirect.com
    Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins
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    sciencedirect.com/science/article/pii/S2211124720315217
  80. Dec 2020
  81. www.sciencedirect.com www.sciencedirect.com
    Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q
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    sciencedirect.com/science/article/pii/S2211124720314820
  82. www.sciencedirect.com www.sciencedirect.com
    Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD
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    sciencedirect.com/science/article/pii/S1097276520308984
  83. Sep 2020
  84. www.sciencedirect.com www.sciencedirect.com
    Genome-Scale CRISPR Screening in Human Intestinal Organoids Identifies Drivers of TGF-β Resistance
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    sciencedirect.com/science/article/pii/S1934590920300606
  85. www.sciencedirect.com www.sciencedirect.com
    Ribosome Recycling by ABCE1 Links Lysosomal Function and Iron Homeostasis to 3ʹ UTR-Directed Regulation and Nonsense-Mediated Decay
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    sciencedirect.com/science/article/pii/S2211124720308767
  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A CRISPR knockout negative screen reveals synergy between CDKs inhibitor and metformin in the treatment of human cancer in vitro and in vivo
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    ncbi.nlm.nih.gov/pmc/articles/PMC7434905/