Hypothesis

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Last 7 days
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

NEK7 Cys298 is important for NLRP3 inflammasome and targetable by dimethyl fumarate

1
1. scibot 10 Jun 2026
  
  in Public
  
  plasmid_75127
  
  DOI: 10.1016/j.chembiol.2026.03.016
  
  Resource: RRID:Addgene_75127
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_75127
  
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  RRID:Addgene_75127
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RRID:Addgene_75127

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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC13108522/
Feb 2026
www.sciencedirect.com www.sciencedirect.com

Aerobic glycolysis promotes NLRP3 inflammasome activation via NLRP3 lactylation

1
1. scibot 05 Feb 2026
  
  in Public
  
  RRID:Addgene_75127
  
  DOI: 10.1016/j.chembiol.2026.01.003
  
  Resource: RRID:Addgene_75127
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_75127
  
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  RRID:Addgene_75127
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RRID:Addgene_75127

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scibot

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sciencedirect.com/science/article/pii/S2451945626000231
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

A bacterial network of T3SS effectors counteracts host pro-inflammatory responses and cell death to promote infection

1
1. scibot 19 May 2025
  
  in Public
  
  RRID:Addgene_75127
  
  DOI: 10.1038/s44318-025-00412-5
  
  Resource: RRID:Addgene_75127
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_75127
  
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  RRID:Addgene_75127
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RRID:Addgene_75127

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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC12048508/
Jul 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

NLRP3, NLRP6, and NLRP12 are inflammasomes with distinct expression patterns

1
1. scibot 31 Jul 2024
  
  in Public
  
  Addgene_75127
  
  DOI: 10.3389/fimmu.2024.1418290
  
  Resource: Addgene_75127
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_75127
  
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  RRID:Addgene_75127
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RRID:Addgene_75127

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scibot

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ncbi.nlm.nih.gov/pmc/articles/PMC11284034/
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Design and discovery of novel NLRP3 inhibitors and PET imaging radiotracers based on a 1,2,3-triazole bearing scaffold

1
1. scibot 14 Apr 2024
  
  in Public
  
  Addgene_75127
  
  DOI: 10.1021/acs.jmedchem.3c01782
  
  Resource: RRID:Addgene_75127
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_75127
  
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  RRID:Addgene_75127
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scibot

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ncbi.nlm.nih.gov/pmc/articles/PMC11002996/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

NLRP3 Cys126 palmitoylation by ZDHHC7 promotes inflammasome activation

3
1. scibot 09 Apr 2024
  
  in Public
  
  Addgene plasmid # 75127.
  
  DOI: 10.1016/j.celrep.2024.114070
  
  Resource: RRID:Addgene_75127
  
  Curator: @abever99
  
  SciCrunch record: RRID:Addgene_75127
  
  What is this?
  
  RRID:Addgene_75127
2. scibot 09 Apr 2024
  
  in Public
  
  plasmid_75127
  
  DOI: 10.1016/j.celrep.2024.114070
  
  Resource: RRID:Addgene_75127
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_75127
  
  What is this?
  
  RRID:Addgene_75127
3. scibot 09 Apr 2024
  
  in Public
  
  plasmid_75127
  
  DOI: 10.1016/j.celrep.2024.114070
  
  Resource: RRID:Addgene_75127
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_75127
  
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  RRID:Addgene_75127
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RRID:Addgene_75127

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scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC11130711/
Nov 2023
www.biorxiv.org www.biorxiv.org

NLRP3 Cys126 palmitoylation by ZDHHC7 Promotes Inflammasome Activation

1
1. scibot 17 Nov 2023
  
  in Public
  
  plasmid_75127
  
  DOI: 10.1101/2023.11.07.566005
  
  Resource: RRID:Addgene_75127
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_75127
  
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  RRID:Addgene_75127
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RRID:Addgene_75127

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scibot

URL

biorxiv.org/content/10.1101/2023.11.07.566005v1
Jun 2023
www.sciencedirect.com www.sciencedirect.com

Secreted ORF8 induces monocytic pro-inflammatory cytokines through NLRP3 pathways in severe patients with COVID-19

1
1. scibot 02 Jun 2023
  
  in Public
  
  RRID:Addgene_75127
  
  DOI: 10.1016/j.isci.2023.106929
  
  Resource: RRID:Addgene_75127
  
  Curator: @jmitrevska
  
  SciCrunch record: RRID:Addgene_75127
  
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  RRID:Addgene_75127
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RRID:Addgene_75127

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scibot

URL

sciencedirect.com/science/article/pii/S2589004223010064
Jun 2022
www.sciencedirect.com www.sciencedirect.com

Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson’s disease

1
1. scibot 02 Jun 2022
  
  in Public
  
  Addgene Cat# 75127
  
  DOI: 10.1016/j.neuron.2022.05.009
  
  Resource: RRID:Addgene_75127
  
  Curator: @sophiastull
  
  SciCrunch record: RRID:Addgene_75127
  
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  RRID:Addgene_75127
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RRID:Addgene_75127

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scibot

URL

sciencedirect.com/science/article/pii/S0896627322004500
Oct 2021
www.sciencedirect.com www.sciencedirect.com

Peli1 facilitates NLRP3 inflammasome activation by mediating ASC ubiquitination

1
1. scibot 30 Oct 2021
  
  in Public
  
  plasmid_75127
  
  DOI: 10.1016/j.celrep.2021.109904
  
  Resource: RRID:Addgene_75127
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_75127
  
  What is this?
  
  RRID:Addgene_75127
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RRID:Addgene_75127

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scibot

URL

sciencedirect.com/science/article/pii/S2211124721013747
Sep 2020
www.sciencedirect.com www.sciencedirect.com

The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation

1
1. scibot 03 Sep 2020
  
  in Public
  
  FLAG-NLRP3
  
  DOI: 10.1016/j.cmet.2020.07.016
  
  Resource: RRID:Addgene_75127
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_75127
  
  Curator comments: pcDNA3-N-Flag-NLRP3
  
  What is this?
  
  RRID:Addgene_75127 RRIDCUR:Missing
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RRID:Addgene_75127

RRIDCUR:Missing

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scibot

URL

sciencedirect.com/science/article/pii/S1550413120304113
Jan 2020
www.sciencedirect.com www.sciencedirect.com

Cell Survival and Cytokine Release after Inflammasome Activation Is Regulated by the Toll-IL-1R Protein SARM

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:Addgene_75127
  
  DOI: 10.1016/j.immuni.2019.04.005
  
  Resource: RRID:Addgene_75127
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:Addgene_75127
  
  What is this?
  
  RRID:Addgene_75127 RRIDCUR:Validated
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RRID:Addgene_75127

RRIDCUR:Validated

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scibot

URL

sciencedirect.com/science/article/pii/S1074761319301852