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The castration-resistant prostate cancer-associated SNP rs11067228 facilitates neuroendocrine differentiation through an enhancer-mediated chromatin interaction with SRRM4

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1. scibot 01 Feb 2026
  
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  75112
  
  DOI: 10.7150/ijbs.124731
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12837743/
Nov 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Reversion of passaged nucleus pulposus cells to notochordal-type cells by FoxA2 upregulation

1
1. scibot 24 Nov 2025
  
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  plasmid_75112
  
  DOI: 10.1038/s41536-025-00437-8
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12578846/
Oct 2025
www.nature.com www.nature.com

PRDM16 regulates smooth muscle cell identity and atherosclerotic plaque composition

1
1. scibot 23 Oct 2025
  
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  Addgene_75112
  
  DOI: 10.1038/s44161-025-00737-8
  
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nature.com/articles/s44161-025-00737-8
Sep 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Post-transcriptional control of KRAS: functional roles of 5′UTR RNA G-quadruplexes, long noncoding RNA, and hnRNPA1

1
1. scibot 22 Sep 2025
  
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  Addgene_75112
  
  DOI: 10.1093/nar/gkaf886
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12449053/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

A methyl-to-acetyl switch in H3K27 drives metabolic reprogramming and resistance to BRAFV600E inhibition in melanoma

1
1. scibot 22 Sep 2025
  
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  Addgene_75112
  
  DOI: 10.1016/j.neo.2025.101223
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12446969/
Jul 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Klf5-adjacent super-enhancer functions as a 3D genome structure-dependent transcriptional driver to safeguard ESC identity

1
1. scibot 20 Jul 2025
  
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  75112
  
  DOI: 10.1038/s41467-025-60389-x
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12215363/
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

RYBP promotes HIV-1 latency through promoting H2AK119ub and decreasing H3K4me3

1
1. scibot 17 May 2025
  
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  75112
  
  DOI: 10.1186/s12964-025-02221-z
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12070685/
Mar 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Lethal co-expression intolerance underlies the mutually exclusive expression of ASCL1 and NEUROD1 in SCLC cells

1
1. scibot 23 Mar 2025
  
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  75112
  
  DOI: 10.1038/s41698-025-00860-6
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11906894/
Feb 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

PRDM16 controls smooth muscle cell fate in atherosclerosis

1
1. scibot 28 Feb 2025
  
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  plasmid_75112
  
  DOI: 10.1101/2025.02.19.639186
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11870537/
Dec 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Direct cardiac reprogramming via combined CRISPRa-mediated endogenous Gata4 activation and exogenous Mef2c and Tbx5 expression

1
1. scibot 27 Dec 2024
  
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  75112
  
  DOI: 10.1016/j.omtn.2024.102390
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11666955/
Jul 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Precise excision of HTLV-1 provirus with a designer-recombinase

1
1. scibot 06 Jul 2024
  
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  RRID:Addgene_75112
  
  DOI: 10.1016/j.ymthe.2023.03.014
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10362392/
Jun 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Genome-wide in vivo CRISPR screen identifies TGFβ3 as actionable biomarker of palbociclib resistance in triple negative breast cancer

1
1. scibot 06 Jun 2024
  
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  75,112
  
  DOI: 10.1186/s12943-024-02029-4
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11145857/
Mar 2024
www.sciencedirect.com www.sciencedirect.com

The sirtuin-associated human senescence program converges on the activation of placenta-specific gene PAPPA

2
1. scibot 14 Mar 2024
  
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  plasmid_75112
  
  DOI: 10.1016/j.devcel.2024.02.008
  
  Resource: RRID:Addgene_75112
  
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  RRID:Addgene_75112
2. scibot 14 Mar 2024
  
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  plasmid_75112
  
  DOI: 10.1016/j.devcel.2024.02.008
  
  Resource: RRID:Addgene_75112
  
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sciencedirect.com/science/article/pii/S1534580724001072
Feb 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Surplus fatty acid synthesis increases oxidative stress in adipocytes and induces lipodystrophy

1
1. scibot 13 Feb 2024
  
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  75112
  
  DOI: 10.1038/s41467-023-44393-7
  
  Resource: RRID:Addgene_75112
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10761979/
Oct 2023
www.sciencedirect.com www.sciencedirect.com

Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation

1
1. scibot 28 Oct 2023
  
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  RRID:Addgene_75112
  
  DOI: 10.1016/j.stem.2023.09.007
  
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sciencedirect.com/science/article/pii/S1934590923003284
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

LINE-1 activation in the cerebellum drives ataxia

2
1. scibot 20 Oct 2023
  
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  Addgene #75112
  
  DOI: 10.1016/j.neuron.2022.08.011
  
  Resource: RRID:Addgene_75112
  
  Curator: @evieth
  
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  RRID:Addgene_75112
2. scibot 20 Oct 2023
  
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  RRID:Addgene_75112
  
  DOI: 10.1016/j.neuron.2022.08.011
  
  Resource: RRID:Addgene_75112
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9588660/
Jan 2023
www.sciencedirect.com www.sciencedirect.com

Resurrection of endogenous retroviruses during aging reinforces senescence

1
1. scibot 07 Jan 2023
  
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  plasmid_75112
  
  DOI: 10.1016/j.cell.2022.12.017
  
  Resource: RRID:Addgene_75112
  
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sciencedirect.com/science/article/pii/S0092867422015306
May 2022
www.nature.com www.nature.com

Transcription Factor 4 loss-of-function is associated with deficits in progenitor proliferation and cortical neuron content

1
1. scibot 03 May 2022
  
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  RRID:Addgene_75112
  
  DOI: 10.1038/s41467-022-29942-w
  
  Resource: RRID:Addgene_75112
  
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nature.com/articles/s41467-022-29942-w
Feb 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Correction of a Factor VIII genomic inversion with designer-recombinases

1
1. scibot 08 Feb 2022
  
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  RRID:Addgene_75112
  
  DOI: 10.1038/s41467-022-28080-7
  
  Resource: RRID:Addgene_75112
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8776779/
May 2021
www.sciencedirect.com www.sciencedirect.com

Non-canonical Targets of HIF1a Impair Oligodendrocyte Progenitor Cell Function

1
1. scibot 09 May 2021
  
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  RRID:Addgene_75112
  
  DOI: 10.1016/j.stem.2020.09.019
  
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sciencedirect.com/science/article/pii/S193459092030494X
www.sciencedirect.com www.sciencedirect.com

A Single-Cell Transcriptomic Atlas of Human Skin Aging

1
1. scibot 05 May 2021
  
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  plasmid_75112
  
  DOI: 10.1016/j.devcel.2020.11.002
  
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sciencedirect.com/science/article/pii/S1534580720308777
Sep 2020
www.sciencedirect.com www.sciencedirect.com

Cell Type-Specific Intralocus Interactions Reveal Oligodendrocyte Mechanisms in MS

1
1. scibot 04 Sep 2020
  
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  RRID:Addgene_75112
  
  DOI: 10.1016/j.cell.2020.03.002
  
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  Curator: @ethanbadger
  
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  RRIDCUR:Validated RRID:Addgene_75112
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sciencedirect.com/science/article/pii/S0092867420302646
Jan 2020
www.sciencedirect.com www.sciencedirect.com

BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis

1
1. scibot 13 Jan 2020
  
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  RRID:Addgene_75112
  
  DOI: 10.1016/j.cell.2019.06.005
  
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  Curator: @ethanbadger
  
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  RRID:Addgene_75112 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S0092867419306336