36 Matching Annotations
  1. Jan 2026
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-wide CRISPR screening reveals a PKA-driven resistance mechanism to metformin for oral cancer prevention that can be exploited by combination with NSAIDs
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    pmc.ncbi.nlm.nih.gov/articles/PMC12826122/
  3. www.sciencedirect.com www.sciencedirect.com
    A shear stress-responsive pathway in monocytes drives cardiopulmonary bypass-induced inflammation via spectrin/RAF1/store-operated calcium entry
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    sciencedirect.com/science/article/pii/S2211124725016754
  4. Oct 2025
  5. www.nature.com www.nature.com
    Inducible CRISPR–Cas9 screening platform to interrogate non-proliferative cellular states
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    nature.com/articles/s41596-025-01251-8
  6. Aug 2025
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    De novo pyrimidine biosynthesis inhibition synergizes with BCL-XL targeting in pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12311037/
  8. Jul 2025
  9. www.sciencedirect.com www.sciencedirect.com
    An updated inventory of genes essential for oxidative phosphorylation identifies a mitochondrial origin in familial Ménière’s disease
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    sciencedirect.com/science/article/pii/S221112472500840X
  10. www.sciencedirect.com www.sciencedirect.com
    HIF-independent oxygen sensing via KDM6A regulates ferroptosis
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    sciencedirect.com/science/article/pii/S1097276525005805
  11. May 2025
  12. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    E3 ubiquitin ligase RMND5A maintains the self-renewal state of human neural stem/precursor cells by regulating Wnt and mTOR signaling pathways
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    febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.70067
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SFSWAP is a negative regulator of OGT intron detention and global pre-mRNA splicing
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    pmc.ncbi.nlm.nih.gov/articles/PMC12017769/
  14. Apr 2025
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cooperative role of PACT and ADAR1 in preventing aberrant PKR activation by self-derived double-stranded RNA
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    pmc.ncbi.nlm.nih.gov/articles/PMC11971382/
  16. Mar 2025
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A genome-wide atlas of human cell morphology
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    pmc.ncbi.nlm.nih.gov/articles/PMC11903339/
  18. www.sciencedirect.com www.sciencedirect.com
    Spatial control of m6A deposition on enhancer and promoter RNAs through co-acetylation of METTL3 and H3K27 on chromatin
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    sciencedirect.com/science/article/pii/S1097276525001479
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Bone morphogenetic protein (BMP) signaling determines neuroblastoma cell fate and sensitivity to retinoic acid
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    pmc.ncbi.nlm.nih.gov/articles/PMC11871043/
  20. Feb 2025
  21. www.sciencedirect.com www.sciencedirect.com
    NSD2 drives t(4;14) myeloma cell dependence on adenylate kinase 2 by diverting one-carbon metabolism to the epigenome
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    sciencedirect.com/science/article/pii/S0006497124009662
  22. Dec 2024
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CRISPR knockout genome-wide screens identify the HELQ-RAD52 axis in regulating the repair of cisplatin-induced single-stranded DNA gaps
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    pmc.ncbi.nlm.nih.gov/articles/PMC11662931/
  24. academic.oup.com academic.oup.com
    CAF-1 promotes efficient PrimPol recruitment to nascent DNA for single-stranded DNA gap formation
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    academic.oup.com/nar/advance-article/doi/10.1093/nar/gkae1068/7903364
  25. Sep 2024
  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome Engineering of Primary and Pluripotent Stem Cell-Derived Hepatocytes for Modeling Liver Tumor Formation
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11428634/
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Unbiased screening identifies regulators of cell-cell adhesion and treatment options in pemphigus
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11399147/
  28. aacrjournals.org aacrjournals.org
    Chromatin Rewiring by Mismatch Repair Protein MSH2 Alters Cell Adhesion Pathways and Sensitivity to BET Inhibition in Gastric Cancer
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    aacrjournals.org/cancerres/article/82/14/2538/706949/Chromatin-Rewiring-by-Mismatch-Repair-Protein-MSH2
  29. Jun 2024
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SMAD4 depletion contributes to endocrine resistance by integrating ER and ERBB signaling in HR + HER2− breast cancer
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11196642/
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Evolution of STAT2 resistance to flavivirus NS5 occurred multiple times despite genetic constraints
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11208600/
  32. May 2024
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR knockout genome-wide screens identify the HELQ-RAD52 axis in regulating the repair of cisplatin-induced single stranded DNA gaps
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11042333/
  34. Apr 2024
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An in vitro CRISPR screen of cell-free DNA identifies apoptosis as the primary mediator of cell-free DNA release
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11006667/
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functional CRISPR screens in T cells reveal new opportunities for cancer immunotherapies
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    ncbi.nlm.nih.gov/pmc/articles/PMC10996278/
  37. Jun 2023
  38. aacrjournals.org aacrjournals.org
    (R)-2-hydroxyglutarate inhibits KDM5 histone lysine demethylases to drive transformation in IDH-mutant cancers
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    aacrjournals.org/cancerdiscovery/article/13/6/1478/726967/R-2-Hydroxyglutarate-Inhibits-KDM5-Histone-Lysine
  39. May 2023
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The genomic landscape of sensitivity to arsenic trioxide uncovered by genome-wide CRISPR-Cas9 screening
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    ncbi.nlm.nih.gov/pmc/articles/PMC10214836/
  41. Feb 2023
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR screening reveals a dependency on ribosome recycling for efficient SARS-CoV-2 programmed ribosomal frameshifting and viral replication
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    ncbi.nlm.nih.gov/pmc/articles/PMC9884621/
  43. Jun 2022
  44. 52.53.155.43 52.53.155.43
    can-21-2072-html.html
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    52.53.155.43/170847d59a031feb550122423bcef303df6c67ab/can-21-2072-html.html
  45. Apr 2022
  46. www.nature.com www.nature.com
    CHMP2A regulates tumor sensitivity to natural killer cell-mediated cytotoxicity
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    nature.com/articles/s41467-022-29469-0
  47. May 2021
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SAM homeostasis is regulated by CFIm-mediated splicing of MAT2A
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    ncbi.nlm.nih.gov/pmc/articles/PMC8139829/
  49. www.sciencedirect.com www.sciencedirect.com
    The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer
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    sciencedirect.com/science/article/pii/S009286742100502X
  50. Jan 2021
  51. www.sciencedirect.com www.sciencedirect.com
    Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins
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    sciencedirect.com/science/article/pii/S2211124720315217
  52. Dec 2020
  53. www.sciencedirect.com www.sciencedirect.com
    Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q
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    sciencedirect.com/science/article/pii/S2211124720314820
  54. www.sciencedirect.com www.sciencedirect.com
    Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD
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    sciencedirect.com/science/article/pii/S1097276520308984
  55. Sep 2020
  56. www.sciencedirect.com www.sciencedirect.com
    Genome-Scale CRISPR Screening in Human Intestinal Organoids Identifies Drivers of TGF-β Resistance
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    sciencedirect.com/science/article/pii/S1934590920300606
  57. www.sciencedirect.com www.sciencedirect.com
    Ribosome Recycling by ABCE1 Links Lysosomal Function and Iron Homeostasis to 3ʹ UTR-Directed Regulation and Nonsense-Mediated Decay
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    sciencedirect.com/science/article/pii/S2211124720308767
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A CRISPR knockout negative screen reveals synergy between CDKs inhibitor and metformin in the treatment of human cancer in vitro and in vivo
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC7434905/